Computer algorithms in the search for unrelated stem cell donors.

Bone Marrow Research Pub Date : 2012-01-01 Epub Date: 2012-11-01 DOI:10.1155/2012/175419
David Steiner
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引用次数: 0

Abstract

Hematopoietic stem cell transplantation (HSCT) is a medical procedure in the field of hematology and oncology, most often performed for patients with certain cancers of the blood or bone marrow. A lot of patients have no suitable HLA-matched donor within their family, so physicians must activate a "donor search process" by interacting with national and international donor registries who will search their databases for adult unrelated donors or cord blood units (CBU). Information and communication technologies play a key role in the donor search process in donor registries both nationally and internationaly. One of the major challenges for donor registry computer systems is the development of a reliable search algorithm. This work discusses the top-down design of such algorithms and current practice. Based on our experience with systems used by several stem cell donor registries, we highlight typical pitfalls in the implementation of an algorithm and underlying data structure.

Abstract Image

Abstract Image

Abstract Image

寻找无血缘关系干细胞捐献者的计算机算法。
造血干细胞移植(HSCT)是血液学和肿瘤学领域的一项医疗程序,通常用于治疗某些血液或骨髓癌症患者。许多患者的家族中没有合适的 HLA 匹配捐献者,因此医生必须启动 "捐献者搜索程序",与国家和国际捐献者登记处互动,由他们在数据库中搜索成年非亲属捐献者或脐带血单位(CBU)。信息和通信技术在国内和国际捐献者登记处的捐献者搜索过程中发挥着关键作用。开发可靠的搜索算法是捐献者登记处计算机系统面临的主要挑战之一。这项工作讨论了这种算法的自上而下的设计和当前的实践。根据我们在几个干细胞捐献者登记处使用的系统中积累的经验,我们强调了算法和基础数据结构实施过程中的典型陷阱。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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