British Journal of Biomedical Science最新文献_第8页

Analytical evaluation and critical appraisal of early commercial SARS-CoV-2 immunoassays for routine use in a diagnostic laboratory. 诊断实验室常规使用早期商用SARS-CoV-2免疫测定法的分析性评价和关键性评价

IF 1.9 4区医学

British Journal of Biomedical Science Pub Date : 2021-07-01 Epub Date: 2021-02-10 DOI: 10.1080/09674845.2020.1864108

A Cramer, N Goodman, T Cross, V Gant, M Dziadzio

{"title":"Analytical evaluation and critical appraisal of early commercial SARS-CoV-2 immunoassays for routine use in a diagnostic laboratory.","authors":"A Cramer, N Goodman, T Cross, V Gant, M Dziadzio","doi":"10.1080/09674845.2020.1864108","DOIUrl":"https://doi.org/10.1080/09674845.2020.1864108","url":null,"abstract":"Background: The objective of this study was to evaluate the performance characteristics of early commercial SARS-CoV-2 antibody assays in mild and asymptomatic subjects to enable the selection of suitable immunoassays for routine diagnostic use.Methods: We used serum samples from a pre-COVID era patient cohort (n = 50, pre-December 2019), designated SARS-CoV-2 negative, and serum samples from a SARS-CoV-2 RT-PCR-positive cohort (n = 90) taken > 14 days post-symptom onset (April-May 2020). Six ELISA assays were evaluated, including one confirmation assay to investigate antibody specificity. We also evaluated one point-of-care lateral flow device (LFIA) and one high throughput electrochemiluminescence immunoassay (CLIA).Results: The ELISA specificities ranged from 84% to 100%, with sensitivities ranging from 75.3% to 90.0%. The LFIA showed 100% specificity and 80% sensitivity using smaller sample numbers. The Roche CLIA immunoassay showed 100% specificity and 90.7% sensitivity. When used in conjunction, the Euroimmun nucleocapsid (NC) and spike-1 (S1) IgG ELISA assays had a sensitivity of 95.6%. The confirmation Dia.Pro IgG assay showed 92.6% of samples tested contained both NC and S1 antibodies, 32.7% had NC, S1 and S2 and 0% had either S1 or S2 only.Conclusions: The Roche assay and the Euroimmun NC and S1 assays had the best sensitivity overall. Combining the assays detecting NC and S1/S2 antibody increased diagnostic yield. These first-generation assays were not calibrated against reference material and the results were reported qualitatively. A portfolio of next-generation SARS-CoV-2 immunoassays will be necessary to investigate herd and vaccine-induced immunity.","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"78 3","pages":"141-146"},"PeriodicalIF":1.9,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2020.1864108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38701263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

XPG gene polymorphisms and glioma susceptibility: a two-centre case-control study. XPG基因多态性与胶质瘤易感性:一项双中心病例对照研究。

IF 1.9 4区医学

British Journal of Biomedical Science Pub Date : 2021-07-01 Epub Date: 2021-02-05 DOI: 10.1080/09674845.2020.1870308

