BMC Women's Health最新文献

{"title":"The effect of educational intervention based on protection motivation theory in improving reproductive health protective behaviors: a quasi-experimental study.","authors":"Zahra Japalaghi, Asieh Bahrami, Reza Beiranvand, Hossein Soltaninejad, Mahdieh Varseh, Nader Sharifi","doi":"10.1186/s12905-025-03680-9","DOIUrl":"10.1186/s12905-025-03680-9","url":null,"abstract":"<p><strong>Background: </strong>Reproductive health has broad implications for individuals, families, and society. This study aims to explore how an educational intervention, centered around PMT, can enhance reproductive health protective behaviors among female students.</p><p><strong>Methods: </strong>This quasi-experimental study was conducted on female students of Khomein University of Medical Sciences in Markazi Province, Iran, from December 2023 to August 2024. A random cluster sampling method was used for sampling, resulting in 51 female students being selected for the intervention group and 54 female students for the control group. The data collection tool was a researcher-developed questionnaire, which included demographic information and PMT constructs with confirmed validity and reliability. The educational intervention for the intervention group consisted of three one-hour sessions spaced one week apart, incorporating methods such as lectures, group discussions, Q&A sessions, brainstorming, role-playing exercises, as well as distribution of educational booklets. The collected data was then analyzed using various statistical methods including independent t-tests, t-tests, chi-square tests, simple linear regression, and multiple linear regression models.</p><p><strong>Results: </strong>After the intervention, the mean score for all constructs in the intervention group was higher than that of the control group, except for perceived cost. A statistically significant difference was noted in the mean scores of most constructs, such as perceived susceptibility, perceived severity, perceived self-efficacy, protection motivation, fear, and behavior, between the two groups being studied (p < 0.05).</p><p><strong>Conclusion: </strong>The PMT-based educational intervention has proven to be effective in promoting reproductive health protective behaviors among female students. Given the significance of infertility issues and the value of preserving fertility in young women, it is recommended to implement PMT-based educational programs to safeguard women's reproductive health.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"154"},"PeriodicalIF":2.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation and psychometrics of the HPV impact profile in Iranian women.","authors":"Fatemeh Nasiri-Amiri, Afsaneh Bakhtiari, Elnaz Safary, Sobhan Rahimi Esbo","doi":"10.1186/s12905-025-03678-3","DOIUrl":"10.1186/s12905-025-03678-3","url":null,"abstract":"<p><strong>Introduction: </strong>The human papillomavirus (HPV) significantly impacts women's physical and psychological health, and there is a notable absence of specialized tools to assess its psychosocial effects comprehensively. The HPV Impact Profile (HIP) was developed to address this need. This study focuses on the translation and validation of the HIP for use among Iranian women.</p><p><strong>Methods: </strong>This methodological study was conducted among women diagnosed with HPV from May 2022 to July 2023. A total of 300 women participated by completing an online self-administered questionnaire. The HIP was translated into Persian following standardized procedures. The psychometric properties of the Persian version were evaluated through multiple validation methods: face validity (qualitative and quantitative), content validity (qualitative and quantitative), construct validity (exploratory factor analysis and confirmatory factor analysis), convergent and divergent validity, and reliability (Cronbach's alpha and McDonald's omega).</p><p><strong>Results: </strong>The original HIP consisted of 29 items. Following the translation process, the Persian version underwent rigorous psychometric validation. During the face validity assessment, no items were removed. However, during the content validity evaluation, 2 items were deleted, resulting in 27 items for further analysis. Exploratory factor analysis led to the removal of an additional 2 items, reducing the number to 25 items. Three factors were extracted, which collectively explained 81.65% of the total variance. Confirmatory factor analysis confirmed a good model fit, with all indices meeting the recommended thresholds. Reliability assessments demonstrated high internal consistency and stability, with Cronbach's alpha calculated at 0.932 and McDonald's omega at 0.996.