British Journal of Biomedical Science最新文献

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Case Report: The Conundrum of What to Pick? Antibiotic Susceptibility Variability in Burkholderia cenocepacia in Cystic Fibrosis: Implications for Antibiotic Susceptibility Testing and Treatment 案例报告:选什么的难题?囊性纤维化患者对伯克霍尔德氏菌的抗生素敏感性变异:对抗生素敏感性测试和治疗的影响
IF 1.9 4区 医学
British Journal of Biomedical Science Pub Date : 2024-06-04 DOI: 10.3389/bjbs.2024.12749
John E. Moore, J. McCaughan, J. Rendall, B. Millar
{"title":"Case Report: The Conundrum of What to Pick? Antibiotic Susceptibility Variability in Burkholderia cenocepacia in Cystic Fibrosis: Implications for Antibiotic Susceptibility Testing and Treatment","authors":"John E. Moore, J. McCaughan, J. Rendall, B. Millar","doi":"10.3389/bjbs.2024.12749","DOIUrl":"https://doi.org/10.3389/bjbs.2024.12749","url":null,"abstract":"Within cystic fibrosis microbiology, there is often mismatch between the antibiotic susceptibility result of an isolated bacterial pathogen and the clinical outcome, when the patient is treated with the same antibiotic. The reasoning for this remains largely elusive. Antibiotic susceptibility to four antibiotics (ceftazidime, meropenem, minocycline and trimethoprim-sulfamethoxazole) was determined in consecutive isolates (n = 11) from an adult cystic fibrosis patient, over a 63 month period. Each isolate displayed its own unique resistotype. The first isolate was sensitive to all four antibiotics, in accordance with Clinical and Laboratory Standards Institute methodology and interpretative criteria. Resistance was first detected at four months, showing resistance to ceftazidime and meropenen and intermediate resistance to minocycline and trimethoprim-sulfamethoxazole. Pan resistance was first detected at 18 months (resistotype IV), with three resistotypes (I, II and III) preceding this complete resistotype. The bacterium continued to display further antibiotic susceptibility heterogeneity for the next 45 months, with the description of an additional seven resistotypes (resistotypes V–XI). The Relative Resistance Index of this bacterium over the 63 month period showed no relationship between the development of antibiotic resistance and time. Adoption of mathematical modelling employing multinomial distribution demonstrated that large numbers of individual colony picks (>40/sputum), would be required to be 78% confident of capturing all 11 resistotypes present. Such a requirement for large numbers of colony picks combined with antibiotic susceptibility-related methodological problems creates a conundrum in biomedical science practice, in providing a robust assay that will capture antibiotic susceptibility variation, be pragmatic and cost-effective to deliver as a pathology service, but have the reliability to help clinicians select appropriate antibiotics for their patients. This study represents an advance in biomedical science as it demonstrates potential variability in antibiotic susceptibility testing with Burkholderia cenocepacia. Respiratory physicians and paediatricians need to be made aware of such variation by biomedical scientists at the bench, so that clinicians can contextualise the significance of the reported susceptibility result, when selecting appropriate antibiotics for their cystic fibrosis patient. Furthermore, consideration needs to be given in providing additional guidance on the laboratory report to highlight this heterogeneity to emphasise the potential for misalignment between susceptibility result and clinical outcome.","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141268556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Faecal Immunochemical Test (FIT) Sensitivity; A Five Year Audit. 粪便免疫化学检验 (FIT) 灵敏度;五年审计。
IF 2.7 4区 医学
British Journal of Biomedical Science Pub Date : 2024-05-29 eCollection Date: 2024-01-01 DOI: 10.3389/bjbs.2024.12862
Eddie Cole, Deepa Narayanan, Ree Nee Tiam, John Shepherd, Mark O R Hajjawi
