BMC Women's Health最新文献

{"title":"Impact of menopausal status on cognitive function in female papillary thyroid carcinoma patients: a longitudinal propensity score matched study.","authors":"Yuenan Zheng, Jie Zhao, Yang Shi, Zhiqiang Gui, Chun Xu, Qingshu Wu, Lili Zhu, Zhihong Wang, Hao Zhang, Liang He","doi":"10.1186/s12905-024-03503-3","DOIUrl":"10.1186/s12905-024-03503-3","url":null,"abstract":"<p><strong>Purpose: </strong>Previous research has documented cognitive deficits in survivors of papillary thyroid carcinoma (PTC).Our longitudinal study with large sample size, aims to assess the impact of menopausal status on cognitive function, elucidate related factors of cognitive impairment, and chart the trajectory of cognitive changes over time in female PTC patients.</p><p><strong>Methods: </strong>In this longitudinal study, we administered the Montreal Cognitive Assessment (MoCA) to 322 female PTC patients over 40 years old, before surgery and at 3 and 6 months after surgery. Propensity score matching (PSM) was used to adjust for baseline disparities, leading to a final analysis of 228 patients (114 premenopausal and 114 postmenopausal). Cognitive scores were compared between groups using the Mann-Whitney U test, and univariate and multivariate logistic regression analyses were performed to identify independent predictors of cognitive impairment.</p><p><strong>Results: </strong>Postmenopausal women demonstrated a significantly higher susceptibility to impairment in delayed recall (p = 0.004) and global cognition (p = 0.006) when compared with premenopausal women. Multivariate analysis identified menopause (p < 0.001) and rural residence (p = 0.001) as independent risk factors for cognitive impairment. Furthermore, a gradual improvement in cognitive function over time was observed across both groups over the course of the study.</p><p><strong>Conclusions: </strong>In female PTC patients, postmenopausal status and rural residence are significant risk factors for cognitive impairment. Postmenopausal women are more susceptible to cognitive deficits than premenopausal women in delayed recall and global cognition.Although cognitive function improves over time, it is crucial for physicians to closely monitor and support these patients to optimize their prognosis.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"24 1","pages":"642"},"PeriodicalIF":2.4,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disturbances and female infertility: a systematic review.","authors":"Jing Li, Yali Huang, Shirong Xu, Ying Wang","doi":"10.1186/s12905-024-03508-y","DOIUrl":"10.1186/s12905-024-03508-y","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Sleep disturbances are more prevalent among women with infertility. Current research increasingly highlights the significant relationship between sleep disturbances and female infertility, suggesting that sleep may be a key factor in reproductive health. In this review, we aim to delve into the complex interplay between sleep disturbances and female infertility, as well as to assess the underlying mechanisms involved, and seek to illuminate the causes of sleep-related fertility issues. The understanding of these contents may help clinicians enhance clinical strategies for managing sleep disturbances in women facing infertility challenges and provide timely support to those seeking fertility treatments.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A comprehensive literature search was conducted in the PubMed and EMBASE databases. Studies that described sleep patterns or any type of sleep disturbance, sleep breathing disorders and their associations with female infertility or female fecundity, published between January 1, 2010, and November 1, 2023, were identified and extracted. The screening, data extraction, and quality assessment processes were independently performed by paired reviewers. The quality of the included studies was assessed using the Joanna Briggs Institute (JBI) Critical Appraisal tools for observational and cohort studies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 1,179 articles were initially identified from the search strategy (PubMed, n = 377; EMBASE, n = 802). After removing duplicates (n = 83) and screening for eligibility (n = 75), 19 studies were reviewed and determined to be eligible for inclusion. Infertile women generally report poorer sleep quality and exhibit more evening sleep chronotypes. Sleep disorders are significantly associated with infertility. Poor sleep quality, extreme sleep durations, and