igm -罗素体阳性骨髓单克隆淋巴浆细胞病1例。

Bone Marrow Research Pub Date : 2011-01-01 Epub Date: 2011-03-07 DOI:10.1155/2011/814372
Hidekazu Kayano, Tsuneyuki Shimada, Naoki Wakimoto, Yuichi Nakamura, Masami Bessho, Hiroshi Yamaguchi, Atsushi Sasaki, Michio Shimizu
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引用次数: 1

摘要

一名71岁的日本男性HCV感染患者被诊断为血小板减少症。骨髓抽吸的组织学检查显示有大量罗素小体的淋巴样聚集体。免疫组织化学和流式细胞术分析显示CD5+ CD23+ B细胞克隆扩增。罗素小体IgM和λ免疫球蛋白轻链阳性。患者还进行了胃活检,发现幽门螺杆菌(HP)感染。随后对细菌的根除使他的血小板减少症得到改善。在15个月的随访中,临床过程保持平稳,与单克隆b细胞淋巴细胞增多症一致。观察到的克隆扩增与浆细胞分化可能是在HCV感染HP的影响下发生的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A Case of Monoclonal Lymphoplasmacytosis of the Bone Marrow with IgM-Positive Russell Bodies.

A Case of Monoclonal Lymphoplasmacytosis of the Bone Marrow with IgM-Positive Russell Bodies.

A Case of Monoclonal Lymphoplasmacytosis of the Bone Marrow with IgM-Positive Russell Bodies.

A Case of Monoclonal Lymphoplasmacytosis of the Bone Marrow with IgM-Positive Russell Bodies.

A 71-year-old Japanese male patient infected with HCV was diagnosed with thrombocytopenia. Histological examination of the bone marrow aspirate showed numerous lymphoid aggregates with Russell bodies. Immunohistochemistry and flow cytometric analysis demonstrated clonal expansion of CD5+ CD23+ B cells. Russell bodies were positive for IgM and lambda immunoglobulin light chain. The patient also underwent gastric biopsy, which revealed Helicobacter pylori (HP) infection. Subsequent eradication of the bacteria resulted in improvement of his thrombocytopenia. The clinical course remained uneventful at 15-month follow-up, consistent with monoclonal B-cell lymphocytosis. The observed clonal expansion with plasmacytic differentiation may have occurred under the influence of HCV with HP infection.

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