Brain connectivity最新文献

{"title":"Charting the Frontiers of Brain Connectivity: From Rehabilitation to Imagination.","authors":"Minji Lee, Steven Laureys","doi":"10.1089/brain.2025.0020","DOIUrl":"https://doi.org/10.1089/brain.2025.0020","url":null,"abstract":"","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":"15 2","pages":"57-58"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal Brain State in Major Depressive Disorder: A Resting-State Magnetic Resonance Study.","authors":"Siyu Fan, Rui Qian, Nanxue Duan, Hongping Wang, Yue Yu, Yang Ji, Xiaohui Xie, Yue Wu, Yanghua Tian","doi":"10.1089/brain.2024.0062","DOIUrl":"10.1089/brain.2024.0062","url":null,"abstract":"<p><p><b><i>Background:</i></b> Respective changes in resting-state linear and nonlinear measures in major depressive disorder (MDD) have been reported. However, few studies have used integrated measures of linear and nonlinear brain dynamics to explore the pathological mechanisms underlying MDD. <b><i>Method:</i></b> Forty-two patients with MDD and 42 sex- and age-matched healthy controls (HC) underwent resting-state functional magnetic resonance imaging to calculate multiscale entropy (MSE) and regional homogeneity (ReHo). The MSE-ReHo coupling of the whole gray matter and the MSE/ReHo ratio (the complexity of intensity homogeneity per unit time series) of each voxel were compared between the two groups. To evaluate the discriminative capacity of ratio features between patients with MDD and HC, we employed the support vector machine (SVM) learning method. <b><i>Results:</i></b> We observed that patients with MDD displayed increased MSE/ReHo ratio mainly in the orbitofrontal cortex, sensorimotor areas, and visual cortex. Moreover, significant correlations were observed between MSE/ReHo ratio and clinical indicators, including depression severity and cognitive function tests. The SVM model demonstrated high accuracy in differentiating patients with MDD from HC, highlighting the potential of the MSE/ReHo ratio as a diagnostic and prognostic tool. <b><i>Conclusions:</i></b> The aberrant MSE/ReHo ratio implicated the underlying mechanisms of depressive symptoms and cognitive impairment in patients with MDD. It may represent a critical state of the brain region, reflecting the degree of chaos and order in the brain region. Integrating linear and nonlinear combinations of brain signals holds promise for diagnosing psychiatric disorders.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"84-97"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Parallel Cognitive-Motor Training Tasks on Hemodynamic Responses in Robot-Assisted Rehabilitation.","authors":"Duojin Wang, Jiankang Zhou, Yanping Huang, Qingyun Meng","doi":"10.1089/brain.2024.0043","DOIUrl":"10.1089/brain.2024.0043","url":null,"abstract":"<p><p><b><i>Objective:</i></b> Previous studies suggest that the combination of robot-assisted training with other concurrent tasks may promote the functional recovery and improvement better than the single task. It is well-established that robot-assisted rehabilitation training is effective. This study aims to characterize the neural mechanisms and inter-regional connectivity changes associated with robot-assisted parallel interactive training tasks. <b><i>Methods:</i></b> Twenty-five healthy young adults (12 females and 13 males) participated in three number-related cognitive-motor parallel interactive training tasks categorized by difficulty: low difficulty (LD), medium difficulty (MD), and high difficulty (HD). Functional near-infrared spectroscopy was used to measure neural responses in the primary sensorimotor cortex (SM1), supplementary motor area (SMA), and prefrontal cortex (PFC). Activation maps and functional connectivity (FC) correlation matrix maps were applied to assess cortical response and connectivity among channels and regions of interest. <b><i>Results:</i></b> Significant differences were observed in both activation and connectivity results across the three training conditions. Stronger activation (<i>p</i> < 0.01) in oxy-hemoglobin was found in the MD conditions, with activation in the HD condition being stronger than in the LD condition. The FC in the PFC increased linearly with rising training difficulty. Trends in FC for SM1 and SMA were consistent with the activation results. <b><i>Conclusions:</i></b> In parallel training tasks of varying difficulty, MD stimulates more neural activity and promotes stronger network connections in the brain. This study enhances the understanding of the neurological processes involved in robot-assisted parallel interactive tasks and may inform more effective robot-assisted rehabilitation therapies.