L Yuan, W M Hu, K Chen, Q Shi, A Lin, H T Chen, Z J Zhuo, L Zeng

{"title":"XPG gene polymorphisms and glioma susceptibility: a two-centre case-control study.","authors":"L Yuan, W M Hu, K Chen, Q Shi, A Lin, H T Chen, Z J Zhuo, L Zeng","doi":"10.1080/09674845.2020.1870308","DOIUrl":"https://doi.org/10.1080/09674845.2020.1870308","url":null,"abstract":"Background: Glioma, the most common tumour in children next to leukaemia, is difficult to treat, with a poor prognosis and high recurrence rate. Xeroderma pigmentosum group G (XPG) plays a key role in the nucleotide excision repair pathway, which may modulate individual susceptibility to developing cancer. We hypothesized links between XPG variants and glioma in children.Methods: We tested our hypothesis in a study comparing 171 glioma cases with 228 age and sex matched controls, determining XPG polymorphisms rs2094258 C > T, rs751402 C > T, rs2296147 T > C, rs1047768 T > C, rs873601 G > A by standard molecular genetic methods.Results: rs2094258 C > T was associated with a decreased glioma risk, but carrying the rs1047768 C or rs873601 A allele brought an increased risk. Subjects carrying 5 risk genotypes had a significantly increased glioma risk at an adjusted odds ratio of 1.97 (95% confidence Interval 1.26-3.08)(p = 0.003) when compared with those carrying 0-4 risk genotypes. Furthermore, children with 5 risk genotypes had a higher glioma risk when aged >60 months, were more likely to be male, and with subtypes of astrocytic tumours, and low-grade clinical stage, when compared to those with 0-4 risk genotypes. Preliminary functional exploration suggested that rs2094258 is linked with the expression of its surrounding genes in the expression quantitative trait locus analysis.Conclusion: Certain variants of XPG are risk factors for paediatric glioma, and so may be useful in early diagnosis.","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"78 3","pages":"135-140"},"PeriodicalIF":1.9,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2020.1870308","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38778617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Homeobox A5 and A9 expression and beta-thalassemia. 同源盒A5和A9表达与-地中海贫血。

IF 1.9 4区医学

British Journal of Biomedical Science Pub Date : 2021-07-01 Epub Date: 2021-03-12 DOI: 10.1080/09674845.2021.1877926

Eae Badr, Ie-T El-Sayed, Mkr Alasadi

{"title":"Homeobox A5 and A9 expression and beta-thalassemia.","authors":"Eae Badr, Ie-T El-Sayed, Mkr Alasadi","doi":"10.1080/09674845.2021.1877926","DOIUrl":"https://doi.org/10.1080/09674845.2021.1877926","url":null,"abstract":"Background and aim: The pathogenesis of β-thalassemia has been attributed to ineffective erythropoiesis. The function of Hox genes in normal haematopoiesis has been widely studied using gene expression analysis. The aim of this study is to evaluate the expression of HoxA9, and HoxA5 genes in beta-thalassemia.Materials and methods: Children with thalassemia major, thalassemia intermediate, and age and sex-matched healthy controls (n = 50/group) were enrolled. Detection of HoxA5 and HoxA9 mRNA expression was performed by real-time polymerase chain reaction (RT-PCR).Results: Expression of HoxA9 increased in a direct linear trend (median 0.5 in controls, 2.4 in intermediate disease, 4.1 in major disease, p = 0.001) and generally correlated with the red cell count, haematocrit, ferritin and levels of beta-globin. In those with thalassemia major, the relative change of HoxA9 was linked to transfusion history, the white blood cell count, ferritin, and beta-globin (all r > 0.5, p < 0.001). Levels of HoxA9 were superior to HoxA5 in differentiating controls from thalassemia intermedia, whilst both differentiated major from the intermediate disease.Conclusion: This study highlights the importance of HoxA genes in early identification of patients, at high risk of developing complications, as it allows specific measures to delay the progression of the disease. HoxA gene expression is a promising diagnostic and prognostic marker in patients with β-thalassemia.","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"78 3","pages":"117-121"},"PeriodicalIF":1.9,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2021.1877926","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38831858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Infectious Mononucleosis: diagnosis and clinical interpretation. 传染性单核细胞增多症的诊断和临床解释。

IF 1.9 4区医学

British Journal of Biomedical Science Pub Date : 2021-07-01 Epub Date: 2021-04-14 DOI: 10.1080/09674845.2021.1903683

