BMC Women's Health最新文献

{"title":"Causal association between gut microbiota and endometrial cancer in European and East Asian populations: a two-sample Mendelian randomization study.","authors":"Jiaqi Chen, Haiqing Li, Xinrui Long, Hao Tong, Xin Xin, Han Zhang, Yeyao Li, Ping Liu, Xiaolin He, Zhuoyuan Chen","doi":"10.1186/s12905-025-03789-x","DOIUrl":"10.1186/s12905-025-03789-x","url":null,"abstract":"<p><strong>Background: </strong>Endometrial cancer (EC) is a significant global health concern. While observational epidemiological studies suggest a potential link between gut microbiota dysbiosis and the development of EC, the direction and causality of this association remain uncertain.</p><p><strong>Methods: </strong>We performed Mendelian randomization (MR) analysis to investigate the causal relationship between gut microbiota and EC. Exposure data were obtained from the MiBioGen study consortium (N = 18,340), and outcome data were sourced from the IEU OpenGWAS database, specifically datasets \"ebi-a-GCST006464\" (N = 121,885) and \"bbj-a-113\" (N = 90,730). The inverse variance-weighted(IVW) method was applied to evaluate the association between gut microbiota composition and EC risk. Sensitivity analyses were conducted to ensure the robustness of the findings.</p><p><strong>Results: </strong>Our study identified several microbial taxa linked to EC risk. In Europeans, genera such as Marvinbryantia, RuminococcaceaeUCG014, and Dorea exhibited protective effects, while family Erysipelotrichaceae (OR:1.224) and FamilyXI (OR:1.090) were significantly correlated with high EC risk. In East Asians, genera Lachnospira (OR:3.561) and family Bifidobacteriaceae (OR:1.715) were found associated with EC risk. Genera Lachnoclostridium and ErysipelotrichaceaeUCG003, family Coriobacteriaceae positively served as protective factors. Sensitivity analyses confirmed the reliability of our results, and there was no evidence of pleiotropy or heterogeneity. Our analysis identified several microbial taxa associated with EC risk. In Europeans, genera such as Marvinbryantia, Ruminococcaceae UCG014, and Dorea demonstrated protective effects, while the families Erysipelotrichaceae (OR: 1.224) and FamilyXI (OR: 1.090) were significantly associated with increased EC risk. In East Asians, the genus Lachnospira (OR: 3.561) and the family Bifidobacteriaceae (OR: 1.715) were linked to higher EC risk, whereas the genera Lachnoclostridium and Erysipelotrichaceae UCG003 and the family Coriobacteriaceae were identified as protective factors. Sensitivity analyses confirmed the reliability of these results, with no evidence of pleiotropy or heterogeneity.</p><p><strong>Conclusion: </strong>This study highlights a relationship between gut microbiota and EC, emphasizing the potential of gut microbiota as therapeutic targets and biomarkers for assessing EC prognosis and treatment efficacy. These findings provide novel insights into the role of gut microbiota in the development and progression of EC.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"283"},"PeriodicalIF":2.4,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of diabetes on postoperative outcomes following hysterectomy: a systematic review and meta-analysis.","authors":"Yuhuan Zeng, Yuanhu Lei, Min Li, Wei Liu, Jie Zhou, Jie Zhong, Guangming Song, Yukun Li, Xiangfang Tan, Qunfeng Zhang","doi":"10.1186/s12905-025-03835-8","DOIUrl":"10.1186/s12905-025-03835-8","url":null,"abstract":"<p><strong>Objective: </strong>Although diabetes mellitus (DM) is considered an important prognostic factor for hysterectomy outcomes, the relationship between DM and postoperative complications remains unclear. The aim of this study was to investigate whether DM is associated with an increased risk of complications following hysterectomy.</p><p><strong>Methods: </strong>We systematically searched PubMed, Embase, and the Cochrane Library for relevant articles published on or before March 15, 2024. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated via random effects meta-analysis. The primary outcome was the risk of complications posthysterectomy, including postoperative infection and hospital readmission. Additionally, we conducted subgroup and sensitivity analyses to explore the main sources of heterogeneity and assess the stability of the results.</p><p><strong>Results: </strong>A total of 19 cohort studies comprising 375,531 participants met the inclusion criteria. This meta-analysis revealed that DM was significantly associated with postoperative infection (OR 2.01, 95% CI 1.46-2.77). Additionally, DM was significantly associated with low postoperative survival (5 years) (OR 4.43, 95% CI 2.98-6.58), readmission (OR 1.59, 95% CI 1.42-1.79), embolism (OR 1.31, 95% CI 1.18-1.46), renal failure (OR 3.88, 95% CI 2.74-5.51) and reintubation (OR 3.23, 95% CI 1.64-6.35), whereas DM was not associated with an extended length of stay (OR 1.39, 95% CI 0.93-2.10), myocardial infarction (OR 1.86, 95% CI 0.58-5.98) or blood transfusion (OR 1.36, 95% CI 0.88-2.11) in patients following hysterectomy.