造血干细胞的发育、生态位和信号通路。

Bone Marrow Research Pub Date : 2012-01-01 Epub Date: 2012-07-30 DOI:10.1155/2012/270425
Kamonnaree Chotinantakul, Wilairat Leeanansaksiri
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引用次数: 94

摘要

造血干细胞(Hematopoietic stem cells, hsc)在造血系统中起着关键作用,主要在造血系统的稳态和免疫应答中发挥作用。造血干细胞移植已被应用于多种疾病的治疗。然而,造血干细胞在体内持续存在少量,多处于静止状态。了解造血干细胞的基本知识有助于干细胞生物学研究和治疗药物的发展。因此,本文将重点阐述造血干细胞的起源、来源、发展、生态位以及支持造血干细胞维持和自我更新与增殖平衡的信号通路,为今后造血干细胞的扩增和移植提供参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Hematopoietic stem cell development, niches, and signaling pathways.

Hematopoietic stem cell development, niches, and signaling pathways.

Hematopoietic stem cell development, niches, and signaling pathways.

Hematopoietic stem cell development, niches, and signaling pathways.

Hematopoietic stem cells (HSCs) play a key role in hematopoietic system that functions mainly in homeostasis and immune response. HSCs transplantation has been applied for the treatment of several diseases. However, HSCs persist in the small quantity within the body, mostly in the quiescent state. Understanding the basic knowledge of HSCs is useful for stem cell biology research and therapeutic medicine development. Thus, this paper emphasizes on HSC origin, source, development, the niche, and signaling pathways which support HSC maintenance and balance between self-renewal and proliferation which will be useful for the advancement of HSC expansion and transplantation in the future.

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