British Journal of Biomedical Science最新文献_第9页

HCC-Mark: a simple non-invasive model based on routine parameters for predicting hepatitis C virus related hepatocellular carcinoma. HCC-Mark:一种基于常规参数预测丙型肝炎病毒相关肝细胞癌的简单无创模型

IF 1.9 4区医学

British Journal of Biomedical Science Pub Date : 2021-04-01 Epub Date: 2020-11-18 DOI: 10.1080/09674845.2020.1832371

M Omar, K Farid, T Emran, F El-Taweel, A Tabll, M Omran

{"title":"HCC-Mark: a simple non-invasive model based on routine parameters for predicting hepatitis C virus related hepatocellular carcinoma.","authors":"M Omar, K Farid, T Emran, F El-Taweel, A Tabll, M Omran","doi":"10.1080/09674845.2020.1832371","DOIUrl":"https://doi.org/10.1080/09674845.2020.1832371","url":null,"abstract":"Background: Early detection of hepatocellular carcinoma (HCC) is crucial in providing more effective therapies. As routine laboratory variables are readily accessible, this study aimed to develop a simple non-invasive model for predicting hepatocellular cancer.Methods: Two groups of patients were recruited: an estimation group (n = 300) and a validation group (n = 625). Each comprised two categories: hepatocellular cancer and liver cirrhosis. Logistic regression analyses and receiver operating characteristic (ROC) curves were used to develop and validate the HCC-Mark model comprising AFP, high-sensitivity C-reactive protein, albumin and platelet count. This model was tested in cancer patients classified by the Barcelona Clinic Liver Cancer (BCLC), Cancer of Liver Italian Program (CLIP) and Okuda systems, and was compared with other non-invasive models for predicting hepatocellular cancer.Results: HCC-Mark produced a ROC AUC of 0.89 (95% CI 0.85-0.90) for discriminating hepatocellular carcinoma from liver cirrhosis in the estimation group and 0.90 (0.86-0.90) in the validation group (both p < 0.0001). This AUC exceeded all other models, that had AUCs from 0.41 to 0.81. AUCs of HCC-Mark for discriminating patients with a single focal lesion, absent macrovascular invasion, tumour size <2 cm, BCLC (0-A), CLIP (0-1) and Okuda (stage Ι) from cirrhotic patients were 0.88 (0.85-0.90), 0.87 (0.85-0.89), 0.89 (0.85-0.93), 0.87 (0.84-0.89), 0.85 (0.82-0.87) and 0.86 (0.83-0.89), respectively (all p < 0.0001).Conclusion: HCC-Mark is an accurate and validated model for the detection of hepatocellular cancer and certain of its clinical features.","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"78 2","pages":"72-77"},"PeriodicalIF":1.9,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2020.1832371","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38555952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Association of miR-146a rs57095329 with Behçet's disease and its complications. miR-146a rs57095329与behet病及其并发症的关系

IF 1.9 4区医学

British Journal of Biomedical Science Pub Date : 2021-04-01 Epub Date: 2020-08-06 DOI: 10.1080/09674845.2020.1786284

O O Abdelaleem, N A Fouad, O G Shaker, H A Hussein, F A Ahmed, D Y Ali, H S Elsayed

{"title":"Association of miR-146a rs57095329 with Behçet's disease and its complications.","authors":"O O Abdelaleem, N A Fouad, O G Shaker, H A Hussein, F A Ahmed, D Y Ali, H S Elsayed","doi":"10.1080/09674845.2020.1786284","DOIUrl":"https://doi.org/10.1080/09674845.2020.1786284","url":null,"abstract":"Background: Behçet's disease is a chronic relapsing and remitting autoimmune multisystem inflammatory disease characterised by oral aphthae, genital ulcers, skin lesions, gastrointestinal involvement, arthritis, vascular lesions and neurological manifestations. We hypothesised a link between rs57095329 of miR-146a and Behçet's disease, with further links with common clinical features.Methods: We tested our hypothesis in 130 Behçet's disease patients and 131 age and sex-matched healthy controls. Behcet's disease current activity index (BDCAI) was used to assess patients' disease activity status. MiR-146a (rs57095329) was genotyped in all participants using RT-PCR and results in patients analysed according to clinical features.Results: The frequency of the GG and AG genotypes in rs57095329 were strongly associated with Behçet's disease (adjusted OR 8.05, 95% CI 3.63-17.82; P < 0.001 and OR 2.26, 95% CI 1.27-4.04; P = 0.006, respectively), and in dominant (GG+AG > AA) and recessive (GG > AA+AG) models (both P < 0.001). Additionally, G allele distribution was significantly greater in Behçet's disease compared with controls (OR 2.85, 95% CI 1.98-4.11, P < 0.001). The AA genotype and A allele were linked to oral ulcers, the GG genotype and G allele to neurological disease, and the GG genotype and G allele to ocular disease (all P < 0.01). There were no links with genital ulceration, skin lesions, vascular disease or the result of the pathergy test.Conclusion: The miR-146a (rs57095329) is associated with Behçet's disease and certain genotypes and alleles with oral ulcers, and with ocular and neurological manifestations.","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"78 2","pages":"63-66"},"PeriodicalIF":1.9,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2020.1786284","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38075917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Certain haplotypes of the 3'-UTR region of the HLA-G gene are linked to breast cancer. HLA-G基因的3'-UTR区域的某些单倍型与乳腺癌有关。