certain sleep chronotypes are associated with poorer fertility treatment outcomes, such as a reduced number of retrieved oocytes, decreased embryo quality, and lower fertilization rates. Obstructive sleep apnea (OSA) is also more prevalent in women with fertility issues, especially those with polycystic ovary syndrome (PCOS), and may negatively impact reproductive outcomes. The circadian rhythms of the Clock gene system, melatonin and hormone dysregulation, oxidative stress and immune response are considered to be potential mechanisms explaining how sleep disturbance impairs reproductive function, remain to be fully elucidated, and therefore, require further investigation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Sleep disturbances are negatively associated with female infertility and poor fertility treatment outcomes. Longitudinal studies are expected to substantiate these findings and inform more nuanced approaches to prior sleep management and lifestyle advisement for infertile women, especially those undergoing fertility treatments.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Trial registration: &lt;/strong&gt;This study was registered in","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"24 1","pages":"643"},"PeriodicalIF":2.4,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Violence against infertile women in an Iranian setting.","authors":"Maryam Gharacheh, Fahimeh Ranjbar, Farzaneh Kashefi, Abdurrahman Charkazi, Shahdokht Azadi, Afsaneh Shahbazi, Shirin Shahbazi Sighaldeh","doi":"10.1186/s12905-024-03496-z","DOIUrl":"10.1186/s12905-024-03496-z","url":null,"abstract":"<p><strong>Background: </strong>Infertility as a distressing condition, is associated with numerous psychological and social consequences for couples. In addition, there is evidence to suggest that infertility may contribute to the occurrence of violence against women. The aim of the study is to determine the prevalence and factors associated with violence against Iranian women with infertility.</p><p><strong>Methods: </strong>A cross-sectional study was carried out in 2020, involving 310 infertile women who sought treatment at an infertility clinic in a referral women's hospital in Tehran. The eligible participants were selected using the consecutive sampling method. The Infertile Women's Exposure to Violence Determination Scale (IWEVDS) was used to collect data on violence. Data were analyzed using descriptive (Mean, frequency) and inferential statistics (Independent sample t-test, Chi-square, regression logistic) through the SPSS version 25.</p><p><strong>Results: </strong>The average score on the IWEVDS was found to be 43.89 ± 18.23, indicating a moderate level of violence. Out of the 310 participating infertile women, 84.2% reported experiencing violence. Among abused women, 67% experienced domestic violence, 76.2% encountered social pressure, 85.4% faced punishment, 88.9% were exposed to traditional practice, and 57.5% experienced exclusion. The main risk factors associated with violence were a low number of children, low economic status, and an increased duration of infertility.</p><p><strong>Conclusions: </strong>This study's findings underline a high rate of violence experienced by infertile women. Therefore, it is crucial to screen women with infertility for violence and provide them with adequate support.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"24 1","pages":"645"},"PeriodicalIF":2.4,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in spatial bodily pain distribution one year after benign hysterectomy with emphasis on prevalence and risk factors for de novo and persistent pelvic pain- a prospective longitudinal multicenter study.","authors":"Peter Lukas, Lena Nilsson, Ninnie Borendal Wodlin, Lars Arendt-Nielsen, Preben Kjølhede","doi":"10.1186/s12905-024-03474-5","DOIUrl":"10.1186/s12905-024-03474-5","url":null,"abstract":"<p><strong>Background: </strong>The objectives were to determine the prevalence of de novo and persistent pelvic pain after benign hysterectomy and to assess risk factors.</p><p><strong>Methods: </strong>A Swedish prospective multicenter study of 440 women undergoing benign hysterectomy was conducted between October 2011 and March 2017. Measures of pain, the spatial extent of bodily pain, and pain sensitivity were assessed using a self-reporting questionnaire, Margolis's patient pain drawing, and quantitative sensory testing of pain thresholds for pressure, heat, and cold, respectively. Quality of life was evaluated by EQ-5D-3L and SF-36. Psychological distress was assessed by the Hospital Anxiety and Depression Scaleand the Stress-Coping Inventory. Logistic regression models were used to assess risk factors, and the outcome was presented as an adjusted odds ratio (aOR) and 95% confidence interval (CI).