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A Microneedle-Microplate Platform to Detect Biomarkers in the Skin 检测皮肤生物标志物的微针-微孔板平台
British Journal of Pharmacy Pub Date : 2022-07-11 DOI: 10.5920/bjpharm.1164
R. Dixon, W. Lau, K. W. Ng
{"title":"A Microneedle-Microplate Platform to Detect Biomarkers in the Skin","authors":"R. Dixon, W. Lau, K. W. Ng","doi":"10.5920/bjpharm.1164","DOIUrl":"https://doi.org/10.5920/bjpharm.1164","url":null,"abstract":"This research aimed to integrate an established signalquantification technique with immunocapture microneedle arrays (MNAs) to improvebiomarker-based disease diagnostics in the skin. In this miniaturized sandwichenzyme-linked immunosorbent assay (ELISA) platform, the capture antibody wasimmobilised onto the surface of microneedles which, when inserted superficiallyinto porcine skin, captured endogenous porcine immunoglobulin G (IgG) intradermally.Signal development was achieved by incubating the microneedles ino-phenylenediamine (OPD) solution in a 384-well microplate and measuring theabsorbance in a microplate spectrophotometer at 450 nm. This technique allowsfor rapid biomarker detection with high-throughput processing. Immunocapture microneedledevices such as these can be easily adapted for targeting different biomarkersor multiplexed leaving plenty of scope for future work and assay optimisation. ","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83266485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multipurpose vaginal rings for HIV prevention and non-hormonal contraception 用于HIV预防和非激素避孕的多用途阴道环
British Journal of Pharmacy Pub Date : 2022-07-11 DOI: 10.5920/bjpharm.1137
Xin Shen, P. Boyd, Y. D. Bashi, C. McCoy, K. Malcolm
{"title":"Multipurpose vaginal rings for HIV prevention and non-hormonal contraception","authors":"Xin Shen, P. Boyd, Y. D. Bashi, C. McCoy, K. Malcolm","doi":"10.5920/bjpharm.1137","DOIUrl":"https://doi.org/10.5920/bjpharm.1137","url":null,"abstract":"Vaginal rings releasing antiretrovirals - either alone or in combination with contraceptive progestins - are being developed for contraception and prevention of human immunodeficiency virus (HIV) transmission via vagina. However, hormonal contraceptives are associated with numerous side effects and contraindications, and many women are interested in using hormone-free contraceptives. The aim of this project is to develop multipurpose vaginal rings to release copper and/or zinc ions and dapivirine over a month for contraception and HIV prevention. Ring manufacture, swell testing, and in vitro drug release testing have been conducted. The experimental results obtained currently are encouraging and support the continued development of these ring formulations as a novel and interesting multipurpose prevention technology strategy.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81523252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fused Deposition Modelling 3D Printed Immediate Release Tablets – Understanding the Impact of Printer Parameters 熔融沉积建模3D打印立即释放片剂-了解打印机参数的影响
British Journal of Pharmacy Pub Date : 2022-07-11 DOI: 10.5920/bjpharm.1159
Zian Zhang, V. Mohylyuk, Shu Li, David S. Jones, G. P. Andrews
{"title":"Fused Deposition Modelling 3D Printed Immediate Release Tablets – Understanding the Impact of Printer Parameters","authors":"Zian Zhang, V. Mohylyuk, Shu Li, David S. Jones, G. P. Andrews","doi":"10.5920/bjpharm.1159","DOIUrl":"https://doi.org/10.5920/bjpharm.1159","url":null,"abstract":"The aim of this study was to prepare tablets that offer an immediate release (IR) of the loaded active ingredient using fused deposition modelling (FDM) 3D printing. Hydrochlorothiazide (HCTZ) was used as a model drug, with polyvinyl alcohol (PVA) as the primary polymeric carrier and sorbitol as a plasticizer. The impact of printer parameters, including infill density, roof and floor (R&F) thickness and nozzle size, on the drug release properties of printed tablets was investigated. The results support the use of FDM-3DP as an approach to manufacture IR tablets and highlighted the importance of the printing design on drug release properties.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"2 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74276852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Precirol ATO5 concentration and twin-screw melt granulation temperature on the physical properties of ascorbic acid granules precrol ATO5浓度和双螺杆熔体造粒温度对抗坏血酸颗粒物性的影响
British Journal of Pharmacy Pub Date : 2022-07-11 DOI: 10.5920/bjpharm.1160
V. Mohylyuk, David S. Jones, Shu Li, Yalin Ding, G. P. Andrews
