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Novel electrospun implants of Sunitinib can depress ex-vivo ocular neovascularization 新型舒尼替尼电纺丝植入物可抑制离体眼新生血管
British Journal of Pharmacy Pub Date : 2022-07-15 DOI: 10.5920/bjpharm.1174
Deepakkumar Mishra, Hákon Hrafn Sigurðsson, A. P. Serro, G. Kalesnykas, R. Donnelly, R. Thakur
{"title":"Novel electrospun implants of Sunitinib can depress ex-vivo ocular neovascularization","authors":"Deepakkumar Mishra, Hákon Hrafn Sigurðsson, A. P. Serro, G. Kalesnykas, R. Donnelly, R. Thakur","doi":"10.5920/bjpharm.1174","DOIUrl":"https://doi.org/10.5920/bjpharm.1174","url":null,"abstract":"Choroidal neovascularization (CNV) is one of the hallmark symptoms of Wet Age-related Macular Degeneration (wAMD) and DiabeticRetinopathy(DR) which involves formation of neoangiogenic i.e. formation of new abnormal blood vessels emerging from the choroidal blood vessels and protruding through the retinal layer. The current management of wAMD involves intravitreal injections of anti-VEGF such as ranibizumab and aflibercept. We hypothesized the delivery of small molecule anti-angiogenesis agents such as the Sunitinib by episcleral route could be an effective and less challenging solution for the management of choroidal neovascularization. In this research, we have fabricated the sunitinib-loaded implants that are able of sustained the release of drug and possess improved ocular pharmacokinetics with a non-invasive administration. The novel episcleral implants were fabricated by electrospinning and were tested for different physiochemical and well as in-vitro pharmacokinetic properties. Further, these implants were tested for in-vitro biocompatibility and ex-vivo efficacy for the estimation of pharmacodynamic properties.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87802240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Eradication of E. coli and S. aureus by Ciprofloxacin-loaded hydrogel 环丙沙星水凝胶对大肠杆菌和金黄色葡萄球菌的清除作用
British Journal of Pharmacy Pub Date : 2022-07-15 DOI: 10.5920/bjpharm.1135
Rania Mohammad Mahafdeh, C. McCoy
{"title":"Eradication of E. coli and S. aureus by Ciprofloxacin-loaded hydrogel","authors":"Rania Mohammad Mahafdeh, C. McCoy","doi":"10.5920/bjpharm.1135","DOIUrl":"https://doi.org/10.5920/bjpharm.1135","url":null,"abstract":"Hospital-acquired infection is one of the major risks to patients and an economic burden on the healthcare system, and multidrug resistance is a serious complicating factor in providing effective treatment. Novel drug delivery systems for antimicrobial agents can act as a solution for infection. In this study we demonstrate a biomaterial with antimicrobial properties through incorporation of ciprofloxacin into p(HEMA: MMA) polymer. The main aim is to prevent bacterial adherence on these surfaces, presenting a valuable strategy for nosocomial infection control. The adherence percentage of both S. aureus and E. coli were significantly decreased, and eradication to below limit of detection was demonstrated for 24 hr, contributing to decreasing biofilm formation.  ","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"50 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72569463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dissolution of theophylline from extended-release tablets under cyclic retrograde peristaltic contractions in the Dynamic Colon Model 动态结肠模型循环逆行蠕动收缩下缓释片中茶碱的溶出
British Journal of Pharmacy Pub Date : 2022-07-14 DOI: 10.5920/bjpharm.1192
Connor O’Farrell, K. Stamatopoulos, M. Simmons, H. Batchelor
{"title":"Dissolution of theophylline from extended-release tablets under cyclic retrograde peristaltic contractions in the Dynamic Colon Model","authors":"Connor O’Farrell, K. Stamatopoulos, M. Simmons, H. Batchelor","doi":"10.5920/bjpharm.1192","DOIUrl":"https://doi.org/10.5920/bjpharm.1192","url":null,"abstract":"The dynamic colon model isa biorelevant in vitro model of the human proximal colon. In vivo, the largeintestine mixes its contents using peristaltic waves that propagate both forwards(antegrade) and backwards (retrograde). This work studies the dissolutionprofile of theophylline from Uniphyllin Continus 200 mg prolonged releasetablets and the distribution of dissolved theophylline in viscosity-enhancedmedia under the influence of a cyclic retrograde peristaltic contraction. At 16-and 24-hours,  and  theophylline dissolved from the tablet and thefluid inside the mimic intestinal system approached homogeneity.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83096879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Population PK modelling as an alternative route to bioequivalence 群体PK模型作为生物等效性的替代途径
British Journal of Pharmacy Pub Date : 2022-07-14 DOI: 10.5920/bjpharm.1186
Parmesh Gajjar, Jake Dickinson, Harri Dickinson, Linette Ruston, Hitesh B. Mistry, Claire Patterson, P. Dickinson
