BMC Pulmonary Medicine最新文献

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Forced vital capacity of healthy Iranian adults in Tehran. 德黑兰健康伊朗成年人的被迫肺活量。
IF 2.8 3区 医学
BMC Pulmonary Medicine Pub Date : 2025-10-22 DOI: 10.1186/s12890-025-03882-9
Hamidreza Jamaati, Maryam Akhtari, Parisa Sadat Madani, Somayeh Lookzadeh, Alireza Eslaminejad, Hooman Sharifi
{"title":"Forced vital capacity of healthy Iranian adults in Tehran.","authors":"Hamidreza Jamaati, Maryam Akhtari, Parisa Sadat Madani, Somayeh Lookzadeh, Alireza Eslaminejad, Hooman Sharifi","doi":"10.1186/s12890-025-03882-9","DOIUrl":"https://doi.org/10.1186/s12890-025-03882-9","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"486"},"PeriodicalIF":2.8,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of non-invasive ventilation in chronic obstructive pulmonary disease management: a systematic review and meta-analysis of randomized controlled trials. 无创通气在慢性阻塞性肺疾病治疗中的疗效:随机对照试验的系统回顾和荟萃分析
IF 2.8 3区 医学
BMC Pulmonary Medicine Pub Date : 2025-10-22 DOI: 10.1186/s12890-025-03857-w
Jiukang Li, Liping Ran
{"title":"Efficacy of non-invasive ventilation in chronic obstructive pulmonary disease management: a systematic review and meta-analysis of randomized controlled trials.","authors":"Jiukang Li, Liping Ran","doi":"10.1186/s12890-025-03857-w","DOIUrl":"https://doi.org/10.1186/s12890-025-03857-w","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"485"},"PeriodicalIF":2.8,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics and risk factors for thrombocytopenia in malignancy patients with pulmonary embolism: a case control study. 恶性肿瘤合并肺栓塞患者血小板减少的特点和危险因素:一项病例对照研究。
IF 2.8 3区 医学
BMC Pulmonary Medicine Pub Date : 2025-10-21 DOI: 10.1186/s12890-025-03946-w
Hongyuan Kong, Kexin Dong, Yuan Wang, Yan Bian, Lin Wang, Limei Qian, Zhaoxing Cui, Jin Yang, Rui Fu, Zhenkun Li
{"title":"Characteristics and risk factors for thrombocytopenia in malignancy patients with pulmonary embolism: a case control study.","authors":"Hongyuan Kong, Kexin Dong, Yuan Wang, Yan Bian, Lin Wang, Limei Qian, Zhaoxing Cui, Jin Yang, Rui Fu, Zhenkun Li","doi":"10.1186/s12890-025-03946-w","DOIUrl":"10.1186/s12890-025-03946-w","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"483"},"PeriodicalIF":2.8,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12538738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global, regional, and national burden of asthma from 1990 to 2021: analysis of data from global disease burden in 2021. 1990年至2021年全球、区域和国家哮喘负担:2021年全球疾病负担数据分析
IF 2.8 3区 医学
BMC Pulmonary Medicine Pub Date : 2025-10-21 DOI: 10.1186/s12890-025-03816-5
Cong Hu, Shuxiong Nong, Yixin Chen, Lin Zhang, Yongfeng Chen, Chenang Liu, Ping Li, Chilin Liao, Meng Wu
{"title":"Global, regional, and national burden of asthma from 1990 to 2021: analysis of data from global disease burden in 2021.","authors":"Cong Hu, Shuxiong Nong, Yixin Chen, Lin Zhang, Yongfeng Chen, Chenang Liu, Ping Li, Chilin Liao, Meng Wu","doi":"10.1186/s12890-025-03816-5","DOIUrl":"10.1186/s12890-025-03816-5","url":null,"abstract":"<p><strong>Background: </strong>Asthma is one of the diseases that pose a serious threat to human health globally. The Global Burden of Disease (GBD) study from 1990 to 2021 conducted a comprehensive assessment of the prevalence, incidence, mortality, and Disability-Adjusted Life Years (DALY) of asthma. This study particularly focuses on the integration of prevalence data with other indicators and carries out stratified analyses at the global, regional, and national levels based on gender, age, and Socio-Demographic Index (SDI).