Brain connectivity最新文献

{"title":"Distinct Neural Connectivity Patterns During Music Listening and Imagination: An Electroencephalography Study.","authors":"Kiarash Fouladi, Hessam Ahmadi, Ali Motie-Nasrabadi","doi":"10.1089/brain.2024.0042","DOIUrl":"https://doi.org/10.1089/brain.2024.0042","url":null,"abstract":"<p><p><b><i>Background:</i></b> The brain's function changes during various activities, and numerous studies have explored this field. An intriguing and significant area of research is the brain's functioning during imagination and periods of inactivity. <b><i>Objective:</i></b> This study explores the differences in brain connectivity during music listening and imagination: by identifying distinct neural connectivity patterns and providing insights into the cognitive mechanisms underlying auditory imagination. <b><i>Methods:</i></b> Effective connectivity matrices were generated using generalized partial directed coherence (GPDC) and directed Directed Transfer Function (dDTF) methods applied to non-invasive electroencephalography data from these two conditions. Statistical tests were performed to illustrate the differences in brain connectivity, followed by the creation of brain graphs and the application of a non-parametric permutation test to demonstrate statistical significance. Data classification between listening to music and imagining it was performed using an Support Vector Machine (SVM) classifier with different feature vectors. <b><i>Results:</i></b> Combining features extracted from GPDC and dDTF achieved an accuracy of 71.3% while using GPDC and dDTF features individually yielded accuracies of 60% and 62.1%, respectively. Among all the graph's global features, only modularity and small-worldness showed statistically significant differences in dDTF and GPDC. Overall, findings reveal that information flows from the left hemisphere to the right hemisphere increases during music imagination compared with listening, highlighting distinct neural connectivity patterns associated with imaginative processes. <b><i>Conclusion:</i></b> The study provides novel insights into the distinct neural connectivity patterns during music listening and imagination, contributing to the broader understanding of cognitive processes associated with auditory imagination and perception.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specific Associations in the Alpha Frequency Between the Subcomponents of Rumination and the Subsystems of the Default Mode Network Among Bipolar I Disorder Patients.","authors":"Hao Tang, Jiabo Shi, Siqi Zhang, Yu Chen, Tingting Xiong, Xumiao Wang, Zhilu Chen, Zhongpeng Dai, Zhijian Yao, Qing Lu","doi":"10.1089/brain.2023.0086","DOIUrl":"10.1089/brain.2023.0086","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Rumination in bipolar disorder (BD) is well documented. Recent neuroimaging studies highlight the role of the default mode network (DMN) in rumination, while few studies have evaluated the DMN activity in BD rumination, particularly the underlying neuroelectrophysiology. <b><i>Methods:</i></b> A total of 44 patients with depressed bipolar I disorder (BD-I) and 46 healthy controls underwent resting-state magnetoencephalography. Two core hubs of the DMN, the posterior cingulate cortex (PCC), and anterior medial prefrontal cortex, together with the dorsal medial prefrontal cortex (dmPFC) and the medial temporal lobe (MTL) subsystems, were identified as the regions of interest. The power envelope method was used to determine the alpha band's cross-subsystem functional connectivity (FC). After comparing the rumination and DMN FC between the groups, Spearman partial correlation analysis was performed to evaluate the relationship between aberrant FC and rumination in BD-I patients. <b><i>Results:</i></b> BD-I patients demonstrated more global rumination, including higher subcomponent scores of brooding and reflection. In addition, the alpha frequency FC of the PCC-dmPFC and dmPFC-MTL subsystems within the DMN was dramatically increased in the BD-I group. The former was strongly associated with reflection, whereas the latter was related to brooding. <b><i>Conclusion:</i></b> The findings suggest that the reflection and brooding components of rumination are selectively related to the alpha frequency FC of the PCC-dmPFC and dmPFC-MTL subsystems, respectively. These associations highlight the significance of DMN activities in rumination among BD-I patients and have implications for future rumination interventions.