BMC Neurology最新文献

{"title":"Extreme dipping blood pressure pattern is associated with increased mortality in hemorrhagic stroke patients: a retrospective cohort study.","authors":"Feng Nong, Wei Zhu, Yan Jiang","doi":"10.1186/s12883-025-04342-x","DOIUrl":"https://doi.org/10.1186/s12883-025-04342-x","url":null,"abstract":"<p><strong>Background: </strong>Blood pressure management strategies in patients with hemorrhagic stroke remain ineffective in reducing mortality. The circadian blood pressure pattern has been shown to be associated with mortality in patients with non-hemorrhagic stroke, but few studies have explored this association in patients with hemorrhagic stroke. We aimed to investigate the relationship between circadian blood pressure pattern and mortality in patients with hemorrhagic stroke.</p><p><strong>Methods and results: </strong>Adult hemorrhagic stroke patients hospitalized in intensive care unit for more than 24 h in the Medical Information Mart for Intensive Care (MIMIC-IV) database were recruited for this retrospective cohort study. All patients were divided into the dipping group, the nondipping group, the reverse dipping group and the extreme dipping group. We used binary logistic regression analysis to explore the relationship between circadian blood pressure patterns and mortality of patients with hemorrhagic stroke. The overall cohort comprised 1040 patients. The patients in the extreme dipping group had higher mortality than other groups (57.1% versus 15.6%,17.0%, and 22.3%, respectively). After adjusting for covariates, the statistical analysis showed that the extreme dipping pattern was significantly associated with the mortality of hemorrhagic stroke patients in intensive care unit (odds ratio: 4.961[95%CI: 1.289-19.086]). Interaction analysis had no statistical significance in all results.</p><p><strong>Conclusions: </strong>The extreme dipping pattern may be an important risk factor for increased mortality in patients with hemorrhagic stroke.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"318"},"PeriodicalIF":2.2,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive predictors of everyday functioning in women with HIV: findings from the women's interagency HIV study.","authors":"David E Vance, Lang Lang, Pauline M Maki, Danyang Yu, Raha Dastgheyb, Yuezhe Wang, Gayle Springer, Kathryn Anastos, Deborah R Gustafson, Kathleen M Weber, Derek M Dykxhoorn, Joel Milam, Monica M Diaz, Seble G Kassaye, Drenna Waldrop, Yanxun Xu, Leah H Rubin","doi":"10.1186/s12883-025-04249-7","DOIUrl":"https://doi.org/10.1186/s12883-025-04249-7","url":null,"abstract":"<p><strong>Background: </strong>As the number of older people with HIV is expected to grow and experience age-related cognitive declines, concerns mount that such existing cognitive impairments may become exacerbated in already cognitively vulnerable subgroups such as women with HIV. These cognitive impairments can develop into everyday functional impairment in either basic or instrumental activities of daily living.</p><p><strong>Methods: </strong>In the Women's Interagency HIV Study, we examined the association between objective cognitive test performance and the self-rated Lawton and Brody scale of Independent Activities of Daily Living (IADL) in 754 older (50+) women with HIV (WWH; 84% virally suppressed). To handle this longitudinal data, weighted logistic mixed effect models examined associations between cognitive domain performance (predictor) and functional outcomes (IADL item level scores).</p><p><strong>Results: </strong>In the total sample, poorer motor performance was associated with impairments in home repairs, housekeeping, and laundry and poorer executive functioning was associated with impairment in planning social activities. Among older virally suppressed-WWH, poorer motor performance was associated with deficits in home repair and poorer executive performance was associated with deficits in planning social activities.</p><p><strong>Conclusion: </strong>Since motor and executive performance were related to impairments in certain IADLs, strategies such as cognitive training targeting these domains could improve everyday functioning. Such approaches could improve autonomy as WWH age.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"317"},"PeriodicalIF":2.2,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive impairment profile in patients with the m.3243A> G variant in mitochondrial DNA.","authors":"Satu Winqvist, Mikko Kärppä, Jukka S Moilanen, Kari Majamaa","doi":"10.1186/s12883-025-04325-y","DOIUrl":"10.1186/s12883-025-04325-y","url":null,"abstract":"<p><strong>Background: </strong>The m.3243A>G variant in mitochondrial DNA is associated with a wide spectrum of clinical features ranging from asymptomatic subjects to severely symptomatic patients. Cognitive involvement is one of the clinical features, but its severity and frequency are not properly known. Here we describe neuropsychological features associated with m.3243 A > G.