{"title":"Population PK modelling as an alternative route to bioequivalence","authors":"Parmesh Gajjar, Jake Dickinson, Harri Dickinson, Linette Ruston, Hitesh B. Mistry, Claire Patterson, P. Dickinson","doi":"10.5920/bjpharm.1186","DOIUrl":"https://doi.org/10.5920/bjpharm.1186","url":null,"abstract":"Demonstratingbioequivalence (BE) is important for the development of lower cost genericproducts, and also for approving post-submission manufacturing changes.However, for many complex parenteral products, BE demonstration can be verychallenging. For example, long-acting injectable products are engineered tohave an extended release over several weeks or months, but this also means thata traditional BE study can take many months or years to perform. Here, we summarisehow population PK modelling, which captures differences in PK profiles due topopulation variation, could be used explore hundreds of virtual formulations,and thus determine a range of products that are bioequivalent after bothmultiple and single dosing. This provides a guide for formulation developmentbut also opens alternative, more streamlined routes to BE assessment. ","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74234354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial cationic surfactant-loaded hydrogel coatings in preventing medical device-associated infections 抗微生物阳离子表面活性剂负载水凝胶涂层在预防医疗器械相关感染中的应用
British Journal of Pharmacy Pub Date : 2022-07-14 DOI: 10.5920/bjpharm.1078
Xiao Teng, C. McCoy, Caoimhe Clerkin
{"title":"Antimicrobial cationic surfactant-loaded hydrogel coatings in preventing medical device-associated infections","authors":"Xiao Teng, C. McCoy, Caoimhe Clerkin","doi":"10.5920/bjpharm.1078","DOIUrl":"https://doi.org/10.5920/bjpharm.1078","url":null,"abstract":"Hydrogels described herein were developedas anti-microbial coating materials. Three different hydrogels, p(HEMA), p(85%HEMA-co-15% MMA) and p(85% HEMA-co-15% MAA) were loaded with twocationic surfactant, BAK and DDAB, respectively. DDAB owned better effectivity thanBAK in killing S. aureus and E. coli. Compared to unmodifiedp(HEMA), all drug-loaded samples exhibited significant anti-adherence abilityagainst E. coli, but on surfaces of all DDAB-loaded hydrogels, bacteriawere below limit of detection, so DDAB was more effective than BAK inconferring anti-adherent properties.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90793738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterizing RAPIDTM platelet and leukocyte-rich plasma gels – an autologous, point-of-care medicine for diabetic foot ulcer treatment. 表征RAPIDTM血小板和白细胞丰富的血浆凝胶-一种用于糖尿病足溃疡治疗的自体点护理药物。
British Journal of Pharmacy Pub Date : 2022-07-13 DOI: 10.5920/bjpharm.1178
A. Olszewska, B. Forbes, S. Pitchford, James Rickard
{"title":"Characterizing RAPIDTM platelet and leukocyte-rich plasma gels – an autologous, point-of-care medicine for diabetic foot ulcer treatment.","authors":"A. Olszewska, B. Forbes, S. Pitchford, James Rickard","doi":"10.5920/bjpharm.1178","DOIUrl":"https://doi.org/10.5920/bjpharm.1178","url":null,"abstract":"In 2017/18 wound healing cost the NHS 8.3 billion pounds. There is an urgent need for more effective, accessible, and safe treatments. Platelet-rich plasma (PRP) therapies have been emerging since the early 2000s, currently they are used across various medical fields treating conditions from cosmetic procedures through burn treatments to wound healing. RAPIDTM gel is a product for the treatment of diabetic foot ulcers that is currently in stage 2b of clinical trials. This project aims to better understand the properties of the gel and how these are affected by the manufacturing process. The PRP gels were characterized physiochemically by exploring the gel time, exudate release and growth factor content. These data provide a baseline for future studies exploring how variations in manufacturing conditions affect the gel properties.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"31 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72549026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating Buffer Effects on Lysozyme Adsorption to Borosilicate Glass 硼硅酸盐玻璃对溶菌酶吸附的缓冲作用研究
British Journal of Pharmacy Pub Date : 2022-07-13 DOI: 10.5920/bjpharm.1157
Jack D. Downey, A. Crean, K. Ryan
{"title":"Investigating Buffer Effects on Lysozyme Adsorption to Borosilicate Glass","authors":"Jack D. Downey, A. Crean, K. Ryan","doi":"10.5920/bjpharm.1157","DOIUrl":"https://doi.org/10.5920/bjpharm.1157","url":null,"abstract":"Proteinadsorption refers to the accumulation and adherence of a protein to the surfaceof a solid, but without surface penetration occurring. Proteins can adsorb to avariety of materials that are used in the manufacture, formulation, and storageof protein medicines. This can have unintended consequences such as loss ofexpensive protein product and aggregate formation. Proteinswith low structural and thermal stability can adsorb to interfaces in higherquantities. This study investigates the role ofbuffer composition, and pH on both the adsorption of lysozyme to borosilicateglass and its thermal stability. Using reverse phase HPLC and dynamic scanningfluorimetry, we quantified the amount of adsorbed protein on the substrate andassessed the thermal stability of lysozyme in the bulk solution. The highest amount of adsorbed lysozyme occurred in the sodiumphosphate and histidine-HCl buffers at pH 7.4. Thermal stability analysisshowed that lysozyme had the lowest melt temperature in these buffers. Theresults indicate that lysozyme adsorption and stability may be mediated by pHand ionic strength. ","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85512764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual stimuli-responsive hydrogels for colon targeted drug delivery. 双重刺激反应水凝胶用于结肠靶向药物递送。
