{"title":"Ectopic Thyroid with Multinodular Goiter-Case Report","authors":"Gabriela Mintegui","doi":"10.19080/jetr.2023.07.555706","DOIUrl":"https://doi.org/10.19080/jetr.2023.07.555706","url":null,"abstract":"","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46836833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cortisol Response in Breast Cancer: The Role of Physical Activity and Exercise","authors":"Margarida Marinho, Sílvia Rocha Rodrigues","doi":"10.30564/jer.v4i2.4943","DOIUrl":"https://doi.org/10.30564/jer.v4i2.4943","url":null,"abstract":"Chronic stress is a consistent sense of feeling pressured and overwhelmedfor a long period of time and it has been defined as a maladaptive state thatis associated with altered hypothalamic pituitary adrenal (HPA) axis. Thehyperactivity of the HPA axis is commonly assessed by cortisol levels.Physical activity (PA) and exercise have been demonstrated to regulatecortisol patterns in different healthy study populations, but also in BCpatients and survivors. The PA and exercise are related but have distinctconcepts that are commonly misused. Nowadays, the regular practice of PAand exercise has been widely recognized as one main strategy to managechronic stress and its related markers, like cortisol, remains elusive. In thepresent review, the authors focused on the evidence of the PA and exerciseon cortisol patterns of BC patients and survivors.","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76634168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluating the Effect of Irisin on Obesity-Concerning Physical Activity","authors":"O. Oral, Pınar Tatlıbal, Evangelia Stavropoulou","doi":"10.30564/jer.v4i2.4955","DOIUrl":"https://doi.org/10.30564/jer.v4i2.4955","url":null,"abstract":"Background: The study aims to investigate and evaluate the impactof irisin on physical activity and obesity. Materials and Methods: Inthe search for scientific literature related to this review the US NationalLibrary of Medicine (PubMed) used MEDLINE and SportDiscus dataand the terms “irisin”, “physical activity”, and “obesity”, were used. Therelevant literature has also taken its source from the research of relevantarticles from reference lists derived from data studies. Results: Irisin, anemerging myokine in the scientific community, has received high attentionas a potential contributor to obesity. This hormone is also associated withphysical activity. Conclusions: Irisin was recently identified as a myokineknown to respond to physical activity. Adequate recognition of thishormone may play an active role in the prevention and treatment of obesity.","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77502095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Ahi, Mohsen Adelpour, Bahareh Haghdoost, A. Jaberi
{"title":"Do Endocrinopathies Differ in Most Prevalent Hemoglobinopathy of Middle East: Beta-thalassemia?","authors":"S. Ahi, Mohsen Adelpour, Bahareh Haghdoost, A. Jaberi","doi":"10.30564/jer.v4i2.4888","DOIUrl":"https://doi.org/10.30564/jer.v4i2.4888","url":null,"abstract":"Repeated blood transfusions in thalassemia patients is followed by endocrinopathies as diabetes, hypothyroidism, hypogonadism, hypoparathyroidism, and disorders in calcium and vitamin D homeostasis. The aimof this study was to evaluate the association of beta-thalassemia patientsendocrinopathies and osteoporosis. Serum level of some factors related tothe function of gonads, thyroid, adrenal, and pancreas along with serumlevels of calcium, phosphate, albumin, vitamin D, and iron were measured.Bone marrow density was tested via dual-energy x-ray absorptiometry(DXA densitometry). In this study, 56 patients with major thalassemia wereinvestigated. Paraclinical analysis indicated osteopenia in 17 (30.4%) andosteoporosis in 39 patients (69.6%) in addition to other types of endocrinedisorders, such as hypogonadism in 29 (51.8%), hypothyroidism in 13(23.2%), hypoparathyroidism in 1 (1.8%), hypocortisolism in 2 (3.6%), anddiabetes in 9 (16.1%) patients. Endocrinopathies had no significant relationship with osteoporosis and osteopenia in men. However, hypogonadismhad a significant relationship with osteoporosis and osteopenia in womenwith thalassemia. Estradiol level was lower in women with osteoporosisin comparison with women with osteopenia. Ferritin levels had neitherassociation with osteoporosis nor with LH levels (P>0.05). Secondary hypogonadism disorders are the main causes of osteoporosis and osteopeniain female beta-thalassemia patients.","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":"108 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80844461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José Filipe Melo, G. Borrecho, N. Martínez-Sánchez, F. Tortosa
{"title":"Histopathological Characteristics of Folliculo-stellate Cells in Pituitary Glands of Wild Type, Obese and High-fat Diet Induced Mice","authors":"José Filipe Melo, G. Borrecho, N. Martínez-Sánchez, F. Tortosa","doi":"10.30564/jer.v4i2.4426","DOIUrl":"https://doi.org/10.30564/jer.v4i2.4426","url":null,"abstract":"The anterior pituitary gland regulates growth, metabolism, and reproductionby secreting hormones. Folliculo-stellate cells (FSC) are non-endocrinecells located among hormone-producing cells in the anterior pituitaryglands, but little is known about the exact roles of those cells. Although,with their net organization, they seem to have an important role in thehormonal cells regulation and maintenance. In this work, the first ever made in this area, 33 pituitaries of three groupsof mice (18 wild type [WT], 11 genetically obese [OB] and 4 under a highfat diet [HFD]) were studied in order to determine if there was any relationbetween the number of FSC and alterations of the basal metabolism in eachgroup of mice. For that, immunohistochemical staining using the S-100protein was used and also the Image-J software, to calculate the percentageof FSC present in each sample. The authors found that, although there wasn’t any significant differencebetween WT and OB mice, the group of HFD mice tend to havesubstantially higher percentage of FSC than the mice from other groups.This