BMC Pulmonary Medicine最新文献

{"title":"Factors associated with low adherence to inhaled therapy in patients with chronic respiratory diseases: a cross-sectional study.","authors":"Esther Ribes Murillo, Josep Ramon Marsal Mora, Marta Micol Bachiller, Leonardo Galván Santiago, Núria Nadal Braqué, Marta Ortega Bravo","doi":"10.1186/s12890-025-03563-7","DOIUrl":"10.1186/s12890-025-03563-7","url":null,"abstract":"<p><strong>Background: </strong>Because of their high prevalence, chronic respiratory diseases, like asthma and chronic obstructive pulmonary disease, represent main public health problems. They are mainly treated through inhaled therapy. There is low adherence to such therapy, resulting in poor control of chronic respiratory diseases. However, more research is needed on the association of several factors with low adherence. The purpose of this study was to estimate the association of age, sex, type of drug, and frequency of administration with low adherence to inhaled therapy. In order to do this, we performed a cross-sectional study.</p><p><strong>Methods: </strong>We selected all patients treated with long-acting anticholinergics (LAMA), long-acting β2-adrenergics (LABA), LAMA/LABA, or inhaled corticosteroid (ICS)/LABA in the Health Area of Lleida on 16 March 2017. For each treatment, we determined the percentage of patients showing low adherence to therapy (less than 50%), calculated as drug boxes collected from the pharmacy with respect to the prescribed ones. Then, we analysed the association of age, sex, type of drug, and frequency of administration, with low adherence to therapy through a multivariate linear model.</p><p><strong>Results: </strong>11,128 people had electronic prescriptions for one of the inhaled therapy; of them, 24.6% (2,741) showed low adherence. The highest percentage of people with low adherence was found among young patients and women. Women 25-34 years of age included the highest percentage of patients with low adherence. As for drugs, the highest percentage of patients with low adherence was found among the ones treated with LABA and ICS/LABA. Finally, a higher percentage of patients with an administration frequency of 12 h presented low adherence, in comparison with patients treated every 24 h, in general and in the LABA and ICS/LABA groups.</p><p><strong>Conclusions: </strong>The differences that we observed in adherence to inhaled therapy according to the different factors analysed should be considered when managing chronic respiratory diseases and their impact on patients' clinical burden, quality of life, and costs for the health system.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"94"},"PeriodicalIF":2.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid and intense onset of granulation tissue formation following walnut aspiration: a case report.","authors":"Gökhan Aykun, Handan İnönü Köseoğlu","doi":"10.1186/s12890-024-03426-7","DOIUrl":"10.1186/s12890-024-03426-7","url":null,"abstract":"<p><p>Foreign body aspiration can affect individuals of all ages and lead to symptoms such as dyspnea, coughing, and wheezing. Complications may arise from the physical and chemical properties of the aspirated material as well as the duration of retention. This case study reports the early bronchoscopic and pathological findings of a 38-year-old male patient who aspirated walnuts. The patient underwent flexible bronchoscopy 14 h after aspiration, and a piece of walnut was successfully removed from the intermediate bronchus. During the procedure, the bronchial mucosa appeared extremely irregular and yellowish-green in color. Follow-up bronchoscopy one month later revealed regression of the previously observed granulation tissue. This case highlights the importance of early intervention in foreign body aspiration cases, especially with substances that can rapidly and intensely react with mucous membranes such as walnuts.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"96"},"PeriodicalIF":2.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative CT and COPD: cluster analysis reveals five distinct subtypes with varying exacerbation risks.","authors":"Chusheng Peng, Zizheng Chen, Haobin Zhou, Chaoyue Dai, Haolei Yuan, Yuan Gao, Fengyan Wang, Zhenyu Liang","doi":"10.1186/s12890-025-03562-8","DOIUrl":"10.1186/s12890-025-03562-8","url":null,"abstract":"<p><strong>Background: </strong>The heterogeneity of chronic obstructive pulmonary disease (COPD) is increasingly recognized. To characterize the heterogeneity of COPD, we aimed to identify subtypes related to quantitative CT by using principal component analysis (PCA) and cluster analysis.