P Naughton, M Healy, F Enright, B Lucey

{"title":"Infectious Mononucleosis: diagnosis and clinical interpretation.","authors":"P Naughton, M Healy, F Enright, B Lucey","doi":"10.1080/09674845.2021.1903683","DOIUrl":"https://doi.org/10.1080/09674845.2021.1903683","url":null,"abstract":"EBV is the sole causative agent of the acute illness in humans described either as infectious mononucleosis (IM), or glandular fever. IM, when not clinically silent, can present in patients with at least two of the classic triad of symptoms of fever, pharyngitis, and lymphadenopathy. Challenges for the clinician arise when atypical cases present. Early, accurate and informed laboratory test results are vital for diagnosis, appropriate treatment, and management. A key challenge for the practitioner, particularly in cases where the illness can present atypically, is distinguishing bacterial tonsillitis infections from early acute IM. The ability to draw on timely, clear, and insightful laboratory results to distinguish viral from bacterial infection is vital. Correct and prompt diagnosis of IM can help prevent the unnecessary administration of antibiotics and mitigate the need for other expensive exploratory tests in cases of IM that present with splenomegaly, lymphadenopathy, or suspect haematological conditions. Good communication between the requesting clinician and those carrying out the investigative process, and between the different laboratory departments involved, is good practice and would ultimately benefit the patient. This communication will comprehensively review the aetiology, clinical presentation, and laboratory findings in IM with a view to promoting further research and so derive a standard diagnostic algorithm of the condition.","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"78 3","pages":"107-116"},"PeriodicalIF":1.9,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2021.1903683","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25480206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Long non-coding RNA EGFR-AS1 in colorectal cancer: potential role in tumorigenesis and survival via miRNA-133b sponge and EGFR/STAT3 axis regulation. 长链非编码RNA EGFR- as1在结直肠癌中的作用:通过miRNA-133b海绵和EGFR/STAT3轴调控在肿瘤发生和生存中的潜在作用

IF 1.9 4区医学

British Journal of Biomedical Science Pub Date : 2021-07-01 Epub Date: 2021-04-14 DOI: 10.1080/09674845.2020.1853913

M M Atef, A I Amer, Y M Hafez, M A Elsebaey, S A Saber, S R Abd El-Khalik

{"title":"Long non-coding RNA EGFR-AS1 in colorectal cancer: potential role in tumorigenesis and survival via miRNA-133b sponge and EGFR/STAT3 axis regulation.","authors":"M M Atef, A I Amer, Y M Hafez, M A Elsebaey, S A Saber, S R Abd El-Khalik","doi":"10.1080/09674845.2020.1853913","DOIUrl":"https://doi.org/10.1080/09674845.2020.1853913","url":null,"abstract":"Background: Colorectal cancer is one of the most common cancers worldwide and a major cause of cancer-related death. Thus molecular biomarkers for colorectal cancer have been proposed. The role of long non-coding RNA EGFR-AS1 in colorectal cancer is still unclear. We aimed to evaluate its expression in different stages of colorectal cancer and determine any possible role in regulating the miR‑133b/EGFR/STAT3 signalling pathway.Materials and methods: The relative expression of EGFR-AS1 and miR‑133b were evaluated by quantitative real-time RT-transcription PCR in 130 colorectal cancer samples and 30 normal tissues. EGFR expression was assessed using immunohistochemistry. Furthermore, levels of p-EGFR, p-STAT3, and apoptotic proteins were determined by ELISA.Results: Both EGFR-AS1 and EGFR overexpression were positively linked with colorectal cancer status (both p < 0.01), grade (both p < 0.01), and metastasis (P < 0.01 and p = 0.019 respectively). EGFR-AS1 and miR-133b were significantly inversely correlated (P < 0.01). Low expression of miR-133b was inversely associated with overexpressed EGFR and increased p-STAT3 levels. EGFR-AS1 was an independent prognostic factor for survival of colorectal cancer patients (P < 0.01, HR 2.06; 95% CI 1.32-3.19) where low EGFR-AS1 expression was associated with higher survival rate (p = 0.003).Conclusion: EGFR-AS1 may have a role in colorectal cancer by regulation of miR‑133b/EGFR/STAT3 signalling. It may be a potential biomarker for early diagnosis and predicting the survival rate of colorectal cancer.","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"78 3","pages":"122-129"},"PeriodicalIF":1.9,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2020.1853913","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38715467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Haplotype-based association study of Opioid Receptor Kappa-type 1 (OPRK1) gene polymorphisms with nicotine dependence among male smokers. 男性吸烟者阿片受体kappa - 1型(OPRK1)基因多态性与尼古丁依赖的单倍型关联研究

IF 1.9 4区医学

British Journal of Biomedical Science Pub Date : 2021-07-01 Epub Date: 2021-03-22 DOI: 10.1080/09674845.2020.1779452

