Journal of endocrinology and thyroid research最新文献

{"title":"Effect of Circuit Training on Resting Blood Pressure: An Experimental Study in Hypertensive Older Women","authors":"Diogo Cardozo","doi":"10.19080/JETR.2020.05.555668","DOIUrl":"https://doi.org/10.19080/JETR.2020.05.555668","url":null,"abstract":"Background: Hypertension is considered a primary risk factor for heart disease in the elderly. However, strength training can help control blood pressure levels. Methods: Twenty elderly hypertensive women (73.6 ± 8.1 years, 61.6 ± 11.8 kg, 153.3 ± 5.8 cm) were recruited to participate in this study. All of them underwent resting blood pressure, anthropometric and muscle strength measurements. The training protocol was performed in a circuit (CT), with three sets of 8 to 10 repetitions with 30-second intervals between sets and 1 minute between sequences. Training was performed twice a week for twelve weeks. The exercises were performed following this sequence: leg press, bench press, knee extension, lat pulldown, plantar flexion, and triceps extension. Results: After 12 weeks of CT, significant improvements in body composition (p≤0.05), increased levels of muscle strength (p = 0.001) and reduced systolic blood pressure (p = 0.001) were observed. There were no differences in body weight, BMI, and diastolic blood pressure (p = ≥0.05). Conclusion: The CT protocol is efficient for improving physical conditioning and reducing systolic blood pressure in hypertensive older women.","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48885877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid Involvement in Eosinophilic Granulomatosis with Polyangiitis","authors":"S. Bouomrani","doi":"10.19080/jetr.2020.05.555667","DOIUrl":"https://doi.org/10.19080/jetr.2020.05.555667","url":null,"abstract":"Thyroid disorders are among the most frequent endocrine pathologies with an overall prevalence estimated at 10%. Autoimmunity plays a crucial role in most thyroid dysfunctions, which explains the frequent associations with other autoimmune diseases. Eosinophilic granulomatosis with polyangiitis (EGPA) (formerly Churg-Strauss syndrome) is a necrotizing systemic vasculitis of small-sized vessels specifically associated with antineutrophil cytoplasmic antibodies (ANCA). Thyroid involvement is exceptional and uncommon in association with systemic vasculitis. It has not been previously reported during EGPA. We discuss the possible theoretical mechanisms of thyroid dysfunction that can be seen during this systemic angiitis.","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45725814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discriminating Bangladesh Adults by the Prevalence of Diabetic Elevated Blood Pressure","authors":"K. C Bhuyan","doi":"10.19080/jetr.2020.05.555666","DOIUrl":"https://doi.org/10.19080/jetr.2020.05.555666","url":null,"abstract":"The analytical results presented here were based on data collected from 960 adults of ages 18 years and above residing in both urban and rural areas of Bangladesh. The data were collected by some doctors and nurses from and nearby their working places according to quota sampling plan. The objective of the study was to investigate the impacts of different socioeconomic variables on simultaneous sufferings of adults from diabetes and high blood pressure and to identify the most responsible variables to discriminate the sufferer and non-sufferer adults. The analysis indicated that 5.4 percent adults were simultaneously suffering from both diabetes and elevated high pressure. The most responsible variable for the diseases was duration of the disease followed by wasting time by sedentary activities, body mass index, age, habit of taking can food and restaurant food, etc. These variables were identified by discriminant analysis.","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47821892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Physical and Mental Development of Children with Diffusive Goiter in the State of Euthyroidism","authors":"Jafarova Parvina Bakhodurovna","doi":"10.19080/jetr.2019.05.555652","DOIUrl":"https://doi.org/10.19080/jetr.2019.05.555652","url":null,"abstract":"","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46776200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidepressant and Stabilizing Effects of Thyroid Hormone Augmentation in Women’s Mood Disorders","authors":"Barbara L Parry","doi":"10.19080/jetr.2020.05.555663","DOIUrl":"https://doi.org/10.19080/jetr.2020.05.555663","url":null,"abstract":"Women are at increased risk for new onsets and recurrences of depressive illness that may occur at puberty, with oral contraceptive use, premenstrual, peripartum and at the perimenopause. Women also may develop thyroid disease during these times of reproductive hormonal change. For patients who develop mood disorders, most studies indicate that thyroid augmentation has the potential to enhance the response to antidepressant medication and to stabilize the mood disorder, particularly in women. Herein, we review the history of using thyroid supplements to enhance antidepressant responses, propose potential mechanisms, and provide selected case reports and prescription guidelines. In sum, thyroid augmentation strategies provide a high likelihood of significant clinical benefit, with relatively minor risks: For treatment-resistant depression, triiodothyronine (T3) (25-50 ug) tends to enhance antidepressant effects more than levothyroxine (T4), works best as an adjunctive agent rather than as monotherapy, is more efficacious in women than in men, and the antidepressant benefits may be observed in the context of euthyroid status. In women prone to rapid-cycling mood disorders, T4 has been shown to stabilize the potentially devastating rapid cycles of mood that occur in this severe form of bipolar illness. The aim of this report is to increase clinician awareness of these treatment strategies to enhance the well-being of women during their lifecycle, as untreated depressions may impair the optimal functioning and quality of life of the woman, deterring her ability to make valuable contributions to her family and society, and potentially leading to increased frequency, severity and more treatment-resistant depressive