might suggest some yet unknown link between diet, precisely with ahigh-fat diet, and the presentation of FSC in the anterior pituitary.","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89451128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Role of Vitamin D on Thyroid Antibodies in Patients with Chronic Autoimmune Thyroiditis","authors":"N. Turashvili, L. Javashvili, E. Giorgadze","doi":"10.30564/jer.v4i1.4408","DOIUrl":"https://doi.org/10.30564/jer.v4i1.4408","url":null,"abstract":"Vitamin D deficiency is a global problem, which has taken the form of apandemic. Existing data indicate that vitamin D is not only a nutrient. Ithas also a hormone-specific activity. Vitamin D is characterized by antiinflammatory and immunomodulatory properties. Chronic autoimmunethyroiditis is a disease of autoimmune genesis, in which lymphocyticinfiltration gradually destroys thyroid tissue. There are some evidencesabout vitamin D deficiency and the development of chronic autoimmunethyroiditis. The article has reviewed the current literature about the impactand the benefits of vitamin D on thyroid antibodies levels.","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":"109 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79547295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lessons from Immune Escape Mechanisms of Embryo Development in Uterus","authors":"Shuang Zhang","doi":"10.30564/jer.v4i1.4356","DOIUrl":"https://doi.org/10.30564/jer.v4i1.4356","url":null,"abstract":"The development of semi-allogenic embryo in uterus during pregnancy is an immunological paradox, the im - mune tolerance in the fetomaternal interface is naturally established to prevent the embryo rejection. Solid tumors exist as a “new life” develop years, employ local or distant body nutrients to adapt, grow and metastasize to different organs of host. The development of embryo and tumor shares numerous similarities across the immune landscape and microenvironmental factors. Lessons from embryo development can increase our understanding on tumorigenesis and its components that could potentially transform anticancer therapeutic interventions","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76151390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Geneş, Z. Pekkolay, Mehmet Şimşek, H. Saraçoğlu, M. Turgut, A. Tuzcu
{"title":"Importance and Risk Prediction of ABO Blood Group and Rh Factor in Papillary Thyroid Cancer","authors":"D. Geneş, Z. Pekkolay, Mehmet Şimşek, H. Saraçoğlu, M. Turgut, A. Tuzcu","doi":"10.30564/jer.v4i1.4133","DOIUrl":"https://doi.org/10.30564/jer.v4i1.4133","url":null,"abstract":"Objective: There are limited data in the literature regarding the potentialrelationship between thyroid cancer and ABO blood types and Rh factor.The aim of our study was to investigate whether papillary thyroid cancer(PTC) is associated with blood type.Materials and Methods: The present study included patients who presented to Dicle University Faculty of Medicine between June 2009 andDecember 2020 and were diagnosed with PTC as a result of postoperative(thyroidectomy) histopathological analysis. The control group consisted ofindividuals whose blood type was analyzed at a random blood center.Results: Of the 223 patients diagnosed with PTC, 163 (73.1%) were females and 60 (26.9%) were males. In the comparison of patients based onABO blood types and Rh factor, A Rh positive blood type was found 31%less frequently in the PTC group compared with the control group, and thusit was associated with a lower risk of PTC (OR:0.69; 95% Confidence Interval: 0.50–0.96, p=0.029).Conclusions: In our study, we found A Rh positive blood type to be significantly less frequent among patients with PTC. A Rh positive blood type canbe considered as a protective factor indicating a reduced risk of PTC.","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90599463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stress Hyperglycemia: A Problem that Cannot be Ignored","authors":"Daxu Peng, Yifan Zhang, Xiuyang Cao, J. Pu","doi":"10.30564/jer.v4i1.3293","DOIUrl":"https://doi.org/10.30564/jer.v4i1.3293","url":null,"abstract":"Stress hyperglycemia is a strong neuroendocrine reaction in thehypothalamic pituitary adrenal cortex under severe infection, trauma, burns,hemorrhage, surgery and other harmful stimulated, resulting in increasedsecretion of counter-regulatory hormones. These hormones promotedthe production of sugar and cause glucose metabolism disorders withcytokines and insulin resistance. In this condition, the production of sugarexceeds the utilization of sugar by the tissues, which eventually leads to anincrease in blood glucose levels in plasma. In the intensive care unit, stresshyperglycemia is very common and can occur in patients with or withoutdiabetes. The incidence is as high as 96%, and it is an independent factorin the death of critically ill patients. Hyperglycemia not only prolongsthe hospitalization time, mechanical ventilation time and increased theincidence of serious infections in critically ill patients, but can also leadto the occurrence of type 2 diabetes. Therefore, it is very important tolearn the pathological mechanism of stress hyperglycemia, the harm ofhyperglycemia and blood sugar management.","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87775479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IGF-1-PI3K-Akt-mTOR and Myostatin-SMAD3 Pathways Signaling for Muscle Hypertophy","authors":"Marco Machado","doi":"10.19080/jetr.2021.06.555689","DOIUrl":"https://doi.org/10.19080/jetr.2021.06.555689","url":null,"abstract":"The control of muscle mass depends mainly on the action of two signaling pathways: IGF-1 axis and Myostatin. While one (IGF-1) signals increases in protein synthesis, the other (myostatin) acts by inhibiting muscle growth. The interaction of these signaling pathways with other mechanisms determines muscle mass. Furthermore, an important player in the process are the satellite cells in a dependente or non-dependent way to hypertrophy process.","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45843531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}