British Journal of Biomedical Science最新文献

{"title":"OX40 genetic variations in patients with breast cancer: a case-control study.","authors":"Z Faghih, E Taherifard, A Daneshmand, A Talei, N Erfani","doi":"10.1080/09674845.2020.1776587","DOIUrl":"https://doi.org/10.1080/09674845.2020.1776587","url":null,"abstract":"","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"78 1","pages":"44-46"},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2020.1776587","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38372575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fine structure of the human retina defined by confocal microscopic immunohistochemistry.","authors":"R Zhang,&nbsp;X Zhang,&nbsp;F Hu,&nbsp;J Wu","doi":"10.1080/09674845.2020.1776586","DOIUrl":"https://doi.org/10.1080/09674845.2020.1776586","url":null,"abstract":"<p><strong>Introduction: </strong>Research in to the pathophysiology of the complex layers of retinal and sub-retinal cells is hampered by inadequate recognition of particular cells and tissues. A comprehensive panel of antibodies recognising retinal tissues is lacking. Our purpose was to determine the value of a panel of antibodies labelling various cells in the human retina.</p><p><strong>Method: </strong>Five groups of antibodies labelled frozen sections of retinas: (1) protein kinase C-α, Glutamine Synthetase (GS) and ionized calcium-binding adapter molecule 1 (Iba1); (2) Parvalbumin, Calretinin and glial fibrillary acidic protein (GFAP); (3) Thy1, GS and Iba1; (4) Rhodopsin, GS and Iba1; and (5) Brn3a, Rhodopsin and protein kinase C-α. The distribution of these antigens were determined by confocal microscopy and calculated grey value of each antibody in each layer of the retina by Image J.</p><p><strong>Results: </strong>Different antibodies determined certain retinal layers. Thy 1 is a good determinant of the ganglion cell layer, whilst GS is present in all layers except the photoreceptor layer. Brn3a is specific for the ganglion cell layer whilst parvalbumin marks the ganglion cell layer and the outer plexiform layer. Rhodopsin strongly marks the photoreceptor layer, but this is also marked weakly by GFAP.</p><p><strong>Conclusion: </strong>The multiple labelling of human retinal cells brings further understanding of the biological characteristics and functions of these cells, and provides a theoretical basis for their possible role in diseases. In the growing field of human retina research, our data may provide a point of reference for future studies of the human retina.</p>","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"78 1","pages":"28-34"},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2020.1776586","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38014617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between <i>SLCO1B1</i> polymorphism distribution frequency and blood lipid level in Chinese adults.","authors":"Q Mo,&nbsp;S Huang,&nbsp;J Ma,&nbsp;J Zhang,&nbsp;R Su,&nbsp;Q Deng","doi":"10.1080/09674845.2020.1785692","DOIUrl":"https://doi.org/10.1080/09674845.2020.1785692","url":null,"abstract":"<p><strong>Background: </strong>The variation of serum lipid levels can be part-related to certain genes. One such gene, <i>SLCO1B1</i>, encodes a transporter that may have a role in lipid metabolism. We hypothesised that differences in certain <i>SLCO1B1</i> genotypes are related to levels of serum lipids.</p><p><strong>Materials and methods: </strong>We recruited 636 subjects who were genotyped for <i>SLCO1B1</i> variants *1a, *1b, *5 and *15. Routine liver function tests, renal function tests and routine lipid indices were measured by standard techniques.</p><p><strong>Results: </strong>The most frequent genotypes were *1b/*1b (29.3%), *1b/*15 (27.5%), *1a/*1b (21.1%), *1a/*15 and *1b/*5 (10.2%) and *1a/*1a (8.5%). There were significant differences in levels of triglycerides and HDL in the four <i>SLCO1B1</i> genotypes *1a/*1a, *1b/*1b, *1a/*1b and *1b/*15 (all p < 0.05).</p><p><strong>Conclusion: </strong>The genotypes *1a/*1a and *1a/*1b indicate a high risk of cardiovascular disease, while the *1b/*1b group may have a relatively low risk. <i>SLCO1B1</i> may be involved in the metabolism of triglycerides and HDL. We have provided a tool for identifying potentially high-risk groups that could be helpful for early diagnosis and prevention, individualized drug therapy and even gene therapy.