BMC Neurology最新文献

{"title":"Cognition, mental health, and quality of life in patients with chronic and episodic migraine during the interictal period.","authors":"Diana Carolina López-Medina, Alejandra Arboleda-Ramírez, Sara Ríos-Díaz, Renato Zambrano-Cruz, Andrés Arboleda-Jaramillo, Cristian Betancur-Henao, Marcela Henao-Pérez","doi":"10.1186/s12883-025-04122-7","DOIUrl":"10.1186/s12883-025-04122-7","url":null,"abstract":"<p><strong>Introduction: </strong>Migraine is a highly prevalent and disabling condition, not only due to its painful symptoms but also because of its significant impact on mental health and cognitive functioning, leading to a considerable deterioration in quality of life. This study aimed to evaluate the cognitive profile, mental health, and quality of life in patients with chronic and episodic migraine during the interictal period, and to explore their relationship with sociodemographic and clinical variables.</p><p><strong>Method: </strong>This observational, descriptive, cross-sectional analytical study included 60 patients diagnosed with chronic or episodic migraine, who were enrolled in a health program for headache patients between 2010 and 2016. Cognitive function, anxiety and/or depression symptoms, and quality of life during the interictal period were assessed. Descriptive analyses were conducted, and associations were evaluated by configuring primary (type of migraine) and alternative events (cognitive impairment, depression and/or anxiety, and poor quality of life).</p><p><strong>Results: </strong>The mean age of the participants was 45 years (SD ± 8), with 83.3% being women and 93.3% belonging to middle and low socioeconomic strata. Of the 60 patients, 83.3% (50) were diagnosed with chronic migraine, while the remaining had episodic migraine. The use of one or more cognition-altering medications was observed in 90% of patients with chronic migraine and 60% of those with episodic migraine (p = 0.02). Anxiety was more prevalent in patients with episodic migraine, whereas depression was more common among those with chronic migraine. Female gender, middle socioeconomic status, and longer disease duration were significantly associated with chronic migraine. Among the 57 patients who completed the Mini-Mental State Examination, 38.6% had cognitive impairment, which decreased with longer migraine duration and better social interaction. Memory and selective attention were the most affected cognitive domains in both groups. No significant associations were found for the other variables after adjusting for confounders.</p><p><strong>Conclusions: </strong>Chronic migraine significantly impacts mental health, cognition, and quality of life, with depression and cognitive impairments being prevalent. Social interaction and longer disease duration may protect against cognitive decline, highlighting the need for multidisciplinary, personalized interventions addressing neurological and psychosocial challenges.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"108"},"PeriodicalIF":2.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of cardiometabolic index and new-onset stroke in middle-aged and elderly Chinese: a national prospective cohort study.","authors":"Yibo Yang, ZhenKun Xiao, Jing Teng, Hailong Zhong, Yonghong Duan, Min Zhou, Bing Wang, Aihua Liu","doi":"10.1186/s12883-025-04129-0","DOIUrl":"10.1186/s12883-025-04129-0","url":null,"abstract":"<p><strong>Background and aims: </strong>The Cardiometabolic Index (CMI), a novel metabolic marker, has been associated with various metabolic diseases in previous studies. However, its relationship with stroke risk remains underexplored. This study investigates the potential correlation between CMI and stroke risk among Chinese adults aged 45 and older.</p><p><strong>Methods: </strong>In the China Health and Retirement Longitudinal Study (CHARLS), participants were categorized into four groups based on CMI quartiles. The primary outcome was the incidence of new strokes during the follow-up period. A Cox proportional hazards model was used to analyze the relationship between CMI and stroke risk among the elderly. Kaplan-Meier survival analysis compared incidence rates across CMI levels, and restricted cubic splines (RCS) assessed potential non-linear relationships between CMI and stroke. Subgroup analyses verified the robustness of these findings.</p><p><strong>Results: </strong>The study included 6620 patients (45% male), with 417 new stroke cases reported over an average follow-up of seven years. Multivariate analysis indicated a significant association between increased CMI and higher stroke risk [HR, 1.132 (1.021-1.273), P = 0.003]. The RCS model revealed a nonlinear increase in stroke risk with rising CMI levels (P for nonlinearity = 0.006). No significant interactions were detected between CMI and the selected subgroups (all P values for interaction > 0.05).