Journal of analytical & pharmaceutical research最新文献

{"title":"New insight into RBC membrane and trypanosome infection","authors":"O. Akinseye, A. Mustapha, O. Moses","doi":"10.15406/japlr.2019.08.00334","DOIUrl":"https://doi.org/10.15406/japlr.2019.08.00334","url":null,"abstract":"Trypanosomiasis is an endemic disease which is invariably fatal if not treated. It is characterized by biochemical and haematological changes which often influence the pathogenesis of the disease. The disease is connected with a rapid decrease RBC counts, haemoglobin (Hb) concentration and packed cell volume (PCV) and unhealthy pale appearance in the mucosa membranes in the infected hosts.1 Red blood cell membrane is a bilayer which consists of proteins, glycolipids and unique molecules and structures which confer distinct properties associated with it. The erythrocytes of humans, form the important cells generally employed in the investigation of biological membranes, have some glycoproteins in their cell membrane.2","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67073512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of cadmium and lead using atomic absorption spectrophotometer in roadside soils of Jimma town","authors":"Bihonegn Sisay, E. Debebe, Asfaw Meresa, Tigist Abera","doi":"10.15406/japlr.2019.08.00329","DOIUrl":"https://doi.org/10.15406/japlr.2019.08.00329","url":null,"abstract":"Cadmium and lead are pollutants of great concern to human health. The analysis of Cadmium and lead content in our environment is crucial for policy makers to make decisions concerning the environment and to secure the wellbeing of the inhabitants. In this study lead and cadmium in roadside soil was analyzed. The soil sample was collected at the distance of 18m, 20m, 25m, 26m and from the roadside. The collected sample was digested on hot plate. The concentration of lead and cadmium was measured by flame atomic absorption spectroscopy (FAAS). Lead concentrations in soil samples varied from 36.47 to 43.42mgkg−1. Lead analyses showed that there was a considerable contamination in soil affected from traffic intensity. Cadmium and lead were determined using AAS in the surface layer (0.0-5.0cm) of soils, situated in areas under different impact of traffic contamination. The Concentration cadmium in soil samples lies between 0.505mg/kg to 1.745mg/kg. The obtained results of Cadmium and lead concentration in the soil around Jimma, Ethiopia; 1.745mg/kg and 43.42mg/ kg respectively, were compared with WHO and EPA. The maximum contaminate level according to WHO, for lead and cadmium in soil is 100 and 3.00mg/Kg respectively and appropriate recommendation and conclusion was forwarded. From this site the concentration of lead is higher than cadmium. The average lead and cadmium concentration in soil samples from the four sites of Jimma were all found to be below the maximum tolerable limit according to WHO standards.","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67073281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and characterization of Cuscuta reflexa (Roxb.) aqueous extract mediated silver nanoparticles","authors":"R. Ranjan, Sukumar Dandapat, Manoj Kumar, M. Sinha","doi":"10.15406/japlr.2019.08.00317","DOIUrl":"https://doi.org/10.15406/japlr.2019.08.00317","url":null,"abstract":"Nanoparticles (NPs) and nanostructured materials (NSMs) represent an active area of research with full expansion in many applications such as engineering, electronics, pharmaceuticals etc. NPs and NSMs have gained prominence in technological advancements due to their marvellous physicochemical characteristics such as melting point, wettability, electrical and thermal conductivity, catalytic activity, great adsorption capacity with ligands, stability in biological solution, light absorption and scattering resulting in enhanced performance over their bulk counterparts.1,2","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67072995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of antioxidant activity of pyrimidinium betaines by DPPH radical scavenging method","authors":"Malki Fatiha, Touati Abdelkader","doi":"10.15406/japlr.2019.08.00308","DOIUrl":"https://doi.org/10.15406/japlr.2019.08.00308","url":null,"abstract":"Free radicals cause various human diseases.1 Antioxidants are substances that eliminate free radicals and serve as a defensive factor against their effects in the body. Antioxidants play an important role in the prevention of diseases induced by free radicals2 and systematically reduce their risk by reducing their concentrations.3 They act by inhibiting the initiation and