Brain connectivity最新文献

{"title":"Clinical Correlates of Resting-State Functional Magnetic Resonance Imaging in Military Personnel with Adulthood-Onset War-Related Post-Traumatic Stress Disorder.","authors":"Olivier Roy, Jean Levasseur-Moreau, Emmanuelle Renauld, Marine Mondino, Luc J Hébert, Jean-Martin Beaulieu, Mathieu Bilodeau, Shirley Fecteau","doi":"10.1177/21580014261456366","DOIUrl":"10.1177/21580014261456366","url":null,"abstract":"<p><strong>Background: </strong>Investigation of the neural substrates of post-traumatic stress disorder (PTSD) in military personnel using whole-brain approaches remains scarce, hindering the development of circuit-based neuromodulatory interventions.</p><p><strong>Objectives: </strong>This study aimed to identify potential associations between clinical symptoms and whole-brain resting-state functional connectivity with magnetic resonance imaging in military personnel with adulthood-onset war-related PTSD.</p><p><strong>Methods: </strong>Thirty-seven soldiers from the Canadian Armed Forces with moderate to severe treatment-resistant PTSD participated in this study. We assessed PTSD, anxiety and depressive symptoms, quality of life, and time since trauma. We characterized the whole-brain functional connectome using independent component analysis and regions of interest (ROI)-to-ROI connectivity, as well as its topology using graph theory.</p><p><strong>Results: </strong>Greater severity of PTSD and anxiety symptoms was associated with lower connectivity (<i>r</i> < 0) between the default mode network (DMN) and frontoparietal network. Greater severity of PTSD symptoms was also associated with a higher nodal clustering coefficient of the inferior parietal lobule from the DMN. Greater severity of anxiety symptoms and longer time since trauma was the only clinical variables that correlated with higher connectivity patterns, all involving the visual networks (the frontoparietal-visual, the visual-DMN, and within-visual networks).</p><p><strong>Conclusions: </strong>This work contributes to identifying brain targets for the development of personalized neuromodulatory interventions. In particular, the DMN may be a promising target to alleviate PTSD symptoms, and the visual network may be a target to treat comorbid anxiety symptoms.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"193-203"},"PeriodicalIF":2.3,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148238773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the Dynamic Brain: From Network Signatures to Targeted Interventions.","authors":"Peng Wang, Steven Laureys","doi":"10.1177/21580014261468416","DOIUrl":"10.1177/21580014261468416","url":null,"abstract":"","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":"16 4-5","pages":"165-166"},"PeriodicalIF":2.3,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148429732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Fingerprinting of the Human Functional Connectome.","authors":"Amin Ghaffari, Yufei Zhao, Xu Chen, Jason Langley, Xiaoping Hu","doi":"10.1177/21580014261420882","DOIUrl":"10.1177/21580014261420882","url":null,"abstract":"<p><strong>Introduction: </strong>Resting-state functional connectivity (FC) has distinct, personalized patterns that could serve as a unique fingerprint of each individual's brain. While previous brain fingerprinting methods have used FC maps over a scanning session (static method), it has been shown that the brain is a dynamic system that switches between several metastable states, each of which has a different FC map. Taking the dynamic nature of brain connectivity into account will likely lead to more subject-specific information and better individual identification.</p><p><strong>Methods: </strong>In this article, we derived the state-specific FCs using sliding window correlation and clustering and evaluated their performance in individual identification and cognitive score prediction.</p><p><strong>Results: </strong>The resultant dynamic fingerprints outperformed the static fingerprints in identification accuracy. Furthermore, some of the brain states were more accurate in predicting cognitive scores, indicating that connectivity in some brain states is informative of cognitive abilities, possibly useful as biomarkers for brain disorders.</p><p><strong>Discussion: </strong>These findings suggest that incorporating dynamic information captures subject-specific connectivity features that are not present in static FC alone. The observation that specific states contribute more to cognitive prediction further highlights their potential utility as biomarkers for brain disorders.