</p><p><strong>Methods: </strong>We studied 45 adult patients with m.3243 A > G and 45 healthy subjects. Comprehensive neuropsychological test battery was applied. Cognitive impairment was defined, if at least five out of seven cognitive domains were impaired compared to matched controls. Major cognitive impairment was diagnosed, if the impairment was general across the domains.</p><p><strong>Results: </strong>Sixteen patients (36%) with m.3243 A > G were diagnosed with cognitive impairment, and six of them (13%) had a major cognitive impairment. The median age at diagnosis of cognitive impairment was 53 years (range, 25-64). The profile consisted of impaired abstract reasoning, memory problems, motor function defects and executive problems. Executive functions were affected most, and verbal memory was affected the least. Higher variant heteroplasmy and more severe global phenotype were associated with cognitive impairment, whereas age and sex were not.</p><p><strong>Conclusion: </strong>Cognitive impairment is found frequently in patients with m.3243 A > G, but major cognitive impairment is not common. The impairment affects all neuropsychological domains and no specific profile could be identified.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"316"},"PeriodicalIF":2.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the link: exploring what risk factor for sleep disorders among paediatric migraine.","authors":"Bei Wang, Liuyi Li, Shuyan Feng, Lin Yu, Shuman Feng","doi":"10.1186/s12883-025-04310-5","DOIUrl":"10.1186/s12883-025-04310-5","url":null,"abstract":"<p><strong>Background: </strong>Migraine is closely related to sleep disorders. Vitamin D is known to regulate sleep, cell proliferation and differentiation. The aim of our study was to measure the predictive value of vitamin D for sleep disorders in paediatric migraine. We hypothesized that vitamin D would be apredictor of sleep disorders in paediatric migraine.</p><p><strong>Methods: </strong>We conducted an analysis of serum vitamin D levels in 150 paediatric migraine. The Pittsburgh Sleep Quality Index (PSQI) was used as a measure of sleep quality. Based on the PSQI scores, the subjects were divided into normal sleep group and sleep disorder group. Correlation analysis and regression analysis were employed to explore the potential etiology of sleep disturbances in paediatric migraine.</p><p><strong>Results: </strong>There was significant difference in the prevalence of sleep disorders between paediatric migraine and the control group (Odds ratio [OR] = 4.91,95% confidence interval [CI] = 3.25-7.40, P = 0.001). Additionally, the regression analysis demonstrated that vitamin D could serve as a predictive factor for sleep disorders in paediatric migraine (OR = 0.008, 95%CI: 0.023-0.225, P = 0.004). The receiver operating characteristic (ROC) analysis revealed an area under the curve (AUC) of 0.957 (95% CI 0.925-0.988), with a cutoff value of 15.84 ng/ml, a sensitivity of 87.5%, and a specificity of 93.7% for serum vitamin D.</p><p><strong>Conclusion: </strong>Our study confirms the association between sleep disorder and vitamin D levels in paediatric migraine. The use of vitamin D supplementation as a treatment strategy for sleep disturbances in paediatric migraine needs further investigation.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"315"},"PeriodicalIF":2.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological analysis and functional connectivity of the insular in patients with dysphagia after cerebral infarction based on resting-state fMRI.","authors":"Ming Guo, Bingjie Li, Jun Zhao, Chen Bai, Weiyong Yu, Hongxia Zhang, Haoyuan Li, Yongxue Yuan, Qingsu Zhang, Tong Zhang","doi":"10.1186/s12883-025-04322-1","DOIUrl":"10.1186/s12883-025-04322-1","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The insula, as a critical hub for multimodal information integration, plays a pivotal role in post-stroke dysphagia(PSD). However, the mechanisms underlying its structural and functional network reorganization remain elusive. This study aims to systematically investigate the alterations in gray matter volume and functional connectivity patterns of the insula in patients with dysphagia after cerebral infarction using multimodal neuroimaging techniques, and to untangle their clinical associations with swallowing function impairments.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Three groups of subjects were recruited: healthy controls (HC, n = 15), cerebral infarction patients without dysphagia (ND, n = 13), and cerebral infarction patients with dysphagia (DYS, n = 11). Resting-state functional magnetic resonance imaging (rs-fMRI) and high-resolution T1-weighted structural imaging data were acquired. Seed-based analysis (using the CONN FC toolbox) was employed to quantify the whole-brain functional connectivity (FC) of the insula, and voxel-based morphometry (VBM) was used to assess gray matter volume changes. Swallowing function was standardized using the Fiberoptic Endoscopic Evaluation of Swallowing (FEES) and the Penetration/Aspiration Scale (PAS).