</p><p><strong>Conclusion: </strong>The Persian version of the HIP-25 exhibits strong psychometric properties, including high validity and reliability. It is a robust tool for assessing the quality of life among Iranian women with HPV, and it can be effectively utilized in clinical and research settings to better understand and address the psychosocial impacts of HPV.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"151"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Canadian contraceptive choices: results of a national survey on hormonal contraceptive use.","authors":"Allison J Campbell, Victoria E Claydon, Sarah Liva, Anita T Cote","doi":"10.1186/s12905-025-03597-3","DOIUrl":"10.1186/s12905-025-03597-3","url":null,"abstract":"<p><strong>Background: </strong>Since the introduction of the birth control pill in 1960, Canadians have been offered a number of different options for hormonal contraceptives, yet oral contraceptives remain the most popular methods. Research from other countries indicates this may be shifting, but the last comprehensive survey of Canadian hormonal contraceptive usage was published in 2009. Therefore, the aim of this study was to determine current hormonal contraceptive usage among pre-menopausal Canadians.</p><p><strong>Methods: </strong>An online survey was distributed to pre-menopausal females aged 19-49 years via a third-party survey company. The survey included questions on respondents' demographics and current and past hormonal contraceptive use. Prevalence of current hormonal contraceptive use was calculated by age. Chi-squared tests were conducted to determine whether there was an association between contraceptive choice and various demographic categories.</p><p><strong>Results: </strong>Responses of 2306 female Canadians (age 33.4 ± 8.1 years) were analyzed and 29% of these respondents were currently using hormonal contraceptives. The most common choices were oral contraceptives (56.4%) and intrauterine device (IUD) (28.4%). Over 30% of hormonal contraceptive users were currently using a long-acting reversible contraceptive method.</p><p><strong>Conclusions: </strong>These findings demonstrate a change in hormonal contraception use, notably an increase in the use of hormonal IUDs from 4 to 28% among Canadian hormonal contraceptive users over the last 15 years. This study also shows a high prevalence of alternative contraceptive options that may influence hormone levels differently than oral forms.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"147"},"PeriodicalIF":2.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of loss to follow-up and associated factors among mothers on antiretroviral therapy in the context of elimination of mother-to-child transmission of HIV in two health districts of Bobo-Dioulasso in Burkina Faso.","authors":"Béninwendé Léticia Delphine Sakana, Ziemlé Clément Meda, Bernard Ilboudo, Abdoulaye Ouattara, Blahima Konate, Bernard Eric Dabone, Manitu Serge Mayaka, Gueswendé Léon Savadogo, Philippe Van De Perre","doi":"10.1186/s12905-025-03658-7","DOIUrl":"10.1186/s12905-025-03658-7","url":null,"abstract":"<p><strong>Introduction: </strong>Since 2017, Burkina Faso has rolled out a plan to eliminate vertical transmission of HIV (eMTCT). Elimination will only be achieved when mothers have regular follow-up and good compliance with antiretroviral therapy (ART). The aim of this article is to study the incidence and associated factors for loss to follow-up (LTFU ), in women living with HIV (WLHIV) monitored as part of the eMTCT.</p><p><strong>Methods: </strong>This study consisted of a retrospective analysis of routinely collected data from pregnant women who were screened and initiated ART in the Do and Dafra health districts of Bobo-Dioulasso between 2017 and 2020 as part of the eMTCT. The study ran from May 2023 to March 2024. The Kaplan-Meier model was used to estimate the rate of LTFU; the Cox model was used for identification of factors associated with LTFU and verification of Kaplan-Meier results.</p><p><strong>Results: </strong>Three hundred and four newly diagnosed pregnant WLHIV were included in this study. The median age of the mothers was 30 [24; 36] years. The incidence of LTFU was 22.9 per 100 person-years. Younger age (HR = 2.40; 95%CI: 1.37-4.20) was associated with a higher incidence of LTFU, whereas urban residence (HR = 0.57; 95%CI: 0.39-0.85), in contrast to rural residence, was associated with a lower incidence of LTFU.</p><p><strong>Conclusion: </strong>The study showed a high incidence of LTFU, associated with younger age and rural residence, in the eMTCT programme in Burkina Faso.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"148"},"PeriodicalIF":2.