{"title":"Faecal Immunochemical Test (FIT) Sensitivity; A Five Year Audit.","authors":"Eddie Cole, Deepa Narayanan, Ree Nee Tiam, John Shepherd, Mark O R Hajjawi","doi":"10.3389/bjbs.2024.12862","DOIUrl":"10.3389/bjbs.2024.12862","url":null,"abstract":"<p><p><b>Introduction:</b> Colorectal cancer has a high prevalence and mortality rate in the United Kingdom. Cancerous colorectal lesions often bleed into the gastrointestinal lumen. The faecal immunochemical test (FIT) detects haemoglobin (Hb) in the faeces of patients and is used as a first line test in the diagnosis of colorectal cancer. <b>Materials and Methods:</b> A retrospective audit of all FIT performed and all colorectal cancers diagnosed in the Hull and East Riding of Yorkshire counties of the United Kingdom (population approximately 609,300) between 2018 and 2022 was conducted. FIT were performed using a HM-JACKarc analyser from Kyowa medical. The predominant symptom suggestive of colorectal cancer which prompted the FIT was recorded. Colorectal cancer was diagnosed using the gold standard of histological biopsy following colonoscopy. <b>Results:</b> Between 2018 and 2022, 56,202 FIT were performed on symptomatic patients. Follow on testing identified 1,511 with colorectal cancer. Of these people, only 450 people with a confirmed colorectal cancer had a FIT within the 12 months preceding their diagnosis. Of these 450 FIT results, 36 had a concentration of <10 μg/g and may be considered to be a false negative. The sensitivity of FIT in the patients identified was 92.00%. The most common reason stated by the clinician for a FIT being performed in patients with colorectal cancer was a change in bowel habits, followed by iron deficient anaemia. The number of patients diagnosed with colorectal cancer decreased in 2020, but increased significantly in 2021. <b>Discussion:</b> This study shows that 8.00% of people diagnosed with colorectal cancer in the Hull and East Riding of Yorkshire regions had a negative FIT. This study also shows that the SARS-CoV-2 pandemic affected the number of people diagnosed with colorectal cancer, and therefore skews the prevalence and pre-test probability of a positive test. There are many reasons why a FIT could produce a false negative result, the most likely being biological factors affecting the stability of haemoglobin within the gastrointestinal tract, or pre-analytical factors influencing faecal sampling preventing the detection of haemoglobin. Some colorectal lesions do not protrude into the gastrointestinal lumen and are less likely to bleed. <b>Conclusion:</b> This is the first study showing data from outside of a structured clinical trial and provides the largest study to date showing the sensitivity of FIT in a routine clinical setting. This study also provides evidence for the impact COVID-19 had on the rate of colorectal cancer diagnosis.</p>","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11167630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Supporting the Biomedical Science UG Project Research Journey Through Staff-Student Partnerships. 通过师生合作支持生物医学本科生的项目研究之旅。
IF 1.9 4区 医学
British Journal of Biomedical Science Pub Date : 2024-05-29 eCollection Date: 2024-01-01 DOI: 10.3389/bjbs.2024.12215
S Veuger, L Cookson, H Creighton, S Gallaher, S Racey, M Ridley, I Robson
{"title":"Supporting the Biomedical Science UG Project Research Journey Through Staff-Student Partnerships.","authors":"S Veuger, L Cookson, H Creighton, S Gallaher, S Racey, M Ridley, I Robson","doi":"10.3389/bjbs.2024.12215","DOIUrl":"10.3389/bjbs.2024.12215","url":null,"abstract":"<p><p><b>Introduction:</b> Developing research skills enhances graduate attributes and student employability. The UG research project is coined the pedagogy of the 21st century but the diversity of supervisory styles is a source of student perceived inequality of experience. The goal of this study was to provide structure and support to undergraduate (UG) biomedical science research students and supervisors by co-creating research informed resources that are accessible, engaging and student centred. We asked 1) How do UG students experience research supervision? 2) What approaches do supervisors use to support UG project students? 3) How do students as partners benefit from being involved in pedagogical research? <b>Materials and Methods:</b> In Stage One, 3 UG student research partners co-developed questionnaires and followed these up with semi-structured interviews. Fifty two UG project students took part in an interactive poll and 14 supervisors answered a questionnaire. Seven students and 4 supervisors were interviewed. These were analysed by thematic analysis. In Stage Two, the questions were asked of UG project students (<i>n</i> = 79) via an interactive poll and the resource developed in Stage One was trialled with students (<i>n</i> = 68) and supervisors (<i>n</i> = 37). <b>Results:</b> The global theme identified was that students feel strongly that the student-supervisor relationship influences their experience, satisfaction and success. In all polls, >90% of students but <60% of supervisors agree that a good student/supervisor partnership has an effect on the success of the final project. A smaller percentage of students felt strongly that they were able to develop a successful partnership with their supervisor. We co-created a visual model and a list of discussion points of how the student-supervisor partnership can be developed, aimed at making supervision more effective whilst being non-prescriptive. <b>Discussion:</b> The resource can be easily adapted. Students believe it helped them to develop a staff-student partnership and supervisors commented that it helps to clarify roles and manage student expectations. This scalable project will support the practice of future UG biomedical science project research students and supervisors. Working with students as partners enabled the development of richer ideas whilst supporting their employability.