episodes.","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43390554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin Inhibitory Effects on Forming Brain Tumor","authors":"S. Khodadadi","doi":"10.19080/JETR.2020.05.555664","DOIUrl":"https://doi.org/10.19080/JETR.2020.05.555664","url":null,"abstract":"Melatonin is a neurohormone secreted by the pineal and extra pineal organs with oncostatic and tumor inhibitory effects. There is considerable evidence that melatonin may be of use in the prevention and treatment of cancer. This manuscript will review some of the underlying molecular mechanisms by melatonin’s antitumor properties with emphasizing on the formation of brain tumors.","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45730711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperglycemia Management for the Non-Eating Hospitalized Patient","authors":"A. Thanopoulou","doi":"10.19080/JETR.2020.05.555661","DOIUrl":"https://doi.org/10.19080/JETR.2020.05.555661","url":null,"abstract":"Hyperglycemia in the hospital setting is a common phenomenon and it may reflect already known diabetes, previously unrecognized diabetes or acute illness-hospital related hyperglycemia. It is well known that treatment of in-hospital hyperglycemia has beneficial effects on the shortand long-term outcomes for the patients. The not-eating hospitalized patients should be preferably treated with continuous intravenous glucose and insulin infusion, in order to benefit from the antihyperglycemic and anabolic effects of insulin. The subcutaneous insulin regimes are not preferred, because intravenous insulin can be titrated more quickly and precisely, making the risk of hyperor hypo-glycemia less likely. It should be noticed that glucose derangements are very easy to happen in a hospitalized patient, because of the illness per se, of the alterations in the co-administered regiment, etc. In conclusion, algorithms for the treatment of hospitalized, “noteating” patients, especially algorithms addressed to non-diabetesspecialist doctors, should focus on continuous intravenous insulin infusion based on frequent bedside glucose measurements, in order to achieve optimal glucose control.","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49053077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2-the Unforeseen Peril of David Winning Against Goliath: the Immune Giant Collapsing Under Its Own Rampaging Cytokine Storm","authors":"Xanya Sofra","doi":"10.30564/JER.V2I1.2517","DOIUrl":"https://doi.org/10.30564/JER.V2I1.2517","url":null,"abstract":"We examined SARS-CoV-2 (Covid-19) available treatments and prophylactic methods that included interventions associated with inhibiting the “type II transmembrane serine protease” (TMPRSS2) to limit the fusion between the Covid-19 Spike proteins and ACE2 receptors, or newly developed therapeutics like Remdesivir that interferes with the viral RNA replication. We explored the dilemma of ACE2 receptors that have a protective function against high blood pressure associated disorders, yet,they serve as the viral points of entry, elevating the probability of infection. Human tissues’ analysis reveals a higher ACE2 expression in adipose tissue, placing obesity-related conditions in the eye of the pandemic storm. It primarily exposes males due to the surge of ACE2 receptors in the testes along with other tissues. Males manifest a relatively higher positive ACE2 orrelations with certain immune cells in the lungs,thyroid, adrenals, liver and colon, while females evidence higher ACE2 correlations with immune cells in the heart. The remaining tissues’ ACE2/immunity expressions are equivalent in both sexes, indicating that despite its preference for males, the threat of Covid-19 can easily target females.Recent reports indicate that Covid-19 is empowered by hindering the critical process of viral recognition during the adaptive immune response leading to the “cytokine storm”, the aggravated immune response that indiscriminately perseveres, rampaging the host’s vital organs. Sedentary lifestyle, age-related hormonal imbalance, and adiposity induced inflammation predispose the body to the immune collapse following Covid-19 invasion, spotlighting the detrimental aftermath of metabolic dysfunction,and excess food consumption provoked by elevated cortisol and dysregulated appetite hormones. ACE 2 expression is suppressed in the skeletal muscle, rendering fitness and weight management an effective Covid-19 preventive intervention, along with social distancing, hygiene, and facial coverings. Physical activity, or exercise alternative methods have recently demonstrated statistically significant reductions of the inflammatory marker C-Reactive Protein (CRP), triglycerides, visceral fat, cortisol and the orexigenic hormone ghrelin, juxtaposed by optimal increases of IGF-1, skeletal muscle mass, Free T3, HDL, and the anorexic hormone leptin.","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86704220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Disorders and Obesity: How Related are These Patologies?","authors":"M. Rodríguez Pérez","doi":"10.19080/jetr.2019.05.555659","DOIUrl":"https://doi.org/10.19080/jetr.2019.05.555659","url":null,"abstract":"","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45352485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on Thyroid Disorders, Epidemiology and Treatment Methods","authors":"R. R. Pamuru","doi":"10.30564/jer.v1i2.1241","DOIUrl":"https://doi.org/10.30564/jer.v1i2.1241","url":null,"abstract":"Thyroid disorders are common overwhelming health conditions reported worldwide. The prevalence of thyroid disorders such as hypothyroidism and hyperthyroidism is increasing in developed and developing countries including India. This is due to change in traditional foods to Besides low/insufficient iodine intake, smoking, ageing, genetic susceptibility, lifestyle, usage of new medicine, endocrine disrupting chemicals and immune status of an individual are the key determinants for thyroid disorders. This review emphasizes the various disorders of thyroid gland and, its epidemiology and treatment methods.","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86492435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}