BMC Neurology最新文献

{"title":"Early NCCT imaging signs for prognostication in intracerebral hemorrhage: a retrospective cohort study with long follow up results.","authors":"Rong Deng, Chuyue Wu, Lina Zhang, Jing Wang, Jing Guo, Zhenjie Yang, Lei He, Shengli Chen","doi":"10.1186/s12883-025-04100-z","DOIUrl":"https://doi.org/10.1186/s12883-025-04100-z","url":null,"abstract":"<p><strong>Objective: </strong>This study intends to investigate the connection between non-contrast computed tomography (NCCT) imaging findings and neurological function scores in patients with intracerebral hemorrhage (ICH) in a long follow up of 451 patients.</p><p><strong>Methods: </strong>Between January 2020 and October 2021, a retrospective review was undertaken on patients with ICH. The NCCT imaging results within 24 h of symptom onset, clinical information, biochemical markers and the one-year outcome post-discharge were collected and analyzed. Subsequently, a prognostic model was devised to predict poor outcomes.</p><p><strong>Results: </strong>A cohort of 451 patients diagnosed with ICH was analyzed in this study. Adverse prognostic outcomes at three months were found to be independently associated with several factors, including the presence of the swirl sign (P = 0.010), advanced age (P = 0.003), post-ICH modified Rankin Scale (mRS) score (P = 0.003,), time elapsed from symptom onset to NCCT scan (P = 0.018), and the presence of ventricular hemorrhage (P = 0.003). Unfavorable prognosis at 12 months was independently associated with the presence of the island sign (P = 0.001), older age (P = 0.003), post-ICH mRS score (P = 0.003), and HE (P = 0.014). Additionally, the integration of NCCT imaging signs into the predictive model significantly improved its accuracy in predicting adverse outcomes at both three months (AUC = 0.817 vs. 0.782 in the model without NCCT, NRI = 0.219, P = 0.033, IDI = 0.080, P = 0.006) and 12 months (AUC = 0.829 vs. 0.797 in the model without NCCT, NRI = 0.235, P = 0.028, IDI = 0.096, P = 0.003).</p><p><strong>Conclusions: </strong>The early imaging features of patients suffering from ICH can provide a more precise prognosis from the analysis of the 12-month follow up results.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"91"},"PeriodicalIF":2.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictive role of composite inflammatory ratio parameters in the conscious awareness recovery after severe acute ischemic stroke: a retrospective cohort study.","authors":"Yiyuan Xu, Yanyan Liu","doi":"10.1186/s12883-024-04016-0","DOIUrl":"https://doi.org/10.1186/s12883-024-04016-0","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory mechanisms play a significant role in ischemic stroke. Peripheral neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), which are indicators capable of reflecting the magnitude of the inflammatory response, have been research hotspots. However, few research findings evaluate the prediction significance of these biomarkers in the recovery of conscious awareness following severe acute ischemic stroke.</p><p><strong>Methods: </strong>This was a retrospective cohort study of 142 patients with consciousness disorders after acute ischemic stroke (GCS score ≤ 8) treated from January 2022 to May 2024. The cases were divided into three groups according to the GCS score at discharge as died/ vegetative state (GCS ≤ 3),moderate/ severe coma(GCS = 4-11) and mild coma/ normal (GCS:12-15). Demographic and clinical assessment data were reviewed and abstracted. NLR, PLR, SII and SIRI were calculated based on the peripheral blood tests at admission. The study investigated the correlation between changes in GCS scores from admission to discharge (calculated as the GCS score at discharge minus the baseline GCS score, where a negative value indicates worsening and a positive value indicates improvement) and the levels of NLR, PLR, SII, and SIRI.