BMC Neurology最新文献

{"title":"Multiple sclerosis patients' journey delay in diagnosis and treatment: a multicenter study.","authors":"Salma Ragab, Basem Hamdy Fouda, Abdallah-Almamun Sarhan, Azza Abbas, Asmaa Mohamed Hassan, Ahmed Embaby, Noha Ali Hashim","doi":"10.1186/s12883-025-04172-x","DOIUrl":"10.1186/s12883-025-04172-x","url":null,"abstract":"<p><strong>Objective: </strong>To determine factors that contribute to delayed diagnosis and treatment of MS patients. Additionally, the study aimed to evaluate the correlation between diagnostic and therapeutic delay and disease outcome.</p><p><strong>Methods: </strong>The current cohort observational multicenter study was performed at neurology clinics in four cities in Egypt. In this study, 239 MS patients were enrolled. Multiple Sclerosis Severity Scale (MSSS) and Expanded Disability Status Scale (EDSS) were utilized to measure disease severity and disability, respectively. Lag times for diagnosis were calculated in months from the time of the first symptoms to the accurate diagnosis.</p><p><strong>Results: </strong>The results revealed that multiple important variables had a negative impact on the timely diagnosis, including the clinical type, as PPMS had longer delayed diagnoses versus RRMS/SPMS (p < 0.001). Conversely, the occurrence of sensory symptoms at disease onset is linked to prolonged diagnostic delay (p < 0.001). Multivariate logistic regression showed that young age, PPMS, and sensory symptoms were independently associated with delay in MS diagnosis. Patients initially sought medical assistance from ophthalmologists and neurologists, resulting in a significantly more delay in diagnosis (p < 0.001). A statistically positive correlation exists between the time for diagnosis and deterioration of MS assessed by EDSS, MSSS, or PI (p < 0.001). In addition, logistic regression analysis demonstrated that EDSS at diagnosis, delayed diagnosis, and illness duration were independently linked to MS severity (p < 0.001).</p><p><strong>Conclusion: </strong>Many factors prolong the duration of MS diagnosis, including the age at disease onset, the delay in being referred from other medical specialties, and the presence of sensory symptoms at disease onset. Furthermore, MS delayed diagnosis and treatment leads to high disease disability with poor functional outcomes.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"377"},"PeriodicalIF":2.2,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12406396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and outcome of intravenous thrombolysis in ischemic stroke related to intracranial artery dissection.","authors":"Wen Yang, Jian-Wei Wang, Mei-Xia Zhang, Hong-Fang Chen","doi":"10.1186/s12883-025-04383-2","DOIUrl":"10.1186/s12883-025-04383-2","url":null,"abstract":"<p><strong>Background: </strong>The clinical efficacy of intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) associated with intracranial artery dissection (IAD) remains uncertain. This study presents a case of basilar artery dissection (BAD) in a 57-year-old Asian female patient devoid of previous risk factors for stroke who experienced a sudden onset of consciousness disturbance. The patient's clinical condition deteriorated during IVT administration, but subsequent medical intervention and rehabilitative exercises facilitated eventual recovery of daily functioning. MRI eventually identified the etiology of the patient's AIS.</p><p><strong>Conclusion: </strong>AIS related to anterior circulation IAD may pose a relatively high risk of hemorrhagic transformation and symptom exacerbation during the early stages of IVT, but the impact on long-term prognosis remains uncertain. Consequently, further investigation is warranted to assess the safety and efficacy of IVT in such patients.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"376"},"PeriodicalIF":2.2,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12406453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of Atogepant in migraine prevention: a systematic review and meta-analysis.","authors":"Naresh Kumar Ladhwani, Priya Bai, Rohan Lal, Aresha Masood Shah, Sheela Bai, Ghazi Uddin Ahmed, Rimsha Zameer, Varisha Fatima Shaikh, Arsalan Hyder, Sikander Ali, Muhammad Hamza Beg, Maheen Adeeb, Mahir Tesfaye","doi":"10.1186/s12883-025-04394-z","DOIUrl":"10.1186/s12883-025-04394-z","url":null,"abstract":"<p><strong>Background: </strong>Atogepant is a CGRP receptor antagonist used in prevention of migraine. This study assesses the safety and efficacy of this drug in management of migraine headaches.