</p><p><strong>Conclusions: </strong>DM increases the risk of postoperative infection following hysterectomy. Special attention should be given to diabetic patients to reduce the incidence of complications after hysterectomy.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"284"},"PeriodicalIF":2.4,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The safety and efficacy of liraglutide combined with metformin in clinical treatment of polycystic ovary syndrome patients: a meta-analysis.","authors":"Rongmei Huang, Yinan He","doi":"10.1186/s12905-025-03787-z","DOIUrl":"10.1186/s12905-025-03787-z","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the effectiveness and safety of the combination of liraglutide and metformin for clinical treatment of patients with polycystic ovary syndrome.</p><p><strong>Methods: </strong>Computerized searches were performed on PubMed, Embase, Web of Science, The Cochrane Library, CNKI, CBM, Wanfang, and VIP databases to collect randomized controlled trials(RCT) on the efficacy of metformin and liraglutide in the treatment of polycystic ovary syndrome. The search period spanned from the inception of the databases to August 2024. Following literature screening, data extraction, and risk of bias assessment in the included studies, two reviewers independently conducted meta-analysis using RevMan 5.4 software.</p><p><strong>Results: </strong>A total of 12 RCT involving 1096 patients were analyzed. The meta-analysis revealed that the group receiving metformin combined with liraglutide demonstrated superiority over the group receiving metformin alone in terms of body mass index (BMI), glucose levels, lipid levels, hormone levels, establishment of menstrual cycles, normal ovulation rate, and rate of spontaneous conception. However, the former group also exhibited a higher incidence of gastrointestinal reactions compared to the latter group.</p><p><strong>Conclusion: </strong>Current data indicates that the combination of liraglutide and metformin can effectively enhance glucose and lipid metabolism in Polycystic Ovary Syndrome infertility patients. Additionally, it can reduce serum sex hormone levels, leading to significant clinical therapeutic effects. This treatment also improves pancreatic islet and ovarian function, ultimately increasing the rate of ovulation and pregnancy. It is important to note that correct administration methods must be followed to minimize adverse reactions.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"282"},"PeriodicalIF":2.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescents, menstruation, and physical activity: insights from a global scoping review.","authors":"Jessica Harvey, Max J Western, Nick P Townsend, Jessica Francombe-Webb, Simon Sebire, Olivia S Malkowski, Masha Remskar, Ella Burfitt, Emma Solomon-Moore","doi":"10.1186/s12905-025-03825-w","DOIUrl":"10.1186/s12905-025-03825-w","url":null,"abstract":"<p><strong>Background: </strong>Adolescent girls tend to be less physically active than boys, a trend that coincides with puberty. Menstruation may act as a barrier to physical activity, which in turn may influence menstrual symptoms. The purpose of this scoping review was to synthesise the global literature on the association between menstruation and physical activity among adolescents.</p><p><strong>Methods: </strong>A systematic search was conducted across five databases, identifying studies on menstruation and physical activity in adolescents (aged 10-18 years) without date restrictions. Studies not in English, including only athlete populations and focusing solely on premenstrual syndrome were excluded. Titles and abstracts, followed by full texts were screened by two independent reviewers.</p><p><strong>Results: </strong>Eighty-six studies were included, spanning 33 countries. Thematic synthesis of data from the selected studies suggests a bidirectional relationship in that menstruation may act as a barrier to physical activity due to symptoms, societal stigma and menstrual product access, while physical activity may alleviate symptoms for some. The review highlights variability in study methodologies, with most relying on self-report data.</p><p><strong>Conclusion: </strong>This review provides insights into the varied experiences of adolescent girls' physical activity and menstruation, influenced by cultural, social, and resource-related factors. It makes important and timely recommendations for the direction of future research, which should employ longitudinal and mixed methods approaches to better understand the association between menstruation and physical activity in this population and address gaps regarding the mechanisms and magnitude of this relationship.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"281"},"PeriodicalIF":2.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of primary dysmenorrhea on chronotypes, social jetlag, and night eating habits: a cross-sectional study of anxiety and depression.","authors":"Senol Senturk, Mehmet Kagitci, Mehmet Baltacioglu, Deniz Dereci Delibas, Isik Ustuner","doi":"10.1186/s12905-025-03830-z","DOIUrl":"10.1186/s12905-025-03830-z","url":null,"abstract":"<p><strong>Background: </strong>To determine the impact of mild, moderate, and severe primary dysmenorrhea (PD) on chronotype, social jetlag, and eating disorders, as well as mood changes such as depression and anxiety.