Bone Marrow Research最新文献_第6页

Role of killer immunoglobulin-like receptor and ligand matching in donor selection. 杀伤免疫球蛋白样受体和配体在供体选择中的作用。

Bone Marrow Research Pub Date : 2012-01-01 Epub Date: 2012-11-10 DOI: 10.1155/2012/271695

Meral Beksaç, Klara Dalva

引用次数: 13

Lineage switching in acute leukemias: a consequence of stem cell plasticity? 急性白血病的谱系转换:干细胞可塑性的结果?

Bone Marrow Research Pub Date : 2012-01-01 Epub Date: 2012-07-19 DOI: 10.1155/2012/406796

Elisa Dorantes-Acosta, Rosana Pelayo

{"title":"Lineage switching in acute leukemias: a consequence of stem cell plasticity?","authors":"Elisa Dorantes-Acosta, Rosana Pelayo","doi":"10.1155/2012/406796","DOIUrl":"https://doi.org/10.1155/2012/406796","url":null,"abstract":"Acute leukemias are the most common cancer in childhood and characterized by the uncontrolled production of hematopoietic precursor cells of the lymphoid or myeloid series within the bone marrow. Even when a relatively high efficiency of therapeutic agents has increased the overall survival rates in the last years, factors such as cell lineage switching and the rise of mixed lineages at relapses often change the prognosis of the illness. During lineage switching, conversions from lymphoblastic leukemia to myeloid leukemia, or vice versa, are recorded. The central mechanisms involved in these phenomena remain undefined, but recent studies suggest that lineage commitment of plastic hematopoietic progenitors may be multidirectional and reversible upon specific signals provided by both intrinsic and environmental cues. In this paper, we focus on the current knowledge about cell heterogeneity and the lineage switch resulting from leukemic cells plasticity. A number of hypothetical mechanisms that may inspire changes in cell fate decisions are highlighted. Understanding the plasticity of leukemia initiating cells might be fundamental to unravel the pathogenesis of lineage switch in acute leukemias and will illuminate the importance of a flexible hematopoietic development.","PeriodicalId":9220,"journal":{"name":"Bone Marrow Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/406796","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30804733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 121

Hematopoietic stem cell development, niches, and signaling pathways. 造血干细胞的发育、生态位和信号通路。

Bone Marrow Research Pub Date : 2012-01-01 Epub Date: 2012-07-30 DOI: 10.1155/2012/270425

Kamonnaree Chotinantakul, Wilairat Leeanansaksiri

引用次数: 94

Role of HLA in Hematopoietic Stem Cell Transplantation. HLA在造血干细胞移植中的作用。

Bone Marrow Research Pub Date : 2012-01-01 Epub Date: 2012-10-02 DOI: 10.1155/2012/680841

Meerim Park, Jong Jin Seo

引用次数: 41

Computer algorithms in the search for unrelated stem cell donors. 寻找无血缘关系干细胞捐献者的计算机算法。

Bone Marrow Research Pub Date : 2012-01-01 Epub Date: 2012-11-01 DOI: 10.1155/2012/175419

David Steiner

引用次数: 0

Hematopoietic stem and progenitor cells as effectors in innate immunity. 造血干细胞和祖细胞在先天免疫中的作用。

Bone Marrow Research Pub Date : 2012-01-01 Epub Date: 2012-06-19 DOI: 10.1155/2012/165107

Jennifer L Granick, Scott I Simon, Dori L Borjesson

{"title":"Hematopoietic stem and progenitor cells as effectors in innate immunity.","authors":"Jennifer L Granick, Scott I Simon, Dori L Borjesson","doi":"10.1155/2012/165107","DOIUrl":"https://doi.org/10.1155/2012/165107","url":null,"abstract":"Recent research has shed light on novel functions of hematopoietic stem and progenitor cells (HSPC). While they are critical for maintenance and replenishment of blood cells in the bone marrow, these cells are not limited to the bone marrow compartment and function beyond their role in hematopoiesis. HSPC can leave bone marrow and circulate in peripheral blood and lymph, a process often manipulated therapeutically for the purpose of transplantation. Additionally, these cells preferentially home to extramedullary sites of inflammation where they can differentiate to more mature effector cells. HSPC are susceptible to various pathogens, though they may participate in the innate immune response without being directly infected. They express pattern recognition receptors for detection of endogenous and exogenous danger-associated molecular patterns and respond not only by the formation of daughter cells but can themselves secrete powerful cytokines. This paper summarizes the functional and phenotypic characterization of HSPC, their niche within and outside of the bone marrow, and what is known regarding their role in the innate immune response.","PeriodicalId":9220,"journal":{"name":"Bone Marrow Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/165107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30740169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 54