</p><p><strong>Results: </strong>The level of NLR, PLR, SII and SIRI in died/ vegetative state group were significantly higher than those in moderate/ severe coma group (p = 0.0429, p = 0.0215, p = 0.0288, p = 0.026, respectively) and mild coma/ normal group (p = 0.0085, p = 0.0079, p = 0.0019, p = 0.0017, respectively). The area under the curve (AUC) values of NLR, PLR, SII, and SIRI to prognosis were 0.670, 0.661, 0.677, and 0.609, respectively. Spearman correlation analysis indicated NLR, PLR and SII were negatively correlated with GCS scores increase during hospitalization (r =- 0.317, p<0.0001 for NLR, r = -0.285, p = 0.001 for PLR, r = -0.3331, p < 0.0001 for SII, r= -0.199,p = 0.018 for SIRI).However, ordinal logistic regression analyses failed to indicate that NLR, PLR, SII and SIRI were independent predictors of poor consciousness response for severe acute ischemic stroke coma patients after adjusting for other confounders.</p><p><strong>Conclusion: </strong>Patients with poorer consciousness outcomes exhibited a tendency towards elevated NLR, PLR, SII, and SIRI levels which were inversely correlated with GCS scores increase during hospitalization. However, the four indexes did not exhibit sufficient promise to be the valuable predictors for the prognosis of recovery from consciousness following severe acute ischemic stroke.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"90"},"PeriodicalIF":2.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of expressive writing on the sexual self-concept in men with multiple sclerosis: a randomized clinical controlled trial.","authors":"Malihe Mohammadzade Sabbaghi, Leila Amini, Seyed Massood Nabavi, Naiemeh Seyedfatemi, Hamid Haghani","doi":"10.1186/s12883-025-04110-x","DOIUrl":"https://doi.org/10.1186/s12883-025-04110-x","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have examined the various outcomes of expressive writing intervention in different populations. The purpose of this study was to evaluate the effect of expressive writing on the sexual self-concept of men with multiple sclerosis.</p><p><strong>Methods: </strong>This parallel randomized controlled clinical trial conducted on 70 men attending an MS clinic in Tehran in 2022. The participants were randomly assigned to expressive writing intervention and control groups. For two weeks, participants in the intervention group disclosed their emotions and expressed their feelings in writing twice a week. Sexual self-concept was evaluated using the Multidimensional Sexual Self-Concept Questionnaire on three occasions, before, after, and 4-week follow-up. The data ware analyzed using SPSS software version 22 (IBM Corp., Armonk, N.Y., USA). The analysis employed Chi-squared test, Fisher's exact test, independent t-test, and repeated measured ANOVA. A p-value < 0.05 was considered to be statistically significant.</p><p><strong>Results: </strong>The mean of age in the intervention group was 38.6 ± 6.85 years, while in the control group it was 38.94 ± 6.07 years. There were no significant differences between the two groups, in terms of these characteristics. According to the results, the dimensions of SSC did not change over time assessments, except for sexual problem self-blame (p = 0.011) and sexual fear/apprehension (p = 0.042) in the expressive writing intervention group, and sexual motivation in the control group (p = 0.002). On the other hand, before the intervention, sexual motivation was significantly higher in the control group compared to the expressive writing intervention group (p = 0.046).</p><p><strong>Conclusions: </strong>Our findings did not support the general effectiveness of a 2-week expressive writing intervention on the sexual self-concept of the men with MS except for the sexual fear/apprehension and sexual problem self-blame dimensions. However, further research is needed to better understand the effects of expressive writing intervention on Sexual self-concept in men with multiple sclerosis, while controlling for the limitations of our study.</p><p><strong>Trial registration: </strong>The present study has been registered on the Iranian Registry of Clinical Trials (IRCT) at https://irct.behdasht.gov.ir/trial/59664 on November 17, 2021, with the code IRCT20211028052892N1.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"88"},"PeriodicalIF":2.