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"98-111"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebello-Cerebral Resting-State Functional Connectivity in Poststroke Aphasia.","authors":"Joan Stilling, Ji Hyun Kim, Sarah Cust, Zafer Keser, Jamie L Murter, Donna C Tippet, Argye E Hillis, Rajani Sebastian","doi":"10.1089/brain.2023.0087","DOIUrl":"10.1089/brain.2023.0087","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> The influence of the cerebellum in poststroke aphasia recovery is poorly understood. Despite the right cerebellum being identified as a critical region involved in both language and cognitive functions, little is known about functional connections between the cerebellum and bilateral cortical hemispheres following stroke. This study investigated the relationship between chronic poststroke naming deficits and cerebello-cerebral resting-state functional connectivity (FC). <b><i>Methods:</i></b> Twenty-five cognitively normal participants and 42 participants with chronic poststroke aphasia underwent resting-state functional magnetic resonance imaging. Participants with aphasia also underwent language assessment. We conducted regions of interest (ROI)-to-ROI analyses to investigate the FC between the right cerebellar Crus I/II (seed ROI; Cereb1r/Cereb2r) and bilateral cortical language regions and compared these results to cognitively normal controls. Single-subject connectivity parameters were extracted and used as independent variables in a stepwise multiple linear regression model associating Boston Naming Test (BNT) score with FC measures. <b><i>Results:</i></b> FC analyses demonstrated correlations between the right cerebellar Crus I/II and both left and right cortical regions for both cognitively normal controls and stroke participants. Additionally, aphasia severity and lesion load had an effect on the cerebello-cerebral network connectivity in participants with aphasia. In a stepwise multiple linear regression, controlling for aphasia severity, time poststroke and lesion load, FC between the right Cereb2-left Cereb1 (standardized beta [std B]= -0.255, <i>p</i> < 0.004), right Cereb2-right anterior MTG (std B = 0.259, <i>p</i> < 0.004), and the right Cereb2-left anterior STG (std <i>B</i> = -0.208, <i>p</i> < 0.018) were significant predictors of BNT score. The overall model fit was <i>R</i>² = 0.786 (<i>p</i> = 0.001). <b><i>Conclusion:</i></b> Functional connections between the right cerebellum and residual bilateral cerebral hemisphere regions may play a role in predicting naming ability in poststroke aphasia.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"40-54"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"New Horizons in Brain Connectivity: A Fresh Start for 2025\".","authors":"Haibo Di, Steven Laureys","doi":"10.1089/brain.2024.0106","DOIUrl":"https://doi.org/10.1089/brain.2024.0106","url":null,"abstract":"","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":"15 1","pages":"1-2"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Modular Degeneracy on Neuroimaging Data.","authors":"Elisabeth C Caparelli, Hong Gu, Yihong Yang","doi":"10.1089/brain.2023.0090","DOIUrl":"10.1089/brain.2023.0090","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> The concept of community structure, based on modularity, is widely used to address many systems-level queries. However, its algorithm, based on the maximization of the modularity index Q, suffers from degeneracy problem, which yields a set of different possible solutions. <b><i>Methods:</i></b> In this work, we explored the degeneracy effect of modularity principle on resting-state functional magnetic resonance imaging (rsfMRI) data, when it is used to parcellate the cingulate cortex using data from the Human Connectome Project. We proposed a new iterative approach to address this limitation. <b><i>Results:</i></b> Our results show that current modularity approaches furnish a variety of different solutions, when these algorithms are repeated, leading to different number of subdivisions for the cingulate cortex. Our new proposed method, however, overcomes this limitation and generates more stable solution for the final partition. <b><i>Conclusion:</i></b> With this new method, we were able to mitigate the degeneracy problem and offer a tool to use modularity in a more reliable manner, when applying it to rsfMRI data.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"19-29"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct Neural Mechanisms Underlying Dual-Task Priority During Gait Across Cognitive and Motor Networks.","authors":"Eunkyung Kim, Seo Jung Yun, Byung-Mo Oh, Han Gil Seo","doi":"10.1089/brain.2024.0014","DOIUrl":"10.1089/brain.2024.0014","url":null,"abstract":"<p><p><b><i>Background:</i></b> Prioritization strategy during gait significantly influences gait performance and successful gait relies on interactions between cognitive and motor functions. This study aimed to examine the within- and between-network connectivities of cognitive and motor networks associated with dual-task priority during gait. <b><i>Methods:</i></b> Twenty-nine healthy individuals (66.86 ± 8.53 years) underwent the timed-up-and-go (TUG) test alone, TUG with a cognitive task, and the cognitive task alone. The cognitive task involved sequentially subtracting three from a random number between 50 and 100. The resting-state functional magnetic resonance imaging was acquired on the same day. Using independent component analysis, the dorsal attention network (DAN), frontoparietal network (FPN), primary motor network (PM), and lateral motor network were assessed. The participants were divided into cognitive and motor priority groups based on the modified attention allocation index (mAAI). Group comparisons of within- and between-network connectivity were conducted using permutation tests. Additionally, correlation analysis was employed to investigate the association between-network connectivity and task priority. <b><i>Results:</i></b> The cognitive priority group showed cognitive dual-task facilitation. In comparison to the motor priority group, they also showed comparable motor dual-task costs and lower combined dual-task costs. They exhibited increased within-network connectivity in the left FPN and enhanced between-network connectivity between the right FPN and both the DAN and PM. These between-network connectivities were negatively correlated with mAAI scores. <b><i>Conclusion:</i></b> The results suggest distinct neural mechanisms across cognitive and motor networks based on individuals' dual-task strategies. This may have implications for understanding gait performance in complex contexts.