</p><p><strong>Methods: </strong>The data for this study is drawn from the 2021 Global Burden of Disease (GBD) study, which provides comprehensive data on diseases, injuries, and risk factors. This study aims to explore the temporal trends of asthma and assess the dynamics of age-standardized prevalence rates (ASPR), incidence rates (ASIR), death rates (ASDR), and disability-adjusted life years (DALYs) for asthma, with the goal achieved by estimating the annual percentage change (EAPC) over the study period. The study conducted a detailed stratification based on gender, 20 age groups, 21 GBD regions, 204 countries and territories, and 5 SDI quintiles.</p><p><strong>Results: </strong>In 2021, asthma continued to impose a substantial burden on the global health landscape, with a total of 260479186.9 (227209547.5-297967236.9) cases and an ASPR of 3340.1 (2905.2-3832.2 per 100,000 people. The ASIR was 37864175.4 (31381241-46919993.7), translating to 516.7 (425.4-646.1) per 100,000 people. In 2021, the number of disability-adjusted life years (DALYs) attributed to asthma was 21422859.9 (16956877.7-26887091.7), and the ASDR was 264.6 (208.3-333.4) per 100,000 people. Analyzing regional disparities, it was observed that High SDI regions had the highest ASPR, and ASIR, while Low SDI regions had the lowest ASDR and Age-standardized DALY rates. Geographically, Kazakstan and Pakistan stood out with the high ASPR, and Papua New Guinea stood out with the highest ASDR, and Age-standardized DALY rates. Asthma primarily affects minors, with no significant difference between males and females. High BMI has emerged as the most important risk factor for asthma-related DALYs globally.</p><p><strong>Conclusion: </strong>This pattern indicates a complex relationship between socio-economic development and health outcomes. Regions with higher Socio-Demographic Index (SDI), which typically represent more developed areas, tend to have a higher prevalence of asthma but lower mortality rates and disease burden. These patterns highlight the necessity for low-income regions to learn from the targeted public health measures of high-income areas in developing asthma management plans, in order to address the inequalities in asthma outcomes.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"481"},"PeriodicalIF":2.8,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12538757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical analysis of the efficacy of bronchial artery embolization with gelatin sponge in our hospital for cryptogenic hemoptysis: a single-center, retrospective, observational study. 我院明胶海绵支气管动脉栓塞治疗隐源性咯血的临床分析:单中心回顾性观察研究。
IF 2.8 3区 医学
BMC Pulmonary Medicine Pub Date : 2025-10-21 DOI: 10.1186/s12890-025-03948-8
Manabu Suzuki, Satoki Hatano, Chie Morita, Akinari Tsukada, Akane Ishida, Yusaku Kusaba, Masao Hashimoto, Go Naka, Jin Takasaki, Hiroshi Nokihara, Shinyu Izumi, Yuichiro Takeda, Masayuki Hojo, Haruhito Sugiyama
{"title":"Clinical analysis of the efficacy of bronchial artery embolization with gelatin sponge in our hospital for cryptogenic hemoptysis: a single-center, retrospective, observational study.","authors":"Manabu Suzuki, Satoki Hatano, Chie Morita, Akinari Tsukada, Akane Ishida, Yusaku Kusaba, Masao Hashimoto, Go Naka, Jin Takasaki, Hiroshi Nokihara, Shinyu Izumi, Yuichiro Takeda, Masayuki Hojo, Haruhito Sugiyama","doi":"10.1186/s12890-025-03948-8","DOIUrl":"10.1186/s12890-025-03948-8","url":null,"abstract":"<p><strong>Background and objective: </strong>Hemoptysis is a life-threatening condition requiring urgent treatment. Bronchial artery embolization (BAE), established as the primary intervention, is an effective treatment for hemoptysis. Common etiologies include bronchiectasis, tumors, tuberculosis, aspergilloma, and cystic fibrosis. Approximately 20% of hemoptysis cases are categorized as cryptogenic. We conducted a retrospective observational study to understand the clinical characteristics of patients with cryptogenic hemoptysis (CH).