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early venous filling is associated with unfavorable outcomes in acute ischemic stroke with large vessel occlusion after mechanical thrombectomy: a real-world analysis.","authors":"Jiaxin Han, Yixuan Wu, Zihan Wang, Jianfeng Han, Guogang Luo, Kang Huo","doi":"10.1186/s12883-025-04111-w","DOIUrl":"https://doi.org/10.1186/s12883-025-04111-w","url":null,"abstract":"<p><strong>Background: </strong>The presence of early venous filling (EVF) post-mechanical thrombectomy (MT) in acute ischemic stroke (AIS) patients has been observed, yet its prognostic value for clinical outcomes remains underexplored. This study aimed to assess the correlation between EVF and poor clinical outcomes in AIS patients who underwent MT.</p><p><strong>Materials and methods: </strong>This retrospective analysis included AIS patients with large vessel occlusions treated with MT at the First Affiliated Hospital of Xi'an Jiaotong University from January 2018 to June 2023. The primary outcome was mRS at 90 days, secondary outcomes included hemorrhagic transformation, symptomatic intracranial hemorrhage, and malignant brain edema. The study used inverse probability weighting for balancing baseline characteristics and employed univariate and multivariate logistic regression analyses to explore the association between EVF and clinical outcomes. G*Power was used to calculate the sample size.</p><p><strong>Results: </strong>Among 307 patients, 75 (24.4%) presented with EVF. Patients with EVF had significantly higher rates of unfavorable outcomes at 90 days (76.00% vs. 46.12%, P < 0.001). Multivariate analysis revealed significant associations between EVF and unfavorable outcome (odds ratio [OR] = 2.69, 95%CI [1.37-5.26], P = 0.004), hemorrhagic transformation (OR = 3.11, 95%CI [1.73-5.62], P < 0.001), symptomatic intracranial hemorrhage (OR = 3.24, 95%CI 1.42 to 7.37, P = 0.005), and malignant brain edema (OR = 3.06, 95%CI [1.56-6.01], P = 0.001). Stratified analysis showed EVF group with a baseline Alberta Stroke Program Early CT (ASPECT) score of ≤ 8 exhibited a higher risk of unfavorable outcomes compared with patients in the non-EVF group (OR = 2.64, 95%CI [1.03-6.73], P = 0.042). Mediation analysis indicated that malignant brain edema accounted for 35.42% of the correlation between EVF and unfavorable outcomes.</p><p><strong>Conclusions: </strong>This study establishes EVF as an independent risk factor for unfavorable outcomes after MT in AIS. Therefore, EVF in conjunction with a low ASPECT score provides essential insights for identifying patients at high risk for unfavorable outcomes.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"92"},"PeriodicalIF":2.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and electrophysiological features of pure sensory Guillain-Barré syndrome: retrospective analysis of 22 patients across 14 provinces in Southern China.","authors":"Songyan Liu, Hong Chu, Bin Peng, Yanping Zeng, Jia Liu, Zuneng Lu, Chao Weng","doi":"10.1186/s12883-025-04103-w","DOIUrl":"https://doi.org/10.1186/s12883-025-04103-w","url":null,"abstract":"<p><strong>Objective: </strong>Currently, there are limited reports, both nationally and internationally, regarding Guillain-Barré Syndrome (GBS) that manifests solely with isolated sensory impairment. This study aims to explore the epidemiological and clinical features of GBS patients experiencing only paresthesia in southern China.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of the medical records of GBS patients admitted to 31 hospitals across 14 provinces in southern China from January 1, 2013, to September 30, 2016.</p><p><strong>Results: </strong>A total of 1,056 patients diagnosed with GBS were identified from medical records, of whom 276 had paresthesia as their first symptom. Among these 276 patients, a total of 41 patients with GBS who exhibited only paresthesia were analyzed. Among them, 19 patients served as a control group and showed abnormal compound muscle action potential (CMAP). We identified 22 cases of pure sensory disturbances in GBS patients and named them \"pure sensory GBS\", characterized by normal CMAP. Comparative analysis revealed no statistically significant differences between the two groups in terms of age at onset, gender, residence, or antecedent events; however, the pure sensory GBS group demonstrated a higher incidence of onset during the spring. Electrophysiological evaluations revealed that the pure sensory GBS group had a lower likelihood of reduced amplitude in sensory nerve action potential (SNAP) compared to the control group. However, there were no significant differences between the two groups in sensory conduction latency, velocity, H-reflex, or F-wave detection. Additionally, no significant differences were observed in cerebrospinal fluid (CSF) studies, treatment modalities, discharge Hughes scores, or peak time. Notably, patients in the pure sensory GBS group had lower Hughes scores at admission and a shorter hospital stay, with these differences reaching statistical significance.