Bone Marrow Research最新文献_第7页

Immune recovery after cyclophosphamide treatment in multiple myeloma: implication for maintenance immunotherapy. 多发性骨髓瘤环磷酰胺治疗后的免疫恢复:对维持免疫治疗的意义。

Bone Marrow Research Pub Date : 2011-01-01 Epub Date: 2011-04-06 DOI: 10.1155/2011/269519

Amir Sharabi, Nechama Haran-Ghera

引用次数: 20

Signaling proteins and transcription factors in normal and malignant early B cell development. 正常和恶性早期B细胞发育中的信号蛋白和转录因子。

Bone Marrow Research Pub Date : 2011-01-01 Epub Date: 2011-05-20 DOI: 10.1155/2011/502751

Patricia Pérez-Vera, Adriana Reyes-León, Ezequiel M Fuentes-Pananá

引用次数: 30

Transplantation for congenital bone marrow failure syndromes. 移植治疗先天性骨髓衰竭综合征。

Bone Marrow Research Pub Date : 2011-01-01 Epub Date: 2010-11-29 DOI: 10.1155/2011/849387

Kenji Morimoto, Theodore B Moore, Gary Schiller, Kathleen M Sakamoto

引用次数: 2

Breast cancer stem cells survive periods of farnesyl-transferase inhibitor-induced dormancy by undergoing autophagy. 乳腺癌干细胞在法尼基转移酶抑制剂诱导的休眠期通过自噬存活下来。

Bone Marrow Research Pub Date : 2011-01-01 Epub Date: 2011-07-07 DOI: 10.1155/2011/362938

Moumita Chaterjee, Kenneth L van Golen

{"title":"Breast cancer stem cells survive periods of farnesyl-transferase inhibitor-induced dormancy by undergoing autophagy.","authors":"Moumita Chaterjee, Kenneth L van Golen","doi":"10.1155/2011/362938","DOIUrl":"10.1155/2011/362938","url":null,"abstract":"A cancer stem cell has been defined as a cell within a tumor that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor. These tumor-forming cells could hypothetically originate from stem, progenitor, or differentiated cells. Previously, we have shown that breast cancer cells with low metastatic potential can be induced into a reversible state of dormancy by farnesyl transferase inhibitors (FTIs). Dormancy was induced by changes in RhoA and RhoC GTPases. Specifically, RhoA was found to be hypoactivated while RhoC was hyperactivated. In the current study we demonstrate that these dormant cells also express certain known stem cell markers such as aldehyde dehydrogenase I (ALDHI) and cluster of differentiation 44 (CD44). We also show that autophagy markers Atg5, Atg12, and LC3-B are expressed in these dormant stem cell-like breast cancer cells. Inhibiting autophagy by inhibitor 3-methyladenine (3-MA) blocked the process of autophagy reversing the dormant phenotype. Further, we show that c-jun NH2 terminal kinase (JNK/SAPK) is upregulated in these dormant stem cell-like breast cancer cells and is responsible for increasing autophagy.","PeriodicalId":9220,"journal":{"name":"Bone Marrow Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40122335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Haploidentical hematopoietic stem-cell transplantation in adults. 成人单倍体造血干细胞移植。

Bone Marrow Research Pub Date : 2011-01-01 Epub Date: 2011-07-13 DOI: 10.1155/2011/303487