</p>","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11167481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Andragogy in Practice: Applying a Theoretical Framework to Team Science Training in Biomedical Research 实践中的教育学:将理论框架应用于生物医学研究中的团队科学培训
IF 1.9 4区 医学
British Journal of Biomedical Science Pub Date : 2024-03-28 DOI: 10.3389/bjbs.2024.12651
Jacqueline M. Knapke, Laura Hildreth, Jennifer Molano, S. Schuckman, Jason T. Blackard, Megan Johnstone, Elizabeth Kopras, M. K. Lamkin, Rebecca C. Lee, John Kues, Angela Mendell
{"title":"Andragogy in Practice: Applying a Theoretical Framework to Team Science Training in Biomedical Research","authors":"Jacqueline M. Knapke, Laura Hildreth, Jennifer Molano, S. Schuckman, Jason T. Blackard, Megan Johnstone, Elizabeth Kopras, M. K. Lamkin, Rebecca C. Lee, John Kues, Angela Mendell","doi":"10.3389/bjbs.2024.12651","DOIUrl":"https://doi.org/10.3389/bjbs.2024.12651","url":null,"abstract":"This study is the first to apply the theoretical principles of Malcolm Knowles’ theory of andragogy to evaluate data collected from learners who participated in team science training workshops in a biomedical research setting. Briefly, andragogy includes six principles: the learner’s self-concept, the role of experience, readiness to learn, orientation to learning, the learner’s need to know, and intrinsic motivation. Using an embedded study design, the primary focus was on qualitative data, with quantitative data complementing the qualitative findings. The deductive analysis demonstrated that approximately 85% of the qualitative data could be connected to at least one andragogical principle. Participant responses to positive evaluation questions were largely related to two principles: readiness to learn and problem-based learning orientation. Participant responses to negative questions were largely connected to two different principles: the role of experience and self-direction. Inductive analysis found an additional theme: meeting biological needs. Quantitative survey results supported the qualitative findings. The study findings demonstrate that andragogy can serve as a valuable construct to integrate into the development of effective team science training for biomedical researchers.","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140370430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role and Limitations of the Reference Interval Within Clinical Chemistry and Its Reliability for Disease Detection. 临床化学参考区间的作用和局限性及其对疾病检测的可靠性。
IF 1.9 4区 医学
British Journal of Biomedical Science Pub Date : 2024-02-28 eCollection Date: 2024-01-01 DOI: 10.3389/bjbs.2024.12339
Nathan E Timbrell
{"title":"The Role and Limitations of the Reference Interval Within Clinical Chemistry and Its Reliability for Disease Detection.","authors":"Nathan E Timbrell","doi":"10.3389/bjbs.2024.12339","DOIUrl":"10.3389/bjbs.2024.12339","url":null,"abstract":"<p><p>Reference intervals (RIs) are a range of values that are supplied alongside laboratory measurements for comparison to allow interpretation of this data. Historically, RIs were referred to as the normal range. However, the perception of what is normal can lead to confusion in clinicians and unnecessary emotional distress in patients. RIs can be acquired using several methods. Laboratories may quote published studies or derive their own using established direct or indirect methods. Alternatively, laboratories may verify RIs provided by assay manufacturers using in-house studies. RIs have several limitations that clinicians should be aware of. The statistical methodology associated with establishment of RIs means that approximately 5% of \"disease free\" individuals will fall outside the RI. Additionally, the higher the number of tests requested, the higher the probability that one will be abnormal, and repeat results in an individual may show regression to the mean. Completion of studies for establishment of RIs can be expensive, difficult, and