</p><p><strong>Conclusion: </strong>CMI significantly correlates with stroke risk in the elderly Chinese population, suggesting its potential utility in early risk stratification.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"105"},"PeriodicalIF":2.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary pineal alveolar rhabdomyosarcoma in an adult patient: a case report and literature review.","authors":"Tao Chang, Chang Ding, Yanhui Liu, Yuan Yang, Qing Mao","doi":"10.1186/s12883-025-04113-8","DOIUrl":"10.1186/s12883-025-04113-8","url":null,"abstract":"<p><strong>Background: </strong>The rarity of adult primary cerebral rhabdomyosarcoma (PCRMS) cases has necessitated the adoption of pediatric rhabdomyosarcoma (RMS) therapeutic protocols, highlighting a critical need for expanded treatment experiences to enhance prognoses.</p><p><strong>Case presentation: </strong>A 21-year-old female presented to our facility with a 20-day history of persistent headache, nausea, and vomiting, along with mild upward gaze palsy for the past 5 to 7 days. A brain magnetic resonance imaging (MRI) revealed a mass in the pineal region, extending into the third ventricle, measuring approximately 2.5 × 2.0 × 3.0 cm. The lesion exhibited mild irregular lobulation and heterogeneous enhancement. Intraoperatively, it displayed characteristics similar to high-grade gliomas, including a grayish appearance, abundant vasculature, firm texture, and indistinct margins adjacent to the bilateral thalamus. Pathology confirmed alveolar PCRMS with FOXO1 gene rearrangement. Whole-body imaging following pathological diagnosis showed no evidence of skull base infiltration or extracranial metastasis. Despite comprehensive multimodal treatment, including surgery, stereotactic radiotherapy, and chemotherapy, tumor recurrence occurred three months after initial surgery, and the patient unfortunately succumbed to the disease eight months after her initial diagnosis.</p><p><strong>Conclusions: </strong>Alveolar PCRMS in the pineal region, a distinct subtype of RMS, is exceptionally rare and typically associated with a bleak prognosis, suggesting unique tumor biology. A multidisciplinary and aggressive management approach is crucial. Further research into the molecular makeup of RMS in adults may pave the way for more effective, tailored treatments for this aggressive disease.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"106"},"PeriodicalIF":2.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences and challenges of people with multiple sclerosis and low attendance to clinical follow-up: a qualitative study.","authors":"Agata Beczek, S G Roikjær, C Simonÿ, E M Landt, L Storr, M Dahl, M Beck","doi":"10.1186/s12883-025-04106-7","DOIUrl":"10.1186/s12883-025-04106-7","url":null,"abstract":"<p><strong>Background: </strong>Many people with Multiple Sclerosis (MS) in Europe face limited treatment and care access. Research on the challenges faced by people who do not access specialized MS care and treatment is limited, leaving a gap in understanding the experiences and challenges of those who do not attend specialized care. Thus, we aimed to explore the experiences of people with MS who do not attend regular clinical follow-up in specialized MS clinics in Denmark, with a special focus on self-care.</p><p><strong>Methods: </strong>A qualitative study was conducted using individual interviews and thematic analysis, following Braun and Clarke's approach. Data were collected in Denmark between September 2022 and February 2024 through semi-structured interviews, guided by the interview guide development principles outlined by Kvale and Brinkmann. NVivo was used to support data management and coding during the analysis.</p><p><strong>Results: </strong>15 participants were included in the study, of whom 73% were female, 53% had relapsing-remitting MS, and 60% were not receiving any treatment. 53% were using mobility aids, most of them were married, had adult children, medium education level, and were on disability pensions. Participants were evenly distributed across regions of Denmark. The analysis identified two main themes that shed light on the experiences and challenges of people with MS who do not regularly attend clinics. Theme 1, Cognitive and Bodily Disruption, highlights how participants experience cognitive and physical fragmentation, requiring constant adjusting and negotiating self-care strategies. Theme 2, Disruptions in Care Pathways, explores how aging and fragmented healthcare gaps impact self-care management.</p><p><strong>Conclusion: </strong>People with MS who do not attend regular specialized care face physical and cognitive challenges that impact their self-care abilities. Participants experienced disruptions in care pathways with inadequate symptom management tools, felt undervalued by the health care system, and struggled with limited recognition of symptoms and disease progression, all of which hindered their ability to manage their health and daily life effectively.