</p><p><strong>Methods: </strong>The data of 1879 participants in the SPIROMICS study were obtained from the NHLBI Biologic Specimen and Data Repository Information Coordinating Center. A combination of PCA and k-means clustering was used to analyze the data from these participants in the SPIROMICS study. We randomly split the samples into training and validation sets. Clusters were evaluated for their relationship with acute exacerbation risk throughout the entire follow-up period. The results of the training set were confirmed in the validation set. To avoid sampling errors, we conducted 10 random sampling cycles. Normalized mutual information (NMI) was applied in every cycle to evaluate the stability of clustering.</p><p><strong>Results: </strong>We identified five clusters related to quantitative CT characterized as follows: (1) male-dominated low disease impact cluster, (2) obesity with relatively high symptom burden cluster, (3) airway wall lesion cluster, (4) lung upper region zone-predominant emphysema cluster, (5) severe emphysema cluster. There are significant differences in acute exacerbation risk among these five clusters.</p><p><strong>Conclusions: </strong>Cluster analysis identified 5 clusters related to quantitative CT of all participants in the SPIROMICS cohort with significant differences in baseline characteristics and acute exacerbation risk. The stability of clustering results was validated through NMI in 10 sampling cycles. In addition, dimensionality reduction results showed high reproducibility in different studies.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"92"},"PeriodicalIF":2.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between lung consolidation size measured by ultrasound and outcome in ICU patients with respiratory failure.","authors":"Na Wang, Yi Chi, Qianling Wang, Yun Long, Dawei Liu, Zhanqi Zhao, Huaiwu He","doi":"10.1186/s12890-025-03564-6","DOIUrl":"10.1186/s12890-025-03564-6","url":null,"abstract":"<p><strong>Background: </strong>Lung ultrasound has been extensively used to assess the etiology of respiratory failure. Additionally, lung ultrasound-based scoring systems have been proposed to semi-quantify the loss of lung aeration in the ICU. The one most frequently used distinguishes four steps of progressive loss of aeration (scores from 0 to 3) and 3 scores mean tissue-like pattern. However, the burden of consolidation is not considered as tissue-like pattern is defined as 3 scores independently of its dimension. In this study, we present an ultrasound method for quantitative measurement of consolidation size and investigate the relationship between consolidation size and outcome in ICU patients with respiratory failure.</p><p><strong>Methods: </strong>A total of 124 patients in ICU were prospectively enrolled and 13 patients were excluded due to failure to obtain LUS measurements. Among the remaining 111 patients, 17 patients were non-intubated, and 94 patients under sedation and analgesia were intubated. All patients underwent lung ultrasound examination for the measurement of lung consolidation size between 24 and 48 h after ICU admission. Lung consolidation size was assessed by consolidation area index (CA), which was determined by tracing the maximum cross-sectional area of the region of consolidation. The Cox-regression model was constructed for 28- and 90-day mortality.</p><p><strong>Results: </strong>Consolidation size was successfully evaluated in all patients. The CA was 24.2cm²[15.9-36.6] (median [25th -75th percentiles]). CA was negatively correlated with PaO₂/FiO₂ ratio (r=-0.26, P < 0.0001). Upon univariate and multivariate analysis, only CA [Odds ratio (OR) 1.04, 95% CI 1.01-1.08, P = 0.004] and APACHEII (OR 1.14, 95% CI 1.05-1.25, P = 0.002) were the risk factors for ICU mortality. Patients with substantial CA (> 29.4cm²) had a higher risk of death in 28-day [Hazard ratio (HR) 4.35, 95%CI 1.70-11.11; Log-rank P = 0.017] and 90-day mortality (HR 4.10, 95%CI 1.62-10.39; Log-rank P < 0.01).</p><p><strong>Conclusions: </strong>The proposed CA parameter, determined by lung ultrasound, was readily accessible at the bedside. It is noteworthy that a larger CA was correlated with impaired oxygenation and increased mortality rates among ICU patients. Further investigation is required to establish the merits of incorporating CA into lung ultrasound assessments in the ICU.</p><p><strong>Trial registration: </strong>ClinicalTrial.gov, Identifier NCT05647967, Date: Dec 13, 2022, retrospectively registered.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"91"},"PeriodicalIF":2.