time consuming. Method bias and differences in populations can greatly influence RIs and prevent them from being transferable between some laboratories. Differences in individual characteristics such as age, ethnicity, and sex can result in large variation in some analytes. Some patients, such as those whose gender differs from that which was presumed for them at birth, may require their own RIs. Alternatively, a decision will need to be made about which to use. Overall, the issue common to these factors lies within interpretation. As such, RIs can be improved with better training in their use, combined with a better understanding of influences that affect them, and more transparent communication from laboratories in how RIs were derived.</p>","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10932992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140118734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Variants Associated With Response to Platinum-Based Chemotherapy in Non-Small Cell Lung Cancer Patients: A Field Synopsis and Meta-Analysis. 与非小细胞肺癌患者对铂类化疗反应相关的基因变异:现场概要和 Meta 分析。
IF 1.9 4区 医学
British Journal of Biomedical Science Pub Date : 2024-02-21 eCollection Date: 2024-01-01 DOI: 10.3389/bjbs.2024.11835
Hilary Sito, Mohamad Ayub Khan Sharzehan, Md Asiful Islam, Shing Cheng Tan
{"title":"Genetic Variants Associated With Response to Platinum-Based Chemotherapy in Non-Small Cell Lung Cancer Patients: A Field Synopsis and Meta-Analysis.","authors":"Hilary Sito, Mohamad Ayub Khan Sharzehan, Md Asiful Islam, Shing Cheng Tan","doi":"10.3389/bjbs.2024.11835","DOIUrl":"10.3389/bjbs.2024.11835","url":null,"abstract":"<p><p><b>Background:</b> Publications on the associations of genetic variants with the response to platinum-based chemotherapy (PBC) in NSCLC patients have surged over the years, but the results have been inconsistent. Here, a comprehensive meta-analysis was conducted to combine eligible studies for a more accurate assessment of the pharmacogenetics of PBC in NSCLC patients. <b>Methods:</b> Relevant publications were searched in PubMed, Scopus, and Web of Science databases through 15 May 2021. Inclusion criteria for eligible publications include studies that reported genotype and allele frequencies of NSCLC patients treated with PBC, delineated by their treatment response (sensitive vs. resistant). Publications on cell lines or animal models, duplicate reports, and non-primary research were excluded. Epidemiological credibility of cumulative evidence was assessed using the Newcastle-Ottawa Scale (NOS) and Venice criteria. Begg's and Egger's tests were used to assess publication bias. Cochran's Q-test and I<sup>2</sup> test were used to calculate the odds ratio and heterogeneity value to proceed with the random effects or fixed-effects method. Venice criteria were used to assess the strength of evidence, replication methods and protection against bias in the studies. <b>Results:</b> A total of 121 publications comprising 29,478 subjects were included in this study, and meta-analyses were performed on 184 genetic variants. Twelve genetic variants from 10 candidate genes showed significant associations with PBC response in NSCLC patients with strong or moderate cumulative epidemiological evidence (increased risk: <i>ERCC1</i> rs3212986, <i>ERCC2</i> rs1799793, <i>ERCC2</i> rs1052555, and <i>CYP1A1</i> rs1048943; decreased risk: <i>GSTM1</i> rs36631, <i>XRCC1</i> rs1799782 and rs25487, <i>XRCC3</i> rs861539, <i>XPC</i> rs77907221, <i>ABCC2</i> rs717620, <i>ABCG2</i> rs2231142, and <i>CDA</i> rs1048977). Bioinformatics analysis predicted possible damaging or deleterious effects for <i>XRCC1</i> rs1799782 and possible low or medium functional impact for <i>CYP1A1</i> rs1048943. <b>Conclusion:</b> Our results provide an up-to-date summary of the association between genetic variants and response to PBC in NSCLC patients.</p>","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10914946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140048787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measuring the Impact of Incorporating Case Study Presentations Into Applied Biomedical Science Placement Workshops for Trainee Biomedical Scientists. 衡量将案例研究演示纳入生物医学科学应用实习研讨会对生物医学科学实习生的影响。
IF 1.9 4区 医学
British Journal of Biomedical Science Pub Date : 2024-02-20 eCollection Date: 2024-01-01 DOI: 10.3389/bjbs.2024.12017
Amreen Bashir, Kathryn Dudley, Karan Singh Rana, Kayleigh Wilkins, Ross Pallett