</p>","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"78 1","pages":"23-27"},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2020.1785692","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38098518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of human immunodeficiency virus, human papillomavirus, herpes simplex virus-1 and -2, human herpesvirus-6 and -8, cytomegalovirus, and hepatitis B and C virus on female fertility and pregnancy.","authors":"M Farsimadan,&nbsp;M Motamedifar","doi":"10.1080/09674845.2020.1803540","DOIUrl":"https://doi.org/10.1080/09674845.2020.1803540","url":null,"abstract":"<p><p>Female infertility may be defined as a woman of reproductive age being unable to become pregnant after a year of regular unprotected sexual intercourse. Social, genetic, endocrine, physiological, and psychological factors as well as lifestyle habits (i.e., smoking and alcohol consumption), either alone or in combination with male factors, are major causes. However, approximately 15-30% of cases of female infertility remain unexplained. Numerous investigations have also indicated that microbiomes play an important role in human reproduction. All parts of the female reproductive system may be influenced by infectious and pathological agents, especially viruses, and these may interfere with reproductive function and so are risk factors for infertility, although in many cases an exact role is unclear. We present an overview of the impact of common viral infections on female reproduction, searching Medline, PubMed, Scopus, and Google scholar databases for potentially relevant studies of viruses known to have a potential effect. Human immunodeficiency virus (HIV), herpes simplex virus (HSV) and human herpesvirus (HHV) increase infertility rates whilst human papillomavirus (HPV), cytomegalovirus (CMV), and hepatitis B and C virus (HBV, HCV) infections mostly lead to higher abortion and miscarriage rates. Moreover, HPV infection is linked to increased tubal infertility, endometriosis, and pelvic inflammatory disease. HPV was the most frequently observed infection and with lower pregnancy rate and foetal death in women undergoing IVF treatments. Assisted reproductive treatment could be a safe and effective approach for HIV and HBV infected women.</p>","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"78 1","pages":"1-11"},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2020.1803540","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38213435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toll-like receptor 7 mRNA is reduced in hepatitis C-based liver cirrhosis and hepatocellular carcinoma, out-performs alpha-fetoprotein levels, and with age and serum aspartate aminotransferase is a new diagnostic index.","authors":"A A Mohamed,&nbsp;D Omran,&nbsp;S El-Feky,&nbsp;H Darwish,&nbsp;Ael Kassas,&nbsp;A Farouk,&nbsp;O Ezzat,&nbsp;S M Abdo,&nbsp;F E Zahran,&nbsp;A El-Demery,&nbsp;M M Omran","doi":"10.1080/09674845.2020.1778842","DOIUrl":"https://doi.org/10.1080/09674845.2020.1778842","url":null,"abstract":"<p><strong>Background: </strong>Hepatitis B and C viruses are leading causes of liver cirrhosis and hepatocellular carcinoma (HCC). Toll-like receptor 7 (TLR-7) has been implicated in the pathogenesis of HCC linked to hepatitis B. We hypothesised a role of leukocyte TLR-7 mRNA in hepatitis C related liver cirrhosis and HCC, using alpha-fetoprotein (AFP) and liver function tests as comparators.</p><p><strong>Methods: </strong>We recruited 102 patients with HCV-related HCC, 97 with HCV-related liver cirrhosis and 60 healthy controls. Quantification of TLR-7 mRNA was performed using real-time PCR, AFP and routine LFTs by standard techniques.</p><p><strong>Results: </strong>TLR-7 mRNA levels were significantly lower in HCC patients compared to cirrhotic patients and lower again in healthy controls (p < 0.001 for trend). In multivariate analysis, age, aspartate transaminase (AST), AFP, and TLR-7 mRNA were significant predictors of HCC. The ROCC/AUC for age, AST and TLR-7 mRNA were all between 0.64 and 0.78 (all <i>P</i> < 0.01), but for AFP was 0.57 (95% CI 0.48-0.65, <i>P</i> = 0.09). We derived an index score using age, AST and TLR-7 mRNA for the diagnosis of HCC. The ROCC/AUC for the index was superior to all three root indices in the prediction of HCC. The index linked significantly with the Tokyo and Vienna liver cancer staging systems, but not with those of the CLIP and Okuda systems, in distinguishing HCC from liver cirrhosis.</p><p><strong>Conclusion: </strong>The combination of TLR-7 mRNA levels with age and AST improves the performance of TLR-7 in HCC diagnosis, out-performs alpha-fetoprotein and predicts early HCC.</p>","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"78 1","pages":"18-22"},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2020.1778842","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38074201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of laparoscopic gastric bypass <i>vs</i> laparoscopic sleeve gastrectomy in treating obesity combined with type-2 diabetes.","authors":"Y Yan,&nbsp;F Wang,&nbsp;H Chen,&nbsp;X Zhao,&nbsp;D Yin,&nbsp;Y Hui,&nbsp;N Ma,&nbsp;C Yang,&nbsp;Z Zheng,&nbsp;T Zhang,&nbsp;N Xu,&nbsp;G Wang","doi":"10.1080/09674845.2020.1798578","DOIUrl":"https://doi.org/10.1080/09674845.2020.1798578","url":null,"abstract":"<p><strong>Objective: </strong>This prospective study compared the efficacy and safety of laparoscopic gastric bypass and laparoscopic sleeve gastrectomy in treating overweight and obese patients with BMI>28 kg/m² and type-2 diabetes.