New rising infection: human herpesvirus 6 is frequent in myeloma patients undergoing autologous stem cell transplantation after induction therapy with bortezomib. 新的上升感染:人疱疹病毒6在骨髓瘤患者接受自体干细胞移植后用硼替佐米诱导治疗是常见的。

Bone Marrow Research Pub Date : 2012-01-01 Epub Date: 2012-11-29 DOI: 10.1155/2012/409765

Netanel Horowitz, Ilana Oren, Noa Lavi, Tsila Zuckerman, Noam Benyamini, Zipi Kra-Oz, Viki Held, Irit Avivi

{"title":"New rising infection: human herpesvirus 6 is frequent in myeloma patients undergoing autologous stem cell transplantation after induction therapy with bortezomib.","authors":"Netanel Horowitz, Ilana Oren, Noa Lavi, Tsila Zuckerman, Noam Benyamini, Zipi Kra-Oz, Viki Held, Irit Avivi","doi":"10.1155/2012/409765","DOIUrl":"https://doi.org/10.1155/2012/409765","url":null,"abstract":"Herpesvirus 6 (HHV-6) infection is a common complication during immunosuppression. Its significance for multiple myeloma (MM) patients undergoing autologous stem cell transplantation (ASCT) after treatment with novel agents affecting immune system remains undetermined. Data on 62 consecutive MM patients receiving bortezomib-dexamethasone (VD) (n = 41; 66%) or thalidomide-dexamethasone (TD) (n = 21, 34%) induction, together with melphalan 200 mg/m(2) autograft between 01.2005 and 09.2010, were reviewed. HHV-6 reactivation was diagnosed in patients experiencing postengraftment unexplained fever (PEUF) in the presence of any level of HHHV-6 DNA in blood. There were no statistically significant differences in patient characteristics between the groups, excluding dexamethasone dosage, which was significantly higher in patients receiving TD. Eight patients in TD and 18 in VD cohorts underwent viral screening for PEUF. HHV-6 reactivation was diagnosed in 10 patients of the entire series (16%), accounting for 35% of those screened; its incidence was 19.5% (n = 8) in the VD group versus 9.5% (n = 2) in the TD group. All patients recovered without sequelae. In conclusion, HHV-6 reactivation is relatively common after ASCT, accounting for at least a third of PEUF episodes. Further studies are warranted to investigate whether bortezomib has an impact on HHV-6 reactivation development.","PeriodicalId":9220,"journal":{"name":"Bone Marrow Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/409765","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31126930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Both optimal matching and procedure duration influence survival of patients after unrelated donor hematopoietic stem cell transplantation. 最佳配型和手术时间影响非亲属供体造血干细胞移植后患者的生存。

Bone Marrow Research Pub Date : 2012-01-01 Epub Date: 2012-10-22 DOI: 10.1155/2012/873695

Sylwia Mizia, Dorota Dera-Joachimiak, Malgorzata Polak, Katarzyna Koscinska, Mariola Sedzimirska, Andrzej Lange

{"title":"Both optimal matching and procedure duration influence survival of patients after unrelated donor hematopoietic stem cell transplantation.","authors":"Sylwia Mizia, Dorota Dera-Joachimiak, Malgorzata Polak, Katarzyna Koscinska, Mariola Sedzimirska, Andrzej Lange","doi":"10.1155/2012/873695","DOIUrl":"https://doi.org/10.1155/2012/873695","url":null,"abstract":"Eighty-six patients suffering from hematological malignancies, immunodeficiencies, and aplastic anemias received alloHSCT from unrelated donors. Donors were selected from the BMDW files and further matching was performed according to the confirmatory typing procedure with the use of PCR SSP and that based on sequencing. The time from the clinical request of the donor search to the final decision of clinicians accepting the donor was from 0.3 to 17.8 months (median 1.6). Matching was analyzed at the allele level, and 50, 27, and 9 donor-recipient pairs were 10/10 matched, mismatched in one or more alleles, respectively. In an univariate analysis we found better survival if patients were transplanted: (i) from donors matched 10/10 (P = 0.025), (ii) not from female donor to male recipient (P = 0.037), (iii) in female donation from those with ≤1 pregnancy than multiparous (P = 0.075). Notably, it became apparent that duration of the confirmatory typing process affected the survival (HR = 1.138, P = 0.013). In multivariate analysis only the level of matching and the duration of the matching procedure significantly affected the survival. In conclusion, the duration of the matching procedure in addition to the level of matching should be considered as an independent risk factor of survival.","PeriodicalId":9220,"journal":{"name":"Bone Marrow Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/873695","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31126931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of bisphosphonate treatment on medullary macrophages and osteoclasts: an experimental study. 双膦酸盐处理对骨髓巨噬细胞和破骨细胞影响的实验研究。