</p><p><strong>Methods: </strong>This cross-sectional study included 128 participants who presented with painful menstruation and were diagnosed with PD. Participants were selected on a voluntary basis from among medical students between the ages of 18-25 who met the study inclusion criteria as a result of the preliminary evaluation. A total of 36 patients were excluded from the study, including 15 patients diagnosed with secondary dysmenorrhea and 21 patients who did not show the typical clinical findings of PD. Dysmenorrhea intensity was assessed using a visual analog scale (VAS) for pain intensity. Ninety-two participants with typical clinical findings of PD were divided into mild (n = 30), moderate (n = 30), and severe PD (n = 32) groups according to their VAS scores, and a questionnaire was administered to them. The \"Morning-Evening Test\", \"Social Jetlag Test\", \"Night Eating Questionnaire\", \"Beck Depression Inventory (BDI)\", and \"Beck Anxiety Inventory (BAI)\" were applied to the participants.</p><p><strong>Results: </strong>Out of a total of 128 participants, 92 (72%) were diagnosed with PD. The VAS pain score in the severe PD group was significantly higher than that in the mild and moderate PD groups (p < 0.001 for each). In the severe PD group, the number of individuals with BAI values ​​above the threshold value (≥ 16) was higher than that in the mild and moderate PD groups (p < 0.05 for each). Similarly, BDI scores in the severe PD group were significantly higher than those in the mild PD group (p < 0.01). The rate of night eating syndrome was significantly higher in the severe than in the moderate and mild PD groups (p < 0.05 for each). There was no significant difference between the chronotypes according to dysmenorrhea severity (p = 0.461). The rate of social jet lag was ≥ 2 h in the severe PD group, significantly higher than in the mild group (p < 0.05).</p><p><strong>Conclusions: </strong>In addition to emotional complaints such as depression and anxiety, PD increases the incidence of night eating habits and social jet lag. No significant association was found between PD and chronotypes.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"279"},"PeriodicalIF":2.4,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of the Risk of Ovarian Malignancy Algorithm (ROMA) index in the detection of ovarian cancer in postmenopausal women: a systematic review and meta-analysis.","authors":"Ali Fathi, Mohammad Heidari, Javad Rasouli, Hojat Ghasemnejad-Berenji","doi":"10.1186/s12905-025-03766-4","DOIUrl":"10.1186/s12905-025-03766-4","url":null,"abstract":"<p><strong>Objective: </strong>Given the significance of ovarian cancer and the importance of early diagnosis, this meta-analysis aimed to assess the diagnostic value of the ROMA index in predicting ovarian cancer in postmenopausal women.</p><p><strong>Methods: </strong>This systematic review and meta-analysis were conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Relevant articles were retrieved from databases, including Web of Science, PubMed (MEDLINE), Google Scholar, Scopus, and Embase. The quality of the included studies was assessed using QUADAS-2. The GRADEPRO tool was used to evaluate and grade the quality of the evidence obtained from the meta-analysis. The diagnostic performance of the ROMA index in postmenopausal women was evaluated and comparisons were made using sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (LR +), negative likelihood ratio (LR-), and inverse negative likelihood ratio (1/LR-). Data were analyzed in STATA software using the \"midas\" and \"metandi\" commands.</p><p><strong>Results: </strong>In this study, 34 out of the 99 identified studies were included in the meta-analysis. Analysis of the ROMA index in postmenopausal Asian women revealed a sensitivity of 88%, specificity of 93%, diagnostic odds ratio (DOR) of 99, positive likelihood ratio (LR +) of 13, negative likelihood ratio (LR-) of 0.131, and inverse negative likelihood ratio (1/LR-) of 8. Furthermore, in cross-sectional studies conducted on postmenopausal women, the ROMA index demonstrated a sensitivity of 90%, specificity of 93%, DOR of 129, LR + of 14, LR - of 0.106, and 1/LR - of 9. Finally, with a cut-off range of 25.1-40, the ROMA index showed a sensitivity of 90%, specificity of 90%, DOR of 76, LR + of 9, LR- of 0.115, and 1/LR- of 9. No significant publication bias was detected in this study (P > 0.05).</p><p><strong>Conclusion: </strong>The ROMA index showed greater efficacy in postmenopausal Asian women than in their European counterparts. Cross-sectional studies produced larger estimates than cohort studies. Furthermore, the highest estimate of the ROMA index was obtained with a cutoff of (25.1-40) as opposed to (10-25).