BMC Neurology最新文献

{"title":"Effectiveness of the Roy adaptation model-based nursing intervention in improving physiological, psychological, and social outcomes in patients with Parkinson's disease.","authors":"Le Chen","doi":"10.1186/s12883-025-04232-2","DOIUrl":"https://doi.org/10.1186/s12883-025-04232-2","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effectiveness of a comprehensive nursing intervention based on Roy's Adaptation Model (RAM) in improving quality of life, psychological adaptation, and social functioning in patients with Parkinson's disease (PD).</p><p><strong>Methods: </strong>A total of 96 patients with idiopathic PD were randomly assigned to the RAM group or the usual care group. The RAM intervention included a 3-month program addressing physiological, psychological, role function, and interdependence adaptation needs. Outcomes were assessed at baseline, 1 month, 3 months, and 6 months using the Scale for Outcomes in Parkinson' s Disease - Autonomic Symptoms (SCOPA-AUT), Pittsburgh Sleep Quality Index (PSQI), Fatigue Severity Scale (FSS), Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), General Self-Efficacy Scale (GSES), Parkinson' s Disease Social Functioning Scale (PDSFS), Multidimensional Scale of Perceived Social Support (MSPSS), and Parkinson' s Disease Questionnaire-39 (PDQ-39).</p><p><strong>Results: </strong>The RAM group demonstrated significant improvements in autonomic function, sleep quality, and fatigue compared to the usual care group (SCOPA-AUT, PSQI, and FSS). Psychological adaptation improved with reduced depressive and anxiety symptoms (BDI-II and BAI) and increased self-efficacy (GSES). Role function and interdependence adaptation were significantly enhanced, as indicated by higher PDSFS and MSPSS scores. Quality of life, assessed using PDQ-39, showed significant and sustained improvements across all domains, including mobility, activities of daily living, emotional well-being, and social support.</p><p><strong>Conclusion: </strong>The RAM-based care intervention effectively enhanced physiological and psychological outcomes, social functioning, and quality of life in PD patients, highlighting its value in promoting holistic, patient-centered nursing care.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"219"},"PeriodicalIF":2.2,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Fast-acting treatment of myasthenic crisis with efgartigimod from the perspective of the neuro intensive care unit.","authors":"Fangyi Shi, Rong Lai, Li Feng, Hongyan Zhou, Xunsha Sun, Cunzhou Shen, Jiezhen Feng, Zhilong Xu, Haiyan Wang, Huiyu Feng","doi":"10.1186/s12883-025-04227-z","DOIUrl":"https://doi.org/10.1186/s12883-025-04227-z","url":null,"abstract":"","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"217"},"PeriodicalIF":2.2,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular recanalization of symptomatic long-segment nonacute vertebral artery occlusion: a case report.","authors":"Yuan Jian, Dong Xiaobo, Wang Wenxin, Wang Gesheng","doi":"10.1186/s12883-025-04224-2","DOIUrl":"10.1186/s12883-025-04224-2","url":null,"abstract":"<p><strong>Background: </strong>Vertebral artery occlusive disease is a leading cause of posterior circulation ischemic stroke. Endovascular recanalization has been described as a viable treatment option for individuals with symptomatic vertebral artery occlusion who fail to respond to appropriate medicinal therapy. However, endovascular recanalization of symptomatic long-segment nonacute vertebral artery blockage is associated with significant surgical risk and the possibility of perioperative complications.</p><p><strong>Case presentation: </strong>Despite rigorous pharmacologic therapy, a patient with a protracted segmental left vertebral artery blockage continues to experience cerebral hypoperfusion and neurologic impairments. Digital subtraction angiography (DSA) revealed a stump at the left vertebral artery ostium of segment V1, the right V4 segment was obviously congenitally thin, and a small amount of reflux was observed at the distal end of the left V4 segment. The posterior communicating artery was closed. We considered the diagnosis of left vertebral artery blockage (near V1 to V4). The patient underwent balloon dilatation of the occlusion and stenting. Finally, revascularization was successfully performed for long-segment occlusion of the left vertebral artery. DSA indicated complete segmental filling 3 months and 2 years after the patient received medication, and there were no new neurologic complaints throughout the 2-year follow-up period.