Salem Alshemmari, Reem Ameen, Javid Gaziev

{"title":"Haploidentical hematopoietic stem-cell transplantation in adults.","authors":"Salem Alshemmari, Reem Ameen, Javid Gaziev","doi":"10.1155/2011/303487","DOIUrl":"https://doi.org/10.1155/2011/303487","url":null,"abstract":"Haploidentical hematopoietic stem-cell transplantation is an alternative transplant strategy for patients without an HLA-matched donor. Still, only half of patients who might benefit from transplantation are able to find an HLA-matched related or unrelated donor. Haploidentical donor is readily available for many patients in need of immediate stem-cell transplantation. Historical experience with haploidentical stem-cell transplantation has been characterised by a high rejection rate, graft-versus-host disease, and transplant-related mortality. Important advances have been made in this field during the last 20 years. Many drawbacks of haploidentical transplants such as graft failure and significant GVHD have been overcome due to the development of new extensive T cell depletion methods with mega dose stem-cell administration. However, prolonged immune deficiency and an increased relapse rate remain unresolved problems of T cell depletion. New approaches such as partial ex vivo or in vivo alloreactive T cell depletion and posttransplant cell therapy will allow to improve immune reconstitution in haploidentical transplants. Results of unmanipulated stem-cell transplantation with using ATG and combined immunosuppression in mismatched/haploidentical transplant setting are promising. This paper focuses on recent advances in haploidentical hematopoietic stem-cell transplantation for hematologic malignancies.","PeriodicalId":9220,"journal":{"name":"Bone Marrow Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/303487","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40122333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Future perspectives: therapeutic targeting of notch signalling may become a strategy in patients receiving stem cell transplantation for hematologic malignancies. 未来展望:notch信号的靶向治疗可能成为接受干细胞移植治疗血液恶性肿瘤患者的一种策略。

Bone Marrow Research Pub Date : 2011-01-01 Epub Date: 2010-10-04 DOI: 10.1155/2011/570796

Elisabeth Ersvaer, Kimberley J Hatfield, Håkon Reikvam, Oystein Bruserud

{"title":"Future perspectives: therapeutic targeting of notch signalling may become a strategy in patients receiving stem cell transplantation for hematologic malignancies.","authors":"Elisabeth Ersvaer, Kimberley J Hatfield, Håkon Reikvam, Oystein Bruserud","doi":"10.1155/2011/570796","DOIUrl":"https://doi.org/10.1155/2011/570796","url":null,"abstract":"The human Notch system consists of 5 ligands and 4 membrane receptors with promiscuous ligand binding, and Notch-initiated signalling interacts with a wide range of other intracellular pathways. The receptor signalling seems important for regulation of normal and malignant hematopoiesis, development of the cellular immune system, and regulation of immune responses. Several Notch-targeting agents are now being developed, including natural receptor ligands, agonistic and antagonistic antibodies, and inhibitors of intracellular Notch-initiated signalling. Some of these agents are in clinical trials, and several therapeutic strategies seem possible in stem cell recipients: (i) agonists may be used for stem cell expansion and possibly to enhance posttransplant lymphoid reconstitution; (ii) receptor-specific agonists or antagonists can be used for immunomodulation; (iii) Notch targeting may have direct anticancer effects. Although the effects of therapeutic targeting are difficult to predict due to promiscuous ligand binding, targeting of this system may represent an opportunity to achieve combined effects with earlier posttransplant reconstitution, immunomodulation, or direct anticancer effects.","PeriodicalId":9220,"journal":{"name":"Bone Marrow Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/570796","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40121232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

One-Year Safety Analysis of the COMPARE-AMI Trial: Comparison of Intracoronary Injection of CD133 Bone Marrow Stem Cells to Placebo in Patients after Acute Myocardial Infarction and Left Ventricular Dysfunction. 为期一年的COMPARE-AMI试验安全性分析:急性心肌梗死和左心室功能障碍患者冠状动脉内注射CD133骨髓干细胞与安慰剂的比较

Bone Marrow Research Pub Date : 2011-01-01 Epub Date: 2011-02-27 DOI: 10.1155/2011/385124

Samer Mansour, Denis-Claude Roy, Vincent Bouchard, Louis Mathieu Stevens, Francois Gobeil, Alain Rivard, Guy Leclerc, François Reeves, Nicolas Noiseux