propagation steps, resulting in the end of the reaction and delaying the oxidation process.4 In biological systems, antioxidants have multiple functions, eg it defends against oxidative damage by participating in the main cell signaling pathways and by preventing cell damage caused by the action of reactive oxygen species (ROS). Therefore, antioxidant consumption and the addition of antioxidant in food materials protect the body as well as food from deterioration of oxidation.5 Numerous methods to evaluate the antioxidant activity of specific compounds have been described, but the most widely documented relates to the 2, 2-diphenyl-1-picrylhydrazyl radical (DPPH).6–9 DPPH is stable free radical that accepts an electron or hydrogen to become a stable diamagnetic molecule. In the DPPH radical-scavenging assay, antioxidants react with DPPH, and convert it to yellowcolored diphenylpicrylhydrazine. The color fading extent proves indirectly the radical-scavenging capacity of the antioxidant.6 The reduction of DPPH radical by antioxidants is evaluated by the decrease in absorbance at 517 nm. The decrease in absorbance of DPPH radical caused by antioxidants is due to the reaction between antioxidant molecules and radical progress which results in the scavenging of the radical by hydrogen donation.10 The DPPH tests provided in the literature are based on the same principle as described by BrandWilliams et al.,8 but the analytical protocols differ in several parameters. Evaluation of the methods and modifications for determination of the radical scavenging activity by DPPH shows that the main factors influenced the reproducibility are the solvent, duration of the reaction, sample to reagent ratio and the wave length for absorbance measurement of the decolouration of the reaction mixture.11 Therefore, it is obvious that these factors are of significance for the radical scavenging activity of the tested compounds. Pyrimidinium betaines constitute a class of mesoionic compounds12 which have raised much interest as biologically active compounds.13 Pyrimidinium betaines remain an important class of bioactive heterocyclics due to the presence of the pyrimidine ring in their structure. The literatures indicated that compounds having pyrimidine nucleus have a broad range of biological activities. As a result of their remarkable pharmacological activity, intensive research on pyrimidine derivatives has been focused on their activity, thus constituting an integral part of pharmaceutical industry.14","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67073038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of HPLC method in determination of miconazole nitrate in environmental samples from el-gharbia governorate in Egypt ","authors":"A. M. Ahmed, M. Ibrahim, A. Mohamad","doi":"10.15406/japlr.2019.08.00331","DOIUrl":"https://doi.org/10.15406/japlr.2019.08.00331","url":null,"abstract":"Miconazole]1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy) phenethyl)imidazole [is an anti-fungal medication related to fluconazole, ketoconazole, itraconazole, and clotrimazole. It is used either on the skin or in the vagina for fungal infections. Miconazole was approved by the FDA in 1974. Miconazole prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.1 Miconazole comes as a cream, lotion, powder, spray liquid, and spray powder to be applied to the skin. It also comes as a cream and suppository to be inserted into the vagina.2 Miconazole has a molecular formula of C18H14Cl4N2O and molecular weight of 416.127g/mol. 3","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67073356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new study on Omeprazole spectrophotometric determination using 9- Fluorenylmethyl chloroformate as derivatizating agent","authors":"A. Elbashir, Iman Ahmed Alamin","doi":"10.15406/japlr.2019.08.00309","DOIUrl":"https://doi.org/10.15406/japlr.2019.08.00309","url":null,"abstract":"Omeprazole (OMZ) chemically known as 5 M e t h o x y 2 [ [ ( 4 m e t h o x y 3 , 5 d i m e t h y l 2 pyridinyl)methyl]sulfinyl]-1H-benzimidazole (Figure 1), is one of irreversible proton pump (H+/K+ATPase) inhibitors that decrease acid secretion from gastric parietal cell, and it is also effective in treatment of Zollinger Ellison syndrome and preventing ulcer rebleeding, and recently it has been used as a potential anti-inflammatory agent to protect the gastric mucosa from the inflammation caused by Helicobacter pylori infection. The therapeutic importance of OMZ helped in development of many methods of determination in pharmaceutical formulations and biological