</p><p><strong>Conclusion: </strong>After detailed evaluation and screening, recanalization of long-segment vertebral artery occlusion in the nonacute phase is feasible.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"215"},"PeriodicalIF":2.2,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations between ATF3 polymorphisms and ischemic stroke in Dali, Yunnan Province, as determined by a case-control study.","authors":"Yunhui Yang, Pengyu Wang, Min Wang, Guangming Wang","doi":"10.1186/s12883-025-04235-z","DOIUrl":"10.1186/s12883-025-04235-z","url":null,"abstract":"<p><strong>Background: </strong>Genetic factors play an important role in ischemic stroke (IS) onset. Activating transcription factor 3 (ATF3) is a known IS biomarker; however, the association between ATF3 polymorphisms and susceptibility to IS remains unclear. Therefore, we aimed to explore the association between ATF3 single-nucleotide polymorphisms (SNPs) and genetic susceptibility to IS in a population in Dali, Yunnan, China.</p><p><strong>Methods: </strong>We included 145 patients with IS and 127 healthy controls in this case-control study. ATF3 SNP sites (rs1105899, rs1008737, rs1195474, and rs1195472) were genotyped using SNaPshot detection.</p><p><strong>Results: </strong>Venous serum glucose (VSG), white blood cell count, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and systolic blood pressure (SBP) were IS risk factors; VSG had the highest impact on IS susceptibility, whereas SBP had the lowest. Genotype distributions of rs1105899, rs1008737, and rs1195472 polymorphisms in the control group conformed to the Hardy-Weinberg equilibrium. Association analysis between ATF3 polymorphisms and IS risk showed that rs1105899, rs1008737, and rs1195474 ATF3 polymorphisms were not significantly associated with IS risk. In the codominant and superdominant model of the rs1195472 [C/T] loci, CT genotype can reduce the risk of stroke, compared with TT and CC genotypes. Haplotype AGAC was an inhibitory factor for IS. The GTEx database showed that the rs1195472 CT genotype increased ATF3 expression and was associated with its expression in individual tissues.</p><p><strong>Conclusion: </strong>The rs1195472 polymorphism was associated with IS risk in our study population; no significant correlation was noted between rs1105899, rs1008737, and rs1195474 polymorphisms and IS.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"216"},"PeriodicalIF":2.2,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Dutch version of the King's Parkinson's disease pain scale.","authors":"Nour Alkaduhimi, Yvonne Kerst, Annemarie Vlaar, Henk Berendse, Henry Weinstein, Erik Scherder","doi":"10.1186/s12883-025-04222-4","DOIUrl":"10.1186/s12883-025-04222-4","url":null,"abstract":"<p><strong>Background: </strong>Pain in patients with Parkinson's disease (PD)is often underdiagnosed and, therefore, undertreated. The King's Parkinson's Pain Scale (KPPS) is one of the few validated tools specifically designed to assess pain in patients with Parkinson's disease but lacks a Dutch version. This study aims to validate the KPPS for patients in the Netherlands and to examine which cognitive functions are related to the comprehension of the KPPS.</p><p><strong>Methods: </strong>The KPPS was translated into Dutch and validated in 70 patients with PD through internal consistency, convergent and discriminant validity testing. Patients had been diagnosed with PD for an average of 5.65 years. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA).</p><p><strong>Results: </strong>The Dutch KPPS showed acceptable reliability (Cronbach's alpha = 0.69), though its factor structure differed from the original. Convergent validity was confirmed via significant correlations with the Numerical Rating Scale (NRS), while discriminant validity was supported through correlations with the Non-Motor Symptoms Scale (NMSS) and EQ-5D-3 L. Verbal memory and abstract thinking showed a tendency toward significance in their association with pain scores.