A Albonaim, A Sharafshah, P Keshavarz

引用次数: 3

Endoscopic management of acute oesophageal variceal bleeding within 12 hours of admission is superior to 12-24 hours. 内镜下治疗急性食管静脉曲张出血在入院12小时内优于12-24小时。

IF 1.9 4区医学

British Journal of Biomedical Science Pub Date : 2021-07-01 Epub Date: 2021-03-17 DOI: 10.1080/09674845.2020.1857049

N Mousa, A Abdel-Razik, T Sheta, A G Deiab, A Habib, M Diasty, A Eldesoky, A Taha, E Mousa, A Yassen, A Fathy, A Elgamal

{"title":"Endoscopic management of acute oesophageal variceal bleeding within 12 hours of admission is superior to 12-24 hours.","authors":"N Mousa, A Abdel-Razik, T Sheta, A G Deiab, A Habib, M Diasty, A Eldesoky, A Taha, E Mousa, A Yassen, A Fathy, A Elgamal","doi":"10.1080/09674845.2020.1857049","DOIUrl":"https://doi.org/10.1080/09674845.2020.1857049","url":null,"abstract":"Background: Acute oesophageal variceal haemorrhage (AOVH) is a medical emergency. The American Association for the Study of Liver Diseases recommends endoscopy management as soon as possible and not more than 12 hours after presentation. The United Kingdom guidelines recommended endoscopy for unstable patients with severe acute upper gastrointestinal bleeding immediately after resuscitation and within 24 hours of admission. We aimed to evaluate the outcome of endoscopic management of AOVH in less than 12 hours compared to 12-24 hours post admission.Methods: 297 patients with AOVH were divided into groups depending on the timing of the endoscopic management: 180 within 12 h of admission and 117 patients at 12-24 hours of admission. Routine clinical and laboratory data were collected.Results: Compared to patients with endoscopic management at 12-24 hours (mean 16 hours), patients with endoscopic management within 12 hours (mean 8.3 hours) of admission had fewer hospital stay days (P = 0.001), significant reduction of ammonia levels (P < 0.0001) and significant improvement in associated hepatic encephalopathy grade 25 (p = 0.048). There were no major clinical events in the 12-hour group, but 8 events in the 12-24 hour group (p < 0.01).Conclusion: Endoscopic management of acute variceal bleeding within 12 hours of admission is superior to endoscopic management at 12-24 hours of admission regarding reduction of hospital stay, ammonia levels, correction of hepatic encephalopathy, re-bleeding and mortality rate, hence, reducing the cost of treatment benefiting patient satisfaction and improving hospital bed availability.","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"78 3","pages":"130-134"},"PeriodicalIF":1.9,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2020.1857049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38699274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Interaction between lncRNAs HOTAIR and MALAT1 tagSNPs in gastric cancer. lncRNAs HOTAIR和MALAT1标签snp在胃癌中的相互作用

IF 1.9 4区医学

British Journal of Biomedical Science Pub Date : 2021-07-01 Epub Date: 2021-04-30 DOI: 10.1080/09674845.2020.1866260

E Abdi, S Latifi-Navid, V Kholghi-Oskooei, F Pourfarzi, A Yazdanbod

引用次数: 13

Evaluation of different haematoxylin stain subtypes for the optimal microscopic interpretation of cutaneous malignancy in Mohs frozen section histological procedure. 莫氏冷冻切片组织学检查中不同血红素染色亚型对皮肤恶性肿瘤最佳显微解释的评价。

IF 1.9 4区医学

British Journal of Biomedical Science Pub Date : 2021-04-01 Epub Date: 2020-12-04 DOI: 10.1080/09674845.2020.1838075