IF 1.9 4区医学

British Journal of Biomedical Science Pub Date : 2021-04-01 Epub Date: 2021-01-18 DOI: 10.1080/09674845.2020.1856495

M Haghi, M Ranjbar, K Karari, S Samadi-Miandoab, A Eftekhari, M A Hosseinpour-Feizi

{"title":"Certain haplotypes of the 3'-UTR region of the HLA-G gene are linked to breast cancer.","authors":"M Haghi, M Ranjbar, K Karari, S Samadi-Miandoab, A Eftekhari, M A Hosseinpour-Feizi","doi":"10.1080/09674845.2020.1856495","DOIUrl":"https://doi.org/10.1080/09674845.2020.1856495","url":null,"abstract":"Background: Human leukocyte antigen G belongs to the family of non-classical HLA class I genes, its expression considered an important immune escape mechanism of cancer cells. The polymorphisms in the 3'-untranslated region (UTR) region of HLA-G influence the magnitude of the protein by modulating HLA-G mRNA stability. We hypothesised links between any of eight (UTR) single nucleotide polymorphisms (SNPs) and their haplotype of the HLA-G gene with breast cancer. Materials and Methods: Peripheral blood DNA from 100 patients affected by breast cancer and 100 controls was PCR sequenced for genotyping of 25 HLA-G 3'-UTR regions, including rs371194629 (+2960), rs1707 (+3003), rs1710 (+3010), rs17179101 (+3027), rs1063320 (+3142), rs9380142 (+3187), rs1610696 (+3196), and rs1233331 (+3227). Results: The 14-bp deletion (p = 0.01), and the +3010 (p = 0.021), +3142 (p = 0.006) and +3187 (p = 0.046) variants were significantly more prevalent in patients than in controls. In combining these data, two haplotypes of all eight SNPs and deletion/insertion (UTR-1 and UTR-4) are associated with breast cancer. Conclusion: Certain variants in the 3-UTR, and their combination as a haplotype, of the HLA-G gene are linked to breast cancer.","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"78 2","pages":"87-91"},"PeriodicalIF":1.9,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2020.1856495","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38641175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Pseudomonas aeruginosa - Candida interplay: effect on in vitro antibiotic susceptibility of Pseudomonas aeruginosa when grown in the presence of Candida culture. 铜绿假单胞菌与念珠菌的相互作用:在念珠菌培养中生长对铜绿假单胞菌体外抗生素敏感性的影响。

IF 1.9 4区医学

British Journal of Biomedical Science Pub Date : 2021-04-01 Epub Date: 2020-09-23 DOI: 10.1080/09674845.2020.1819003

R McIlroy, B C Millar, D W Nelson, A Murphy, J R Rao, D G Downey, J E Moore

引用次数: 1

KISS1R polymorphism rs587777844 (Tyr313His) is linked to female infertility. KISS1R多态性rs587777844 (Tyr313His)与女性不孕有关。

IF 1.9 4区医学

British Journal of Biomedical Science Pub Date : 2021-04-01 Epub Date: 2021-01-18 DOI: 10.1080/09674845.2020.1856496

Z Siahpoosh, M Farsimadan, M Pazhohan, H Vaziri, M Mahmoudi Gomari

引用次数: 17

Overexpression of long non-coding RNA MCM3AP-AS1 in breast cancer tissues compared to adjacent non-tumour tissues. 与邻近非肿瘤组织相比，长链非编码RNA MCM3AP-AS1在乳腺癌组织中的过表达

IF 1.9 4区医学

British Journal of Biomedical Science Pub Date : 2021-04-01 Epub Date: 2020-09-07 DOI: 10.1080/09674845.2020.1798058

A Riahi, M Hosseinpour-Feizi, A Rajabi, M Akbarzadeh, V Montazeri, R Safaralizadeh