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequential therapy of dienogest following relugolix for adenomyosis and impact on symptoms and serum CA125 levels: a case series.","authors":"Haruka Nishida, Kohei Takehara, Takako Onodera, Saya Watanabe, Kazuki Takasaki, Yuko Takahashi, Takayuki Ichinose, Mana Hirano, Haruko Hiraike, Kazunori Nagasaka","doi":"10.1186/s12905-025-03681-8","DOIUrl":"10.1186/s12905-025-03681-8","url":null,"abstract":"<p><strong>Background: </strong>Adenomyosis, characterized by endometrial tissue within the uterine muscle, often presents with severe pelvic pain and menorrhagia. This case series demonstrates the efficacy of sequential therapy involving relugolix followed by dienogest in managing adenomyosis.</p><p><strong>Case presentation: </strong>In five patients with adenomyosis, the gonadotropin-releasing hormone antagonist relugolix initially mitigated symptoms and reduced the levels of serum CA125, a marker associated with disease activity. After six months of relugolix, patients were transitioned to dienogest. This sequential approach maintained symptom relief and further stabilized CA125 levels.</p><p><strong>Conclusions: </strong>Our findings demonstrate that sequential therapy provides effective symptom management and long-term disease control. Further, CA125 remains a valuable biomarker for monitoring therapeutic success.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"150"},"PeriodicalIF":2.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world breast cancer treatment patterns and guideline-concordant treatment completion among Malawian women.","authors":"Jennifer Morgan, Shekinah Elmore, Takondwa Zuze, Lusayo Simwinga, Richard Nyasosela, Precious Makondi, Agnes Manda BSc, Chifundo Kajombo, Anthony Charles, Lisa A Carey, Maurice Mulenga, Katherine Reeder-Hayes, Tamiwe Tomoka","doi":"10.1186/s12905-025-03667-6","DOIUrl":"10.1186/s12905-025-03667-6","url":null,"abstract":"<p><strong>Purpose: </strong>In Sub-Saharan Africa (SSA), resource-stratified guidelines for breast cancer treatment are increasingly recommended, but treatment receipt and outcomes according to these guidelines are underreported. Here, we describe breast cancer treatment patterns by stage and curative-intent guideline-concordant treatment (GCT) receipt among Malawian women.</p><p><strong>Methods: </strong>A prospective cohort of breast cancer patients were enrolled from December 2016 to October 2018 at Kamuzu Central Hospital with an assessment of demographics, stage, and treatment received, including neoadjuvant (NAC), adjuvant (AdC) and palliative chemotherapy and breast surgery. Curative-intent GCT was defined as having completed breast surgery and at least 4 cycles of chemotherapy. Overall survival (OS) was calculated using Kaplan Meier methods and odds ratios using logistic regression.</p><p><strong>Results: </strong>91 patients were included, of whom 13 (14%) presented as stage II, 54 (59%) as stage III, and 24 (26%) as stage IV. Curative treatment was recommended for 65 of 91 (71%) patients, of whom 47 (72%) were initiated on NAC, 14 (22%) on upfront breast surgery, and 4 (6%) received no treatment. Only 63% (41/65) of patients received curative-intent GCT as recommended with non-GCT associated with stage III (vs. stage II) disease (OR 0.10 CI (0.01-0.89)), HIV positivity ((OR 0.25 CI (0.06-0.99)) and hormone receptor (HR) negative/HER2 positive subtype ((OR 0.07 CI (0.01-0.49)). Curative-intent GCT was associated with improved OS (44.1 vs. 23.2 months; p = 0.00) compared to non-GCT.</p><p><strong>Conclusion: </strong>While curative-intent GCT was associated with improved survival in this Malawian cohort, treatment completion rates were suboptimal. Resource-stratified guidelines must be paired with locally relevant, multilevel implementation strategies to target barriers to treatment completion.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"149"},"PeriodicalIF":2.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Women's experiences of head and neck cancer: an interpretative phenomenological analysis\".","authors":"Charlotte Vandamme, Sophie Cremades, Sylvie Testelin, Sophie Lelorain","doi":"10.1186/s12905-025-03671-w","DOIUrl":"10.1186/s12905-025-03671-w","url":null,"abstract":"<p><strong>Purpose: </strong>Head and neck cancers (HNCs) are predominantly studied in men. This study aimed to explore women's experiences of HNC.</p><p><strong>Methods: </strong>The study was based on the secondary analysis of interviews conducted by using the life story methodology with patients who underwent surgery for HNC. We selected seven particularly rich interviews regarding the experience of cancer and first conducted a thematic analysis to identify key patterns in the data. We then applied interpretative phenomenological analysis (IPA) to explore in depth how participants made sense of their experiences.</p><p><strong>Results: </strong>Key themes were identified across different phases of the illness journey, including diagnosis, treatment, post-treatment, recurrence, and future projection. A major challenge was diagnostic wandering, as many women did not fit the typical head and neck cancer (HNC) profile-typically a man who consumes alcohol and tobacco. Identity loss was a central issue, with themes of reclaiming one's body post-surgery and the loss of feminine symbolism (infertility, hair loss, self-recognition). Coping strategies varied: some sought social support and aimed to return to work, while others viewed surgery as essential for recovery.