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"142-154"},"PeriodicalIF":2.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracking Brain Network and Cognitive Recovery in DAVF: A Longitudinal rsfMRI Study of Low-Frequency Fluctuations.","authors":"Jithin Sivan Sulaja, Santhosh Kumar Kannath, Adarsh Anil Kumar, Smitha Karavallil A, Sushama S Ramachandran, Parvathy P Karunakaran, Ramshekhar N Menon, Bejoy Thomas","doi":"10.1177/21580014261420411","DOIUrl":"10.1177/21580014261420411","url":null,"abstract":"<p><strong>Background: </strong>Intracranial dural arteriovenous fistula (DAVF) disrupts cerebral hemodynamics and can lead to widespread alterations in brain network connectivity and cognitive function. This study aimed to evaluate spontaneous brain activity and cognitive changes in DAVF patients using resting-state functional MRI (rsfMRI) and neuropsychological assessment, with evaluations conducted at baseline, 1 month, and 1 year postembolization to capture dynamic recovery-related changes in brain function and cognition.</p><p><strong>Methods: </strong>Fifty DAVF patients and 50 age and sex-matched healthy controls underwent rsfMRI. Amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) metrics were computed at both whole-brain and network levels. Cognitive performance was assessed using Addenbrooke's Cognitive Examination (ACE). All patients underwent embolization, followed by rsfMRI and ACE evaluations at 1 month and 1 year. ACE scores were included as covariates to explore cognitive-network associations.</p><p><strong>Results: </strong>Compared with controls, DAVF patients showed significantly increased ALFF in cerebellar regions and decreased ALFF/fALFF in frontal, insular, and parietal areas, especially within the Default Mode Network (DMN) and Dorsal Attention Network (DAN). Postembolization, rsfMRI metrics showed normalization trends, especially in DMN and DAN, mirroring improvements in ACE scores. ACE-based covariate analysis revealed domain-specific correlations: memory scores correlated with ALFF in the DMN (r = 0.62), and visuospatial scores with DAN (r = 0.55).</p><p><strong>Conclusions: </strong>This study provides longitudinal evidence that DAVF disrupts brain network integrity and cognition, with partial recovery following treatment. rsfMRI-derived ALFF and fALFF measures, particularly when analyzed alongside cognitive scores, may provide preliminary support for future clinical applications in DAVF prognosis and monitoring.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"128-141"},"PeriodicalIF":2.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the Neural Connectivity Changes of Repetitive Head Impacts in Youth Football Players: A Cross-Sectional MEG Analysis.","authors":"Natalie M Bell, Yin Xi, Natascha Cardoso da Fonseca, Jillian E Urban, Alexander K Powers, Ben Wagner, Christopher T Whitlow, Amy L Proskovec, Joel D Stitzel, Fang F Yu, Joseph A Maldjian, Elizabeth M Davenport","doi":"10.1177/21580014261425220","DOIUrl":"10.1177/21580014261425220","url":null,"abstract":"<p><strong>Introduction: </strong>The widespread participation of children in contact sports raises public interest and concern regarding neurological conditions later in life that may be related to repetitive head impacts (RHIs). Advanced neuroimaging techniques are advantageous for understanding functional brain changes. Particularly, magnetoencephalography (MEG) has shown promise as a clinical tool for concussion diagnosis and prognosis as well as understanding of RHI.</p><p><strong>Methodology: </strong>In this study, we utilized preseason and postseason eyes-open resting state MEG data to evaluate changes in functional connectivity correlated with RHI in 72 football players (μ_age = 12.2 years). In addition, MEG scans were acquired at baseline and follow-up for 17 control participants (μ_age = 11.5 years). Standard preprocessing techniques were followed, and coherence values were computed for regions of interest defined via the Desikan-Killiany atlas. The network-based statistic toolbox was used, and standard analysis of covariance (ANCOVAs) were implemented with corrections for multiple comparisons.</p><p><strong>Results: </strong>Postseason comparisons between football players and controls showed global hypoconnectivity in the delta frequency band for football players and hyperconnectivity in the theta and beta frequency bands in left cortical regions. No significant differences were found in preseason versus postseason comparisons within the football and control groups or between the two groups during preseason.