</p><p><strong>Results: </strong>Preoperatively, 18.0% of the women reported no bodily pain, 41.5% had pelvic pain, either as the only location (7.0%) or along with pain in other locations (34.5%), and 40.5% had non-pelvic pain only. Postoperatively, 6.2% developed de novo pelvic pain and 16.4% had persistent pelvic pain. De novo pelvic pain developed exclusively in women who preoperatively had non-pelvic pain only. Risk factors for de novo pelvic pain were a long hospital stay (aOR 1.50 (95%CI) 1.02-2.21)), high preoperative pain intensity (aOR 1.25 (95%CI 1.01-1.62)) and a high number of pain areas (aOR 1.15 (95%CI 1.05-1.27)), along with anxiety (aOR 10.61 (95%CI 1.84-61.03)) and low EQ-5D-3L health index (aOR 0.02 (95%CI 0.00-0.31)). Risk factors for persistent pelvic pain were lower age (aOR 0.89 (95%CI 0.81-0.97)), higher number of pain areas (aOR 1.08 (95%CI 1.02-1.14)), and a higher frequency of preoperative pain (aOR 12.75 (95%CI 2.24-72.66)).</p><p><strong>Conclusion: </strong>Although hysterectomy appeared to be reasonably effective in curing pelvic pain, a non-negligible proportion of women developed de novo pelvic pain or had persistent pelvic pain. De novo pelvic pain seemed to affect only those who preoperatively had widespread bodily pain. Women at risk for de novo and persistent pelvic pain after hysterectomy could be identified preoperatively.</p><p><strong>Trial registrations: </strong>The study was retrospectively registered in ClinicalTrial.gov (NCT01526668) on 01/27//2012.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"24 1","pages":"644"},"PeriodicalIF":2.4,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between immune cells and endometriosis: a bidirectional two-sample mendelian randomization study.","authors":"Lele Pan, Yuying Chen, Ziwei Zhou, Song Ma, Yuzhen Cao, Ying Ma","doi":"10.1186/s12905-024-03493-2","DOIUrl":"10.1186/s12905-024-03493-2","url":null,"abstract":"<p><strong>Objectives: </strong>Endometriosis (EM), a prevalent estrogen-dependent inflammatory disorder affecting women of reproductive age, is characterized by the presence of endometrial-like tissue outside the uterus, resulting in pelvic scarring, pain, and infertility. Although the pathogenesis of EM remains poorly understood, there is growing evidence suggesting the involvement of the immune system in its etiology, pathophysiology, and associated morbidities such as pain, infertility, and adverse pregnancy outcomes. While previous studies have indicated a close relationship between the immune system and EM, the specific underlying mechanism remains incompletely elucidated.</p><p><strong>Methods: </strong>Through the utilization of publicly available genetic data, a two-sample Mendelian randomization (MR) analysis was conducted to establish an association between 731 immune cell phenotypes and EM. Comprehensive sensitivity analyses were performed to validate the robustness, heterogeneity, and potential horizontal pleiotropy of the findings.</p><p><strong>Results: </strong>The MR analysis revealed potential associations between 22 immune cell phenotypes and EM. Conversely, reverse MR analysis identified 11 immune phenotypes demonstrating potential associations between genetic liability in the immune phenotypes and EM.</p><p><strong>Conclusion: </strong>This study provides evidence of a potential correlation between immune cell phenotypes and EM, including the existence of reverse causation. These findings open up new avenues for investigating the underlying mechanisms of EM.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"24 1","pages":"641"},"PeriodicalIF":2.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new subtype of papillary ductal carcinoma in situ with tall cell and reversed polarity morphology: a rare case report.","authors":"Ruiqi Zhong, Ziyi Chang, Xiuhong Wang, Dingrong Zhong","doi":"10.1186/s12905-024-03489-y","DOIUrl":"10.1186/s12905-024-03489-y","url":null,"abstract":"<p><strong>Background: </strong>According to previous studies, tall cell carcinoma with reversed polarity can be easily distinguished from ductal carcinoma in situ based on the absence of myoepithelium and a typical histologic feature. However, to the best of our knowledge, no cases of papillary ductal carcinoma exhibiting tall cell and reversed polarity features with intact myoepithelium have been reported, and thus its diagnosis and prognosis remain unclear.