BMC Pulmonary Medicine最新文献

{"title":"Cost effectiveness of a novel swallowing and respiratory sensation assessment and a modelled intervention to reduce acute exacerbations of COPD.","authors":"Isabella Epiu, Christine R Jenkins, Norma B Bulamu, Andreas Kuznik","doi":"10.1186/s12890-025-03615-y","DOIUrl":"https://doi.org/10.1186/s12890-025-03615-y","url":null,"abstract":"<p><p>Swallowing impairment observed in ~ 20% of people with Chronic Obstructive Pulmonary Disease (COPD) may increase the risk of aspiration pneumonia and acute exacerbations. We designed a decision analytic model to assess the cost-effectiveness of the Swallowing and Respiratory Sensation Assessment (SwaRSA) tests and swallowing rehabilitation to reduce COPD exacerbations. We believe that swallowing rehabilitation to improve coordination of swallowing and breathing may reduce exacerbations in people with COPD.From the Australia health system perspective, we assessed the cost effectiveness of four tests relative to standard of care, or no testing, over a time horizon of one year. The SwaRSA tests assessed relative to a standard of care arm of no testing: included the Eating Assessment Tool (EAT-10) score, Swallowing Capacity of Liquids, Tongue Strength Assessment, and Respiratory Sensation Assessment, in people with moderate to severe COPD. Outcome measures were COPD exacerbations per year, which were converted into quality adjusted life years (QALYs). Model inputs including costs, test sensitivities and specificities, COPD exacerbation risks, and exacerbation-related utilities were derived from published sources. Our assumptions on the costs, recovery, and risk reduction are based on the available data on pulmonary rehabilitation in COPD.Relative to no-SwaRSA, three individual testing strategies were found to be cost-effective at incremental cost effectiveness ratio per QALY ranging from $27,000 to $37,000 AUD assuming a willingness to pay of $50,000 AUD. The EAT-10 and the tongue strength were the two dominant options on the cost-effectiveness frontier. Model results were robust to variations in one-way and probabilistic sensitivity analyses.In COPD, SwaRSA modelling suggests that self-assessment with the EAT-10 and subsequent intervention is highly cost-effective relative to no-SwaRSA.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"165"},"PeriodicalIF":2.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between oxidative balance score and lung function and FeNO and mortality in the US population.","authors":"Chang Liu, Dan Liang, Guoan Xiang, Kun Xiao, Lixin Xie","doi":"10.1186/s12890-025-03626-9","DOIUrl":"https://doi.org/10.1186/s12890-025-03626-9","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The Oxidative Balance Score (OBS) is a new indicator of overall antioxidant/oxidant balance that provides a comprehensive picture of the body's overall oxidative stress status, with higher OBS indicating greater antioxidant exposure. A limited number of studies have examined the association between OBS and lung function and FeNO, and we aimed to investigate the possible relationship between OBS and lung function and FeNO.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Data utilized in this study were sourced from the 2007-2012 NHANES. Multivariable logistic regression was employed to investigate the association between OBS/lifestyle OBS (lifestyle antioxidants such as physical activity, etc., and lifestyle pro-oxidants such as alcohol, smoking, etc.)/dietary OBS (dietary antioxidants such as fiber, β-carotene, riboflavin, etc., and dietary pro-oxidants, such as total fat, etc.) and FEV1, FVC, PEF, FEF 25%- 75%, FeNO, as well as obstructive ventilation dysfunction. The dose-response association between the OBS and FEV1, FVC and PEF was explored using RCS analysis. Subgroup analysis and interaction tests were also conducted. We also used multivariable Cox regression modeling to explore the between OBS/lifestyle OBS/dietary OBS and all-cause and respiratory-related mortality.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 8,568 participants were enrolled. A statistically significant association was observed between OBS/lifestyle OBS/dietary OBS and FEV1, FVC, and PEF levels. There was no statistical association between OBS, lifestyle OBS, dietary OBS, and FeNO levels. RCS revealed a linear relationship between OBS and both FEV1 and FVC levels. Notably, the positive correlation between OBS and dietary OBS with FEV1 was more significant in male participants. Conversely, the relationship between OBS and FVC levels was influenced by gender and BMI. The effects of the overall OBS, lifestyle OBS, and dietary OBS on lung function parameters were independent of whether participants had restrictive ventilatory dysfunction or obstructive ventilatory dysfunction.In addition, both the overall OBS and dietary OBS demonstrated significant inverse associations with all-cause mortality, whereas no statistically significant relationships were observed between these scores and respiratory-related mortality. Notably, only lifestyle OBS exhibited a significant inverse association with respiratory-related mortality.