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"107"},"PeriodicalIF":2.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid resolution of newly formed carotid free-floating thrombus through anticoagulation therapy.","authors":"Fuli Xie, Lili Liang, Yuzhou Wang","doi":"10.1186/s12883-025-04062-2","DOIUrl":"10.1186/s12883-025-04062-2","url":null,"abstract":"<p><strong>Background: </strong>Carotid free-floating thrombi (CFFT) are uncommon but pose a high risk of embolic stroke. While vascular intervention is often favored, this case study demonstrates the potential of short-term anticoagulation, guided by thorough imaging, as an alternative treatment strategy.</p><p><strong>Case presentation: </strong>We present a patient with an acute ischemic stroke (NIHSS 15) due to middle cerebral artery (MCA) occlusion. Intravenous alteplase successfully revascularized the MCA. However, subsequent imaging revealed a CFFT as the likely source of the occlusion. Rather than immediate surgical intervention, we opted for a treatment strategy guided by comprehensive radiological assessments, including high-resolution MRI and serial ultrasounds. These assessments suggested the thrombus was newly formed. Based on this, we hypothesized it would be responsive to anticoagulation. Indeed, short-term enoxaparin therapy resulted in significant resolution of the CFFT.</p><p><strong>Conclusions: </strong>This case highlights the efficacy of anticoagulation for treating newly formed CFFT, suggesting a potential alternative to immediate intervention when guided by detailed radiological evaluation. This case introduces a novel approach that may expand treatment options for this challenging condition.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"102"},"PeriodicalIF":2.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stigmatizing attitudes toward people with migraine by people without active migraine: results of the OVERCOME (US) study.","authors":"Robert E Shapiro, Lars Viktrup, Eva Jolanda Muenzel, Dawn C Buse, Anthony J Zagar, Sait Ashina, Susan Hutchinson, Robert A Nicholson, Richard B Lipton","doi":"10.1186/s12883-025-04039-1","DOIUrl":"10.1186/s12883-025-04039-1","url":null,"abstract":"<p><strong>Background: </strong>Migraine is associated with various types of stigma. This study aims to evaluate stigmatizing attitudes towards people with migraine by people without active migraine.</p><p><strong>Methods: </strong>OVERCOME (US) was a web survey among adults from a representative US population-based sample that collected information about stigmatizing attitudes of people without active migraine (i.e., no migraine/severe headaches in the previous 12 months) toward people with migraine and related conditions. The following associations were examined in the current analysis: (1) association between stigma toward migraine and relationship to people with migraine, (2) association between stigma toward migraine and sex, and (3) association between stigma toward migraine and historical headache/migraine status. We further compared stigmatizing attitudes toward people with migraine compared to people with chronic low back pain and epilepsy.</p><p><strong>Results: </strong>In this observational, population-based study, a total of 11,997 respondents without active migraine were queried about attitudes and beliefs about people with migraine. With a mean age of 47.4 (standard deviation 17.3) years, the majority of the respondents were female (51.1%), White (75.6%), and non-Hispanic (82.3%). Nearly 70% of people queried endorsed ≥ 1 stigmatizing attitude from eleven possibilities. Stigmatizing attitudes and beliefs were more prevalent among those with a closer relationship to someone with migraine (family or friend) or those who knew multiple people with migraine, in particular among those who felt personally impacted by knowing a family member or co-worker/supervisor/employee with migraine or severe headache. Respondents with prior migraine endorsed more stigmatizing attitudes than those without migraine/headache history. Lastly, the analysis showed that stigmatizing attitudes toward people with migraine were much more prevalent than those toward people with epilepsy and similar to those toward people with chronic low back pain.</p><p><strong>Conclusions: </strong>Stigma towards people with migraine is widespread but surprisingly more common the closer the relationship(s) to a person/persons with migraine and in those who have experienced migraine themselves. Raising awareness about the stigma towards people with migraine that exists in public may help people with migraine feel more confident to advocate for themselves and seek care, as well as creating more public and social support for accommodations, research funding, and treatment.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"103"},"PeriodicalIF":2.