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The DYS, ND, and HC groups showed significant differences in grey matter volume in the left insula (pFDR =0.041). Compared to the HC group, both cerebral infarction groups (ND and DYS) demonstrated increased functional connectivity between the left insula and the left lateral occipital cortex (superior division), left precuneus, and left cerebellum. In contrast, functional connectivity with the right insula cortex, right frontal operculum cortex, left anterior cingulate, and right frontal pole was decreased. Among these differences, compared to the ND group, the DYS group showed a more significant reduction in functional connectivity within the right frontal operculum cortex and a more pronounced increase in functional connectivity within the left lateral occipital cortex superior division and left cerebellum. Compared to the HC group, patients in both cerebral infarction groups (ND and DYS) showed significantly enhanced functional connectivity between the right insula and the right posterior cingulate gyrus, left lateral occipital cortex (superior division), right precuneus, left frontal pole and right frontal pole. Conversely, functional connectivity with the left insula cortex and left anterior cingulate gyrus was significantly reduced. Moreover, compared to the ND group, the DYS group demonstrated more pronounced increases in functional connectivity within the right posterior cingulate gyrus and right superior cerebellar peduncle, along with a more significant decrease in functional connectivity within the right insula cortex. Enhanced FC between the left insula and the left lateral occipital cortex (superior division) correlated positively with P","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"307"},"PeriodicalIF":2.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The link between red blood cell distribution width and 3-month prognosis in acute ischemic stroke patients: a secondary analysis of a cohort study.","authors":"Qin Xiong, Dong Kang, Shu-Ming Xiong, Dong-Ping Wu, Xin Luo, Wen-Pei Zhang, Jing Tang, Zheng-Guang He","doi":"10.1186/s12883-025-04309-y","DOIUrl":"10.1186/s12883-025-04309-y","url":null,"abstract":"","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"305"},"PeriodicalIF":2.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the role of PSD95 phosphorylation after traumatic brain injury: insights from phosphoproteomic analysis.","authors":"Zhongxiang Zhang, Junpeng Gao, Gang Li, Jin Cheng, Jiangtao Yu, Pengcheng Wang, Ruining Liu, Cheng Jiang, Haoli Ma, Yan Zhao","doi":"10.1186/s12883-025-04303-4","DOIUrl":"10.1186/s12883-025-04303-4","url":null,"abstract":"<p><strong>Background: </strong>Traumatic brain injury (TBI) is a global public health problem. Pathophysiology of TBI remains unclear. Thus, methods of TBI treatment are limited. Phosphorylation plays a vital role in many neurological diseases, including TBI. As an emerging technique, phosphoproteomic has been widely applied in many fields.</p><p><strong>Methods: </strong>Rats were subjected to controlled cortical impact (CCI) or divided to sham group. Protein was extracted from cortex, digested and labeled by iTRAQ. After undergoing mass spectrometry (MS), differential expressed phosphorylated sites (DEPSs) were identified, and proteins of these DEPSs were also listed. PSD95 was chosen as a target protein for further research. ZL006 was used to treat TBI rats. Nissl staining was applied to assess lesion volume, apoptosis was evaluated by TUNEL immunofluorescence staining, and PSD95 phosphorylation was further validated by Western blot.</p><p><strong>Results: </strong>A total of 2753 phosphorylation sites across 1001 proteins were identified. A total of 221 DEPSs were identified. Phosphorylation of PSD95 at serine 417 and 418 were significantly upregulated after TBI. PSD95 had most interactions with other differential expressed phosphorylated proteins (DEPPs). Following ZL006 treatment, brain lesion volume and apoptotic rate were significantly reduced, and phosphorylation of PSD95 at Ser418 was decreased.</p><p><strong>Conclusions: </strong>After TBI, PSD95 was significantly phosphorylated at Ser417 and Ser418. ZL006 markedly reduced brain lesion volume and apoptotic rate and suppressed the phosphorylation of PSD95 at Ser418.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"311"},"PeriodicalIF":2.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basal ganglia infarct secondary to moya moya disease in a child with traumatic head injury: a case report and review of literature.","authors":"Sagun Ghimire, Shikher Shrestha, Dinuj Shrestha, Kajan Ranabhat, Naresh Kharbuja, Sudarshan Awal","doi":"10.1186/s12883-025-04340-z","DOIUrl":"10.1186/s12883-025-04340-z","url":null,"abstract":"<p><strong>Background: </strong>Basal ganglia infarct following traumatic head injury is considered rare. Moreover moya moya disease resulting basal ganglia infarct in a child with traumatic head injury is much unusual. Though the line of management in such cases is straightforward along with good outcome following conservative management but early identification and diagnosis is mandatory to avoid grievous complications.