{"title":"Effect of Precirol ATO5 concentration and twin-screw melt granulation temperature on the physical properties of ascorbic acid granules","authors":"V. Mohylyuk, David S. Jones, Shu Li, Yalin Ding, G. P. Andrews","doi":"10.5920/bjpharm.1160","DOIUrl":"https://doi.org/10.5920/bjpharm.1160","url":null,"abstract":"The pharmaceuticalindustry has a growing interest in continuous manufacturing, particularly forhigh-volume dosage forms such as solid oral tablets. This is driven by the obviousbenefits such as small footprint, batch size flexibility, the relative simplicityof scale-up and process control. Tablets are the most popular solid dosageform, while batch granulation is one of the most often used technologies intablet manufacturing. Using ascorbic acid as a model, we show the possibility ofproducing granules and tablets with a sustained-release profile using threetechnological operations: mixing, continuous melt-granulation, and tabletting.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90320815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reporting guidelines for medicinal plant extracts used in pharmacological and toxicological research: ConPhyMP 药理学和毒理学研究中使用的药用植物提取物报告指南:ConPhyMP
British Journal of Pharmacy Pub Date : 2022-07-11 DOI: 10.5920/bjpharm.1123
M. Heinrich, B. Jalil, Mona Abdel-Tawab, J. Echeverría, Ž. Kulić, L. McGaw, J. Pezzuto, O. Potterat, Jia-bo Wang
{"title":"Reporting guidelines for medicinal plant extracts used in pharmacological and toxicological research: ConPhyMP","authors":"M. Heinrich, B. Jalil, Mona Abdel-Tawab, J. Echeverría, Ž. Kulić, L. McGaw, J. Pezzuto, O. Potterat, Jia-bo Wang","doi":"10.5920/bjpharm.1123","DOIUrl":"https://doi.org/10.5920/bjpharm.1123","url":null,"abstract":"Summary: Every year, the number of studies that evaluate the pharmacological effects, (clinical) efficacy or the toxicity of medicinal plant extracts is constantly increasing, but the reporting quality remains unsatisfactory. One of the main reasons is that there is a lack of detailed reporting standards for guidance. In response to this long-standing challenge, a core group of nine experts with proficiency in phytochemical analysis, including editors-in-chief of leading specialist journals, and based in different research settings globally, developed the Consensus based reporting guidelines for Phytochemical Characterisation of Medicinal Plant extracts (ConPhyMP) through a multi-staged development process. This incorporated a) a global survey among medicinal plant researchers, b) a core group, who reviewed and developed the guidelines through a Delphi process, and c) an advisory group of 20 experts, including editors of leading journals and scientific societies in medicinal plants research, who provided feedback and sanctioned the final guidelines. The ConPhyMP guidelines comprise two tables with accompanying explanatory figures. The first table provides recommendations for reporting the starting material and its initial processing, and the second table presents recommendations for conducting and reporting the analytical methods for defining the chemical profile based on the type of extracts used in the research. The group hopes that the ConPhyMP will support authors as well as peer reviewers and editors assessing these studies for publication and assist the production of evidence-based guidance of studies utilising medicinal plant extracts.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89801983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Synthesis and modification of silver-seeded PVC for use as anti-adherent materials to prevent ventilator-associated pneumonia 用于抗粘附材料的银籽聚氯乙烯的合成和改性，以防止呼吸机相关性肺炎
British Journal of Pharmacy Pub Date : 2022-07-11 DOI: 10.5920/bjpharm.1126
Jia Li, M. Wylie, C. McCoy
{"title":"Synthesis and modification of silver-seeded PVC for use as anti-adherent materials to prevent ventilator-associated pneumonia","authors":"Jia Li, M. Wylie, C. McCoy","doi":"10.5920/bjpharm.1126","DOIUrl":"https://doi.org/10.5920/bjpharm.1126","url":null,"abstract":"In this research, silver-seeded PVC was synthesised and modified to combat ventilator-associated pneumonia by preventing bacterial adherence. The silver-seeded PVC was synthesised by in situ deposition of silver particles, and the silver-seeded PVC was further modified by reacting with 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanethiol to create a superhydrophobic surface with static water contact angle more than 150°. The silver-coated PVC and superhydrophobic silver-coated PVC both exhibited excellent anti-adherent activity against MRSA and Pseudomonas aeruginosa.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82987248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaginal formulations containing prebiotics and probiotics for treatment of bacterial vaginosis 含有治疗细菌性阴道病的益生元和益生菌的阴道制剂
British Journal of Pharmacy Pub Date : 2022-07-11 DOI: 10.5920/bjpharm.1158
Caixuan Wang, R. Malcolm, V. Kett, D. Gilpin