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The systemic inflammation response index as risks factor for all-cause and cardiovascular mortality among individuals with respiratory sarcopenia.","authors":"Ying Liu, Xuejun Yin, Yutong Guo, Jixiong Xu, Ruitai Shao, Yunyuan Kong","doi":"10.1186/s12890-025-03525-z","DOIUrl":"10.1186/s12890-025-03525-z","url":null,"abstract":"<p><strong>Background: </strong>Respiratory sarcopenia is associated with poor outcomes, yet effective biomarkers for risk stratification remain limited. This study investigates the associations between complete blood count (CBC)-derived inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), neutrophil-monocyte-to-lymphocyte ratio (NMLR), and systemic inflammation response index (SIRI) and both all-cause and cardiovascular mortality in patients with respiratory sarcopenia.</p><p><strong>Methods: </strong>We conducted a cohort analysis of 1,673 adults with possible respiratory sarcopenia using data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2012, with mortality follow-up through December 31, 2019. Possible respiratory sarcopenia was assessed via peak expiratory flow rate (PEFR). Multivariable Cox regression models evaluated associations between NLR, NMLR, SIRI, and mortality outcomes, adjusted for demographic, socioeconomic, and health-related covariates. Additional CBC-derived biomarkers (PLR, dNLR, MLR, SII) were analysed, and mediation analysis assessed albumin's role as a partial mediator of mortality.</p><p><strong>Results: </strong>Over a median follow-up of 116 months, 263 deaths occurred, including 68 from cardiovascular causes. Elevated NLR, NMLR, and SIRI were significantly associated with increased risks of all-cause and cardiovascular mortality. SIRI emerged as the strongest predictor, with adjusted hazard ratios (HRs) of 1.65 (95% CI, 1.23-2.22) for all-cause mortality and 3.18 (95% CI, 1.83-5.53) for cardiovascular mortality. Albumin partially mediated the relationship between SIRI and all-cause mortality (12.1%).</p><p><strong>Conclusion: </strong>Elevated NLR, NMLR, and SIRI are associated with increased mortality risks in respiratory sarcopenia, with SIRI demonstrating the highest predictive power. Integrating SIRI into clinical assessments may aid in identifying high-risk patients, allowing for targeted interventions.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"90"},"PeriodicalIF":2.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Middle lobe tumors and lymphovascular invasion as independent predictors of recurrence-free survival in stage I NSCLC.","authors":"Mustafa Akyıl, Serkan Bayram","doi":"10.1186/s12890-025-03560-w","DOIUrl":"10.1186/s12890-025-03560-w","url":null,"abstract":"<p><strong>Background: </strong>Recurrence and metastases are prevalent in lung cancer, contributing to a concerning rate of treatment failure. As a result, there is a pressing need for multivariate analyses of prognostic utility in non-small cell lung cancer (NSCLC). This study reports on the factors influencing metastasis and recurrence-free survival (RFS) in patients with clinical stage I NSCLC who have undergone anatomic lung resection.</p><p><strong>Methods: </strong>This study included patients diagnosed with stage I NSCLC who received surgical treatment at our institution between January 2016 and December 2022. A careful examination was conducted of the patients' demographic, clinical, radiological, and histopathological data. The prognostic value of the recorded parameters was assessed according to recurrence and/or metastasis, considering RFS during follow-up assessments.</p><p><strong>Results: </strong>Among the 616 patients included in this study, the average age was 63 ± 8.9 years, with 506 (82.1%) of patients being male. During a median follow-up period of 50.4 ± 23.7 months (ranging from 1 to 89 months), 79 patients (12.8%) experienced recurrence or metastasis, while 41 patients (6.7%) died. Multivariate analysis showed no significant differences (p > 0.05) regarding recurrence or metastasis development when considering demographic characteristics, tumor size, operation forms, histopathologic types involved, perineural and visceral pleural invasion status, and aspects of oncological treatment. Conversely, the presence of lymphovascular invasion (p < 0.003) and tumor localization in the middle node (p < 0.045) emerged as significant predictors of RFS.</p><p><strong>Conclusion: </strong>In patients with early-stage NSCLC, the presence of lymphovascular invasion and localization of the tumor in the middle lobe are independent predictors of RFS.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"93"},"PeriodicalIF":2.