</p><p><strong>Methods: </strong>PubMed, Scopus, Web of Science, and Cochrane CENTRAL were searched until March 24, 2025. Outcomes assessed included monthly migraine and headache day change from baseline at 12 weeks, ≥ 50% reduction in monthly migraine days (MMD), acute medication use days at 12 weeks, treatment-emergent adverse events (TEAE), score on Role Function-Restrictive domain of MSQ at 12 weeks, score on daily activity performance and physical impairment domains of AIM-D at 12 weeks. Subgroup analysis was performed based on different doses of atogepant.</p><p><strong>Results: </strong>Six RCTs comprising of 4052 patients were included. Atogepant showed significant improvement in patients with migraine in terms of MMD over 12 weeks at all doses, 10 mg, 30 mg, and 60 mg. Moreover, it also reduced monthly headache days, had 50% reduction in MMD, and reduced days requiring acute medication use. Atogepant was shown to increase the risk of TEAE, particularly gastrointestinal (GI) side effect including constipation and nausea, however, occurrence of other side effects with atogepant use was insignificant.</p><p><strong>Conclusion: </strong>Atogepant is a highly effective CGRP antagonist for migraine prevention, however, it is associated with increased incidence of GI side effects. Further studies are needed to comprehensively investigate the relationship between atogepant dosage and migraine improvement and safety profile.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"375"},"PeriodicalIF":2.2,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12406345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between low-grade inflammation and distal sensorimotor polyneuropathy in type 2 diabetes: a cross-sectional study.","authors":"Sihua Huang, Yan Lan, Cheng Zheng, Hongyun Liang, Yanhong Wei, Bing Chen","doi":"10.1186/s12883-025-04379-y","DOIUrl":"10.1186/s12883-025-04379-y","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;As inflammatory processes may be involved in the pathogenesis of diabetic distal sensorimotor polyneuropathy (DSPN), the first aim of the present study was to determine the clinical characteristics of type 2 diabetes mellitus (T2DM) with distal sensorimotor polyneuorpathy (DSPN). Next goal was to investigate inflammatory biomarkers, insulin-like growth factor- 1 and lipid profile in these patients. Finally, we aimed to compare the renal function in these patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In a cross-sectional study, we included 160 patients diagnosed with T2DM. The control group was included 22 non-diabetic healthy subjects (HC). The patients with diabetes were divided into four groups, absent (n = 74), mild (n = 38), moderate (n = 24), and severe (n = 24) using a nomogram based on the MNSI features for a DSPN severity grading probability.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Patients with moderate and severe DSPN were a little older and had longer duration of diabetes compared to patients with absent and mild DSPNS (p &lt; 0.05). Serum levels of interferon-gamma (INF-γ), interleukin (IL)-1β, IL-4, IL- 6 levels in patients with severe DSPN were significantly higher than HC, absent, mild and moderate of DSPN (p &lt; 0.05). The circulating levels of insulin-like growth factor-1 (IGF-1) were significantly lower in patients with severe DSPN (p &lt; 0.05) compared to absent, mild and moderate of DSPN and HC. Diabetic patients with moderate DSPN showed increased circulating levels of TC, LDL-C, APOB (p &lt; 0.05) compared to HC and patients with absent, mild and severe DSPN. Moreover, APO-A1/APOB was significantly lower in patients with diabetes compared to HC. In addition, patients with severe DSPN showed increased Cystatin C (p &lt; 0.05) compared to HC and absent, mild, and moderate DSPN. Multivariate ordered logistic regression analysis showed that the levels of IL-6 (OR = 3.166, 95%CI 1.461-6.860, p = 0.003, IL-1β(OR = 1.148, 95%CI 1.070-2.232; p = 0.000), TC (OR = 1.174, 95%CI 1.011-1.364; p = 0.035), LDL-C (OR = 1.246, 95%CI 1.098-3.618; p = 0.003), Cystatin C (OR = 1.867, 95%CI 1.245-3.434; p = 0.004), ages (OR = 1.043, 95%CI 1.009-1.078; p = 0.012), and duration of diabetes (OR = 1.157, 95%CI 1.049-1.277; p = 0.004) were positively associated with increasing the odds ration of DSPN in T2DM. Conversely, the level of IGF-1 (OR = 0.922, 95%CI 0.961-0.982; p = 0.000) and ratio of APO-A1/APOB (OR = 0.212, 95%CI 0.078-0.567; p = 0.002) were significantly associated with decreasing the odds ratio of DSPN in T2DM.