Bone Marrow Research Pub Date : 2012-01-01 Epub Date: 2012-09-13 DOI: 10.1155/2012/526236

Natalia Daniela Escudero, Patricia Mónica Mandalunis

{"title":"Influence of bisphosphonate treatment on medullary macrophages and osteoclasts: an experimental study.","authors":"Natalia Daniela Escudero, Patricia Mónica Mandalunis","doi":"10.1155/2012/526236","DOIUrl":"https://doi.org/10.1155/2012/526236","url":null,"abstract":"Nitrogen-containing bisphosphonates are widely used for treating diverse bone pathologies. They are anticatabolic drugs that act on osteoclasts inhibiting bone resorption. It remains unknown whether the mechanism of action is by decreasing osteoclast number, impairing osteoclast function, or whether they continue to effectively inhibit bone resorption despite the increase in osteoclast number. There is increasing evidence that bisphosphonates also act on bone marrow cells like macrophages and monocytes. The present work sought to evaluate the dynamics of preosteoclast fusion and possible changes in medullary macrophage number in bisphosphonate-treated animals. Healthy female Wistar rats received olpadronate, alendronate, or vehicle during 5 weeks, and 5-bromo-2-deoxyuridine (BrdU) on day 7, 28, or 34 of the experiment. Histomorphometric studies were performed to study femurs and evaluate: number of nuclei per osteoclast (N.Nu/Oc); number of BrdU-positive nuclei (N.Nu BrdU+/Oc); percentage of BrdU-positive nuclei per osteoclast (%Nu.BrdU+/Oc); medullary macrophage number (mac/mm(2)) and correlation between N.Nu/Oc and mac/mm(2). Results showed bisphosphonate-treated animals exhibited increased N.Nu/Oc, caused by an increase in preosteoclast fusion rate and evidenced by higher N.Nu BrdU+/Oc, and significantly decreased mac/mm(2). Considering the common origin of osteoclasts and macrophages, the increased demand for precursors of the osteoclast lineage may occur at the expense of macrophage lineage precursors.","PeriodicalId":9220,"journal":{"name":"Bone Marrow Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/526236","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30930827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Differential Secondary Reconstitution of In Vivo-Selected Human SCID-Repopulating Cells in NOD/SCID versus NOD/SCID/γ chain Mice. NOD/SCID与NOD/SCID/γ链小鼠体内选择的人类SCID-再填充细胞的差异二次重构

Bone Marrow Research Pub Date : 2011-01-01 Epub Date: 2010-12-26 DOI: 10.1155/2011/252953

Shanbao Cai, Haiyan Wang, Barbara Bailey, Jennifer R Hartwell, Jayne M Silver, Beth E Juliar, Anthony L Sinn, Arthur R Baluyut, Karen E Pollok

{"title":"Differential Secondary Reconstitution of In Vivo-Selected Human SCID-Repopulating Cells in NOD/SCID versus NOD/SCID/γ chain Mice.","authors":"Shanbao Cai, Haiyan Wang, Barbara Bailey, Jennifer R Hartwell, Jayne M Silver, Beth E Juliar, Anthony L Sinn, Arthur R Baluyut, Karen E Pollok","doi":"10.1155/2011/252953","DOIUrl":"https://doi.org/10.1155/2011/252953","url":null,"abstract":"Humanized bone-marrow xenograft models that can monitor the long-term impact of gene-therapy strategies will help facilitate evaluation of clinical utility. The ability of the murine bone-marrow microenvironment in NOD/SCID versus NOD/SCID/γ chain(null) mice to support long-term engraftment of MGMT(P140K)-transduced human-hematopoietic cells following alkylator-mediated in vivo selection was investigated. Mice were transplanted with MGMT(P140K)-transduced CD34(+) cells and transduced cells selected in vivo. At 4 months after transplantation, levels of human-cell engraftment, and MGMT(P140K)-transduced cells in the bone marrow of NOD/SCID versus NSG mice varied slightly in vehicle- and drug-treated mice. In secondary transplants, although equal numbers of MGMT(P140K)-transduced human cells were transplanted, engraftment was significantly higher in NOD/SCID/γ chain(null) mice compared to NOD/SCID mice at 2 months after transplantation. These data indicate that reconstitution of NOD/SCID/γ chain(null) mice with human-hematopoietic cells represents a more promising model in which to test for genotoxicity and efficacy of strategies that focus on manipulation of long-term repopulating cells of human origin.","PeriodicalId":9220,"journal":{"name":"Bone Marrow Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/252953","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40122331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21