</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"280"},"PeriodicalIF":2.4,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The massive bladder diverticulum mimicking an ovarian cyst is the diagnosis challenge of pelvic masses in postmenopausal women: a rare case report.","authors":"Kuniaki Ota, Hirohiko Kamiyama, Tomo Shimizu, Yoshiki Ajiro, Shigeo Nohara, Yasutaka Shuno, Takashi Kobayashi, Yoshiaki Ota, Toshifumi Takahashi","doi":"10.1186/s12905-025-03837-6","DOIUrl":"10.1186/s12905-025-03837-6","url":null,"abstract":"<p><strong>Background: </strong>Bladder diverticulum is a rare pelvic mass that arises from a defect between the detrusor muscle fibers. It does not often cause distinct symptoms and is most commonly detected accidentally in postmenopausal women as an ovarian cyst while investigating unrelated ailments. Therefore, preoperative diagnosis is difficult, and there are cases of intraoperative embarrassment in the absence of an ovarian cyst.</p><p><strong>Case presentation: </strong>A 76-year-old woman who was diagnosed with an ovarian cyst using abdominal computed tomography (CT) at another institution was referred to our department for further evaluation. Magnetic resonance imaging (MRI) showed similar findings, and the radiologist diagnosed it as a serous ovarian cyst, for which laparoscopic surgery was planned. Laparoscopic findings however, did not reveal any evidence of the preoperatively diagnosed ovarian cyst in the pelvic cavity. Furthermore, due to swelling in the left retroperitoneal cavity, the area was further explored. A mass with serous content was identified and resected. During the procedure, the ureteral balloon catheter was exposed, revealing that the excised mass was a bladder diverticulum complicated by bladder injury. Subsequently, the bladder injury site was laparoscopically sutured and repaired. Four weeks post-surgery, urological imaging confirmed complete reconstruction of the bladder injury, and the indwelling ureteral balloon catheter was successfully removed.</p><p><strong>Conclusion: </strong>We experienced a case of complete laparoscopic excision and bladder injury repair of a massive bladder diverticulum mimicking an ovarian cyst. Bladder diverticula, though rare, should be considered in the differential diagnosis of pelvic masses, particularly in post-menopausal women with equivocal preoperative diagnoses to avoid unnecessary surgical interventions.</p><p><strong>Precis: </strong>Bladder diverticula should be considered in the differential diagnosis of pelvic masses, particularly in postmenopausal women, as they can mimic ovarian cysts.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"278"},"PeriodicalIF":2.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for the prognostic effects of patients with pelvic abscesses: a clinical retrospective study.","authors":"Lei Yang, Juhua Zhong, Huihua Chen, Chen Gao, Tingting Lin, Liangyu Chen, Zhenwen Zhang, Yang Lin, Yiyi Zheng","doi":"10.1186/s12905-025-03838-5","DOIUrl":"10.1186/s12905-025-03838-5","url":null,"abstract":"<p><strong>Background: </strong>Pelvic abscesses represent acute gynecological emergencies requiring timely intervention. This study evaluated prognostic predictors and treatment modalities in patients with pelvic abscesses.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 127 consecutive pelvic abscess cases treated at Ningde Municipal Hospital between 2016 and 2021. Patients were stratified by treatment modality (non-surgical, laparoscopic, open surgery). Multiple linear regression analyses were performed to assess the associations between risk factors and prognostic outcomes.</p><p><strong>Results: </strong>Non-surgical management was associated with smaller abscess size but longer recovery times compared to surgical interventions. Laparoscopic approaches exhibited superior outcomes versus open surgery in both operative time and blood loss. Multivariate analysis identified key prognostic factors included treatment modality, duration from onset to admission, pre-admission temperature, CA125 levels, and maximum mass diameter.</p><p><strong>Conclusions: </strong>These findings underscore the prognostic value of early intervention, biomarker-guided decision-making, and minimally invasive approaches in pelvic abscess management. By identifying these factors, healthcare providers could effectively stratify patients based on their risk profiles, facilitating more personalized treatment strategies and improved prognostic outcomes.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"276"},"PeriodicalIF":2.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum creatinine as a risk factor for endometriosis: insights from cross-sectional study, mendelian randomization analysis, and diagnostic model study.","authors":"Yanan Duan, Yiqing Peng, Aiping Chen","doi":"10.1186/s12905-025-03808-x","DOIUrl":"10.1186/s12905-025-03808-x","url":null,"abstract":"<p><strong>Background: </strong>Endometriosis (EM) is a prevalent gynecological condition impacting roughly 10% of women of reproductive age worldwide, causing chronic pain, infertility, and menstrual irregularities. Traditional diagnosis typically relies on invasive surgical methods, and non-invasive diagnostic techniques remain underdeveloped. This study seeks to investigate the association between creatinine levels and endometriosis through cross-sectional analysis and mendelian randomization (MR) analysis, while also developing and assessing diagnostic models.