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"30-39"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontal Cortex Acts as Causality Transition Hub from Mirror Network to Mentalizing Network During Action Intention Understanding.","authors":"Li Zhang, Lei Zhang, Jing Wang, Yanmei Zhu","doi":"10.1089/brain.2024.0032","DOIUrl":"10.1089/brain.2024.0032","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> While understanding other's action intention, mirror and mentalizing systems of human brain are successively activated in action perception and intention inference processes. <b><i>Methods:</i></b> To reveal the relationship between mirror and mentalizing systems during the two stages, this electroencephalogram study adopted the method of time-varying orthogonalized partial directed coherence (OPDC) to assess causal interaction between mirror and mentalizing networks during a \"hand-cup interaction\" action intention understanding task. <b><i>Results:</i></b> Task-related causal connectivity was found in gamma frequency band (30-45 Hz), primarily manifested as directed edges from sensorimotor to frontal areas in poststimulus 400-600 ms interval and directed links from frontal to parietal and temporal regions in 600-800 ms period. The analysis of event-related potential and source currents suggests that the change of inter-regional causality is related with functional transition of the brain from mirror matching to intention inference. The OPDC network modeling further finds that frontal area contains more inflow nodes in mirror network, whereas more outflow nodes in mentalizing network, with high betweenness centrality in temporally changing functional communities. Compared with intention-oriented actions, identification of unintelligible action intention particularly induces stronger OPDC from right superior frontal to inferior frontal gyrus and from sensorimotor to right frontotemporal regions during mentalizing inference process. <b><i>Conclusion:</i></b> These findings collectively suggest that, in the time ordering of information transfer within the directed networks, frontal area plays an important role of bridging hub between mirror and mentalizing systems, from maintaining and supervising perceptual information for mirror matching to controlling the mentalizing process for decoding other's action intention.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"3-18"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgment of Reviewers 2024.","authors":"","doi":"10.1089/brain.2024.91224.revack","DOIUrl":"https://doi.org/10.1089/brain.2024.91224.revack","url":null,"abstract":"","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":"15 1","pages":"55"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specific Associations in the Alpha Frequency Between the Subcomponents of Rumination and the Subsystems of the Default Mode Network Among Bipolar I Disorder Patients.","authors":"Hao Tang, Jiabo Shi, Siqi Zhang, Yu Chen, Tingting Xiong, Xumiao Wang, Zhilu Chen, Zhongpeng Dai, Zhijian Yao, Qing Lu","doi":"10.1089/brain.2023.0086","DOIUrl":"10.1089/brain.2023.0086","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Rumination in bipolar disorder (BD) is well documented. Recent neuroimaging studies highlight the role of the default mode network (DMN) in rumination, while few studies have evaluated the DMN activity in BD rumination, particularly the underlying neuroelectrophysiology. <b><i>Methods:</i></b> A total of 44 patients with depressed bipolar I disorder (BD-I) and 46 healthy controls underwent resting-state magnetoencephalography. Two core hubs of the DMN, the posterior cingulate cortex (PCC), and anterior medial prefrontal cortex, together with the dorsal medial prefrontal cortex (dmPFC) and the medial temporal lobe (MTL) subsystems, were identified as the regions of interest. The power envelope method was used to determine the alpha band's cross-subsystem functional connectivity (FC). After comparing the rumination and DMN FC between the groups, Spearman partial correlation analysis was performed to evaluate the relationship between aberrant FC and rumination in BD-I patients. <b><i>Results:</i></b> BD-I patients demonstrated more global rumination, including higher subcomponent scores of brooding and reflection. In addition, the alpha frequency FC of the PCC-dmPFC and dmPFC-MTL subsystems within the DMN was dramatically increased in the BD-I group. The former was strongly associated with reflection, whereas the latter was related to brooding. <b><i>Conclusion:</i></b> The findings suggest that the reflection and brooding components of rumination are selectively related to the alpha frequency FC of the PCC-dmPFC and dmPFC-MTL subsystems, respectively. These associations highlight the significance of DMN activities in rumination among BD-I patients and have implications for future rumination interventions.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"542-549"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}