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The levels of inflammatory biomarkers such as INF-γ, IL-1β, IL-4, IL- 6 were increased in patients with severe DSPN in T2DM. Ages, duration of diabetes as well as high circulating levels of IL-6, IL-1β, TC, LDL-C and Cystatin C were positively associated with DSPN in T2DM. Conversely, the level of IGF-1 and the ratio of APOA1/APOB were independent protective factors for DSPN in T2DM. Our","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"378"},"PeriodicalIF":2.2,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12406448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creating a delirium risk assessment model for geriatric patients with femoral neck fractures through artificial intelligence techniques: a theoretical exploration.","authors":"Yu Zhu, Ning Zhou, Renrui Liang, Jian-Jun Yang, Cheng-Mao Zhou","doi":"10.1186/s12883-025-04389-w","DOIUrl":"10.1186/s12883-025-04389-w","url":null,"abstract":"","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"373"},"PeriodicalIF":2.2,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ETRAISI registry report: clinical characteristics and related factors of outcome in reperfusion-eligible AIS patients.","authors":"Mojdeh Ghabaee, Sharareh Eskandarieh, Neda Izadi, Siavash Hosseini, Iman Kiani, Melika Jameie, Zahra Azizan, Nahid Mojahed","doi":"10.1186/s12883-025-04406-y","DOIUrl":"10.1186/s12883-025-04406-y","url":null,"abstract":"<p><strong>Background: </strong>Stroke remains a major cause of disability and mortality worldwide, requiring comprehensive data collection for better management strategies. The Endovascular Thrombolysis Registry in Acute Ischemic Stroke of Iran (ETRAISI) was established March 21, 2023, to systematically document stroke epidemiology, treatment approaches, and outcomes in Iran. This study presents an analysis of registry data, focusing on patient characteristics, treatment time scales, and functional outcomes.</p><p><strong>Methods: </strong>A total of 115 patients diagnosed with acute stroke were enrolled at ETRAISI between March 21, 2023, and March 19, 2024. Clinical and demographic data, including stroke subtype, risk factors, treatment modalities, and outcome measures, were collected. Treatment time scales, such as door-to-needle time (DTN) for thrombolysis and door-to-groin puncture time (DTP) for thrombectomy, were analyzed. Factors associated with National Institutes of Health Stroke Scale (NIHSS) at discharge were assessed using multiple linear regression.</p><p><strong>Results: </strong>Among 313 patients admitted at hospital as possible acute ischemic stroke (AIS), a total of 158 patients' candidate for intra-venous thrombolysis (IVT) or mechanical thrombectomy (MT) within 6-hours of onset, 115 enrolled, 81 patients (70.4%) underwent IVT, 8 (7.0%) patients received MT, and 26 patients (22.6%) underwent bridging therapy. The most common stroke risk factors were hypertension in 77 patients (67.0%), followed by diabetes in 39 (33.9%), and ischemic heart disease in 33 patients (28.7%). The median (IQR) of DTN was 65 (48-84.5) minutes, while the median (IQR) of DTP was 109 (75-158) minutes. The most frequent stroke etiology was undetermined observed in 33% patients. Multiple linear regression identified National Institutes of Health Stroke Scale (NIHSS) at admission, age, diastolic blood pressure, and treatment related complication were significantly associated with functional outcomes (p < 0.05).</p><p><strong>Conclusion: </strong>This study reported stroke management and outcomes in Iran. Identifying treatment time tracker and outcome related factors may inform policy changes and improve acute stroke care in Iran and Other developing countries. Benchmarking these findings against international registries can guide targeted interventions for optimizing stroke treatment.