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;In this study, OBS, lifestyle OBS, and dietary OBS levels were positively correlated with lung function parameters (FEV1, FVC and PEF) in U.S. adults. Exploring this association can enhance our understanding of how oxidative homeostasis influences lung function changes. This could provide valuable interventions for lung function decline. We also found that higher OBS was associated with lower all-cause mortality. Adopting a healthy lifestyle and consuming an antioxidant-rich diet may significantly improve the p","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"164"},"PeriodicalIF":2.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of pulmonary function pre and post mild SARS-CoV-2 infection among healthy adults.","authors":"Raz Roje Taib, Yuval Kozlov, Aya Ekshtein, Barak Gordon, Ori Wand, Oded Ben-Ari","doi":"10.1186/s12890-025-03613-0","DOIUrl":"https://doi.org/10.1186/s12890-025-03613-0","url":null,"abstract":"<p><strong>Background: </strong>SARS-CoV-2 infection frequently involves the respiratory system and may impact on pulmonary function tests (PFT) of recovered individuals. Studies which compare post-COVID-19 PFT to pre-illness measurements are scarce. The primary objective of this study was to assess the effect of COVID-19 on PFT soon after infection.</p><p><strong>Methods: </strong>In this prospective observational study, PFT were measured early following recovery from COVID-19 among healthy military aircrew. Spirometry values were compared to pre-COVID-19 measurements, and abnormality rates of lung volumes and diffusion capacity for carbon monoxide (DLCO) were assessed.</p><p><strong>Results: </strong>The study included 252 aviators, 97.6% males, mean age 34.9-years, following recovery from SARS-CoV-2 infection. Participants manifested mild symptoms (79.4%) or were asymptomatic (20.6%). Post-COVID-19 spirometry results 10.79 ± 5.67 days following infection were compared to measurements performed 41.3 ± 28.59 months earlier. Pre- and post-COVID-19 results were comparable, with similar minimal abnormalities rates (2% and 4.4%, respectively). In addition, there were no restrictive abnormalities following infection, and just 7.7% of individuals had a marginally low DLCO of 70-80% of predicted.</p><p><strong>Conclusion: </strong>Among vaccinated, healthy adults, mild COVID-19 had no significant impact on PFT early post-infection. The data suggest that systematic PFT testing might not be necessary for asymptomatic healthy individuals who recovered from mild COVID-19.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"163"},"PeriodicalIF":2.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative diagnostic accuracy of pre-test clinical probability scores for the risk stratification of patients with suspected pulmonary embolism: a systematic review and Bayesian network meta-analysis.","authors":"Ali Etemadi, Mohammadmobin Hosseini, Hamed Rafiee, Amir Mahboubi, Tara Mahmoodi, Toshiki Kuno, Yaser Jenab, Claire E Raphael, Wilbert S Aronow, Kaveh Hosseini, Jay Giri","doi":"10.1186/s12890-025-03637-6","DOIUrl":"https://doi.org/10.1186/s12890-025-03637-6","url":null,"abstract":"<p><strong>Background: </strong>The primary evaluation of pulmonary embolism (PE) is complicated by the presence of various pre-test clinical probability scores (pCPS) with different cut-offs, all equally recommended by guidelines. This lack of consensus has led to practice variability, unnecessary imaging, and worse patient outcomes. We aim to provide more definitive insights through a holistic comparison of available pCPS.</p><p><strong>Methods: </strong>PubMed, Embase and Web of Science, and Google Scholar were searched for studies evaluating pCPS in patients clinically suspected of PE until June 2023. Risk of bias was evaluated using QUADAS-2. Included pCPS were evaluated based on their diagnostic accuracy in: (1) Ruling-out PE (2) Utilization of imaging, and (3) Differentiating between patients needing d-dimer from imaging. Diagnostic test accuracy indices were synthesized using beta-binomial Bayesian methods.</p><p><strong>Results: </strong>Forty studies (37,027 patients) were included in the meta-analysis. Three-tier revised Geneva (RG) and three-tier Wells performed similarly in ruling-out PE (negative likelihood ratio (LR-) [95% credible interval (CI)]: 0·39[0·27-0·58] vs 0·34[0·25-0·45]). However, RG performed better in utilization of imaging (LR + : 6·65[3·75-10·56] vs 5·59[3·7-8·37], p < 0.001) and differentiating between patients needing d-dimer vs imaging (diagnostic odds ratio (DOR): 8·03[4·35-14·1] vs. 7·4[4·65-11·84], p < 0.001). The two-tier Wells score underperformed in all aspects (LR-: 0·56[0·45-0·68], LR + : 2·43[1·81-3·07], DOR: 4·41[2·81-6·43]). PERC demonstrated a reliable point estimate for ruling out PE, albeit with a wide CI (LR-: 0·36[0·17-0·78]).