{"title":"Measuring the Impact of Incorporating Case Study Presentations Into Applied Biomedical Science Placement Workshops for Trainee Biomedical Scientists.","authors":"Amreen Bashir, Kathryn Dudley, Karan Singh Rana, Kayleigh Wilkins, Ross Pallett","doi":"10.3389/bjbs.2024.12017","DOIUrl":"10.3389/bjbs.2024.12017","url":null,"abstract":"<p><p><b>Introduction:</b> Successfully completing the Institute of Biomedical Science (IBMS) registration portfolio is essential to becoming a Health and Care Professions Council (HCPC) registered Biomedical Scientist. In the West Midlands, a unique collaboration between four universities (Aston, Wolverhampton, Coventry, and Keele) and local NHS Trusts supports student placements and portfolio development. The universities support Training Officers in delivering components of the registration portfolio through the delivery of eight combined placement workshops. These have been designed to align to the IBMS registration portfolio and help students meet the HCPC Standards of Proficiency. This study aimed to evaluate the effectiveness of a redesigned workshop where students generated and presented medical case studies to peers, academics, and training leads. <b>Materials and Methods:</b> The three phases of the case study intervention included a pre-intervention survey, academic-led sessions focussing on medical case presentations and delivery of the presentation followed by a post-intervention survey. <b>Results:</b> Analysing survey responses pre- and post-intervention, students demonstrated enhanced confidence in their understanding of clinical conditions (<i>p</i><0.0001), connecting lab findings to diseases, and in delivering a case presentation to their peers (<i>p</i><0.001). Students reported an increased confidence in structuring case presentations and their critical thinking ability (<i>p</i><0.0001). All students agreed engaging with the case study workshop improved their ability to communicate knowledge of scientific concepts orally. Thematic analysis revealed that the case presentation deepened students' understanding of multidisciplinary teams. 98% of respondents agreed patient communication should be integrated into Biomedical Sciences courses and 85% would like to see case study presentations embedded into the curriculum. <b>Discussion:</b> Combined placement workshops are an integral part of the Applied Biomedical Science placement journey. Case study presentations are clearly a valuable teaching and learning tool to nurture and develop key transferable skills and competencies in conjunction with Biomedical Science expertise. The collaborative approach in the West Midlands effectively prepares graduates with essential pathology knowledge, skills, and a completed IBMS registration portfolio. This study highlights a successful framework for a collaborative partnership with local NHS trusts that has allowed the completion of numerous pathology placements and could be adopted by other universities delivering accredited Biomedical Science courses.</p>","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10912474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140038793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Landscape View of the Female Genital Tract Microbiome in Healthy Controls and Women With Reproductive Health Conditions Associated With Ectopic Pregnancy. 健康对照组和患有与宫外孕相关的生殖健康问题的妇女的女性生殖道微生物组景观图。
IF 2.7 4区 医学
British Journal of Biomedical Science Pub Date : 2024-01-12 eCollection Date: 2023-01-01 DOI: 10.3389/bjbs.2023.12098
Hui En Teh, Cheng Khee Pung, Valliammai Jayanthi Thirunavuk Arasoo, Polly Soo Xi Yap
{"title":"A Landscape View of the Female Genital Tract Microbiome in Healthy Controls and Women With Reproductive Health Conditions Associated With Ectopic Pregnancy.","authors":"Hui En Teh, Cheng Khee Pung, Valliammai Jayanthi Thirunavuk Arasoo, Polly Soo Xi Yap","doi":"10.3389/bjbs.2023.12098","DOIUrl":"10.3389/bjbs.2023.12098","url":null,"abstract":"<p><p>Disruption of the female genital microbiome is associated with several pregnancy complications, including miscarriage, preterm onset of labour, and tubal pregnancy. Ectopic pregnancy is a known cause of maternal morbidity and mortality, but early diagnosis and treatment of ectopic pregnancy remain a challenge. Despite growing established associations between genital microbiome and female reproductive health, few studies have specifically focused on its link with ectopic pregnancy. Therefore, the current review aims to provide a comprehensive account of the female genital microbiome in healthy and fertile women compared to those in ectopic pregnancy and its associated risk factors. The microbial diversity from various sites of the female genital tract was explored for a reliable proxy of female reproductive health in sequencing-based ectopic pregnancy research. Our report confirmed the predominance of <i>Lactobacillus</i> in the vagina and the cervix among healthy women. The relative abundance decreased in the vaginal and cervical microbiome in the disease state. In contrast, there were inconsistent findings on the uterine microbiome across studies. Additionally, we explore a spectrum of opportunities to enhance our understanding of the female genital tract microbiome and reproductive conditions. In conclusion, this study identifies gaps within the field and emphasises the need for visionary solutions in metagenomic tools for the early detection of ectopic pregnancy and other gynaecological diseases.