{"title":"Vaginal formulations containing prebiotics and probiotics for treatment of bacterial vaginosis","authors":"Caixuan Wang, R. Malcolm, V. Kett, D. Gilpin","doi":"10.5920/bjpharm.1158","DOIUrl":"https://doi.org/10.5920/bjpharm.1158","url":null,"abstract":"Bacterial vaginosis (BV) is a common dysbiosis of the human vagina in which commensal vaginal lactobacilli are displaced by mixed pathogenic bacterial populations. Current treatments by antibiotics result in short- term cure but often lead to recurrence. Lactobacilli are being actively developed as a probiotic treatment option for BV, given their ability to inhibit growth of pathogenic microorganisms and to maintain the health and stability of the vaginal tract microbiota. Therefore, incorporation of freeze-dried lactobacillus and metronidazole (MET) into matrix-type silicone elastomer vaginal rings (VR) is a long-effective novel treatment of BV which can also prevent recurrence. Here, MED-4870 matrix-type VRs containing four different lyoprotectants of three concentrations were manufactured by reaction injection molding, and Shore M Hardness test, compression test and twist test were applied to determine the impact of incorporation of lyoprotectants on mechanical characteristics of VRs. Results indicated that incorporation of lyoprotectants can increase the resistance force and decrease the rotational angles of the VRs. As the category and concentration of incorporated lyoprotectant also have impact on the releasing profile of MET and protecting ability of lactobacillus during freeze-drying process, more research such as in-vitro release tests and microbiology tests will be needed.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80451167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation of liposomes via 3D printed microfluidics arrays 通过3D打印微流体阵列制备脂质体
British Journal of Pharmacy Pub Date : 2022-07-11 DOI: 10.5920/bjpharm.1163
kanza Rahali, Atabak Ghanizadeh Tabriz, D. Douroumis
{"title":"Preparation of liposomes via 3D printed microfluidics arrays","authors":"kanza Rahali, Atabak Ghanizadeh Tabriz, D. Douroumis","doi":"10.5920/bjpharm.1163","DOIUrl":"https://doi.org/10.5920/bjpharm.1163","url":null,"abstract":"Microfluidics is a technology that allows handling small volumes and mixing them in narrow channels. In this study, we used three different 3D printed microfluidics arrays to prepare liposomes by mixing an aqueous phase with an organic phase made of S75 and Cholesterol at ratios of 8:2 and 6:4 respectively. Liposomes were collected at Total Flow Rates of 3, 5 and 10 ml/min.All arrays produced liposomes varying from 40 to 70 nm, the particle size decreases with increasing TFR from 3 to 10 ml/min for all arrays and both FRRs. Zeta values varies from -40.5 to -86.6 mV indicating excellent stability for all nano dispersions. After 4 weeks storage at 4°C, a slight increase in the particle size was observed for both FRRs. Our study demonstrates the successful use of 3D printed microfluidic arrays for the design and development of liposomes.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85818966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation into the biocompatibility and antibacterial performance of TiO2 silicone nanocomposites 二氧化钛有机硅纳米复合材料的生物相容性及抗菌性能研究
British Journal of Pharmacy Pub Date : 2022-07-11 DOI: 10.5920/bjpharm.1125
J. Quinn, Eugénie Guimier, L. Carson, K. Malcolm
{"title":"Investigation into the biocompatibility and antibacterial performance of TiO2 silicone nanocomposites","authors":"J. Quinn, Eugénie Guimier, L. Carson, K. Malcolm","doi":"10.5920/bjpharm.1125","DOIUrl":"https://doi.org/10.5920/bjpharm.1125","url":null,"abstract":"Incorporationof nanoparticles into silicone elastomers to form silicone nanocomposites is anarea of ongoing research, with a broad range of biomedical applications. Addition-curesilicone nanocomposite dispersions were prepared, containing TiO2 ofvarying nanoparticle sizes and concentrations. All TiO2 silicone nanocompositesremained biocompatible (cell viability >70% relative to control silicone) whenassessed via direct contact MTT assay. However, results from bacterialadherence studies demonstrated that 1000 nm and 200 nm TiO2 nanocompositesdisplayed a greater antibacterial effect in comparison to 100 nm and 20 nm TiO2nanocomposites. The data suggests TiO2 silicone nanocompositespossess antibacterial properties (that is dependent on particle size) andare cytocompatible, warranting further research into potential uses forbiomedical applications.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82709187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Use of Compaction Simulation as a Tool to Aid Successful Tablet Formulation 使用压实模拟作为辅助成功片剂配方的工具
British Journal of Pharmacy Pub Date : 2022-07-11 DOI: 10.5920/bjpharm.1146
Sarah Stewart, Inidigo Lily Dean, Mark Lawlor, S. Lawrence
{"title":"The Use of Compaction Simulation as a Tool to Aid Successful Tablet Formulation","authors":"Sarah Stewart, Inidigo Lily Dean, Mark Lawlor, S. Lawrence","doi":"10.5920/bjpharm.1146","DOIUrl":"https://doi.org/10.5920/bjpharm.1146","url":null,"abstract":"Early assessment of compaction properties of both APIs and formulations is an important consideration in early tablet development and can help to de-risk scale up from R&D to production scale. In this work, three model APIs and a tablet formulation were assessed using a compaction simulator. Compaction simulation was shown to be able to differentiate between the compaction properties of APIs and formulations and when combined with additional information on API properties (flowability, solubility) and tablet requirements (size, strength) can guide formulation strategy. ","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83595836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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