British Journal of Pharmacy最新文献_第10页

The distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependence in mice 阿片受体在减轻小鼠吗啡/甲基苯丙胺(多种药物)依赖复发中的独特作用

British Journal of Pharmacy Pub Date : 2018-07-17 DOI: 10.5920/bjpharm.2017.20

I. E. Ridzwan, Maryam Saadah Suhaimi, Nur Syafinaz Wasli, A. Kasmuri, Marwan Saad Azzubaidi, R. Hashim, Q. Ahmed, L. Ming, Nornisah Mohamed, Syed Mohd Syhami

{"title":"The distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependence in mice","authors":"I. E. Ridzwan, Maryam Saadah Suhaimi, Nur Syafinaz Wasli, A. Kasmuri, Marwan Saad Azzubaidi, R. Hashim, Q. Ahmed, L. Ming, Nornisah Mohamed, Syed Mohd Syhami","doi":"10.5920/bjpharm.2017.20","DOIUrl":"https://doi.org/10.5920/bjpharm.2017.20","url":null,"abstract":"A Combination of 0.3mg/kg buprenorphine and 1.0 mg/kg naltrexone treatment shows a promising result due to its ability to attenuate reinstatement (relapse) in morphine/methamphetamine (polydrug)-dependent mice in a conditioned place preference (CPP) model. This prompted us to identify which opioid receptor that contributes to its anti-relapse activity. Using the same CPP model, 10 mg/kg nor- BNI (a selective kappa opioid receptor [KOR] antagonist) was used to evaluate the involvement of KOR in mediating relapse to polydrug dependence. By applying the immunohistochemistry (IHC) technique, the investigation was extended to the mice brain using KOR antibody (EPR18881), focusing on the brain regions that are abundant in KOR density. The results showed that nor-BNI alone failed to attenuate relapse to polydrug dependence. However, the IHC results proved that the number of KOR significantly increased in the striatum during reinstatement compared to post-conditioning (p <0.05). The KOR was significantly suppressed in the treatment group which strengthens the findings from previous studies proving that the KOR plays an important role in mediating relapse to polydrug dependence.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79362059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}