</p><p><strong>Methods: </strong>Patients were randomized into a gastric bypass group (n = 77) or a gastrectomy group (n = 80). The surgery time, intraoperative blood loss, recovery time, and hospitalization time were collected. BMI, waistline, hipline, C-peptide level, insulin resistance index (HOMA-IR), and their blood and lipid profile were also measured.</p><p><strong>Results: </strong>Surgery time and blood loss were significantly higher in the gastrectomy group, when compared to the gastric bypass group (<i>P </i>< 0.05). In both groups, the levels of BMI, waist circumference and hip circumference (but not their ratio) gradually and significantly decreased after surgery compared with baseline (<i>P </i>< 0.05), and no significant difference was found between these two groups. The C-peptide level, HOMA-IR, fasting blood glucose, 2-hour postprandial blood glucose and glycosylated haemoglobin gradually and significantly decreased after surgery compared with the values before treatment (<i>P </i>< 0.05). The levels of total cholesterol, triglyceride, LDL, and monocyte chemoattractant protein-1 were also lower after surgery in both groups, while HDL and glucagon-like peptide-1 were significantly higher after surgery compared with the values before treatment (<i>P </i>< 0.05). However, no significant difference was found between these two groups of patients.</p><p><strong>Conclusion: </strong>Both laparoscopic gastric bypass and laparoscopic sleeve gastrectomy improved the BMI and diabetic conditions of overweight/obese diabetics, while laparoscopic sleeve gastrectomy had a shorter surgical time and less blood loss.</p>","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"78 1","pages":"35-40"},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2020.1798578","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38182151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating micro RNA-223 and angiopoietin-like protein 8 as biomarkers of gestational diabetes mellitus.","authors":"A Abdeltawab,&nbsp;M E Zaki,&nbsp;Y Abdeldayem,&nbsp;A A Mohamed,&nbsp;S M Zaied","doi":"10.1080/09674845.2020.1764211","DOIUrl":"https://doi.org/10.1080/09674845.2020.1764211","url":null,"abstract":"<p><strong>Background: </strong>Gestational diabetes mellitus (GDM) is a serious health problem associated with both foetal and maternal complications. New biomarkers that can predict or help in the early diagnosis of GDM are needed to minimize the hazards of hyperglycaemia in pregnant women and their offspring. We hypothesised a link between levels of microRNA-223 (miRNA-223) and Angiopoietin-Like Protein 8 (ANGPTL8) and GDM.</p><p><strong>Materials and methods: </strong>The study included 109 patients with confirmed early diagnosed GDM and 103 healthy control pregnant women in their second or third trimester. miRNA-223 and ANGPTL8 blood levels were assessed by real-time RT-PCR and sandwich ELISA, respectively, laboratory markers by standard methods.</p><p><strong>Results: </strong>There was a significant increase in mean [SD] miRNA-223 and ANGPTL8 in GDM (0.31 [0.06] relative units) and (692 [199] pg/ml), respectively, in the GDM women compared to healthy pregnant women (0.17[0.05] relative units) and (261 [127] pg/ml), respectively, <i>P</i> <i> < 0.001</i>. miRNA-223 and ANGPTL8 correlated significantly with each other (<i>r </i>= 0.38, <i>P </i> <i>< 0.001</i>) and with fasting, 1-h and 2-h postprandial blood glucose levels (all <i>P</i> <i>≤ 0.002</i>) HbA1 c (<i>P</i> <i> < 0.025</i>), total cholesterol (<i>P < 0.01</i>), LDL-C and triglycerides (both <i>P ≤ 0.005</i>). The ROC area under curve (AUC) (95%CI) was 0.94 (0.91-0.97) for ANGPTL8, 0.92 (0.88-0.96) for miRNA-223 and 0.97 (0.95 - 0.99) for their combination.</p><p><strong>Conclusions: </strong>These findings support the hypothesis of involvement of both miRNA-223 and ANGPTL8 in the pathogenesis of GDM. The difference between levels in GDM patients and in control pregnant women indicates potential use for early diagnosis or prediction of GDM.</p>","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"78 1","pages":"12-17"},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2020.1764211","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37948241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical and novel presentations of Coronavirus Disease 2019: a case series of three children.","authors":"M S Ekbatani,&nbsp;S A Hassani,&nbsp;L Tahernia,&nbsp;B Yaghmaei,&nbsp;S Mahmoudi,&nbsp;A Navaeian,&nbsp;M Rostamyan,&nbsp;F Zamani,&nbsp;S Mamishi","doi":"10.1080/09674845.2020.1785102","DOIUrl":"https://doi.org/10.1080/09674845.2020.1785102","url":null,"abstract":"<p><p>Typical presentations of Coronavirus Disease 2019 (Covid-19) including respiratory symptoms (cough, respiratory distress and hypoxia), fever and dyspnoea are considered main symptoms in adults, but atypical presentation in children could be a diagnostic challenge. We report three children whose initial presentation was gastrointestinal, and in whom Covid-19 infection was found, concluding that cases of acute appendicitis, mesenteric adenitis and flank tenderness may mask an infection with this virus, and should therefore be investigated.