</p><p><strong>Conclusion: </strong>The Dutch KPPS is a reliable and valid tool for assessing pain in Dutch patients with PD, though its structure differs from the original. These differences may reflect variability in pain perception or classification, highlighting the need for further research integrating the PD-PCS framework to refine pain assessment in PD.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"214"},"PeriodicalIF":2.2,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Effect of different maneuvers of repositioning on benign paroxysmal vertigo: a network meta‑analysis.","authors":"Nannan Si, MengYuan Liu, Wei Chang","doi":"10.1186/s12883-025-04238-w","DOIUrl":"10.1186/s12883-025-04238-w","url":null,"abstract":"","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"212"},"PeriodicalIF":2.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of nonmotor symptoms in progressive supranuclear palsy and Parkinson's disease.","authors":"Ying Chen, Yiming Li, Jieming Huang, Yajing Cai, Xiaochun Chen, Qinyong Ye","doi":"10.1186/s12883-025-04225-1","DOIUrl":"10.1186/s12883-025-04225-1","url":null,"abstract":"<p><strong>Background: </strong>Nonmotor symptoms (NMSs) are under-recognized in progressive supranuclear palsy (PSP), despite their considerable impact on quality of life. The full spectrum and impact of NMSs in PSP remain insufficiently understood. This study is aimed to investigate NMSs in patients with PSP and compare the difference of NMSs between patients with PSP and patients with Parkinson's disease (PD).</p><p><strong>Methods: </strong>The study involved 44 patients diagnosed with PSP and 132 patients with PD. NMSs were assessed using a range of evaluation tools. Additionally, the relationship between NMSs and disease severity, as well as the impact on quality of life was analyzed.</p><p><strong>Results: </strong>The Non-Motor Symptom Scale (NMSS) and Movement Disorders Society-revised Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part I scores were significantly higher in patients with PSP than in patients with PD (42.52 ± 25.64 vs. 32.06 ± 21.45, p = 0.007; 11.89 ± 6.24 vs. 9.80 ± 5.61, p = 0.049). The severity of urinary symptoms was also greater in patients with PSP than in those with PD. Although clinically suspected rapid eye movement sleep behavior disorder (RBD), which was not assessed using polysomnography but rather through RBD Screening Questionnaire, was less common in patients with PSP compared with those with PD, cognitive impairment was more frequent and severe in patients with PSP. Hyposmia, cardiovascular symptoms, constipation, sleep disturbances, emotional symptoms, fatigue, and pain exhibited similar severity and frequency in both patient groups. Only emotional symptoms in patients with PSP were associated with the 39-item Parkinson's Disease Questionnaire scores, and none of the NMSs were associated with Hoehn & Yahr stage or MDS-UPDRS Part III scores.</p><p><strong>Conclusion: </strong>PSP is characterized by a higher burden of NMSs than PD, with some different and common symptom profiles. The impact of emotional symptoms on the quality of life in PSP underscores the importance of addressing these symptoms in clinical care to improve patient outcomes.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"213"},"PeriodicalIF":2.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel neutrophil extracellular traps related diagnostic signature for intracranial aneurysm.","authors":"Xiangmao Zhang, Hanhan Feng, Zongxiang Li, Chunying He, Junxiang Cui, Jinyang Li, Yu Han","doi":"10.1186/s12883-025-04068-w","DOIUrl":"10.1186/s12883-025-04068-w","url":null,"abstract":"<p><p>Neutrophil extracellular traps (NETs) released by neutrophils can exacerbate inflammation, leading to rupture of intracranial aneurysms (IA). This study aims to explore potential NETs-related genes in IA. RNA sequencing data for IA were downloaded from the Gene Expression Omnibus database. NETs-related genes were screened using weighted gene co-expression network analysis (WGCNA) and differentially expressed gene (DEG) analyses. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed. LASSO Cox regression analysis identified optimal genes for model construction. Immune cell infiltration in IA was studied using CIBERSORT. Five NETs-related hub genes were identified in IA, involved in pathways like neutrophil chemotaxis, Toll-like receptor signaling, and regulation of inflammatory response. A risk score model was developed based on TLR7, TLR2, IL1B, ENTPD4, and FPR1. Immune cell infiltration analysis showed significant variations between low-risk-IA and high-risk-IA groups. Monocytes and neutrophils infiltration proportions were significantly positively correlated with the risk score. The ROC analysis showed AUC values exceeding 0.85 for both training and validation sets, confirming the model's excellent performance. A novel NETs-related diagnostic signature for IA was created, offering new insights into the pathogenesis and diagnosis of IA.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"211"},"PeriodicalIF":2.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A feasibility study on the use of cranial nerve non-invasive neuromodulation to improve affected arm function in people in the chronic stage of a stroke.","authors":"Maureen Ahiatsi, Guillaume Léonard, Eléonor Riesco, Marie-Claude Girard, Marie-Hélène Milot","doi":"10.1186/s12883-025-04213-5","DOIUrl":"10.1186/s12883-025-04213-5","url":null,"abstract":"<p><strong>Background: </strong>Chronic stroke survivors are often left with residual arm muscle weakness impeding arm function, daily life activities and quality of life. Exercise is one of the main post-stroke interventions to improve arm function, with cranial nerve non-invasive neuromodulation (CN-NINM) emerging as a potentially interesting complementary therapy to enhance its benefits. Only one study has evaluated the impact of CN-NINM combined with a lower-limb training program on improved balance in subacute stroke survivors. The aim of this study was to assess the feasibility and explore the effects on motor function of an arm strengthening program combined with CN-NINM in chronic stroke survivors (> 6 months).</p><p><strong>Methods: </strong>Twelve (12) participants (69 ± 11 years) took part in this feasibility study. Recruitment and drop-out rates, number of people who elected not to participate, adherence and adverse events were collected to assess feasibility. The effects of CN-NINM + exercise on motor function were evaluated by changes in arm motor function, measured using the Fugl-Meyer Assessment (FMA), and functional performance, evaluated through the Wolf Motor Function Test (WMFT), following a 4-week arm strengthening program (60 min, 3 sessions/week) combined with CN-NINM (tongue stimulation, 20 min at a comfortable intensity). Descriptive and non-parametric statistics (Wilcoxon signed-ranks test) were used to describe feasibility data and explore CN-NINM effects.</p><p><strong>Results: </strong>Feasibility was confirmed with a recruitment rate of 1.3 person/month, no dropout, a 100% adherence rate, and no serious adverse events. A significant gain in FMA (p = 0.003) with a trend for WMFT (P = 0.11) were noted post-intervention.</p><p><strong>Conclusion: </strong>This study suggests that CN-NINM combined with an arm strengthening program is feasible and may improve arm function in chronic stroke survivors. Further research is needed to validate the results.</p><p><strong>Trial registration: </strong>This clinical trial was registered on ClinicalTrials.gov (NCT05370274) on April 27, 2022.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"208"},"PeriodicalIF":2.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Effect of environmental pollutants particulate matter (PM_2.5, PM₁₀), nitrogen dioxide (NO₂), sulfur dioxide (SO₂), carbon monoxide (CO) and ground level Ozone (O₃) on epilepsy.","authors":"Bandar Nasser Aljafen, Narmeen Shaikh, Joud Mohammed AlKhalifah, Sultan Ayoub Meo","doi":"10.1186/s12883-025-04228-y","DOIUrl":"10.1186/s12883-025-04228-y","url":null,"abstract":"","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"210"},"PeriodicalIF":2.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}