{"title":"Overexpression of long non-coding RNA MCM3AP-AS1 in breast cancer tissues compared to adjacent non-tumour tissues.","authors":"A Riahi, M Hosseinpour-Feizi, A Rajabi, M Akbarzadeh, V Montazeri, R Safaralizadeh","doi":"10.1080/09674845.2020.1798058","DOIUrl":"https://doi.org/10.1080/09674845.2020.1798058","url":null,"abstract":"Background: Altered expression of several long non-coding RNAs (lncRNAs) has been described in numerous malignancies, including breast cancer, and some may have a role in carcinogenesis. We hypothesised differences in the expression of lncRNA MCM3AP-AS1 in breast cancer tissues compared to nearby healthy tissues and potential links with clinical features.Methods: We tested our hypothesis in 102 pairs of breast cancer tumours and adjacent non-tumour tissues from female patients. After RNA extraction, cDNA synthesis was performed for all specimens. The differential gene expression was assessed using Quantitative Real-Time PCR Technique.Results: There was a significant overexpression of the lncRNAs in tumour tissues as compared with their adjacent non-tumour tissues (P < 0.001). Expression was significantly linked with the tumour oestrogen receptor expression (P = 0.023) and tumour progesterone receptor expression (P < 0.001). ROC analysis showed an AUC of 0.67 (95% CI 0.60-0.75) (P < 0.001) with sensitivity and specificity of 58% and 76%, respectively.Conclusion: The lncRNA MCM3AP-AS1 may be a novel breast cancer lncRNA with high expression levels in breast cancer patients' tissue. Further investigations are needed to confirm its uses as a potential molecular marker and therapeutic target.","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"78 2","pages":"53-57"},"PeriodicalIF":1.9,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2020.1798058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38163992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Value of serum collagen triple helix repeat containing-1(CTHRC1) and 14-3-3η protein compared to anti-CCP antibodies and anti-MCV antibodies in the diagnosis of rheumatoid arthritis. 血清胶原三螺旋重复包含-1(CTHRC1)和14-3-3η蛋白与抗ccp抗体和抗mcv抗体在类风湿关节炎诊断中的价值

IF 1.9 4区医学

British Journal of Biomedical Science Pub Date : 2021-04-01 Epub Date: 2020-09-07 DOI: 10.1080/09674845.2020.1810400

T Hu, Y Liu, L Tan, J Huang, J Yu, Y Wu, Z Pei, X Zhang, J Li, L Song, W Dai, Y Xiang

{"title":"Value of serum collagen triple helix repeat containing-1(CTHRC1) and 14-3-3η protein compared to anti-CCP antibodies and anti-MCV antibodies in the diagnosis of rheumatoid arthritis.","authors":"T Hu, Y Liu, L Tan, J Huang, J Yu, Y Wu, Z Pei, X Zhang, J Li, L Song, W Dai, Y Xiang","doi":"10.1080/09674845.2020.1810400","DOIUrl":"https://doi.org/10.1080/09674845.2020.1810400","url":null,"abstract":"Introduction: Serological markers are important in the diagnosis of rheumatoid arthritis (RA) and other connective tissues diseases This study explored the clinical value of collagen triple helix repeat containing-1 (CTHRC1) and 14-3-3η protein, compared to routine markers, in the diagnosis of RA.Methods: We recruited 103 RA patients, 105 non-RA patients (osteoarthritis, ankylosing spondylitis, systemic lupus erythematosus) and 59 healthy controls. CTHRC1, 14-3-3η, anti-cyclic citrullinated peptide antibody (anti-CCP), anti-mutated citrullinated vimentin antibody (anti-MCV), rheumatoid factor and erythrocyte sedimentation rate (ESR) levels were measured, and their diagnostic value for RA evaluated and compared.Results: All laboratory indices were elevated in RA (P < 0.05). Of these, anti-MCV had the highest sensitivity (86.4%) and anti-CCP the highest specificity (94.5%). The areas under the curve (AUC) of CTHRC1, 14-3-3η, anti-CCP, anti-MCV, rheumatoid factor and ESR were 0.84, 0.81, 0.89, 0.91, 0.85 and 0.77 respectively (all P < 0.01). Anti-CCP and anti-MCV were the most valuable in the diagnosis of RA. The combination of anti-CCP and anti-MCV had the maximum Youden index, followed by the combination of anti-CCP and 14-3-3η. Binary logistic regression analysis showed that 14-3-3η had the largest odds ratio value (95% CI) at 5.1 (2.1-12.5) for RA.Conclusion: CTHRC1 and 14-3-3η are promising serological indicators of RA, and when combined with anti-CCP, anti-MCV and ESR, can improve the diagnosis of this disease.","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"78 2","pages":"67-71"},"PeriodicalIF":1.9,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2020.1810400","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38288818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Epidermal growth factor +61A/G (rs4444903) promoter polymorphism and serum levels are linked to idiopathic male infertility. 表皮生长因子+61A/G (rs4444903)启动子多态性和血清水平与特发性男性不育症有关

IF 1.9 4区医学

British Journal of Biomedical Science Pub Date : 2021-04-01 Epub Date: 2020-06-11 DOI: 10.1080/09674845.2020.1774034

M Aminmalek, F Mashayekhi, Z Salehi

引用次数: 2

Next-generation sequencing-based clinical metagenomics identifies Prevotella pleuritidis in a diabetic adolescent with large parapneumonic effusion and negative growth of pleural fluid culture: a case report. 基于新一代测序的临床宏基因组学在糖尿病青少年中发现了大量肺旁积液和胸膜液培养阴性生长的胸膜炎普雷沃氏菌:一个病例报告。

IF 1.9 4区医学

British Journal of Biomedical Science Pub Date : 2021-04-01 Epub Date: 2021-01-13 DOI: 10.1080/09674845.2020.1827846

T Galliguez, P Y Tsou, A Cabrera, J Fergie

引用次数: 4

Association of hTERT SNP (rs2736100) with implantation failure after in vitro fertilization and embryo transfer (IVF-ET). hTERT SNP (rs2736100)与体外受精和胚胎移植(IVF-ET)后着床失败的关联