{"title":"One-Year Safety Analysis of the COMPARE-AMI Trial: Comparison of Intracoronary Injection of CD133 Bone Marrow Stem Cells to Placebo in Patients after Acute Myocardial Infarction and Left Ventricular Dysfunction.","authors":"Samer Mansour, Denis-Claude Roy, Vincent Bouchard, Louis Mathieu Stevens, Francois Gobeil, Alain Rivard, Guy Leclerc, François Reeves, Nicolas Noiseux","doi":"10.1155/2011/385124","DOIUrl":"https://doi.org/10.1155/2011/385124","url":null,"abstract":"Bone marrow stem cell therapy has emerged as a promising approach to improve healing of the infarcted myocardium. Despite initial excitement, recent clinical trials using non-homogenous stem cells preparations showed variable and mixed results. Selected CD133(+) hematopoietic stem cells are candidate cells with high potential. Herein, we report the one-year safety analysis on the initial 20 patients enrolled in the COMPARE-AMI trial, the first double-blind randomized controlled trial comparing the safety, efficacy, and functional effect of intracoronary injection of selected CD133(+) cells to placebo following acute myocardial infarction with persistent left ventricular dysfunction. At one year, there is no protocol-related complication to report such as death, myocardial infarction, stroke, or sustained ventricular arrhythmia. In addition, the left ventricular ejection fraction significantly improved at four months as compared to baseline and remained significantly higher at one year. These data indicate that in the setting of the COMPARE-AMI trial, the intracoronary injection of selected CD133(+) stem cells is secure and feasible in patients with left ventricle dysfunction following acute myocardial infarction.","PeriodicalId":9220,"journal":{"name":"Bone Marrow Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/385124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40122336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 48

A Case of Monoclonal Lymphoplasmacytosis of the Bone Marrow with IgM-Positive Russell Bodies. igm -罗素体阳性骨髓单克隆淋巴浆细胞病1例。

Bone Marrow Research Pub Date : 2011-01-01 Epub Date: 2011-03-07 DOI: 10.1155/2011/814372

Hidekazu Kayano, Tsuneyuki Shimada, Naoki Wakimoto, Yuichi Nakamura, Masami Bessho, Hiroshi Yamaguchi, Atsushi Sasaki, Michio Shimizu

引用次数: 1

Innovative analyses support a role for DNA damage and an aberrant cell cycle in myelodysplastic syndrome pathogenesis. 创新分析支持DNA损伤和异常细胞周期在骨髓增生异常综合征发病机制中的作用。

Bone Marrow Research Pub Date : 2011-01-01 Epub Date: 2011-06-07 DOI: 10.1155/2011/950934

David R Head, James W Jacobberger, Claudio Mosse, Madan Jagasia, William Dupont, Stacey Goodman, Leanne Flye, Andrew Shinar, Sara McClintock-Treep, Greg Stelzer, Robert Briggs, Keith Shults

{"title":"Innovative analyses support a role for DNA damage and an aberrant cell cycle in myelodysplastic syndrome pathogenesis.","authors":"David R Head, James W Jacobberger, Claudio Mosse, Madan Jagasia, William Dupont, Stacey Goodman, Leanne Flye, Andrew Shinar, Sara McClintock-Treep, Greg Stelzer, Robert Briggs, Keith Shults","doi":"10.1155/2011/950934","DOIUrl":"https://doi.org/10.1155/2011/950934","url":null,"abstract":"We used flow cytometry to analyze the cell cycle, DNA damage, and apoptosis in hematopoietic subsets in MDS marrow. Subsets were assigned using CD45, side scatter, CD34, and CD71. Cell cycle fractions were analyzed using DRAQ 5 (DNA content) and MPM-2 (mitoses). DNA damage was assessed using p-H2A.X, and apoptosis using Annexin V. Compared to controls, MDS patients demonstrated no increased mitoses in erythroid, myeloid, or CD34+ cells. Myeloid progenitors demonstrated increased G2 cells, which with no increased mitoses suggested delayed passage through G2. Myeloid progenitors demonstrated increased p-H2A.X, consistent with DNA damage causing this delay. Annexin V reactivity was equivalent in MDS and controls. Results for each parameter varied among hematopoietic compartments, demonstrating the need to analyze compartments separately. Our results suggest that peripheral cytopenias in MDS are due to delayed cell cycle passage of marrow progenitors and that this delayed passage and leukemic progression derive from excessive DNA damage.","PeriodicalId":9220,"journal":{"name":"Bone Marrow Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/950934","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40122722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

T-cell costimulatory molecules in acute-graft-versus host disease: therapeutic implications. 急性移植物抗宿主病中的t细胞共刺激分子:治疗意义。

Bone Marrow Research Pub Date : 2011-01-01 Epub Date: 2010-09-21 DOI: 10.1155/2011/976793

Javier Briones, Silvana Novelli, Jorge Sierra

引用次数: 53