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencing factors and predictive models of early post-stroke depression in patients with acute ischemic stroke.","authors":"AiNi Xiao, RuiYang Wang, CongJie Liu, XiangYu Wang","doi":"10.1186/s12883-025-04090-y","DOIUrl":"10.1186/s12883-025-04090-y","url":null,"abstract":"<p><strong>Background: </strong>Post-stroke depression (PSD) refers to a depressive state that appears after stroke onset and is one of the most common complications in ischemic stroke patients. The occurrence of PSD exacerbates the risk of disability and increases the mortality of patients. Current diagnosis of PSD is severely underdiagnosed.</p><p><strong>Methods: </strong>Patients hospitalized for acute ischemic stroke between December 2019 and November 2022 in the Department of Neurology of Sinopharm Gezhouba Central Hospital were retrospectively collected. Patients' basic clinical information, test data and related questionnaire scores were collected. They were divided into PSD group and NPSD group. Multivariate regression was used to analyze the risk factors of post-stroke depression and establish a risk prediction model to draw nomograms. Receiver Operating Characteristic Curve (ROC), Calibration curve and Decision Curve Analysis (DCA) decision curve were drawn using R language to assess the clinical efficacy and clinical utility of the model.</p><p><strong>Results: </strong>Post-stroke depression in Acute Ischemic Stroke (AIS) patients was associated with single factors such as hypertension, living alone, education level, homocysteine level, National Institute of Health Stroke Scale (NIHSS) score, lymphocyte count, neutrophil count (P < 0.05). Among them, living alone, CRP level, hypertension, homocysteine level, education level, systemic immune inflammation index (SII), and NIHSS score were independent risk factors for post-stroke depression in AIS patients (P < 0.05). The seven selected variables were used to construct a risk prediction model, nomograms were drawn, and ROC curves were used to assess model discrimination, AUROC = 0.881. Calibration curve is used to evaluate the consistency of the model, DCA decision curve is used to evaluate the practicability of the model, and this model has good discrimination ability, calibration and clinical practicability.</p><p><strong>Conclusion: </strong>The probability of PSD in AIS patients in this study was 26.51%. Independent risk factors for developing PSD, including CRP level, living alone, history of hypertension, homocysteine level, education level, SII, NIHSS score to establish risk prediction model and draw nomograms. The model was demonstrated to have good discrimination, calibration and clinical utility by internal validation.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"104"},"PeriodicalIF":2.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11900648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombus rooting in the pulmonary arteriovenous fistula in a patient with cryptogenic stroke, a case report.","authors":"Ming Song, Honggang Dai, Weida Lu, Xiao Meng","doi":"10.1186/s12883-025-04120-9","DOIUrl":"10.1186/s12883-025-04120-9","url":null,"abstract":"<p><strong>Background: </strong>Cryptogenic stroke constitutes approximately 40% of ischemic strokes in young adults, imposing a significant socioeconomic burden. However, the source of embolus has been specifically investigated in a few number of studies. In this report, We document the first case of a cryptogenic stroke associated with a pulmonary arteriovenous fistula (PAVF), providing evidence of mural thrombus formation within the PAVF vessel.</p><p><strong>Case presentation: </strong>A 52-year-old woman present with sudden-onset blurriness, right-sided numbness and paresthesia, speech difficulties, and salivation. It was confirmed as embolic stroke with magnetic resonance imaging. No evidence of cerebral arteriosclerosis or stenosis was identified, and cardiogenic embolism was ruled out. Further investigation was conducted to determine the cause of the anomalous embolism. A right-to-left shunt was detected using trans-cranial Doppler and transthoracic echocardiogram. Pulmonary arteriography revealed a simple PAVF. Optical coherence tomography (OCT) was used to examine the interior structure of the fistula vessel, revealing the presence of mural thrombus and a rough endangium.</p><p><strong>Conclusions: </strong>This case provides the initial evidence regarding the location of thrombus formation assessed and raises the awareness of a potential emboligenic mechanism in PAVF.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"99"},"PeriodicalIF":2.