</p><p><strong>Conclusions: </strong>RG outperforms other pCPS for primary evaluation of suspected PE. While the difference is not large, RG's independence from subjective items supports its recommendation over three-tier Wells. Two-tier Wells underperforms significantly compared to the rest of pCPS. PERC shows considerable promise for minimizing unnecessary D-dimer testing in crowded emergency departments; however, more evidence is needed before its definitive recommendation.</p><p><strong>Protocol registration: </strong>PROSPERO (CRD42023464118).</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"162"},"PeriodicalIF":2.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnostic value of combined pulmonary function test and exhaled nitric oxide monitoring in cough variant asthma with or without gastroesophageal reflux disease: a retrospective study.","authors":"Sen Li, Siyao Xu, Yuan Yang, Zhe Wang, Yaru Hou","doi":"10.1186/s12890-025-03636-7","DOIUrl":"https://doi.org/10.1186/s12890-025-03636-7","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate the effect of fractional exhaled nitric oxide (FeNO), a marker of airway inflammation, together with small airway function tests in diagnosing cough variant asthma (CVA), particularly in patients with gastroesophageal reflux disease (GERD).</p><p><strong>Methods: </strong>This retrospective cohort study included adult patients with chronic cough for more than eight weeks who were divided into a CVA group and a control group. Participants underwent pulmonary function tests and FeNO measurements. Statistical tests and ROC curve analysis were used to assess diagnostic accuracy.</p><p><strong>Results: </strong>CVA patients had higher FeNO levels than controls, regardless of with or without GERD. There were no significant differences in FEV1, FVC, and FEV1/FVC ratio between the control and CVA groups, but CVA patients had significantly lower MEF25, MEF50, MEF75, and MMEF values. FeNO was negatively correlated with MEF50, MEF75, and MMEF. The AUC of FeNO in diagnosing CVA was 0.862. Combining FeNO with MMEF resulted in the highest diagnostic accuracy (AUC = 0.909). The diagnostic benefits of FeNO and FeNO + MMEF were similar in GERD patients.</p><p><strong>Conclusion: </strong>Combining FeNO with small airway function tests, especially MMEF, can improve the diagnostic accuracy of CVA, while FeNO and FeNO + MMEF performed similar diagnostic accuracy in patients with GERD.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"161"},"PeriodicalIF":2.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting survival and prognosis in extensive stage small cell lung cancer.","authors":"Mert Erciyestepe, Ömer Burak Ekinci, Hale Gülçin Yıldırım Doğan, Ahmet Emin Öztürk, Okan Aydın, Aslı Büyükkuşcu, Tugay Atasever, Beyza Soylu Uslu, Kübra Akkaya, Emir Çelik, Kayhan Ertürk, Muhammed Mustafa Atcı","doi":"10.1186/s12890-025-03625-w","DOIUrl":"https://doi.org/10.1186/s12890-025-03625-w","url":null,"abstract":"<p><p>Although chemotherapy significantly improves the quality of life and prolongs survival in patients with extensive-stage small cell lung cancer (ES-SCLC), relapse is almost inevitable, with only 5% of patients surviving two years after the initial diagnosis. Prophylactic cranial irradiation (PCI) is considered for patients who achieve a complete response, as it has been shown to improve survival rates in this population. Recent studies have also demonstrated that adding PD-L1 inhibitors, such as atezolizumab or durvalumab, to chemotherapy in first-line treatment significantly enhances survival compared to chemotherapy alone. Our study was conducted retrospectively at a single center, including 280 patients with ES-SCLC who began therapy at our institution between July 2009 and February 2023. Patients who underwent thoracic residual radiotherapy (p< 0.001) and PCI (p< 0.001) showed statistically significant improvements in OS. In the first-line treatment group, the median overall survival (OS) for patients receiving cisplatin+etoposide was 12.0 months (10.71 - 13.28), while those treated with carboplatin+etoposide had a median OS of 7.0 months (4.58 - 9.41). For patients receiving carboplatin+etoposide+atezolizumab, the median OS was 35.0 months (21.32 - 48.67), and a statistically significant difference was observed (p< 0.001). In our study, the median OS was 7 months in patients who received ≤ 4 cycles of treatment in the first line and 14 months in patients who received > 4 cycles of treatment. After first-line treatment, the proportion of patients with progression-free survival (PFS) between 0 - 3 months was 21%, and between 3 - 6 months was 24%. PFS was notably worse in those with bone, liver, or brain metastases at diagnosis in the first-line treatment. Multivariate analysis revealed that carboplatin+etoposide+atezolizumab in the first line and cisplatin+etoposide in the second line reduced the risk of both progression and death, while PCI reduced the risk of death. In conclusion, ES-SCLC remains one of the most challenging malignancies, characterized by poor survival rates and short progression-free intervals. Multiple factors influence OS and PFS, some of which are intrinsic to the patient and disease at diagnosis. In contrast, others, such as treatment modalities, the number of treatment cycles, and the application of radiotherapy, can be modified by clinicians.