</p><p><strong>Case presentation: </strong>A 54-year-old female with a palpable lump in her right breast for 3 years. There were no other symptoms found. A preoperative ultrasound examination showed an oval, well-circumscribed, anechoic cystic appearance with hypoechoic adnexal nodules, classified as 3-4a in the Breast Imaging Reporting Data System. Surgical excision revealed an in-situ breast carcinoma exhibiting a solid papillary pattern and tall cell with reversed polarity of nuclei. After thorough postoperative pathology, immunohistochemistry, and next-generation sequencing, we hypothesized that it might be a new ductal carcinoma in situ subtype with tall cells and reversed polarity of the mammary gland.</p><p><strong>Conclusions: </strong>We herein present a rare case of papillary ductal carcinoma in situ with tall cell and reversed polarity morphology breast cancer, which can closely mimic tall cell carcinoma with reversed polarity and ductal carcinoma in situ. Thorough evaluations of histologic features, immunohistochemistry results, and genetic alterations are significant in identifying this rare entity. In addition, this type of breast cancer is low-malignant and has a favorable prognosis without any adjuvant therapy after complete resection.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"24 1","pages":"640"},"PeriodicalIF":2.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11658091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P53 marker expression in epithelial ovarian tumours in a centre in Nigeria - a descriptive study.","authors":"Andrew Olushola Anjorin, Olaejirinde Olaniyi Olaofe, Atinuke Olu Anjorin, Ganiat Olutoyin Omoniyi-Esan, Akinwumi Oluwole Komolafe","doi":"10.1186/s12905-024-03487-0","DOIUrl":"10.1186/s12905-024-03487-0","url":null,"abstract":"<p><strong>Background: </strong>p53 is a tumor suppressor gene. p53 expression in epithelial ovarian tumors (EOTs) is correlated with their biological behavior and predicts patient overall survival. However, there is a dearth of knowledge regarding p53 expression in these tumors among women from southwest Nigeria. Our study aimed to determine the patterns of p53 expression in various types of epithelial ovarian tumours.</p><p><strong>Methods: </strong>We conducted a retrospective study of epithelial ovarian tumours. We retrieved formalin-fixed, paraffin-embedded (FFPE) tissue blocks of previously diagnosed epithelial tumors from the departmental archive. We performed immunohistochemical analysis using p53 antibodies. We scored the expression and staining intensity of p53 as follows: negative (0), focal/weakly positive (1 +), and diffuse/strongly positive (2 +) on the basis of the recommended Cytomation scoring system.</p><p><strong>Results: </strong>The spectrum of p53 expression in the 51 histologically diagnosed cases revealed that 29 cases had no expression, consisting of 21 benign EOTs, two borderline EOTs, and six malignant EOTs. Nine cases exhibited wild-type expression, including six serous carcinomas, two mucinous carcinomas, and one signet ring cell carcinoma. p53 overexpression was observed in 13 patients overall, with 12 having serous carcinomas and one having endometrioid carcinoma. Among the 21 serous carcinoma patients, 28.6% (6 patients) presented with wild-type p53 expression, 57.1% (12 patients) presented with p53 overexpression, and 14.3% (three patients) presented negative p53 expression. There was a significant association between p53 expression and the histological grade of serous carcinoma.</p><p><strong>Conclusion: </strong>Most epithelial ovarian carcinomas in our hospital are high grade, with many serous carcinomas showing either p53 overexpression or loss of expression. This may contribute to the poor patient survival rate.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"24 1","pages":"639"},"PeriodicalIF":2.4,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11619170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of a lifestyle promotion program on anthropometric and clinical manifestations in adolescents with polycystic ovarian syndrome: a randomized controlled trial.","authors":"Fatemeh Nahidi, Fahimeh Ramezani Tehrani, Delaram Ghodsi, Mahdi Jafari, Hamid Alavi Majd, Somayeh Abdolahian","doi":"10.1186/s12905-024-03455-8","DOIUrl":"10.1186/s12905-024-03455-8","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Lifestyle modification can have beneficial effects on improving symptoms of ovary syndrome and anthropometric changes, particularly in obese individuals… However, it is not clear whether these affects in obese adolescents with PCOS are the same as non-PCOS adolescents. We had a study question\" Can lifestyle promotion programs, which focus on changing behavioral habits, have an effect on anthropometric parameters and the manifestation of polycystic ovary syndrome (PCOS) in adolescents?