The effect of working memory training on patient and informant reported executive function in mild cognitive impairment: an interventional study.

IF 2.2 3区 医学 Q3 CLINICAL NEUROLOGY
Per R Nordnes, Trine Holt Edwin, Marianne M Flak, Gro Christine Christensen Løhaugen, Jon Skranes, Linda Chang, Haakon R Hol, Ingun Ulstein, Susanne S Hernes
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引用次数: 0

Abstract

Background: Self-reported outcome measures are rarely described in individuals with mild cognitive impairment (MCI). In this study, we investigated the effect of computerized working memory training on self- and relatives reported executive function measures.

Methods: A total of 50 individuals with MCI were recruited from five memory clinics in Southern Norway and underwent a 5-week/20-25 sessions computerized working memory training program. Both individuals and relatives scored the "Behavior Rating Inventory of Executive Function for Adults" (BRIEF-A) before, and at least four months after finalizing training. Statistical analyses included paired t-tests and mixed ANOVA with rater type (participant/informant) and time (baseline/4-months).

Results: Mixed ANOVA revealed significant (adjusted p ≤ 0.025) participant-informant x time interactions for Working Memory, Metacognition Index and Global Executive Composite, suggesting that the changes in ratings over time differed between participants and informants. Post hoc tests revealed that at baseline participants rated themselves as significantly more impaired (adjusted p ≤ 0.036) than informants on the Working Memory scale, the Metacognitive Index and the Global Executive Composite. After training, no significant differences were found between participant and informant reports. After training participants reported significant improvements on Working Memory (adjusted p = 0.038), Metacognition Index (adjusted p = 0.038), with working memory improving from above the established clinically significant impairment threshold to the normal range. The change in Global Executive Composite was not significant after correction for multiple comparisons (adjusted p = 0.057). No significant changes were found for relatives' reported scores between the two time points. Excluding participants developing dementia during the study enhanced the difference in mean values before and after the intervention for these outcomes.

Conclusion: Computerized working memory training significantly improved self-reported executive function in individuals with MCI. While informant reports remained stable, the prior significant discrepancy between self- and informant ratings converged after training due to this improvement. These findings suggest that training can enhance subjective cognitive experience and awareness, offering potential clinical benefits for individuals with MCI. Our study highlights self-report measures as valuable and sensitive outcomes in MCI interventions, capturing the personal experiences of cognitive change.

Trial registration: ClinicalTrials.gov, NCT01991405. Registered on 18.11.2013.

一项介入性研究:工作记忆训练对轻度认知障碍患者和报告者执行功能的影响。
背景:在轻度认知障碍(MCI)个体中很少描述自我报告的结果测量。在本研究中,我们调查了计算机化工作记忆训练对自我和亲属报告的执行功能测量的影响。方法:从挪威南部的五家记忆诊所招募了50名MCI患者,并进行了为期5周/20-25次的计算机化工作记忆训练计划。在训练结束前和训练结束后至少4个月,受试者及其亲属都要对“成人执行功能行为评定量表”(BRIEF-A)进行评分。统计分析包括配对t检验和与评分者类型(参与者/被调查者)和时间(基线/4个月)的混合方差分析。结果:混合方差分析显示,工作记忆、元认知指数和全球执行综合指数在x时间上的交互作用显著(调整后p≤0.025),表明评分随时间的变化在被试和被试之间存在差异。事后测试显示,在基线时,参与者认为自己在工作记忆量表、元认知指数和全球执行综合能力上的受损程度明显高于被调查者(调整后p≤0.036)。培训后,参与者报告和举报人报告之间没有发现显著差异。训练后,参与者在工作记忆(调整p = 0.038)和元认知指数(调整p = 0.038)方面均有显著改善,工作记忆从既定的临床显著损伤阈值以上改善到正常范围。经过多次比较校正后,Global Executive Composite的变化不显著(调整后p = 0.057)。亲属报告的得分在两个时间点之间没有明显变化。排除在研究期间发生痴呆的参与者,增强了干预前后这些结果的平均值差异。结论:计算机化工作记忆训练显著改善轻度认知障碍患者自我报告的执行功能。虽然举报人的报告保持稳定,但由于这种改进,先前自我和举报人评分之间的显着差异在培训后收敛了。这些发现表明,训练可以增强主观认知体验和意识,为轻度认知障碍患者提供潜在的临床益处。我们的研究强调自我报告测量是MCI干预中有价值和敏感的结果,捕捉了认知变化的个人经历。试验注册:ClinicalTrials.gov, NCT01991405。2013年11月18日注册
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来源期刊
BMC Neurology
BMC Neurology 医学-临床神经学
CiteScore
4.20
自引率
0.00%
发文量
428
审稿时长
3-8 weeks
期刊介绍: BMC Neurology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of neurological disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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