Journal of analytical & pharmaceutical research最新文献

{"title":"Comparison of particle swarm optimization and genetic algorithm for multiproduct batch plant design of protein production","authors":"Y. Hamzaoui, J. Arellano","doi":"10.15406/JAPLR.2018.07.00282","DOIUrl":"https://doi.org/10.15406/JAPLR.2018.07.00282","url":null,"abstract":"Pharmaceutical researchers and biotechnology companies are devoted to developing medicines, such as: therapeutic proteins, human insulin, vaccines for hepatitis, food grade protein, chymosin detergent enzyme, and cryophilic protease. This allows patients to live longer, heathier, and more productive. However, in recent years, there has been an increased interest development of systematic method for the design of batch process in chemicals, food products, and pharmaceutical industries. Basically, batch plants are composed of items operating in a discontinuous way, where each batch then visits a fixed number of equipment items, as required by a given synthesis sequence so called production recipe. Many works in the literature on batch process design are based on expressions that relate the batch sizes linearly with the equipment sizes.1–10 The number required of volume and size of parallel equipment units in each stage is to be determined. Nevertheless, the design of batch plants requires involving how equipment may be utilized. However you look at it the optimal design of a multiproduct batch chemical process involves the production requirement of each product and the total production time available for all products has been considered. The number and size of parallel equipment units in each stage as well as the location and size of intermediate storage are to be determined in order to minimize the investment cost.","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67072416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicochemical properties of some pyrimidine derivatives in some organic solvents","authors":"S. Baluja, Asmita Hirapara, D. Lava","doi":"10.15406/JAPLR.2018.07.00280","DOIUrl":"https://doi.org/10.15406/JAPLR.2018.07.00280","url":null,"abstract":"Heterocyclic compounds play an immense role in many biochemical processes1 and numerous heterocyclic compounds are biosynthesized by plants and animals, which are also associated to significant biological properties. Nitrogen containing heterocyclic compounds are known to play an essential role in many living systems. The nucleic acid bases are the derivatives of pyrimidine and purine,2 found in RNA and DNA in the form of uracil, thymine, cytosine, adenine and guanine. These nitrogen containing heterocycles are synthetically challenging models for a number of physiologically active natural products.3","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42347137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of antimicrobial potentiality of the purified terpenoids from two moss species Thuidium tamariscellum (C. Muell.) Bosch. & Sande-Lac and Brachythecium buchananii (Hook.)A. Jaeger","authors":"Greeshma Gm, K. Murugan","doi":"10.15406/JAPLR.2018.07.00279","DOIUrl":"https://doi.org/10.15406/JAPLR.2018.07.00279","url":null,"abstract":"Mosses are small nonvascular spore bearing land plants distributed throughout the temperate and tropical parts of the world. There are approximately 14,500 species which constitutes around 75% among the bryophyte species. They are commonly found in moist shady locations. The species originated as early as the Permian period and more than 100 species have been recorded from fossils of the Paleogene and Neogene periods.1 Mosses perform various important ecological roles such as filtering and retaining water, stabilizing the ground and removing CO2 from the atmosphere. Many moss species were reported to possess unique natural products or secondary metabolites such as phenols, flavonoids, alkaloids, terpenoids and other aromatic compounds with therapeutic potentialities. Historically, the therapeutic features of herbals are the concept of doctrine of signatures. Bryophytes form the basement of Chinese medicinal treatment. For example, liverwort was used to cure hepatic disorders, Polytrichum commune induce women’s hair growth. Gaddi tribes of Himachal Pradesh, used Plagiochasma appendiculatum for treating skin diseases, Targionia hypophylla used by Irular tribec of Attappady to cure skin diseases due to resembles of thallus to the warty surface of the diseased region and Frullania ericoides, liverwort for hair-related applications by tribal people of South India. Species like Sphagnum, Barbula, Bryum, Octeblepharum and Fontinalis are used to treat different diseases, including cardiovascular diseases, inflammation, fever, lung diseases, infections, wounds and skin prone diseases.1 The aqueous extract of the three mosses like Brachythecium rutabulum, Calliergonella cuspidate and Hypnum mammillatum showed potent antioxidant activity.2,3 The species like Polytrichum commune were used as antipyretic and anti-inflammatory agent and boiled with tea for treating the cold. Rhodobryum giganteum is another species traditionally used to treat diseases like cardiovascular diseases or angina.1","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42129613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorescence properties of some transition metal complexes of Schiff bases- A review","authors":"Kiran Singh, Sunita Raparia","doi":"10.15406/japlr.2018.07.00274","DOIUrl":"https://doi.org/10.15406/japlr.2018.07.00274","url":null,"abstract":"Metal complexes with Schiff base ligands are promising materials for optical applications due to their ability to show enhanced photoluminiscent properties, the ease of synthesis that readily permits structural modifications for optimization of material properties.1–6 Motivated by the success of tris(8-hydroxyquinoline) aluminium in vacuum deposited LED’S, metal complexes have attracted a lot of attention and offer attractive light emission properties.7–8 In view of the above, we review the photo physical properties of metal complexes and their fluorescence behavior in comparison to the ligands.","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41922698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrophotometric, thermal and determination of trace amount of palladium (II) nickel (II) and silver (I) by using pyrazolone azo derivative","authors":"Hussain J Mohammed, Aayad Ammar Syhood","doi":"10.15406/japlr.2018.07.00275","DOIUrl":"https://doi.org/10.15406/japlr.2018.07.00275","url":null,"abstract":"","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67072406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary pharmacognostic and phytochemical study on Argyreia cymosa root","authors":"V. G, G. S","doi":"10.15406/japlr.2018.07.00273","DOIUrl":"https://doi.org/10.15406/japlr.2018.07.00273","url":null,"abstract":"","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67072342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and characterization of bioactive compound berberine in the Berberis vulgaris root extract using HR-LC-MS analysis","authors":"Ishrat Naaz, Sharique A. Ali","doi":"10.15406/JAPLR.2018.07.00268","DOIUrl":"https://doi.org/10.15406/JAPLR.2018.07.00268","url":null,"abstract":"Ayurvedic medicines and formulations acquired from ancient Indian herbal systems are well-known for their various important applications. Recently, the interest and investigation in medicinal plants have augmented immensely. Berberis vulgaris L. is a shrub of family Berberidaceae produces in Asia and Europe; it is named in English as barberry.1 It is a deciduous shrub growing up to 4m high. The leaves are small oval, 2–5cm long and 1–2cm broad, with a serrated margin; they are borne in clusters of 2-5 together, subtended by a three-branched spine 3–8mm long. The flowers are yellow, 4–6mm across, produced on 3–6cm long panicles in late spring. The fruit is an oblong red berry 7–10mm long and 3–5 mm broad, ripening in late summer or autumn; they are edible but very sour, and rich in Vitamin C.2 The plant has been used widely for centuries for the treatment of various ailment. A broad range of medicinally and nutritionally important phytochemical components have been isolated from various parts of the plants such as alkaloids, saponins, cardioactive glycosides, anthocyanins, tanins, carbohydrates, protein, lipid, vitamins, fiber contents, β carotein. Phytic acid and phytate phosphorus etc.3","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43602266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heavy metal toxins in breakfast cereals – a baseline study using hybrid plasma mass spectrometry","authors":"Pillay Ae, S. Stephen, G. Xavier","doi":"10.15406/JAPLR.2018.07.00270","DOIUrl":"https://doi.org/10.15406/JAPLR.2018.07.00270","url":null,"abstract":"Breakfast cereals are made for public consumption and are widely popular all over the world, especially with children. Cereals are derived from plants, therefore, trace metal contamination of the cereal itself has its origin in the vegetable matter from which it is produced.1 Heavy metals2,3 could also infiltrate foodstuff from the equipment that is deployed to process them. However, some toxic elements such as mercury and arsenic, for example, are unlikely to be found at appreciable levels in equipment, thus, any form of contamination could mainly originate from environmental sources.4 Growth of plants linked to cereals depends on certain agricultural conditions and if these conditions lend themselves to pollution, elemental uptake in the plant could result in elevated metal toxins. Contaminated soil conditioners, polluted irrigation water and noxious pesticides could all play a role in contaminating vegetable matter that are associated with cereal production. Our investigation is, therefore, an environmental study and any remedial measures for minimising trace metals in cereals should seriously consider remediating environmental factors associated with plant-based foodstuff.","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44751170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on increasing the solubility and dissolution rate of sulfamethoxazole by cyclodextrins","authors":"Sahin Julide, O. Nurten","doi":"10.5897/ajpp2017.4741","DOIUrl":"https://doi.org/10.5897/ajpp2017.4741","url":null,"abstract":"","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"140 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5897/ajpp2017.4741","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71126958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"oncepts in development of fast, simple, stability indicating HPLC method for analysis of atorvastatin related compounds in tablets","authors":"M. Piponski, Tanja Bakovska Stoimenova, Magdalena Piponska, Gordana Trendovska Serafimovska","doi":"10.15406/japlr.2018.07.00265","DOIUrl":"https://doi.org/10.15406/japlr.2018.07.00265","url":null,"abstract":"New, fast, simple and mild conditioned High Performance Liquid Chromatography (HPLC) method for determination of atorvastatin and its 7 main specified impurities, as well as unspecified impurities that might possibly appear, was developed. Chromatographic runs last between 25 and 40 minutes, with simple stepwise gradient elution. The main accent in our method development strategy was focused on mobile phase, composed of simple binary system composed of phosphate buffer and acetonitrile, at pH 4.1, without use of tetrahydrofuran, ion-pair reagents, trifluoroacetic acid and other modifiers with high Ultraviolet (UV) cut-off like absorptive acetate or formiate buffers or amines. With our concept of mobile phase, different columns from myriad were tested, with different efficiency, dimensions and properties, which resulted in different separation efficiency and run time. The best results, concerning essential critical peak resolution, run time length including column preparation and equilibration and column backpressure, were achieved with: YMC C18 Triart 150mm x 4.6mm, 3µm (YMC America, Inc.), afterwards with Nucleodur 100-3-C18ec 250mm x 4.6mm, 3µm (Macherey-Nagel GmbH & Co., Germany), Waters Symmetry C18 250mm x 4.6mm, 5µm (Waters, USA) and Superspher C18e 125mm x 4mm, 4µm (Merck, Darmstadt, Germany). All this columns achieve excellent results regarding obligated critical resolution between atorvastatin impurity B and atorvastatin (according to European Pharmacopoeia),1 or in some cases between atorvastatin impurity B and atorvastatin impurity C, to be minimum about 1.5, in both cases.","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43702422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}