</p><p><strong>Case presentation: </strong>A 3 years old male with recent history of traumatic head injury following road traffic accident presented with weakness of left upper and lower limbs. On diagnostic evaluation there was right sided basal ganglia acute infarct. On further investigations basal ganglia infarct was secondary to moya moya disease. Patient was managed conservatively with single low dose anti platelets therapy, anti epileptic and was discharged with good functional outcome.</p><p><strong>Conclusion: </strong>This case highlights that basal ganglia infarct can be secondary to moya moya disease in the background of traumatic head injury hence there is need for rigorous clinical correlation and timely diagnosis for the betterment of patients functional outcome.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"310"},"PeriodicalIF":2.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of touching-communication-relief therapy on Parkinson's disease patients: a spiritual care perspective study.","authors":"Jia Gao, Lu Yao, Limei Yin, Qunjuan Wang","doi":"10.1186/s12883-025-04300-7","DOIUrl":"10.1186/s12883-025-04300-7","url":null,"abstract":"<p><strong>Objective: </strong>This study sought to assess the effectiveness of Touching-Communication-Relief therapy in providing nursing care for individuals with Parkinson's disease (PD) with a focus on spiritual care.</p><p><strong>Methods: </strong>Patients admitted between February and August 2022 were assigned to the observation group, while patients admitted from September 2022 to February 2023 comprised the control group; each consisted of 45 patients. The control group received standard nursing care, whereas the observation group underwent \"touch, communication, and relief\" therapy based on spiritual care principles. Quality of life parameters, including sleep quality, anxiety, depression, and nursing satisfaction, were assessed before and after the intervention to compare outcomes between the two groups.</p><p><strong>Results: </strong>Forty-five patients from the control and observation groups completed the study. Significant differences were noted between the treatment groups (p < 0.05) in the Hamilton Depression Scale, Parkinson's Disease Sleep Scale, and Newcastle Nursing Satisfaction Scale. Nevertheless, no significant variance was identified in the post-nursing scores of the 39-item Parkinson's Quality of Life Questionnaire (p > 0.05) between the two groups.</p><p><strong>Conclusion: </strong>The spiritual care perspective through multidisciplinary teamwork highlights the efficacy of Touching-Communication-Relief therapy in bolstering mood and sleep in individuals with PD, which ultimately enhanced the quality of life. This intervention is a valuable and essential complement to conventional medical, surgical, and primary care practices.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"306"},"PeriodicalIF":2.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety and depression symptoms mediate the impact of neuroticism on insomnia in adults with epilepsy: a cross-sectional study.","authors":"Pan Hu, Kairui Li, Yu Han, Xuefeng Wang, Zheng Xiao","doi":"10.1186/s12883-025-04313-2","DOIUrl":"10.1186/s12883-025-04313-2","url":null,"abstract":"<p><strong>Objective: </strong>Comorbid insomnia is a common global occurrence among patients with epilepsy (PWE). Neuroticism could be a significant underlying factor for insomnia in this population. This study aimed to explore whether and how neuroticism, anxiety, and depressive symptoms interact and impact insomnia in PWE.</p><p><strong>Methods: </strong>We recruited a continuous cohort of adult PWE. Demographic, clinical data, and information on neuroticism, anxiety, depression, and insomnia were collected. Assessments were conducted using the Eysenck Personality Questionnaire-Revised, Short Scale for Chinese (EPQ-RSC), Generalized Anxiety Disorder-7 (GAD-7), Neurological Disorders Depression Inventory for Epilepsy (NDDI-E), and Insomnia Severity Index (ISI). Process mediation analysis were employed to Investigate the relationships between neuroticism, anxiety, depression, and insomnia. Significant mediation effects were determined using the Bootstrap method with the SPSS PROCESS macro.</p><p><strong>Results: </strong>We enrolled a total of 231 adult epilepsy patients in our study. Neuroticism demonstrated a significant positive association with symptoms of anxiety, depression, and insomnia. Neuroticism significantly predicted insomnia in patients. Anxiety symptoms and depressive symptoms exhibited multiple mediating effects between neuroticism and insomnia. Specifically, the direct effect of neuroticism on insomnia accounted for 40.20% of the total effect, while the indirect effects through anxiety symptoms and depressive symptoms, respectively, accounted for 31.52% and 28.28% of the total effect of neuroticism on insomnia.</p><p><strong>Conclusions: </strong>Neuroticism, anxiety, and depressive symptoms are interrelated and associated with insomnia in patients with epilepsy. Partially mitigating the negative impact of neuroticism on insomnia by reducing the occurrence of anxiety and depressive symptoms may help reduce the risk of insomnia in PWE.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"312"},"PeriodicalIF":2.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}