British Journal of Pharmacy Pub Date : 2022-07-13 DOI: 10.5920/bjpharm.1134
Mohmmad Imad Rabeh, C. McCoy, M. Wylie
{"title":"Dual stimuli-responsive hydrogels for colon targeted drug delivery.","authors":"Mohmmad Imad Rabeh, C. McCoy, M. Wylie","doi":"10.5920/bjpharm.1134","DOIUrl":"https://doi.org/10.5920/bjpharm.1134","url":null,"abstract":"Colon targeted drug deliverysystems are promising for the treatment of local diseases. The colon possessesa diverse microbiome that secretes a number of biomolecules, such as enzymes,that can be exploited for targeted drug delivery. Here, we report the synthesisof 2-hydroxyethyl methacrylate and methacrylic acid  copolymer hydrogels crosslinked with an enzyme-sensitivecrosslinking agent. The swelling and drug release properties of hydrogels were observedin pH 1.2, pH 6.5 and pH 7.4, and in the presence of rat cecal content. Swellingstudies revealed pH responsivity of the hydrogels while the release kinetics ofmetronidazole from hydrogels containing an enzyme-labile crosslinker were fasterin the presence of rat cecal content. The results show that dual responsive hydrogelscould provide a promising platform for colonic drug delivery","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74033544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Formulation Design and Functional Characterisation of a Novel Vaginal Mucosal Drug Delivery System 一种新型阴道粘膜给药系统的配方设计和功能表征
British Journal of Pharmacy Pub Date : 2022-07-13 DOI: 10.5920/bjpharm.1085
Ahmed Alzainy, J. Boateng
{"title":"Formulation Design and Functional Characterisation of a Novel Vaginal Mucosal Drug Delivery System","authors":"Ahmed Alzainy, J. Boateng","doi":"10.5920/bjpharm.1085","DOIUrl":"https://doi.org/10.5920/bjpharm.1085","url":null,"abstract":"The aim of this research wasthe development, characterisation, and optimisation of composite polymer-basedformulations for vaginal drug delivery using metronidazole (MTz) as a modeldrug to treat bacterial infection in the vagina. Blank (BLK) composite waferscomprising carrageenan (CARR) and sodium alginate (SA) were initiallyformulated and tested. However, due to poor physico-chemical properties,further formulations were developed involving combination of carbopol (CARB)with SA or CARB with CARR, modified with hydroxypropylmethyl cellulose (HPMC)in different weight ratios and plasticised with polyethylene glycol (PEG 200).Drug loaded (DL) wafers were obtained by loading selected optimised compositeCARB-CARR or CARR-SA based gels with 0.75% of MTz prior to freeze-drying.Formulations were characterised using texture analyser (hardness,mucoadhesion), scanning electron microscopy (SEM), X-ray diffractometry (XRD), swellingcapacity and in vitro drug dissolution study using HPLC.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89744430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors governing the formation of THEDESs: A case study with propionic acid NSAIDs and lidocaine 控制theess形成的因素:丙酸非甾体抗炎药和利多卡因的案例研究
British Journal of Pharmacy Pub Date : 2022-07-13 DOI: 10.5920/bjpharm.1080
Magdy M. Abdelquader, G. P. Andrews, Shu Li, David S. Jones
{"title":"Factors governing the formation of THEDESs: A case study with propionic acid NSAIDs and lidocaine","authors":"Magdy M. Abdelquader, G. P. Andrews, Shu Li, David S. Jones","doi":"10.5920/bjpharm.1080","DOIUrl":"https://doi.org/10.5920/bjpharm.1080","url":null,"abstract":"Deep eutectic solvents (DES) are products of interaction betweensolid parent compounds resulting in a liquid at room temperature due to significantmelting point depression. Such phenomenon has been employed to improve drugs’ biopharmaceuticalbehavior by including at least one API as DES former to produce a therapeuticDES (THEDES). DES physicochemical characteristics are affected by those of the parentcompounds. Investigating such relation can help in tailoring THEDES formationfor specific outcomes. This was done by comparing THEDES of lidocaine witheither of structurally similar ibuprofen or ketoprofen through thermalanalysis, FTIR and rheological studies to highlight the effect of differentphysicochemical properties on the formed THEDES. Eutectic composition for bothproducts was similar, indicating the important role of supramolecularcomplementarity in eutectic point determination. Glass transition (Tg)of drugs seemed to have direct impact on Tg of the formed THEDESwhere higher Tg ketoprofen produced a higher Tg THEDES. Similarly,higher number of hydrogen bonding sites within ketoprofen structure led to moreviscous and thermally stable product. Moreover, the degree of chargeinvolvement in the interaction network was related to pKa of thedrugs. Such findings can help to construct a structural based approach to selectTHEDES components. ","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"298 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75455967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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