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"160"},"PeriodicalIF":2.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of video-assisted thoracic surgery versus open thoracotomy on postoperative wound infections in lung cancer patients: a systematic review and meta-analysis.","authors":"Jie-Qiong Wang, Zhao-Juan Ma","doi":"10.1186/s12890-025-03589-x","DOIUrl":"10.1186/s12890-025-03589-x","url":null,"abstract":"<p><strong>Background: </strong>Lung cancer surgery has evolved significantly, with minimally invasive video-assisted thoracic surgery (VATS) procedures being compared with traditional open thoracotomies. The incidence of postoperative wound infections is a significant factor influencing the choice of surgical technique. This systematic review and meta-analysis aim to evaluate the impact of thoracoscopic versus open thoracotomy procedures on postoperative wound infections in lung cancer patients.</p><p><strong>Methods: </strong>Following PRISMA guidelines, a comprehensive search across PubMed, Embase, Web of Science, and the Cochrane Library was conducted on September 19, 2023, without time or language restrictions. Peer-reviewed randomized controlled trials, cohort studies, and case-control studies reporting on postoperative wound infections were included. Studies not differentiating between surgical techniques or focusing on irrelevant populations were excluded. Data extraction and quality assessment were independently carried out by two reviewers, using a fixed-effect model for meta-analysis due to the absence of significant heterogeneity (I² = 0.0%, P = 0.766).</p><p><strong>Results: </strong>A total of six articles were included. The quality assessment indicated a low risk of bias in most domains. The pooled results showed that open thoracotomy procedures had a twofold increased risk of postoperative wound infections (OR = 2.00, 95% CI: 1.04-3.85) compared to VATS procedures. Publication bias assessment using funnel plots and Egger's test revealed no significant biases (P > 0.05).</p><p><strong>Conclusions: </strong>The findings suggest that VATS is associated with a lower risk of postoperative wound infections compared to open thoracotomy, which has implications for surgical decision-making in lung cancer treatment.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"159"},"PeriodicalIF":2.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of tracheal diameter with respiratory function and fibrosis severity in idiopathic pulmonary fibrosis patients.","authors":"Nevin Fazlıoğlu, Hadi Sasani, Mithat Fazlıoğlu, Ezgi Pınar Çiftçi, Levent Cem Mutlu","doi":"10.1186/s12890-025-03624-x","DOIUrl":"10.1186/s12890-025-03624-x","url":null,"abstract":"<p><strong>Background: </strong>In this research project, we examined the relationship between tracheal size and respiratory function in individuals with Idiopathic Pulmonary Fibrosis (IPF). IPF is a long-term condition that affects the functioning of the lungs.</p><p><strong>Methods: </strong>This retrospective study included 86 patients diagnosed with IPF. Tracheal and bronchial diameters were measured using high-resolution computed tomography (HRCT) and pulmonary function tests (PFTs); Force vital capacity (FVC), diffusion capacity for carbon monoxide (DLCO) and the gender, age, physiology (GAP) index was calculated. Patients were grouped according to demographic characteristics such as age, gender and smoking.</p><p><strong>Results: </strong>There was a significant positive correlation between the anteroposterior (AP) and transverse diameters of the trachea in the subcricoid region and the GAP index (r = 0.318, p = 0.003 and r = 0.312, p = 0.004, respectively). Similarly, subcricoid and carina areas were significantly correlated with both GAP index (r = 0.307, p = 0.006 and r = 0.334, p = 0.003, respectively) and FVC/DLCO ratio (r = 0.218, p = 0.049 and r = 0.245, p = 0.027, respectively). The main bronchial areas were also positively correlated with the GAP index, but no significant correlation was found between FVC and DLCO values and airway measurements. Each unit increase in GAP index was associated with a 1.69-fold increase in mortality risk (p = 0.0016, 95% confidence interval: 1.22-2.34).</p><p><strong>Conclusion: </strong>Tracheal and main bronchial areas can be used as potential biomarkers in the assessment of disease severity and prognosis in IPF patients. In particular, the significant correlation of subcricoid and carina areas with both GAP index and FVC/DLCO ratio suggests that these measurements may be useful in the evaluation of disease progression.