</p>","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"78 1","pages":"47-52"},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2020.1785102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38055998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of bone marrow MUC4 expression in acute myeloid leukaemia.","authors":"A S Abdelhady,&nbsp;F F Abdel Hamid,&nbsp;N M Hassan,&nbsp;D M Ibrahim","doi":"10.1080/09674845.2020.1754583","DOIUrl":"https://doi.org/10.1080/09674845.2020.1754583","url":null,"abstract":"<p><p><b>Background:</b> Aberrant expression of mucin-4 (MUC4) is present in a variety of solid cancers, but the expression pattern of <i>MUC4</i> and its clinical relevance in acute myeloid leukaemia (AML) is unknown. We aimed to evaluate the expression level of <i>MUC4</i> and explore its prognostic value in newly diagnosed adult patients with AML. <b>Methods:</b> Bone marrow from 70 AML patients and 26 healthy donors was obtained. <i>MUC4</i> levels were quantified by quantitative real-time PCR. Routine blood indices were measured by standard techniques. <b>Results:</b> Bone marrow <i>MUC4</i> expression levels were significantly elevated in AML patients compared to controls at median (range) 2.77 (0.7-16.6) and 1.14 (0.5-1.99) respectively (p = 0.005). Moreover, lower <i>MUC4</i> expression was strongly associated with persistent remission (p = 0.001) while higher <i>MUC4</i> levels were associated with worse overall as well as disease-free survival (p = 0.011 and p = 0.006, respectively). Thus, its level may act as an indicator of disease progression. High <i>MUC4</i> expression was identified as an independent prognostic predictor for both overall survival and disease-free survival. <b>Conclusion:</b> <i>MUC4</i> over-expression is an independent predictor of a poor prognosis in AML patients.</p>","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"77 4","pages":"202-207"},"PeriodicalIF":1.9,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2020.1754583","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37818782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationships between maternal and placental polymorphisms of miR-196a2 and miRNA-499 genes and preeclampsia.","authors":"M Asadi-Tarani,&nbsp;M Saravani,&nbsp;B Teimoori,&nbsp;M Ghasemi,&nbsp;S Salimi","doi":"10.1080/09674845.2020.1769331","DOIUrl":"https://doi.org/10.1080/09674845.2020.1769331","url":null,"abstract":"<p><p><b>Background</b>: miRNAs are small non-coding RNAs with potential roles in the complications of pregnancy. We hypothesised links between polymorphisms in miRNA-196a2 and miRNA-499 in maternal blood and the placentas of patients with preeclampsia. <b>Methods</b>: The blood of 315 women with preeclampsia and 317 controls and the placentas of 103 PE and 133 healthy women were collected. The genotyping of both polymorphisms was performed by PCR-RFLP. <b>Results</b>: The maternal blood rs11614913 was unrelated to preeclampsia in genotype and allele models, but in placental tissue, the CT (odds ratio [95% CI] 0.5 [0.3-0.9, p = 0.018) and TT (0.4 [0.2-0.9] p = 0.033) genotypes alone and together (CT+TT v CC 0.5 [0.3-0.8] p = 0.009), and the T allele (0.6 [0.4-0.9], p = 0.019) were associated with lower risk of preeclampsia. The maternal blood rs3746444 CC genotype was more frequent in preeclampsia (2.2 [1.2-3.8] p = 0.008) and the recessive model (CC v TC+TT) was also significant (1.9 [1.1-3.3], p = 0.018), as was the C allele (1.4 [1.1-1.7] p = 0.014). In placental tissue, the increase in the frequency of the CC genotype was marginally significant (2.4 [1.0-5.8] p = 0.046). The maternal or placental miRNA-196a2 rs11614913 and miRNA-499 rs3746444 polymorphisms were unrelated to the severity of preeclampsia. <b>Conclusion</b>: The placental but not maternal miRNA-196a2 rs11614913 variant could be a protective factor for preeclampsia predisposition in all models except the recessive model. The maternal/placental rs3746444 CC genotype was in association with higher preeclampsia risk.</p>","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"77 4","pages":"191-195"},"PeriodicalIF":1.9,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2020.1769331","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38179018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}