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The first case of a solitary peripheral adenopapilloma of the lung with a risk of cancer.","authors":"Gui-Jiang Liu, Hu Chen, Chao Xu, Rui-Dong Ma, Xun Xia","doi":"10.1186/s12890-025-03541-z","DOIUrl":"10.1186/s12890-025-03541-z","url":null,"abstract":"<p><strong>Background: </strong>Solitary peripheral ciliated adenopapilloma of the lung (SPCAP) is a rare benign lung tumor, rarely located in the peripheral lung, and there is no report of canceration. Our case report suggests that it is likely to be cancerous. SPCAP classification remains inconclusion.Therefore, our case report can enrich the pathological database, improve clinicians' understanding of this disease and provide help for clinical diagnosis.</p><p><strong>Case presentation: </strong>A 41-year-old woman found a pulmonary nodule for 2 years by chest computed tomography (CT) and this chest -enhanced CT follow-up found that the wall of the nodule was slightly thickened, which could not rule out malignant tumor. Therefore, we recommend that patients be hospitalized for surgery.The patient had no notable habits such as a smoking history, drug dependence, or history of sexual misconduct. Physical examination and blood tumor markers were normal. Initially diagnosed with a benign lung tumor, SPCAP was finally diagnosed by thoracoscopic wedge resection of the right lower lobe, accompanied by a small area of atypical adenomatous hyperplasia of the alveolar epithelium.One week after the operation, the patient re-examined the chest CT, and was discharged without secondary lesions.</p><p><strong>Conclusions: </strong>SPCAP is a benign tumor with no previous reports of carcinoma in the literature, and the pathological manifestations of our case suggest atypical adenomatous hyperplasia and nuclear atypia.This may suggest the possibility of cancerous transformation of this tumor, and this case provides more knowledge about this tumor and it also provides a basis for surgical treatment.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"89"},"PeriodicalIF":2.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and clinical impact of coronary artery disease confirmed by coronary CT angiography in patients with interstitial lung disease.","authors":"Hyun Seok Kwak, Ho Cheol Kim, Hyun Jung Koo, Seung-Whan Lee, Pil Hyung Lee, Tae Oh Kim","doi":"10.1186/s12890-025-03554-8","DOIUrl":"10.1186/s12890-025-03554-8","url":null,"abstract":"<p><strong>Background: </strong>Patients with interstitial lung disease (ILD) who undergo routine chest computed tomography (CT) often have findings suggestive of coronary artery disease (CAD). However, the incidence and prognostic impact of significant CAD, confirmed by coronary CT angiography (CCTA), are not well established.</p><p><strong>Methods: </strong>From January 2013 to February 2024, we evaluated 215 patients from a retrospective ILD registry at our institute, who underwent CCTA as part of ILD management. Using the CAD-Reporting and Data System, we investigated the incidence of significant CAD and evaluated its impact on 5-year mortality and rehospitalization for respiratory or cardiovascular causes through multivariable Cox proportional hazards regression.</p><p><strong>Results: </strong>During a median follow-up of 2.3 years, CCTA was performed at a median of 5 months postdiagnosis of ILD in the cohort. Significant CAD was identified in 92 patients (42.8%), with 27 (12.6%) undergoing coronary revascularization. The presence of significant CAD was significantly associated with an increased risk of mortality (adjusted hazard ratio [HR]: 2.31; 95% confidence interval [CI]: 1.07 - 5.01; P = 0.03) and a higher risk of rehospitalization (adjusted HR: 2.03; 95% CI: 1.23 - 3.34; P = 0.01). Key clinical variables associated with significant CAD included older age (≥ 63 years), hypertension, and coronary calcification observed on non-gated chest CT.</p><p><strong>Conclusions: </strong>CCTA-identified CAD was associated with a worse clinical prognosis in patients with ILD, with significant risk factors including older age, hypertension, and coronary calcification observed on non-gated chest CT. These findings suggest that obtaining CCTA may be beneficial for managing patients with ILD, particularly those with identified risk factors.