Dissolution of theophylline from extended-release tablets under cyclic retrograde peristaltic contractions in the Dynamic Colon Model

Abstract

The dynamic colon model isa biorelevant in vitro model of the human proximal colon. In vivo, the largeintestine mixes its contents using peristaltic waves that propagate both forwards(antegrade) and backwards (retrograde). This work studies the dissolutionprofile of theophylline from Uniphyllin Continus 200 mg prolonged releasetablets and the distribution of dissolved theophylline in viscosity-enhancedmedia under the influence of a cyclic retrograde peristaltic contraction. At 16-and 24-hours,  and  theophylline dissolved from the tablet and thefluid inside the mimic intestinal system approached homogeneity.