\"&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This was a cluster randomized trial (CRT) that started from January 2021 and follow-up ended in March 2022. 128 participants included adolescent girls (from 14 to 18 years old). The status of PCOS was determined for the participants, following which both the PCOS-afflicted and non-PCOS cohorts were subjected to randomization to either partake in a lifestyle promotion program or to proceed without it. This program included eight sessions that were designed to be implemented for two months. This intervention provides recommendations for a balanced diet and regular exercise, as well as advice on behavior change for adolescents, including those with PCOS, regardless of their weight. All participants were followed up for 12 months and were evaluated at three time points: baseline, 6 and 12 months. Outcomes included changes in the anthropometric indices (weight, hip and waist circumstance), regularity of menstrual cycle, hirsutism score by the modified-Ferriman-Gallwey scale, acne score by the Investigator's Global Assessment Scale, hair loss scores by the Sinclair Graphic Instrument and then physical activity by the Caspian tool and dietary intake status by the Food Frequency Questionnaire. Data was analyzed using the non-parametric Mann-Whitney test for variables with two-time point assessments and generalized estimation equations (GEE) for variables with three time point assessments.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In the study, the intervention group of girls with PCOS exhibited a significant reduction in weight and waist circumference, with an average decrease of 3.14 kg and 4.68 cm, respectively (P &lt; 0.001), compared to the PCOS control group. Similarly, the non-PCOS intervention group showed a decrease in these factors by 2.60 kg and 4.95 cm (P &lt; 0.001) when compared to the non-PCOS control group. After 12 months of intervention, the odds ratio (OR) for menstrual regularity in the PCOS intervention group increased to 3.30 (95% CI: 2.06, 5.25), and the acne score significantly decreased with an OR of 0.46 (95% CI: 0.31, 0.70). In contrast, the non-PCOS intervention group experienced an increase in the OR for menstrual regularity to 2.45 (95% CI: 1.33, 4.25) and an improved in acne score with an OR of 0.44 (95% CI: 0.28, 0.69). No notable differences were observed in the nutritional status among all groups post-intervention. However, a significant increase in physical activity levels, measured in metabo","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"24 1","pages":"637"},"PeriodicalIF":2.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11619654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness, attendance, and attitudes toward cervical cancer screening among HIV-positive Chinese women in Yunnan province: a cross-sectional study.","authors":"Jiawei Hu, Rufei Duan, Hongyun Zhang, Xuelian Zhao, Aihui Wu, Le Li, Fanghui Zhao, Yong Zhang","doi":"10.1186/s12905-024-03478-1","DOIUrl":"10.1186/s12905-024-03478-1","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer is a major health threat in the female population. Human immunodeficiency virus (HIV)-positive women encounter a higher risk of cervical cancer. It is significant to promote cervical cancer screening attendance among HIV-positive women. Little is known about the awareness, attendance, and attitudes toward cervical cancer screening, as well as the associated factors, among Chinese HIV-positive women.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among 411 HIV-positive women attending a large ART clinic in Yunnan, an HIV-endemic province in China. Participants were recruited using the convenient sampling method from January 2019 to August 2020. An interviewer-administered semi-structured questionnaire was utilized to collect information on socio-demographic and behavioral characteristics, clinical characteristics related to HIV infection, awareness, attendance, and attitudes toward cervical cancer screening. Binary logistic regression analyses were used to determine factors associated with awareness, attendance, and attitude toward cervical cancer screening.