</p><p><strong>Discussion: </strong>The combination of hypo- and hyperconnectivity may reflect compensatory mechanisms activated during postseason that deviate from typical cognitive development in this critical developmental age group. Further research is needed to explore the long-term effects of RHI on brain connectivity and cognitive development.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"118-127"},"PeriodicalIF":2.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time, Theta, and Theory: A Critical Look at Recurring Cortical Rhythms.","authors":"Nicola Thibault, Naranayan Srinivasan","doi":"10.1177/21580014251392234","DOIUrl":"10.1177/21580014251392234","url":null,"abstract":"","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"155-157"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145387286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Maturation of Functional Connectivity within Dorsal Brain Networks.","authors":"Kristina T R Ciesielski, Sheraz Khan, Koene R Van Dijk, Matti S Hämäläinen, Bruce R Rosen","doi":"10.1177/21580014261421825","DOIUrl":"10.1177/21580014261421825","url":null,"abstract":"<p><strong>Introduction: </strong>Prior visual neuroscience research has contributed ample evidence on functional anatomy of two long-range systemic visual networks, dorsal (DVN) and ventral (VVN). Their developmental course of functional connectivity was rarely studied.</p><p><strong>Methods: </strong>We examined within- and between-network connectivity using cortical periodic alpha band 8-13 Hz, a well-elaborated developmental marker of cognitive inhibitory control. Resting state magnetoencephalography (rsMEG) investigated age differences in functional network connectivity between carefully screened male participants: younger group (YG, 6:10-12 years) and older group (OG, 18:7-29 years). The morphology of cortical network nodes was informed <i>a priori</i> by pilot resting state functional magnetic resonance imaging (rsfMRI) and MRI morphometry studies. Phase Lag Index was employed to compute within- and between-network connectivity. We summarized the age differences in connectivity using graph theory metrics.</p><p><strong>Results: </strong>The power spectral density across cortical areas was comparable between YG and OG, indicating similar signal-to-noise ratios across the age groups. The dorsal brain in YG showed higher within-network connectivity for the inferior parietal/occipital (DVN) and medial posterior nodes (cingulate/precuneus) of the default mode network (DMN), functionally/anatomically linked to DVN. A significantly reduced anterior brain connectivity for VVN in YG suggested its protracted maturation. The topography of alpha connectivity between age groups displayed no statistically significant differences in the <i>posterior dorsal nodes</i> of DVN/DMN but significantly lower connectivity in <i>the anterior</i> dorsal/medial cortex <i>in YG as compared with OG</i>.</p><p><strong>Discussion: </strong>The current rsMEG finding on intrinsic alpha-band oscillatory connectivity in <i>child participants</i> is consistent with prior neuroimaging evidence in humans and primates securing an early maturational course of posterior dorsal brain networks.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"103-117"},"PeriodicalIF":2.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Development to Disruption, and Back Again: Mapping the Dynamic Trajectories of <i>Brain Connectivity</i>.","authors":"Tonghe Zhuang, Steven Laureys","doi":"10.1177/21580014261455728","DOIUrl":"https://doi.org/10.1177/21580014261455728","url":null,"abstract":"","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":"16 2-3","pages":"101-102"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Online Learning Framework for Neural Decoding in Embedded Neuromodulation Systems.","authors":"Yaesop Lee, Rong Chen, Shuvra Bhattacharyya","doi":"10.1177/21580014251374627","DOIUrl":"10.1177/21580014251374627","url":null,"abstract":"<p><strong>Introduction: </strong>Advancements in brain-computer interfaces (BCIs) have improved real-time neural signal decoding, enabling adaptive closed-loop neuromodulation. These systems dynamically adjust stimulation parameters based on neural biomarkers, enhancing treatment precision and adaptability. However, existing neuromodulation frameworks often depend on high-power computational platforms, limiting their feasibility for portable, real-time applications.