samples.1,2","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67072589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacologically relevant drug interactions of Glucagon-like peptide-1 receptor agonists","authors":"Naina Mohamed Pakkir Maideen ","doi":"10.15406/japlr.2019.08.00311","DOIUrl":"https://doi.org/10.15406/japlr.2019.08.00311","url":null,"abstract":"","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67072657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of HPLC methods for simultaneous analysis of 6 antiretrovirals in pharmaceutical formulations","authors":"Mankulu Kakumba Jocelyn, M. Augustin, Mbenza Puati Adelard, M. Jeremie, Kimbeni Malongo Tresor","doi":"10.15406/japlr.2019.08.00339","DOIUrl":"https://doi.org/10.15406/japlr.2019.08.00339","url":null,"abstract":"HIV/AIDS is one the world’s most serious public health problems and affects an important number of populations in Africa; particularly in the Democratic Republic of the Congo (DRC) where the access to a good antiretrovirals (ARVs) treatment remains a big issue. To increase the life quality of people living with HIV/AIDS, it is urgent to secure medicines of good quality and in good quantity for everyone in need. The drugs efficiency and safety depend first on their quality, and secondly on their use.1 In the particular case of DRC, we estimated that among one million people living with HIV/AIDS2 only 350,000 were having ARV treatment in 2011-2015. This number, decreased only in 44 000 patients who were effectively treated with ARVs,3 which represented a coverage of 14 % ARV treatment. This was the lowest rate in the world and shows that more than 300 000 people were in need but were not served.4 Nowadays, one can tell that the situation remains unchanged and there is an emergency for the HIV/AIDS living people. In addition to poor accessibility to ARV treatment, another important question may arise from the ARV products, and this concerns their quality! Antiretrovirals are medicines used to treat the HIV infection. They act by reducing the viral DNA replication speed, stopping at the same time its propagation in the body5. Since the launch of Monetary Found and Medicines Access Program projects, the ARV treatment is given to the public for free, but their access stills a problem in some countries. This is unfortunately the case of the DRC, where the national guide of HIV treatment was elaborated in 2003 and reviewed in 2005, 2008 and 2010, following the new recommendations of WHO.6,7 For importer countries, it is very important to certify the ARV quality according to the national guidelines and the manufacturer data submitted to the public health authorities before their launch in the market for use.8","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67073303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of gelatin using various separation and detection technologies","authors":"X. M. Liu, Dawn Z. Herrick, E. P. Maziarz","doi":"10.15406/JAPLR.2018.07.00299","DOIUrl":"https://doi.org/10.15406/JAPLR.2018.07.00299","url":null,"abstract":"Abbreviations: SEC, size exclusion chromatography; FFF, field-flow fractionation; AFIFFF-MALS, asymmetrical flow fieldflow fraction coupled with multi-angle light scattering detection systems; APIs, active pharmaceutical ingredients; CoA, certificate of analysis; GPC, gel permeation chromatography; PD, polydispersity index; SEC-TD, SEC with triple detection; SEC-MALS, SEC with multi angle light scattering; AFIFFF, asymmetric flow field-flow fractionation","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45805080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food consumption pattern and nutritional status in venezuelan vegetarian athletes","authors":"Garcia Milaidi, R. Maria, Cadenas Iscarely, Bravo Alida, Barboza Mariosca, G. Andreina","doi":"10.15406/JAPLR.2018.07.00298","DOIUrl":"https://doi.org/10.15406/JAPLR.2018.07.00298","url":null,"abstract":"It exists unlimited sorts of diets and it may cause confusion among people. In this sense, first, few patterns of food consumption have been studied in detail, especially, those developed from western countries defined as “western diet”; second, vegetarian eating habits and third, semi-vegetarian diets known as “prudent diet”. These diets are characterized by the predominance of plant’s products and while animal products were not considered. Finally, “Mediterranean diet” has been assumed by 3 to 9 percent of the European and North American population.1","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42736377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}