</p><p><strong>Conclusion: </strong>Among GBS patients, those presenting solely with sensory disturbances are relatively uncommon, with only 22 cases. Compared to the control group, those patients are more frequently diagnosed in the spring, demonstrate a milder degree of reduction in amplitude of SNAP, present with milder symptoms at admission, and have shorter hospital stays.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"87"},"PeriodicalIF":2.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic changes in neuron-specific enolase level to glasgow coma scale score ratio predict long-term neurological function of diffuse axonal injury patients.","authors":"Weiliang Chen, Jiayi Wu, Shengwen Li, Chunyu Yao, Rui Chen, Wen Su, Guanjun Wang","doi":"10.1186/s12883-025-04116-5","DOIUrl":"https://doi.org/10.1186/s12883-025-04116-5","url":null,"abstract":"<p><strong>Background: </strong>Patients with diffuse axonal injury (DAI) are often plagued by sequelae, and the current indicators for predicting long-term neurological function are not accurate enough. Our previous studies have found that serum Neuron-specific enolase (NSE) level to Glasgow Coma Scale (GCS) score ratio(NGR) at admission could be used as an independent predictor of DAI.</p><p><strong>Objective: </strong>To explore the accuracy of dynamic changes of NGR in predicting long-term neurological function in patients with DAI.</p><p><strong>Methods: </strong>Patients with DAI were included based on clinical MRI as the diagnostic standard, and divided into two groups with favorable and unfavorable outcome according to the 6-month Extended Glasgow Outcome Scale (GOSE) as the prognosis indicator. The differences in clinical parameters between the two groups of patients were compared by Pearson correlation analysis. The trend of dynamic changes in NSE, GCS, and NGR at 1st, 3rd, 5th, 7th and 14th days after injury were shown by line graphs. The predictive efficacy of various parameters for long-term neurological function were further analyzed by receiver operator characteristic (ROC) curves.</p><p><strong>Results: </strong>Among the 102 DAI patients, 75 (73.5%) were classified to favorable outcome group (GOSE5-8) and 27 (26.5%) to unfavorable outcome (GOSE1-4). The NSE, NGR and Marshall CT grade at the first day after injury in the favorable outcome group were significantly lower than those in the unfavorable outcome group (p = 0.005, p < 0.001, p = 0.002), but the GCS score was significantly higher than that of the latter (p = 0.006). There was a negative correlation between NGR at 1st, 3rd, 5th, 7th, and 14th days post-TBI (r1=-0.557, r3=-0.746, r5=-0.761, r7=-0.727, r14=-0.694), and the 6-month GOSE. DAI patients with a favorable outcome exhibited a gradual decline in NGR. The area under the ROC curves (AUC) of NGR at 1st, 3rd and 5th days post-TBI were 0.751 (95% CI, 0.646-0.856, p < 0.001), 0.913 (95% CI, 0.859-0.967, p < 0.001), 0.934 (95% CI, 0.886-0.982, p < 0.001), which were the largest among the three parameters.</p><p><strong>Conclusions: </strong>The dynamic changes of NGR may be an accurate predictor of long-term neurological function in patients with DAI.</p><p><strong>Clinical trial registration: </strong>Trial Registration Number ChiCTR2100044352, registration date was March 17, 2021.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"89"},"PeriodicalIF":2.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the causal relationship between serum EFNB2 levels and epilepsy: a bidirectional Mendelian randomization and co-localization analysis.","authors":"Xudong Zhang, Yuhao Xu, Zehan Wu, Xiang Zou","doi":"10.1186/s12883-025-04115-6","DOIUrl":"https://doi.org/10.1186/s12883-025-04115-6","url":null,"abstract":"<p><strong>Background: </strong>Epilepsy is a severe neurological disorder characterized by persistent seizures and, in some patients, associated neurobiological, cognitive, and psychosocial consequences. It is influenced by various genetic factors, including the Ephrin-B2 (EFNB2) gene.