</p>","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10811206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139569257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Group Assessments to Help Build Online Learning Communities in Biomedical Science Distance Learning Programmes 小组评估有助于在生物医学远程学习课程中建立在线学习社区
IF 1.9 4区 医学
British Journal of Biomedical Science Pub Date : 2023-12-15 DOI: 10.3389/bjbs.2023.11891
B. Millar, Harriet Purkis, J. Moore, Stephen McClean, C. Lowery
{"title":"Group Assessments to Help Build Online Learning Communities in Biomedical Science Distance Learning Programmes","authors":"B. Millar, Harriet Purkis, J. Moore, Stephen McClean, C. Lowery","doi":"10.3389/bjbs.2023.11891","DOIUrl":"https://doi.org/10.3389/bjbs.2023.11891","url":null,"abstract":"Introduction: Biomedical Science distance learning courses offer flexibility in study while in employment. Asynchronous and self-learning approaches are common within such courses and often student-student interaction is limited. The aims of this study were to establish learning communities, develop confidence in participating in online teamwork and foster an appreciation of transferable skills including digital capabilities through remote group activities.Materials and Methods: Two cohorts of students (n = 20/n = 21) were enrolled in a microbiology module of an IBMS accredited MSc distance learning course. Groups of 4–5 students produced a digital output relating to current global infection-related issues, namely, assignment 1, production of a slide deck, which peers could use as learning resources and assignment 2, a voiceover PowerPoint debate, and infographic, voting assessment and peer/self-marking. Students also prepared reflections using written format and a FlipGrid video-recording. A qualitative content analysis was conducted on reflections from all students. Students completed a pre- and post-assignment survey focused on the development of transferable skills for the biomedical sector.Results: Students’ skills and confidence increased following completion of the group assignment, as evident from the pre- and post-questionnaire responses, namely, possession of digital skills and digital creation abilities (29% v 83%), applying for jobs which require digital skills (54% v 89%), talking about examples of using digital media during job interviews (21% v 78%) and demonstration of creativity during assignment tasks (33% v 90%). Critical thinking was more commonly demonstrated during the debate in comparison to the slide deck activity (p = 0.001). The importance of developing digital skills, was higher following completion of the group activities (p = 0.03). Students reflected on the value of the group activities in relation to knowledge acquisition (85%, 86%), collegiality (70%, 71%), digital skills development (80%, 90%), the fact that the activities were enjoyable (70%, 67%) and the development of peer interaction and support (50%, 67%) in relation to assignment 1 and 2, respectively.Discussion: Increasingly digital technologies are being used in the healthcare sector resulting in updated HCPC Standards of Proficiency. This study highlights that virtual group activities promote the establishment of supportive learning communities and the development of transferable skills including digital capabilities for application within the biomedical science workplace.","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138996583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Cytomegalovirus (CMV) Case Study to Promote Interprofessional Learning (IPL) Between Audiology and Biomedical Science Students in Higher Education. 巨细胞病毒 (CMV) 案例研究促进听力学和生物医学科学专业学生在高等教育中的跨专业学习 (IPL)。
IF 2.7 4区 医学
British Journal of Biomedical Science Pub Date : 2023-11-29 eCollection Date: 2023-01-01 DOI: 10.3389/bjbs.2023.11680
Amreen Bashir, Ross Pallett, Karan Singh Rana, Saira Hussain
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