Role of HLA in Hematopoietic Stem Cell Transplantation.

Bone Marrow Research Pub Date : 2012-01-01 Epub Date: 2012-10-02 DOI:10.1155/2012/680841
Meerim Park, Jong Jin Seo
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引用次数: 41

Abstract

The selection of hematopoietic stem cell transplantation (HSCT) donors includes a rigorous assessment of the availability and human leukocyte antigen (HLA) match status of donors. HLA plays a critical role in HSCT, but its involvement in HSCT is constantly in flux because of changing technologies and variations in clinical transplantation results. The increased availability of HSCT through the use of HLA-mismatched related and unrelated donors is feasible with a more complete understanding of permissible HLA mismatches and the role of killer-cell immunoglobulin-like receptor (KIR) genes in HSCT. The influence of nongenetic factors on the tolerability of HLA mismatching has recently become evident, demonstrating a need for the integration of both genetic and nongenetic variables in donor selection.

HLA在造血干细胞移植中的作用。
造血干细胞移植(HSCT)供体的选择包括对供体的可用性和人类白细胞抗原(HLA)匹配状态的严格评估。HLA在造血干细胞移植中起着至关重要的作用,但由于技术的变化和临床移植结果的变化,其在造血干细胞移植中的作用不断变化。随着对允许的HLA错配和杀伤细胞免疫球蛋白样受体(KIR)基因在HSCT中的作用有了更全面的了解,通过使用HLA错配的相关和非相关供体来增加HSCT的可用性是可行的。非遗传因素对HLA错配耐受性的影响最近变得明显,表明在供体选择中需要整合遗传和非遗传变量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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