</p><p><strong>Method: </strong>This research integrates data from the NHANES database (1999-2006) and the affiliated hospital of Jining Medical College in China. The study cohort consists of women aged 20-60, with data collection covering age, race, education level, marital status, family income, weight, height, body mass index(BMI), and serum creatinine levels. Logistic regression models were used for univariate and multivariate analyses. Bidirectional MR analysis, utilizing genetic variation data from Large Genome Association Studies (GWAS), was performed to evaluate causal relationships using the inverse variance weighted (IVW) method, complemented by sensitivity analysis. A diagnostic model based on data from top-tier hospitals in China was constructed and its performance assessed through receiver operating characteristic(ROC) curves, area under the curve(AUC) values, and calibration curves.</p><p><strong>Result: </strong>In the NHANES dataset, univariate analysis indicated a significant correlation between creatinine levels and endometriosis (OR = 1.01, 95% CI: 1.00-1.01, P = 0.0048), while multivariate analysis maintained significant results after adjustment (OR = 1.00, 95% CI: 1.00-1.01, P = 0.0431). Bidirectional MR analysis demonstrated a causal relationship between creatinine levels and endometriosis, with a positive IVW result of 1.001 (95% CI: 1.00-1.002, P = 0.0350). In the chinese tertiary hospital dataset, the AUC for the diagnostic model on both training and validation sets were 0.721 and 0.730, respectively. An increase of 10 μmol/L in creatinine levels raised the risk of endometriosis by approximately 8% (OR = 1.08, 95% CI: 1.07-1.09, P < 0.001).</p><p><strong>Conclusion: </strong>This study establishes a significant link between creatinine levels and endometriosis, confirming creatinine as an independent risk factor. Elevated creatinine levels could be used as non-invasive biomarkers for the early detection and diagnosis of endometriosis. Future research should aim to validate these findings in larger, multicenter studies and delve into the specific biological mechanisms, paving the way for novel therapeutic strategies.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"277"},"PeriodicalIF":2.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary intracranial immature teratoma in an adult woman: case report and literature review.","authors":"Yulun He, Haifeng Ran, Xiaojiao He, Daoen Zhang, Junwei Liu, Guiqin Chen, Qian E Yu, Yuxin Xie, Tijiang Zhang","doi":"10.1186/s12905-025-03815-y","DOIUrl":"10.1186/s12905-025-03815-y","url":null,"abstract":"<p><strong>Background: </strong>Primary immature teratoma of the parietal lobe is an exceptionally rare intracranial germ cell tumor, accounting for < 1% of all primary intracranial malignancies. Due to its rarity and overlapping radiological features with other tumors, such as glioma, immature teratomas are often misdiagnosed. Here, we report the case of a 48-year-old woman with a parietal lobe immature teratoma, initially misdiagnosed as a \"glioma,\" highlighting the diagnostic challenges and management strategies.</p><p><strong>Case presentation: </strong>A 48-year-old woman presented with progressive headaches. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a space-occupying lesion in the right parietal lobe with inhomogeneous density, distinct margins, and perilesional edema. Initial radiological interpretation suggested a glioma; however, postoperative histopathological examination confirmed the diagnosis of an immature teratoma. Following the first surgery, the patient underwent radiotherapy. Eight months later, MRI detected tumor recurrence, prompting a second surgical resection. The patient had an uneventful recovery and was discharged.</p><p><strong>Conclusions: </strong>This case underscores the diagnostic and therapeutic challenges of intracranial immature teratomas in adults. Key radiological features include: CT: Inhomogeneous density with fatty components and /or calcifications. MRI: Mixed signal intensity, perilesional edema, and contrast-enhanced annular enhancement with an enhancing mural nodule. Early and accurate diagnosis is critical for optimizing treatment outcomes. Surgical resection remains the cornerstone of management, with adjuvant therapies reserved for recurrent or residual disease. Clinicians should consider immature teratoma in the differential diagnosis of atypical brain parenchymal masses, particularly when imaging findings include inhomogeneous density on CT and mixed signals with annular enhancement on MRI.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"275"},"PeriodicalIF":2.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}