</p><p><strong>Conclusion: </strong>These findings highlight the need for personalized support tailored to women's specific needs and challenges.</p><p><strong>Implications for cancer survivors: </strong>This study emphasize the importance of providing personalized support that closely aligns with the needs of female head and neck cancer survivors. It is crucial to consider their subjectivity, recognizing that each experience is unique, to better assist them in overcoming adversity. Tailoring care to their individual realities will more effectively address their emotional and physical difficulties.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"145"},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and evaluation of a machine learning model for osteoporosis risk prediction in Korean women.","authors":"Minkyung Je, Seunghyeon Hwang, Suwon Lee, Yoona Kim","doi":"10.1186/s12905-025-03669-4","DOIUrl":"10.1186/s12905-025-03669-4","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to develop a machine learning (ML) model for classifying osteoporosis in Korean women based on a large-scale population cohort study. This study also aimed to assess ML model performance compared with traditional osteoporosis screening tools. Furthermore, this study aimed to examine the factors influencing the risk of osteoporosis through variable importance.</p><p><strong>Methods: </strong>Data was collected from 4199 women aged 40-69 years in the baseline survey of the Ansan and Ansung cohort of the Korean Genome and Epidemiology Study. Osteoporosis was set as the dependent variable to develop ML classification models. Independent variables included 122 factors related to osteoporosis risk, such as socio-demographic characteristics, anthropometric parameters, lifestyle factors, reproductive factors, nutrient intakes, diet quality indices, medical history, medication history, family history, biochemical parameters, and genetic factors. The six classification models were developed using ML techniques, including decision tree, random forest, multilayer perceptron, support vector machine, light gradient boosting machine, and extreme gradient boosting (XGBoost). The six ML classification models were compared with two traditional osteoporosis screening tools, including the osteoporosis risk assessment instrument (ORAI) and the osteoporosis self-assessment tool (OST). The ML model performances were evaluated and compared using the confusion matrix and area under the curve (AUC) metrics. Variable importance was assessed using the XGBoost technique to investigate osteoporosis risk factors.</p><p><strong>Results: </strong>The XGBoost model showed the highest performance out of the six ML classification models, with an accuracy of 0.705, precision of 0.664, recall of 0.830, and F1 score of 0.738. Moreover, the XGBoost model showed a higher performance on AUC than ORAI and OST. Variable importance scores were identified for 69 out of the 122 variables associated with osteoporosis risk factors. Age at menopause ranked first in variable importance. Variables of arthritis, physical activities, hypertension, education level, income level; alcohol intake, potassium intake, homeostatic model assessment for insulin resistance; energy intake, vitamin C intake, gout; and dietary inflammatory index ranked in the top 20 out of the 69 variables, using the XGBoost technique.</p><p><strong>Conclusions: </strong>This study found that an XGBoost model can be utilized to classify osteoporosis in Korean women. Age at menopause is a significant factor in osteoporosis risk, followed by arthritis, physical activities, hypertension, and education level.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"146"},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlates and effects of information, motivation and behavioral skills on primary sexual abstinence among female university students in Ethiopia: a cross-sectional study.","authors":"Banti Negero Feyisa, Gurmessa Tura Debelew, Zewdie Birhanu Koricha","doi":"10.1186/s12905-025-03664-9","DOIUrl":"10.1186/s12905-025-03664-9","url":null,"abstract":"<p><strong>Background: </strong>The burden of sexually transmitted infections (STIs) and unintended pregnancies continue to pose significant public health challenges, disproportionately affecting young women. The information-motivation-behavioral (IMB) skills model is useful for understanding risky and safe sexual behavior. However, while the IMB models have been used primarly to understand and promote HIV prevention with condom use behavior, there is limtted research using the IMB model to understand and promote safer sexual dual-protection behaviors, such as abstinence, to address the risk of both STI/HIV and unwanted pregnancy among youth in Ethiopia. This study aimed to fill this gap by applying the IMB model to assess the correlates and effects of information, motivation, and behavioral skills on primary sexual abstinence among female university students in Ethiopia.