</p><p><strong>Methods: </strong>This study utilized bidirectional Mendelian randomization (MR) to explore the potential causal relationship between serum levels of EFNB2 and epilepsy using data from extensive genome-wide association studies (GWAS). We selected serum levels of EFNB2 and generalized epilepsy traits, applying strict criteria for instrumental variables to ensure validity and mitigate confounding influences. The analysis included sensitivity tests like the MR pleiotropy residuals and outliers test, as well as co-localization to evaluate shared genetic influences.</p><p><strong>Results: </strong>Our results indicated a significant causal relationship between serum levels of EFNB2 and epilepsy, suggesting that EFNB2 could be involved in the pathogenesis of epilepsy through mechanisms that may not be directly linked to shared genetic pathways.</p><p><strong>Conclusion: </strong>These results suggest a potential association between EFNB2 and epilepsy, highlighting the need for further studies to clarify its role and explore its possible relevance as a therapeutic target.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"84"},"PeriodicalIF":2.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute onset of anti-IgLON5 disease with meningeal enhancement: a case report.","authors":"Huasheng Huang, Yizhi Wei, Jie Li","doi":"10.1186/s12883-025-04104-9","DOIUrl":"https://doi.org/10.1186/s12883-025-04104-9","url":null,"abstract":"<p><strong>Background: </strong>Anti-IgLON5 disease is a relatively rare autoimmune disease of the nervous system. The clinical course of this disease is generally chronic and progressive, exhibiting heterogeneity in clinical presentation and the lack of specific imaging features. We now report a case of a Anti-IgLON5 antibody-positive patient demonstrated two distinctive features. Firstly, the onset was marked by acute encephalopathy symptoms, including fever, with consciousness disturbance as the initial manifestation. Secondly, imaging studies revealed multiple lesions within the meninges and intracranial regions, characterized by extensive thickening and enhancement of the dura mater.</p><p><strong>Case presentation: </strong>A previously healthy 78-year-old male patient presented with impaired consciousness and was admitted to the hospital. Brain MRI demonstrated abnormal signal located in the bilateral basal ganglia, frontal and parietal lobes. Post-contrast enhancement demonstrated thickening and enhancement of the dura mater in the bilateral frontal regions, along with mild enhancementin the cortical areas of the bilateral temporal lobes. Cerebrospinal fluid (CSF) analysis indicated the presence of oligoclonal bands in both serum and CSF, with a higher count in the CSF compared to serum. IgG antibodies against IgLON5 were detected in serum and CSF at a titer of 1:100. CSF concentrations of total Tau protein (t-Tau) and phosphorylated Tau protein (p-Tau) were normal. In conjunction with a positive serum and CSF IgLON5 antibody and exclusion of other diseases, diagnosis of anti-IgLON5 disease was made. Symptoms resolved completely after intravenous methylprednisolone and immunoglobulin therapy were administered. At 3-week follow-up the small patchy abnormal signal in the bilateral basal ganglia, frontal and parietal lobes have resolved. Additionally, post-contrast imaging reveals the absence of the previously noted abnormal dural enhancement. and there was no recurrence 18 months after the onset of the disease.</p><p><strong>Conclusions: </strong>Anti-IgLON5 disease is a heterogeneous disorder characterized by a wide spectrum of clinical manifestations. IgLON5 encephalopathy characterized mainly by symptoms of acute neurological symptoms and MRI evidence of meningeal enhancement has not been reported previously. The appropriate diagnostic strategy should encompass a thorough clinical evaluation, testing for anti-IgLON5 antibodies in both CSF and serum, as well as HLA genotyping. Timely diagnosis and early Intravenous methylprednisolone and/or IVIG therapy are beneficial in improving prognosis and preventing recurrence.