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"374"},"PeriodicalIF":2.2,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12406374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-read sequencing identifies ATXN3 repeat expansions, and transcriptomics reveals disease progression biomarkers and druggable targets for spinocerebellar ataxia type 3.","authors":"Chang Liu, Xin Wang, Chao Xu, Xiaoxiang Liu, Liyan Ke, Ying Li, Hang Zhang, Jianqiang Tan, Senwei Tan, Zitong Zhang, Liang Cheng, Yaqiong Ren, Lei Shi","doi":"10.1186/s12883-025-04378-z","DOIUrl":"10.1186/s12883-025-04378-z","url":null,"abstract":"<p><strong>Background: </strong>Hereditary ataxias (HAs) are neurodegenerative disorders characterized by progressive cerebellar degeneration, with autosomal dominant spinocerebellar ataxias (SCAs) representing the most prevalent subtype. SCA3, the most common form worldwide, is caused by CAG repeat expansions in ATXN3, resulting in pathogenic ataxin-3 aggregation. However, the underlying molecular mechanisms driving disease progression remain incompletely understood.</p><p><strong>Methods: </strong>We utilized an integrated multi-omics strategy to investigate a five-generation Chinese HA pedigree. Genetic analyses included targeted ataxia panel sequencing (TS), whole-exome sequencing (WES), and long-read whole-genome sequencing (LR-WGS) of blood-derived DNA to identify causal variants and confirm diagnosis. Transcriptomic profiling revealed disease-associated gene expression signatures, followed by functional annotation and cross-species validation. To ensure analytical rigor, we further validated our bioinformatic pipeline using an independent ulcerative colitis (UC) dataset.</p><p><strong>Results: </strong>Genetic analysis identified pathogenic ATXN3-CAG repeat expansions that co-segregated with clinical symptoms in affected family members. Transcriptomic profiling showed significant enrichment in ECM-receptor interaction and focal adhesion pathways, along with immune dysregulation and RNA splicing defects associated with disease progression. Cross-species analysis discovered conserved blood biomarkers (C3/ALS2/SLC35A2↓ and THBS1/CAMTA1↑), strongly correlated with clinical progression. Protein-protein interaction network emphasized AKT1 as a central regulator, along with other key hubs (e.g., TGFB1, MAPK3, CALM3, APP), while brain-specific analyses highlighted Mobp, Mal, Gja1 and Klk6 as potential therapeutic targets.</p><p><strong>Conclusions: </strong>This study genetically confirms SCA3 in a Chinese pedigree using LR-WGS, overcoming the diagnostic limitations of short-read sequencing. Comprehensive analyses revealed conserved SCA3 progression signatures with potential biomarkers for future non-invasive monitoring. Mechanistically, this study identified dysregulation in ECM-receptor interaction/focal adhesion, immune response, and RNA splicing as key pathogenic contributors. These findings provide both actionable therapeutic targets and demonstrate the clinical utility of integrated multi-omics approaches for SCA3 diagnosis and patient stratification, with broader implications for repeat expansion disorders.</p><p><strong>Trial registration: </strong>Not Applicable.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"370"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemichorea as the sole clinical manifestation of spinocerebellar ataxia type 8: a case report.","authors":"Makoto Kobayashi","doi":"10.1186/s12883-025-04391-2","DOIUrl":"10.1186/s12883-025-04391-2","url":null,"abstract":"<p><strong>Background: </strong>Spinocerebellar ataxia type 8 (SCA8) is a rare neurodegenerative disease that is caused by CAG/CTG repeat expansion in the overlapping ATXN8 and ATXN8OS genes and basically entails slowly progressive cerebellar dysfunction with resultant dysarthria, limb incoordination, and gait instability. Moreover, patients with SCA8 may also exhibit pyramidal and extrapyramidal signs, cognitive decline, and involuntary movements. Although SCA8 is an autosomal dominant inheritance disorder, it sometimes seems to be sporadic because of reduced penetrance. Due to the wide variety of neurological findings and seemingly unclear inheritance pattern, the diagnosis of SCA8 can be difficult in the absence of cerebellar signs or family history.