Yuhuan Zeng, Yuanhu Lei, Min Li, Wei Liu, Jie Zhou, Jie Zhong, Guangming Song, Yukun Li, Xiangfang Tan, Qunfeng Zhang
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引用次数: 0
Abstract
Objective: Although diabetes mellitus (DM) is considered an important prognostic factor for hysterectomy outcomes, the relationship between DM and postoperative complications remains unclear. The aim of this study was to investigate whether DM is associated with an increased risk of complications following hysterectomy.
Methods: We systematically searched PubMed, Embase, and the Cochrane Library for relevant articles published on or before March 15, 2024. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated via random effects meta-analysis. The primary outcome was the risk of complications posthysterectomy, including postoperative infection and hospital readmission. Additionally, we conducted subgroup and sensitivity analyses to explore the main sources of heterogeneity and assess the stability of the results.
Results: A total of 19 cohort studies comprising 375,531 participants met the inclusion criteria. This meta-analysis revealed that DM was significantly associated with postoperative infection (OR 2.01, 95% CI 1.46-2.77). Additionally, DM was significantly associated with low postoperative survival (5 years) (OR 4.43, 95% CI 2.98-6.58), readmission (OR 1.59, 95% CI 1.42-1.79), embolism (OR 1.31, 95% CI 1.18-1.46), renal failure (OR 3.88, 95% CI 2.74-5.51) and reintubation (OR 3.23, 95% CI 1.64-6.35), whereas DM was not associated with an extended length of stay (OR 1.39, 95% CI 0.93-2.10), myocardial infarction (OR 1.86, 95% CI 0.58-5.98) or blood transfusion (OR 1.36, 95% CI 0.88-2.11) in patients following hysterectomy.
Conclusions: DM increases the risk of postoperative infection following hysterectomy. Special attention should be given to diabetic patients to reduce the incidence of complications after hysterectomy.
目的：虽然糖尿病（DM）被认为是子宫切除术预后的重要因素，但糖尿病与术后并发症的关系尚不清楚。本研究的目的是调查糖尿病是否与子宫切除术后并发症的风险增加有关。方法：系统检索PubMed、Embase和Cochrane Library，检索2024年3月15日及之前发表的相关文章。通过随机效应荟萃分析计算合并优势比（ORs）和95%置信区间（ci）。主要观察指标是胆囊切除术后并发症的风险，包括术后感染和再入院。此外，我们还进行了亚组分析和敏感性分析，以探索异质性的主要来源并评估结果的稳定性。结果：共有19项队列研究，包括375,531名参与者符合纳入标准。该荟萃分析显示，DM与术后感染显著相关（OR 2.01, 95% CI 1.46-2.77）。此外，DM与术后低生存率（5年）（OR 4.43, 95% CI 2.98-6.58）、再入院（OR 1.59, 95% CI 1.42-1.79）、栓塞（OR 1.31, 95% CI 1.18-1.46）、肾功能衰竭（OR 3.88, 95% CI 2.74-5.51）和再插管（OR 3.23, 95% CI 1.64-6.35）显著相关，而DM与延长住院时间（OR 1.39, 95% CI 0.93-2.10）、心肌梗死（OR 1.86, 95% CI 0.58-5.98）或输血(OR 1.36，95% CI 0.88-2.11)。结论：DM增加子宫切除术后感染的风险。应特别注意糖尿病患者，以减少子宫切除术后并发症的发生。
期刊介绍：
BMC Women''s Health is an open access, peer-reviewed journal that considers articles on all aspects of the health and wellbeing of adolescent girls and women, with a particular focus on the physical, mental, and emotional health of women in developed and developing nations. The journal welcomes submissions on women''s public health issues, health behaviours, breast cancer, gynecological diseases, mental health and health promotion.
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