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multicenter validation and calibration of automated software package for detecting anterior circulation large vessel occlusion on CT angiography.","authors":"Kyu Sun Yum, Jong-Won Chung, Sue Young Ha, Kwang-Yeol Park, Dong-Ick Shin, Hong-Kyun Park, Yong-Jin Cho, Keun-Sik Hong, Jae Guk Kim, Soo Joo Lee, Joon-Tae Kim, Woo-Keun Seo, Oh Young Bang, Gyeong-Moon Kim, Myungjae Lee, Dongmin Kim, Leonard Sunwoo, Hee-Joon Bae, Wi-Sun Ryu, Beom Joon Kim","doi":"10.1186/s12883-025-04107-6","DOIUrl":"10.1186/s12883-025-04107-6","url":null,"abstract":"<p><strong>Purpose: </strong>To validate JLK-LVO, a software detecting large vessel occlusion (LVO) on computed tomography angiography (CTA), within a multicenter dataset.</p><p><strong>Methods: </strong>From 2021 to 2023, we enrolled patients with ischemic stroke who underwent CTA within 24-hour of onset at six university hospitals for validation and calibration datasets and at another university hospital for an independent dataset for testing model calibration. The diagnostic performance was evaluated using area under the curve (AUC), sensitivity, and specificity across the entire study population and specifically in patients with isolated middle cerebral artery (MCA)-M2 occlusion. We calibrated LVO probabilities using logistic regression and by grouping LVO probabilities based on observed frequency.</p><p><strong>Results: </strong>After excluding 168 patients, 796 remained; the mean (SD) age was 68.9 (13.7) years, and 57.7% were men. LVO was present in 193 (24.3%) of patients, and the median interval from last-known-well to CTA was 5.7 h (IQR 2.5-12.1 h). The software achieved an AUC of 0.944 (95% CI 0.926-0.960), with a sensitivity of 89.6% (84.5-93.6%) and a specificity of 90.4% (87.7-92.6%). In isolated MCA-M2 occlusion, the AUROC was 0.880 (95% CI 0.824-0.921). Due to sparse data between 20 and 60% of LVO probabilities, recategorization into unlikely (0-20% LVO scores), less likely (20-60%), possible (60-90%), and suggestive (90-100%) provided a reliable estimation of LVO compared with mathematical calibration. The category of LVO probabilities was associated with follow-up infarct volumes and functional outcome.</p><p><strong>Conclusion: </strong>In this multicenter study, we proved the clinical efficacy of the software in detecting LVO on CTA.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"100"},"PeriodicalIF":2.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of general population stigmatization toward marriage in patients diagnosed with multiple sclerosis: a cross-sectional study.","authors":"Nazgol Behgam, Amirhossein Sahraian, Zahra Ebadi, Shima Jahani, Mohammad Ali Sahraian","doi":"10.1186/s12883-025-04092-w","DOIUrl":"10.1186/s12883-025-04092-w","url":null,"abstract":"<p><strong>Background: </strong>Multiple Sclerosis (MS) is a long-term condition affecting the central nervous system that typically manifests in young adults. Stigma poses significant psychosocial challenges for patients with MS, negatively impacting their personal and social lives. However, limited research has examined how MS-related stigmatization influences marriage. This study focused on unmarried individuals aged 20-40 years in Iran to determine the prevalence of societal stigma and their willingness to marry someone with MS.</p><p><strong>Methods: </strong>A researcher-designed questionnaire was used to collect data from 343 unmarried individuals in a cross-sectional study. In-person interviews were conducted to assess participants' overall understanding of MS and their views on marrying someone with the condition. The questionnaire measured sociodemographic variables and the degree of stigmatization toward MS by including concerns related to marriage with MS patients and their families.</p><p><strong>Results: </strong>Data were collected from 343 participants (53% female), with a mean age of 25.96 ± 6.05 years. Overall, 77.6% expressed reluctance to marry someone diagnosed with MS-primarily due to concerns about physical disabilities. Additionally, 47.2% were hesitant if a potential spouse's parent had MS, while 46.6% and 28.4% reported similar reservations regarding siblings and second-degree relatives, respectively. Participants employed in healthcare fields demonstrated significantly lower levels of stigma (p = 0.031). Younger individuals tended to hold more stigmatizing views (p = 0.04), and significant variations were also observed across different ethnic groups (p < 0.001).</p><p><strong>Conclusions: </strong>This study contributes to a more nuanced understanding of the social consequences of MS by providing valuable insights that can inform the development of strategies aimed at mitigating societal stigma. By enhancing awareness and promoting supportive interventions, it is possible to cultivate an inclusive environment that not only improves the quality of life for those affected by MS but also reduces stigma across various social contexts, including interpersonal relationships and marital dynamics.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"101"},"PeriodicalIF":2.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}