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"542-549"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Precision Therapies in Brain Connectivity.","authors":"Francisco Gómez, Jitka Annen, Steven Laureys","doi":"10.1089/brain.2024.0090","DOIUrl":"https://doi.org/10.1089/brain.2024.0090","url":null,"abstract":"","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":"14 10","pages":"511-512"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repetitive Transcranial Magnetic Stimulation on Individualized Spots Based on Task functional Magnetic Resonance Imaging Improves Swallowing Function in Poststroke Dysphagia.","authors":"Meiyuan Chen, Ziyang Huang, Yi Chen, Xiaochuan Wang, Xiaojun Ye, Wenjie Wu","doi":"10.1089/brain.2024.0021","DOIUrl":"10.1089/brain.2024.0021","url":null,"abstract":"<p><p><b><i>Background:</i></b> Functional magnetic resonance imaging (fMRI) has not previously been used to localize the swallowing functional area in repetitive transcranial magnetic stimulation (rTMS) treatment for poststroke dysphagia; Traditionally, the target area for rTMS is the hotspot, which is defined as the specific region of the brain identified as the optimal location for transcranial magnetic stimulation (TMS). This study aims to compare the network differences between the TMS hotspot and the saliva swallowing fMRI activation to determine the better rTMS treatment site and investigate changes in functional connectivity related to poststroke dysphagia using resting-state fMRI. <b><i>Methods:</i></b> Using an information-based approach, we conducted a single case study to explore neural functional connectivity in a patient with poststroke dysphagia before, immediately after rTMS, and 4 weeks after rTMS intervention. A total of 20 healthy participants underwent fMRI and TMS hotspot localization as a control group. Neural network alterations were assessed, and functional connections related to poststroke dysphagia were examined using resting-state fMRI. <b><i>Results:</i></b> Compared to the TMS-induced hotspots, the fMRI activation peaks were located significantly more posteriorly and exhibited stronger functional connectivity with bilateral postcentral gyri. Following rTMS treatment, this patient developed functional connection between the brainstem and the bilateral insula, caudate, anterior cingulate cortex, and cerebellum. <b><i>Conclusion:</i></b> The saliva swallowing fMRI activation peaks show more intense functional connectivity with bilateral postcentral gyri compared to the TMS hotspots. Activation peak-guided rTMS treatment improves swallowing function in poststroke dysphagia. This study proposes a novel and potentially more efficacious therapeutic target for rTMS, expanding its therapeutic options for treating poststroke dysphagia.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"513-526"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Functional Coupling of the Bed Nucleus of the Stria Terminalis and Amygdala in Spider Phobic Fear.","authors":"Elisabeth Jehli, Niklaus Denier, Andrea Federspiel, Thomas Dierks, Werner Strik, Leila M Soravia, Matthias Grieder","doi":"10.1089/brain.2024.0031","DOIUrl":"10.1089/brain.2024.0031","url":null,"abstract":"<p><p><b><i>Background:</i></b> Individuals with spider phobic (SP) fear show hypervigilance and amygdala hyperactivity toward fear-associated stimuli, which may promote the development of other anxiety disorders. The amygdala is a key region within the fear network, which is connected to the anxiety system, where the bed nucleus of the stria terminalis (BNST) plays a crucial role. However, the BNST's involvement in phobic fear is unknown. Therefore, this study investigated the association of phobic fear and anxiety on these regions' functional connectivity (FC) in SP compared to healthy controls (HC). <b><i>Methods:</i></b> 7T-functional MRI resting-state FC of 30 individuals with SP and 45 HC was assessed to detect network differences between these groups. The association of phobic fear severity, trait anxiety, and social anxiety on FC was explored using linear regressions combined with seed-to-voxel analyses with amygdala and BNST as primary seeds, corrected for age and sex. <b><i>Results:</i></b> In SP, phobic fear was associated with reduced FC between the left amygdala and the right supramarginal gyrus. In contrast, anxiety severity was related to increased FC between the right BNST and the left inferior frontal gyrus. Moreover, social anxiety was related to decreased FC between bilateral BNST and left precuneus. <b><i>Conclusions:</i></b> These findings show changes in FC in SP, connecting fear with altered activity in the BNST and amygdala. The results suggest that persistent anxiety in phobic fear is associated with abnormal brain function in these regions, potentially explaining susceptibility to anxiety disorders and processes involved in phobic fear, such as threat perception, avoidance, and salience.