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with a sample of 1,020 female university students at Mattu University between May and June 2023. Data were collected using a self-administered questionnaire and analyzed using SPSS version 23. Descriptive statistics were used to summarize the percentage distribution of participants by their sociodemographic characteristics and levels of HIV risk reduction/dual protection information, motivation, behavioral skills, and risky and safer sexual behaviors. Bivariate and multivariate analyses were conducted using structural equation modeling (SEM) with AMOS 23 to examine the correlations and effects of information, motivation, and behavioral skills on primary sexual abstinence.</p><p><strong>Results: </strong>Of 1,020 participants, 624 (61.2%) reported having practiced primary sexual abstinence.Multivariate analyses showed that primary sexual abstinence was significantly predicted by motivation (β = 0.34, P < 0.001), behavioral skills (β = 0.24, P < 0.001) and information (β = 0.11, P < 0.001) after controlling for the effects of other confounding variables. Overall, approximately 28% of the variance in primary sexual abstinence was explained by the IMB model constructs.</p><p><strong>Conclusions: </strong>The findings indicate that the IMB model is a useful tool for identifying powerful determinants of sexual abstinence, which has potential implications for interventions aimed at enhancing specific information, motivation, and behavioral skills to promote sexual abstinence and reduce the risk of HIV/STI and unintended pregnancy among youth in settings with high HIV burdens.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"144"},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of human papillomavirus-related cervical lesions in postmenopausal women: a cross-sectional study.","authors":"Hongmin Zeng, Qianling Dai, Jieru Peng, Juan Li, Jing Chen, Zhipeng Lan, Xia Wu, Ting Shu, Liu Yang, Wenyi Lin, Mulan Li, Xiao Yang, Yonghong Lin","doi":"10.1186/s12905-025-03675-6","DOIUrl":"10.1186/s12905-025-03675-6","url":null,"abstract":"<p><strong>Background: </strong>The incidence of cervical cancer is increasing in postmenopausal women globally, particularly in less-developed nations, including China. However, research on cervical cancer screening methods and related factors in China is limited. In the present study, we aimed to identify the independent risk factors associated with cervical lesions in postmenopausal women. Additionally, we compared the clinical characteristics and demographic information between women diagnosed with low-grade squamous intraepithelial lesions (LSIL) and those with high-grade squamous intraepithelial lesions+ (HSIL+).</p><p><strong>Methods: </strong>We conducted a cross-sectional study using qualitative human papillomavirus (HPV) DNA testing for cervical cancer screening among postmenopausal women across 23 districts and counties in Chengdu, China. Multivariate logistic analysis was employed to analyze demographic information, clinical history, and auxiliary examinations to identify independent risk factors for cervical lesions in postmenopausal women.</p><p><strong>Results: </strong>A total of 917 patients participated in the study and were categorized as: 624 patients with LSIL (68.0%) and 293 patients with HSIL+ (32.0%). Multivariate analysis revealed that factors showing significant differences between two categories included co-infection with types 16 and 18 (adjusted odds ratio [aOR] = 0.348, 95% confidence interval [CI] = 0.138-0.881, p = 0.026), mixed infections involving other types, HPV 16/18 (aOR = 0.514, 95% CI = 0.336-0.785, p = 0.002), transformation zone (TZ) 3 (aOR = 1.604, 95% CI = 1.018-2.528, p = 0.041), and colposcopy impressions indicating high-grade features and worse (aOR = 11.846, 95% CI = 2.132-65.807, p = 0.005).</p><p><strong>Conclusions: </strong>Co-infection with HPV types 16 and 18, as well as mixed infections involving HPV 16/18 and other types, TZ 3, and colposcopic features indicative of high-grade lesions and cancer, were identified as independent risk factors for HPV-related cervical lesions in postmenopausal women. Therefore, postmenopausal women with these high-risk factors need to undergo frequent cervical screening, and histopathological examination, if necessary.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"143"},"PeriodicalIF":2.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}