A new study on Omeprazole spectrophotometric determination using 9- Fluorenylmethyl chloroformate as derivatizating agent

Omeprazole (OMZ) chemically known as 5 M e t h o x y 2 [ [ ( 4 m e t h o x y 3 , 5 d i m e t h y l 2 pyridinyl)methyl]sulfinyl]-1H-benzimidazole (Figure 1), is one of irreversible proton pump (H+/K+ATPase) inhibitors that decrease acid secretion from gastric parietal cell, and it is also effective in treatment of Zollinger Ellison syndrome and preventing ulcer rebleeding, and recently it has been used as a potential anti-inflammatory agent to protect the gastric mucosa from the inflammation caused by Helicobacter pylori infection. The therapeutic importance of OMZ helped in development of many methods of determination in pharmaceutical formulations and biological samples.1,2