</p><p><strong>Methods: </strong>We propose RONDO (Recursive Online Neural DecOding), a resource-efficient neural decoding framework that employs dynamic updating schemes in online learning with recurrent neural networks (RNNs). RONDO supports simple RNNs, long short-term memory networks, and gated recurrent units, allowing flexible adaptation to different signal type, accuracy, and real-time constraints.</p><p><strong>Results: </strong>Experimental results show that RONDO's adaptive model updating improves neural decoding accuracy by 35% to 45% compared to offline learning. Additionally, RONDO operates within real-time constraints of neuroimaging devices without requiring cloud-based or high-performance computing. Its dynamic updating scheme ensures high accuracy with minimal updates, improving energy efficiency and robustness in resource-limited settings.</p><p><strong>Conclusions: </strong>RONDO presents a scalable, adaptive, and energy-efficient solution for real-time closed-loop neuromodulation, eliminating reliance on cloud computing. Its flexibility makes it a promising tool for clinical and research applications, advancing personalized neurostimulation and adaptive BCIs.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"7-17"},"PeriodicalIF":2.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Lack of Neurofeedback Training Regulation Guidance and Process Evaluation May be a Source of Controversy in Post-Traumatic Stress Disorder-Neurofeedback Research: A Systematic Review and Statistical Analysis.","authors":"Peng Ding, Lize Tan, He Pan, Anming Gong, Wenya Nan, Yunfa Fu","doi":"10.1089/brain.2024.0084","DOIUrl":"10.1089/brain.2024.0084","url":null,"abstract":"<p><strong>Objectives: </strong>Neurofeedback (NF) based on brain-computer interface (BCI) is an important direction in adjunctive interventions for post-traumatic stress disorder (PTSD). However, existing research lacks comprehensive methodologies and experimental designs. There are concerns in the field regarding the effectiveness and mechanistic interpretability of NF, prompting this study to conduct a systematic analysis of primary NF techniques and research outcomes in PTSD modulation. The study aims to explore reasons behind these concerns and propose directions for addressing them.</p><p><strong>Methods: </strong>A search conducted in the Web of Science database up to December 1, 2023, yielded 111 English articles, of which 80 were excluded based on predetermined criteria irrelevant to this study. The remaining 31 original studies were included in the literature review. A checklist was developed to assess the robustness and credibility of these 31 studies. Subsequently, these original studies were classified into electroencephalogram-based NF (EEG-NF) and functional magnetic resonance imaging-based NF (fMRI-NF) based on BCI type. Data regarding target brain regions, target signals, modulation protocols, control group types, assessment methods, data processing strategies, and reported outcomes were extracted and synthesized. Consensus theories from existing research and directions for future improvements in related studies were distilled.</p><p><strong>Results: </strong>Analysis of all included studies revealed that the average sample size of PTSD patients in EEG and fMRI NF studies was 17.4 (SD 7.13) and 14.6 (SD 6.37), respectively. Due to sample and neurofeedback training protocol constraints, 93% of EEG-NF studies and 87.5% of fMRI-NF studies used traditional statistical methods, with minimal utilization of basic machine learning (ML) methods and no studies utilizing deep learning (DL) methods. Apart from approximately 25% of fMRI NF studies supporting exploratory psychoregulatory strategies, the remaining EEG and fMRI studies lacked explicit NF modulation guidance. Only 13% of studies evaluated NF effectiveness methods involving signal classification, decoding during the NF process, and lacking in process monitoring and assessment means.</p><p><strong>Conclusion: </strong>In summary, NF holds promise as an adjunctive intervention technique for PTSD, potentially aiding in symptom alleviation for PTSD patients. However, improvements are necessary in the process evaluation mechanisms for PTSD-NF, clarity in NF modulation guidance, and development of ML/DL methods suitable for PTSD-NF with small sample sizes. To address these challenges, it is crucial to adopt more rigorous methodologies for monitoring NF, and future research should focus on the integration of advanced data analysis techniques to enhance the effectiveness and precision of PTSD-NF interventions.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"18-35"},"PeriodicalIF":2.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}