J A Gabriel, M Shams, G E Orchard

{"title":"Evaluation of different haematoxylin stain subtypes for the optimal microscopic interpretation of cutaneous malignancy in Mohs frozen section histological procedure.","authors":"J A Gabriel, M Shams, G E Orchard","doi":"10.1080/09674845.2020.1838075","DOIUrl":"https://doi.org/10.1080/09674845.2020.1838075","url":null,"abstract":"Background: The Mohs technique employs mainly H&E-stained frozen sections for surgical margin assessment of cutaneous excisions, utilising microscopic evaluation of the complete, circumferential, peripheral and deep margins. This study aimed to determine which mordant based haematoxylin (Ehrlich's, Cole's, Mayer's, Gill's I, Gill's II, Gill's III, Weigert's, Harris' or Carazzi's) produced the optimal morphological clarity of staining for the identification of cellular and tissue morphology of cutaneous basal cell carcinoma (BCC).Material and methods: In total, 100 anonymised patient cases were selected, sectioned and stained with each haematoxylin subtype. The slides were independently evaluated microscopically by two assessors. A combined score was generated to determine the sensitivity (defined as the intensity of haematoxylin staining being too weak or too strong and the colour appearance of the haematoxylin not being blue/black) and specificity (defined as the appearance of background staining with haematoxylin, uneven staining and staining deposits) for each of the nine haematoxylin subtypes. The scoring criteria were based on the UKNEQAS CPT Mohs procedure assessment criteria.Results: The scores generated for specificity identified Carazzi's haematoxylin as best performing (99.2%) followed by Gill's III (98.4%), Ehrlich's (98.2%) and Harris' (85.0%). The sensitivity score again identified Carazzi's as producing the best result (85.0%) followed by Weigert's (83.4%), Ehrlich's (81.6%) and Gill's III (80.4%).Discussion: Carazzi's haematoxylin is the most optimal staining dye for the identification of BCC tumour for use as part of the Mohs micrographic surgery procedure.","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"78 2","pages":"78-86"},"PeriodicalIF":1.9,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2020.1838075","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38589468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Long non-coding RNA ANRIL polymorphisms in papillary thyroid cancer and its severity. 长链非编码RNA ANRIL在甲状腺乳头状癌中的多态性及其严重程度。

IF 1.9 4区医学

British Journal of Biomedical Science Pub Date : 2021-04-01 Epub Date: 2021-01-20 DOI: 10.1080/09674845.2020.1829853

R Maruei-Milan, Z Heidari, A Aryan, M Asadi-Tarani, S Salimi

{"title":"Long non-coding RNA ANRIL polymorphisms in papillary thyroid cancer and its severity.","authors":"R Maruei-Milan, Z Heidari, A Aryan, M Asadi-Tarani, S Salimi","doi":"10.1080/09674845.2020.1829853","DOIUrl":"https://doi.org/10.1080/09674845.2020.1829853","url":null,"abstract":"Background: Long non-coding RNAs are likely to have a role in the pathogenesis of many diseases, including cancer. We hypothesised an effect of certain ANRIL single nucleotide polymorphisms (SNPs) in papillary thyroid cancer. Methods: Genomic ANRIL SNPs in rs11333048, rs4977574, rs1333040 and rs10757274 were determined in 134 papillary thyroid cancer patients and 155 age- and sex-matched controls. Results: None of the ANRIL SNPs were individually linked to papillary thyroid cancer. However, the AAAC haplotype (A from rs11333048, A from rs4977574, A from rs1333040 and C from rs10757274, respectively) showed a protective effect from papillary thyroid cancer whilst the CAAC and CAGT haplotypes were associated with cancer. The rs1333048 CC variant was more frequent in patients with larger tumour size (≥1 cm) in a recessive model (OR 3.4 [95%CI, 1.1-11], P = 0.035). The rs4977574 AC variant was associated with smaller tumour size in an over-dominant model (OR 0.4 [95%CI, 0.2-1.0], P = 0.041). SNPs in rs10757274 (AA: p = 0.045) and rs1333040 (CC: p = 0.019) are linked to a lower likelihood of III-IV cancer stages in dominant or codominant models. Conclusions: Certain haplotypes of ANRIL SNPs are associated with papillary thyroid cancer. ANRIL rs1333048 and rs4977574 variants were associated with larger and smaller tumour sizes, respectively. rs10757274 and rs1333040 variants might lead to lower III-IV cancer stages. These SNPs may be important in the diagnosis of this form of thyroid cancer.","PeriodicalId":9236,"journal":{"name":"British Journal of Biomedical Science","volume":"78 2","pages":"58-62"},"PeriodicalIF":1.9,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09674845.2020.1829853","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38601822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10