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"157"},"PeriodicalIF":2.6,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of active tuberculosis with pulmonary thromboembolism.","authors":"Yue Jia, Haimei Bo, Liang Tang, Zhiling Li, Ziyi Yu, Zhili Hou, Hongzhi Yu, Qi Wu","doi":"10.1186/s12890-025-03602-3","DOIUrl":"10.1186/s12890-025-03602-3","url":null,"abstract":"<p><strong>Background: </strong>In this study, we summarized clinical characteristics in patients with active tuberculosis (ATB) complicated by pulmonary thromboembolism (PTE), to further determine the influencing factors of PTE in ATB patients.</p><p><strong>Methods: </strong>The study population consisted of ATB patients who were first seen and hospitalized from January 2014 to January 2022 in Haihe Hospital. The diagnosis of PTE was confirmed by computed tomography pulmonary angiography (CTPA), and the ATB patients were divided into a test group with PTE and a control group without PTE in this study. The Padua score is a guideline-recommended validated tool for venous thromboembolism (VTE) risk assessment in medical patients. The two groups were retrospectively compared and analyzed by clinical characteristics, including gender, age, Padua score, clinical symptoms, tuberculosis (TB) classification, routine blood tests, coagulation indexes, inflammatory indexes, imaging manifestations, and rifampicin application, etc. RESULTS: There are 43 patients diagnosed with ATB complicated by PTE in this study, including 27 males (62.8%) and 16 females (37.2%), with a ratio of 1.69. Compared with the control group, test group showed higher Padua score, more frequent chest tightness and dyspnea, higher D-dimer, but with lower arterial partial pressure of carbon dioxide. Pathologically, more lobes in the test group patients had pulmonary lesions, with higher occurance in the lower and middle lobes, more image manifestations of pulmonary infarction and atelectasis. Lastly, CTPA traits showed that peripheral types are more than central types in the test group.</p><p><strong>Conclusions: </strong>ATB patients should be alert to the occurrence of PTE and consider initiating anticoagulant therapy, if they have anemia, hypoproteinemia, increased D-dimer, increased inflammatory indicators, serious imaging, more pulmonary lobe involvement and lower lobe involvement.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"156"},"PeriodicalIF":2.6,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide analysis of m6A-modified circRNAs in the mouse model of myocardial injury induced by obstructive sleep apnea.","authors":"Jiuhuang Lan, Yuhui Wang, Chang Liu, Hongli Chen, Qingshi Chen","doi":"10.1186/s12890-025-03609-w","DOIUrl":"10.1186/s12890-025-03609-w","url":null,"abstract":"<p><strong>Background: </strong>The peculiar expression of N6-methyladenosine (m6A) in Circular RNAs (circRNAs) is closely linked to the occurrence of many diseases. However, roles of m6A-modified circRNAs in OSA-induced cardiovascular disease are unknown. Here, we use bioinformatics analysis to investigate the expression profiles of m6A-modified circRNAs and reveal their potential functional roles in the mouse models of chronic intermittent hypoxia (CIH).</p><p><strong>Methods: </strong>Firstly, the expression profiles of m6A-modified circRNA in left ventricular tissue of the CIH mouse model were examined using circRNA microarray analysis. Then, the expression level of selected circrRNA was compared by folding change filtration, and the consistency between them and microarray results was verified by MeRIP-qPCR. GO analyses and KEGG analyses were conducted to predict the potential functions of these m6A-modified circRNAs. Finally, we conducted a ceRNA analysis, and a network was constructed to clarify the relationship between the selected circRNAs and miRNAs as well as the targeted genes.</p><p><strong>Results: </strong>In total, 255 circRNAs with m6A peaks in CIH-treated cardiac tissues were identified. 250 were up-regulated, 5 were down-regulated. The results of MeRIP-qPCR were consistent with the microarray results. 73 pathways were detected in the up-regulated transcripts and no relevant pathways were detected in the down-regulated transcripts. Finally, three circRNAs (mmu_circRNAs_22543, mmu_circRNAs_29768, and mmu_circRNAs_34841) were selected for ceRNA analysis, and the circRNA-miRNA-mRNA network was constructed.</p><p><strong>Conclusion: </strong>Our findings are the first to show that m6A-modified circRNAs play a key role in OSA-induced cardiovascular disease. This study highlights the pivotal role of m6A-modified circRNAs in regulating gene expression and their potential implications in understanding the molecular pathogenesis of OSA-induced cardiac injury.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"158"},"PeriodicalIF":2.6,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}