</p><p><strong>Results: </strong>Some 69.8% (287) of the participants were aware of cervical cancer screening, but only 27.7% (114) had attended screening within 3 years. After receiving a brief health education, 72.3% (297) of the participants exhibited a positive attitude toward cervical cancer screening. Participants with a higher education background and longer duration of antiretroviral therapy were more likely to be aware of cervical cancer screening and have up-to-date screening. The up-to-date screening attendance was also influenced by age, smoking status, and health insurance. Single participants were less likely to show a positive attitude toward cervical cancer screening compared married or cohabiting counterparts. The main facilitators to attending cervical cancer screening were health promotion activity and well-organized programs, while the main barriers were high costs of the service and inadequate awareness.</p><p><strong>Conclusions: </strong>Although most HIV-positive women attending a large ART clinic in Yunnan were aware of cervical cancer screening, the up-to-date attendance was low. It is crucial to conduct health education and promotion through efficient channels to improve awareness and attendance. The discrepancy between awareness and attendance also emphasized the importance of adopting appropriate screening strategies and powerful health policies that can foster the attendance of cervical cancer screening among HIV-positive women. Efforts should be devoted to constructing a comprehensive healthcare system with high accessibility in China for cervical cancer prevention and management for HIV-positive women.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"24 1","pages":"636"},"PeriodicalIF":2.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11616238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring heterogeneity of perimenopause with application of multivariable analysis approaches.","authors":"Zhongyu Huang, Huazhi You, Lijuan Li, Shuang Wang, Zipan Lyu, Xiaoqin Zeng, Changyan Zhu, Minqing Li, Han Yan, Yaojuan He","doi":"10.1186/s12905-024-03483-4","DOIUrl":"10.1186/s12905-024-03483-4","url":null,"abstract":"<p><strong>Objectives: </strong>Heterogeneity of clinical appearance had made it a challenge to make individualized and comprehensive management of perimenopause. This study aimed to estimate the profiles over heterogenous appearances of perimenopause with application of latent variable analysis methods over an optimized multidimensional assessing framework.</p><p><strong>Methods: </strong>A two-phase clinical study was designed and advanced in the research center in Guangzhou, China. The assessing framework was developed over the initial item pool as integration of 4 scales including Insomnia severity index, Modified Kupperman index, Self-rating anxiety scale, and Self-rating depression scale. Validity and reliability of the instrument were evaluated and the psychometric properties of the items were estimated with multidimensional item response theory(MIRT). And then computer adaptive testing(CAT) was developed with the estimated model. We used latent profile analysis (LPA) to cluster patients into subgroups as patterns characterized by multidimensional latent trait scores. Finally, interpretability and efficiency were analyzed via comparison between the two assessing strategies.</p><p><strong>Result: </strong>There were in total 336 patients diagnosed with perimenopause enrolled for the assessment. A conceptual framework was estimated consisting of 6 factors including sleep disturbance, mood swings, vasomotor symptoms, positive attitude towards life, multisystem abnormality, and fatigue. The construct validity was evaluated as optimized with CMIN/df = 1.814, GFI = 0.619, CFI = 0.721, TLI = 0.707 and RMSEA = 0.075. With scores in the simulated CAT, the 4 latent profiles model was estimated indicating the heterogeneity of perimenopause characterized by different severity of psychological and physical discomforts in the LPA.</p><p><strong>Conclusion: </strong>The quantitative paradigm raised in this study revealed the potential patterns presenting heterogeneity of perimenopause offering better interpretation for clinical assessment.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"24 1","pages":"638"},"PeriodicalIF":2.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11619569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}