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"88"},"PeriodicalIF":2.6,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel, rapid, and effective technique for whole lung lavage in patients with pulmonary alveolar proteinosis and silicosis: retrospective study.","authors":"Eviatar Naamany, Karam Azem, Shai M Amor, Safo Awad, Lev Freidkin, Dror Rosengarten, Shimon Izhakian, Mordechai R Kramer","doi":"10.1186/s12890-025-03540-0","DOIUrl":"10.1186/s12890-025-03540-0","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary alveolar proteinosis (PAP) presents a significant challenge due to its progressive and potentially fatal nature. Whole lung lavage (WLL) is a key treatment for primary PAP with respiratory failure. Despite its efficacy, the lack of standardised protocols has led to diverse practice techniques across different institutions. Our study introduces a novel approach, employing a cardiopulmonary bypass (CPB) system for infusing lavage fluid, a method not previously utilised. This paper will share our pioneering experience with this technique at a tertiary referral centre, focusing on its implementation and safety profile.</p><p><strong>Methods: </strong>This retrospective study included patients aged ≥ 18 who underwent WLL for PAP or silicosis. Pre-lavage preparations included chest X-rays and pulmonary function tests (PFT). Preprocedural empiric antibiotics were administered. During lavage, warm saline was infused using a CPB, with cycles of normal saline infusion and degassing until fluid clarity was reached. Positioning techniques facilitated saline drainage. The procedure concluded with intravenous furosemide administration.</p><p><strong>Results: </strong>Fifty-two WLLs were identified between 2010 and 2024; complete data was available for 33 procedures. Of these, 91% were due to PAP, and 9% to silicosis. Almost half of the patients did not require additional WLL, while 43% needed sequential contralateral WLL. Median operative and mechanical ventilation times were 65 [58.5, 67.5] and 118 [97, 195] minutes, respectively. The median length of hospital stay was two days [2, 3]. Although not statistically significant, O2 saturation and a 6-minute walk distance increase were observed after the WLL.</p><p><strong>Conclusion: </strong>This study outlines our novel approach to WLL, which incorporates rapid saline infusion via a CPB system. Our findings indicate reduced procedure time while maintaining safety and efficacy for treating PAP and silicosis. Despite promising results, the retrospective design and small sample size limit generalizability. Further high-quality studies are warranted to validate and refine this technique.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"87"},"PeriodicalIF":2.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence and pattern of post tuberculosis lung disease including pulmonary hypertension from an Australian TB service; a single-centre, retrospective cohort study.","authors":"Anthony Byrne, Yasmeen Al-Hindawi, Marshall Plit, Louis Yeung, Standish Rigava, Meredith King, Kenneth Ng, Sean F Mungovan","doi":"10.1186/s12890-025-03549-5","DOIUrl":"10.1186/s12890-025-03549-5","url":null,"abstract":"<p><strong>Introduction: </strong>Post Tuberculosis Lung Disease (PTLD) is increasingly recognised as a significant cause of morbidity internationally, but has not been described in an Australian setting. We aimed to determine the prevalence of PTLD among adult TB survivors from an Australian TB service and describe the pattens of lung function abnormalities and pulmonary disease, including pulmonary hypertension.</p><p><strong>Methods: </strong>We conducted a single-centre retrospective cohort study in Sydney, Australia, including all adults who successfully completed TB treatment between January 2013 and December 2022. Baseline characteristics, post treatment pulmonary function, and thoracic computed tomography (CT) data were analysed to determine the prevalence and patterns of PTLD, defined as any lung function and/or radiological abnormality attributable to TB.</p><p><strong>Results: </strong>Among 119 confirmed TB patients (mean age 46 ± 21 years, 61% males) PTLD was identified in 81/119 (68%). Pulmonary function testing was available for 51/119 (43%), of whom 38/51(75%) exhibited abnormalities. Obstructive deficits were found in 25/51 (49%), restrictive deficits in 11/51 (22%), and impaired gas transfer capacity in 26/51 (51%). Chest CT scans were completed in 76/119 (64%), with 70/76 (92%) demonstrating significant abnormalities, including pulmonary fibrosis 43/76 (57%), bronchiectasis 22/76 (29%), and emphysema 11/76 (15%). Pulmonary hypertension was suspected in 52/76 (68%) patients based on radiological findings.</p><p><strong>Conclusion: </strong>Despite successful treatment, PTLD was frequently observed among our cohort of Australian TB survivors. Further research into optimal screening practices to diagnose chronic pulmonary diseases and pulmonary hypertension could provide opportunities for earlier intervention and management.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"84"},"PeriodicalIF":2.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}