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"527-541"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connectivity Changes Following Episodic Future Thinking in Alcohol Use Disorder.","authors":"Jeremy Myslowski, Samuel M McClure, Jonathan Lisinski, Devin C Tomlinson, Anita S Kablinger, James MacKillop, Mikhail N Koffarnus, Rafaela M Fontes, Warren K Bickel, Stephen M LaConte","doi":"10.1089/brain.2024.0025","DOIUrl":"10.1089/brain.2024.0025","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Recent addiction and obesity-related research suggests that episodic future thinking (EFT) can serve as a promising intervention to promote healthy decision-making. We used data from a pilot study to investigate the acute neural effects of EFT in alcohol use disorder (AUD). Because of the limitations of those data, we additionally used data from a previously published functional MRI (fMRI) study in which participants had not received any intervention for their AUD. <b><i>Methods:</i></b> In an out-of-scanner, guided interview, participants (<i>n</i> = 24; median age = 37.3 years; median AUDIT = 22.5) generated scenarios and cues about their future (EFT intervention, <i>n</i> = 15) or recent past (control episodic thinking [CET] control intervention, <i>n</i> = 9). Then, they performed both resting-state and task-based (delay discounting [DD]) fMRI. We used nodes from the default mode network and salience networks as well as the hippocampus to perform seed-based analyses of the resting-state data. The results then guided psychophysiological interaction analyses in the DD task. In addition, we used data from a larger, previously reported study as a \"no intervention\" group of AUD participants (<i>n</i> = 50; median age = 43.3; median Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) alcohol dependence score = 7) to reproduce and aid in interpreting our key findings. <b><i>Results:</i></b> EFT, but not CET, participants showed statistically improved DD rates-a behavioral marker for addiction. Resting-state analyses of the left hippocampus revealed connectivity differences in the frontal poles. The directionality of this difference suggested that EFT may reduce a hypo-connectivity relationship between these regions in AUD. We also found resting-state connectivity differences between the salience network and the right dorsolateral prefrontal cortex (R DLPFC), which then led us to discover R-to-L DLPFC psychophysiological interaction differences during DD. Moreover, the resting-state salience-to-DLPFC functional connectivity showed an inverse relationship to DD rate while hyperconnectivity between left and right DLPFC reflected slower reaction times during DD trials. <b><i>Discussion:</i></b> These findings suggest that previously noted benefits of EFT such as the improved DD replicated here might coincide with changes in neural connectivity patterns in AUD. The alterations in connectivity highlight potential mechanisms underlying the effectiveness of EFT in improving decision-making in AUD. Understanding these neural effects may contribute to the further development of targeted interventions for AUD and related disorders.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"550-559"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Neuroscience Through Innovative Methods and Clinical Applications.","authors":"Prejaas K B Tewarie, Carlo Cavaliere, Steven Laureys","doi":"10.1089/brain.2024.0075","DOIUrl":"10.1089/brain.2024.0075","url":null,"abstract":"","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"457-458"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intersubject Dynamic Conditional Correlation: A Novel Method to Track the Framewise Network Implication during Naturalistic Stimuli.","authors":"Lifeng Chen, Shiyao Tan, Chaoqun Li, Zonghui Lin, Xin Hu, Tianyi Gu, Jiaxuan Liu, Xiaolin Guo, Zhiheng Qu, Xiaowei Gao, Yaling Wang, Wanchun Li, Zhongqi Li, Junjie Yang, Wanjing Li, Zhe Hu, Junjing Li, Yien Huang, Jiali Chen, Dongqiang Liu, Hui Xie, Binke Yuan","doi":"10.1089/brain.2023.0075","DOIUrl":"10.1089/brain.2023.0075","url":null,"abstract":"<p><p><b><i>Background:</i></b> Naturalistic stimuli have become increasingly popular in modern cognitive neuroscience. These stimuli have high ecological validity due to their rich and multilayered features. However, their complexity also presents methodological challenges for uncovering neural network reconfiguration. Dynamic functional connectivity using the sliding-window technique is commonly used but has several limitations. In this study, we introduce a new method called intersubject dynamic conditional correlation (ISDCC). <b><i>Method:</i></b> ISDCC uses intersubject analysis to remove intrinsic and non-neuronal signals, retaining only intersubject-consistent stimuli-induced signals. It then applies dynamic conditional correlation (DCC) based on the generalized autoregressive conditional heteroskedasticity to calculate the framewise functional connectivity. To validate ISDCC, we analyzed simulation data with known network reconfiguration patterns and two publicly available narrative functional Magnetic Resonance Imaging (fMRI) datasets. <b><i>Results:</i></b> (1) ISDCC accurately unveiled the underlying network reconfiguration patterns in simulation data, demonstrating greater sensitivity than DCC; (2) ISDCC identified synchronized network reconfiguration patterns across listeners; (3) ISDCC effectively differentiated between stimulus types with varying temporal coherence; and (4) network reconfigurations unveiled by ISDCC were significantly correlated with listener engagement during narrative comprehension. <b><i>Conclusion:</i></b> ISDCC is a precise and dynamic method for tracking network implications in response to naturalistic stimuli.