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"86"},"PeriodicalIF":2.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and incidence of multiple sclerosis in healthcare district IV of Asturias, Spain.","authors":"Pedro Oliva-Nacarino, Marina Simal Antuña, Carmen Santos Varela, Javier Villafani Echazú, Jessica Fernández Domínguez, Raquel García Rodríguez, Agustín Oterino Durán, Patricia Suarez Santos, Miguel Ángel Llaneza González","doi":"10.1186/s12883-025-04108-5","DOIUrl":"https://doi.org/10.1186/s12883-025-04108-5","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis is an inflammatory demyelinating autoimmune disease of the central nervous system. Studies conducted in recent years point to an increase in its prevalence and a change in the age profile of patients. This study aims to analyse the prevalence and incidence of multiple sclerosis in healthcare district IV of the region of Asturias, in north-western Spain.</p><p><strong>Methods: </strong>We conducted a retrospective epidemiological study of the population of said healthcare district with a diagnosis of multiple sclerosis according to the 2017 McDonald criteria. The prevalence of the disease was calculated cross-sectionally (prevalence date: December 31, 2022), while the incidence was determined retrospectively over a six-year period, from 2017 to 2022. We gathered data from the registries and databases of the tertiary hospital in healthcare district IV, and from one private hospital. Relevant demographic and clinical data were gathered from electronic records.</p><p><strong>Results: </strong>The prevalence of multiple sclerosis in the population studied was 198 cases per 100 000 population. The incidence of multiple sclerosis during the study period (2017-2022) was 6.6 cases per 100 000 person-years. On the prevalence date, 66.5% of patients were women and 82.4% presented relapsing-remitting multiple sclerosis. Mean age was 33.98 years at symptom onset and 50.84 years on the prevalence date.</p><p><strong>Conclusions: </strong>Asturias currently presents the highest multiple sclerosis prevalence rate in Spain; the estimated rate represents an increase with respect to those reported in studies conducted in the same region in the 1990s.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"85"},"PeriodicalIF":2.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between blood triglycerides and stroke-associated pneumonia: a prospective cohort study.","authors":"Xiujuan Yuan, Shicun Huang, Jianqiang Ni, Wanli Dong","doi":"10.1186/s12883-025-04060-4","DOIUrl":"10.1186/s12883-025-04060-4","url":null,"abstract":"<p><strong>Background: </strong>Cerebral infarction requires the reduction of blood lipids, but low triglycerides are associated with poor prognosis. stroke-associated pneumonia (SAP) can also lead to poor prognosis. Therefore, the purpose of this study is to investigate the correlation between triglycerides (TG) and SAP.</p><p><strong>Methods: </strong>This prospective cohort study was conducted at the First Affiliated Hospital of Soochow University and enrolled consecutive patients with acute ischemic stroke admitted between March 2019 and March 2021. Univariate analysis, Multivariable logistic regression analysis, subgroup analysis, curve fitting, inflection point analysis, stratified and interaction analyses was performed to examine the relationship between blood TG and SAP.</p><p><strong>Results: </strong>The study included 240 patients with acute ischemic stroke (92 females, mean age 68 years), of whom 94 developed SAP. Multivariate logistic regression analysis demonstrated that TG levels were independently associated with SAP. The fitting curve shows a linear relationship between TG level and SAP incidence, with a decrease in SAP incidence as TG increases. The inflection point value is TG = 2.6mmol/L.</p><p><strong>Conclusions: </strong>The findings suggest that TG levels may be inversely associated with the risk of SAP in elderly patients with acute ischemic stroke.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"83"},"PeriodicalIF":2.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}