</p><p><strong>Case presentation: </strong>A 62-year-old woman presented with involuntary movements in her right limbs that occurred intermittently for two weeks. Her medical and medication history was unremarkable and she had a paternal grandmother who was diagnosed with Parkinson's disease. Neurological examination revealed right-sided hemichorea without other abnormalities. Head magnetic resonance imaging (MRI) did not reveal acute ischemic or hemorrhagic lesions; instead, it displayed mild cerebellar atrophy. In addition, dopamine transporter-single photon emission computed tomography (DAT-SPECT) detected bilaterally decreased striatal tracer uptake. Although she had no relatives with similar symptoms or SCA, a set of genetic molecular tests for SCA was conducted because she had mild cerebellar atrophy found on MRI. It detected CTA/CTG repeat expansion in the ATXN8OS gene (18/125 repeats; normal range: 15-50). She was diagnosed with SCA8, which was considered the cause for her hemichorea. Oral haloperidol was initiated as symptomatic treatment and it largely resolved her hemichorea.</p><p><strong>Conclusions: </strong>We should remember that patients with SCA8 can present with hemichorea as the sole clinical manifestation. Moreover, DAT-SPECT may detect their nigrostriatal hypofunction even if they do not have clinically apparent parkinsonism.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"372"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia index based on serum creatinine and cystatin C is associated with the risk of stroke in middle-aged and older adults in Chinese: a prospective cohort study from the China health and retirement longitudinal study.","authors":"Haofei Hu, Aiting Li, Wenhao Zhang, Jihua Hou, Dinglin Liu, Zhijin Chen, Caiyan Zheng, Lele Qin, Yong Han, Lixia Xu, Zhiming Ye","doi":"10.1186/s12883-025-04327-w","DOIUrl":"10.1186/s12883-025-04327-w","url":null,"abstract":"","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"371"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial impact on parents Raising children with cerebral palsy at Gondar comprehensive specialized hospital, Northwest Ethiopia.","authors":"Kaleab Tesfaye Tegegne, Aemero Asmamaw Chalachew, Moges Tadesse Abebe, Tadele Kassahun Wudu, Abrham Degu Melese, Eleni Tesfaye Tegegne, Mekibib Kassa Tessema, Jenberu Mekurianew Kelkay","doi":"10.1186/s12883-025-04397-w","DOIUrl":"10.1186/s12883-025-04397-w","url":null,"abstract":"<p><strong>Background: </strong>Cerebral palsy (CP) is a complex and lifelong neurological disorder that affects movement, muscle tone, and coordination, often leading to significant physical and cognitive impairments in children. CP has significant long-term consequences not only for the child but also for their family, particularly parents who are responsible for the child's care and development.</p><p><strong>Objective: </strong>The objective of the present study was to explicitly explore the psychosocial effects, challenges faced, coping mechanisms, and the nature of mother-child relationships among parents raising children with cerebral palsy in North West Ethiopia.</p><p><strong>Method: </strong>The study employed a qualitative approach with a phenomenological research design. The researchers recruited ten biological mothers of children, eight biological fathers of children and selected them using purposive sampling method. Eight fathers of children with cerebral palsy participated in an in-depth interview and ten mothers of children with CP participated in focus group discussion. The data was collected through semi-structured interview and FGD. Then analyzed qualitatively, using thematic analysis approach.</p><p><strong>Result: </strong>Fathers experienced shock, grief, worry, and isolation, often struggling with depression and fears about their child's future. Despite these challenges, both parents showed resilience, finding strength in faith, spirituality, and community support. Mothers emphasized the emotional and physical demands of caregiving, the deep bonds with their children, and the importance of coping mechanisms like patience and religious practices in managing daily struggles.</p><p><strong>Conclusion: </strong>Parenting children with cerebral palsy (CP) entails significant psychosocial challenges, including grief, anxiety, and caregiving stress. Despite this, parents demonstrate resilience through community and spiritual support. Our findings underscore the need for culturally sensitive interventions, such as accessible mental health services integrated into maternal and child health care, peer-led support groups, and mobile mental health units to reach underserved areas. Incorporating disability awareness and psychosocial support into physiotherapy, maternal health, and religious programs offers practical, culturally grounded strategies to enhance coping and promote family well-being.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"369"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}