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"471-488"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Exercise with Better Olfactory Performance and Higher Functional Connectivity Between the Olfactory Cortex and the Prefrontal Cortex: A Resting-State Functional Near-Infrared Spectroscopy Study.","authors":"Chenping Zhang, Xiaochun Wang","doi":"10.1089/brain.2024.0015","DOIUrl":"10.1089/brain.2024.0015","url":null,"abstract":"<p><p><b><i>Background:</i></b> Olfactory deterioration is suggested to be a predictor of some neurodegenerative diseases. Recent studies indicate that physical exercise has a positive relationship with olfactory performance, and a subregion in the prefrontal cortex (PFC) may play an important role in olfactory processing. The PFC is not only related to olfactory function but it also engages in complex functions such as cognition and emotional processing. <b><i>Methodology:</i></b> Our study compared the functional connectivity between the olfactory cortex and the PFC in healthy individuals who exercised regularly and healthy persons who did not. Those who exercised more than three times/week for at least 30 min each time were considered the exercise group, and those who did not meet this exercise criteria were considered the nonexercise group. We also assessed their odor threshold. Participants were aged 55 years or older, and the two groups were balanced for age, sex, body mass index, and educational level. <b><i>Results:</i></b> We found that compared with individuals who did not exercise, exercisers had a significantly lower threshold for detecting odors. In addition, the olfactory cortex had stronger connectivity with the PFC in exercisers than in nonexercisers. More specifically, when the PFC was grouped into three subregions, namely, the ventrolateral prefrontal cortex (VLPFC), dorsolateral prefrontal cortex (DLPFC), and frontopolar cortex (FPA), Pearson correlation analysis revealed stronger connectivity between the VLPFC and the orbitofrontal cortex (OFC), between the OFC and the FPA, and between the left and right OFC hemispheres in the exercisers. In addition, Granger causality indicated higher directional connectivity from the DLPFC to the OFC in exercisers than in nonexercisers. <b><i>Conclusion:</i></b> Our findings indicated that the exercise group not only had better olfactory performance but also had stronger functional connectivity between the olfactory cortex and the PFC than nonexercise group.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"500-510"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atlas-Based Structural Disconnectomes Are Associated with Cognitive Performance in Brain Tumors.","authors":"Hibba Yousef, Brigitta Malagurski Törtei","doi":"10.1089/brain.2024.0028","DOIUrl":"10.1089/brain.2024.0028","url":null,"abstract":"<p><p><b><i>Background:</i></b> Brain tumors are associated with impaired cognitive functioning, which may result from disruptions in brain structural connectivity. Estimating structural disconnections is a more advantageous representation of tumor impact and can be performed indirectly through normative brain atlases. <b><i>Materials and Methods:</i></b> Using a publicly available dataset of glioma and meningioma patient MRI scans and tumor masks, latent correlations were estimated between measures of structural disconnection and attention-based cognitive functioning. These measures included gray matter (GM) parcel damage, white matter tract damage, GM parcel-to-parcel disconnections, and reaction time (RTI) as part of the Cambridge Neuropsychological Test Automated Battery to assess attention. <b><i>Results:</i></b> Preprocessing pipelines with two different methods of minimizing the pathology impact on MRI normalization were utilized: cost-function masking and lesion filling. The results across both pipelines were nearly consistent, with significant correlations mainly found between RTI measures and the damage to the left inferior fronto-occipital and uncinate fasciculus, as well as the left prefrontal-visual disconnections. <b><i>Conclusions:</i></b> This alludes to the importance of left-hemispheric prefrontal-visual coupling in attention-based tasks, particularly those involving object- and feature-based attention.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"489-499"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}