</p><p><strong>Methods: </strong>The clinical characteristics, angiographic findings, and immediate and long-term efficacies of BAE were retrospectively analyzed in 36 consecutive patients between January 2010 and December 2022. Superselective BAE was successfully performed in all patients by using a gelatin sponge (GS).</p><p><strong>Results: </strong>The median age was 68 years, and 21 patients (58.3%) were male. Among them, 15 patients (41.7%) presented with massive hemoptysis, and 7 (19.4%) required intubation. Angiographic evaluation revealed the treatment of total 57 vessels, comprising 51 (89.5%) bronchial arteries, 5 (8.8%) intercostal arteries, and 1 (1.8%) inferior transverse artery. The recurrence-free rates were 100% at 1 month, 94.4% at 3 months, 94.4% at 12 months, and 86.1% at more than 12 months. Only one patient required a second BAE for hemoptysis, while others were managed for recurrences with oral hemostatic agents. No serious complications, such as spinal cord infarction, were observed during the study period.</p><p><strong>Conclusion: </strong>BAE treatment with GS for CH proved to be a suitable therapeutic modality, demonstrating high efficacy in halting bleeding in both the short and long terms, with the absence of severe complications, including spinal cord infarction.</p><p><strong>Trial registration: </strong>This study was retrospectively registered for the UMIN Clinical Trial Registry (UMIN000042050) on October 8th, 2020.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"480"},"PeriodicalIF":2.8,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12539079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deep learning based CT images for lung function prediction in patients with chronic obstructive pulmonary disease. 基于深度学习的CT图像预测慢性阻塞性肺疾病患者肺功能。
IF 2.8 3区 医学
BMC Pulmonary Medicine Pub Date : 2025-10-21 DOI: 10.1186/s12890-025-03957-7
Ruihan Li, Hui Guo, Qian Wu, Jinhuan Han, Shuqin Kang
{"title":"Deep learning based CT images for lung function prediction in patients with chronic obstructive pulmonary disease.","authors":"Ruihan Li, Hui Guo, Qian Wu, Jinhuan Han, Shuqin Kang","doi":"10.1186/s12890-025-03957-7","DOIUrl":"10.1186/s12890-025-03957-7","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The World Health Organization predicts that by 2030, chronic obstructive pulmonary disease (COPD) will be the third leading cause of death and the seventh leading cause of morbidity worldwide. Pulmonary function tests (PFT) are the gold standard for COPD diagnosis. Since COPD is an incurable disease that takes a considerable amount of time to diagnose, even by an experienced specialist, it becomes important to provide an analysis of abnormalities in a simple manner. Although many deep learning (DL) methods based on computed tomography (CT) have been developed to identify COPD, the pathological changes of COPD based on CT are multi-dimensional and highly spatially heterogeneous, and their predictive performance still needs to be improved.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The purpose of this study was to develop a DL-based multimodal feature fusion model to accurately estimate PFT parameters from chest CT images and verify its performance.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;In this retrospective study, participants underwent chest CT examination and PFT at the Fourth Clinical Medical College of Xinjiang Medical University between January 2018 and July 2024. In this study, the 1-s forced expiratory volume (FEV1), forced vital capacity (FVC), 1-s forced expiratory volume ratio forced vital capacity (FEV1/FVC), 1-s forced expiratory volume to predicted value (FEV1%), and forced vital capacity to predicted value (FVC%) of PFT parameters were used as predictors and the corresponding chest CT of 3108 participants. The data were randomly assigned to the training group and the validation group at a ratio of 9:1, and the model was cross-validated using 10-fold cross-validation. Each parameter was trained and evaluated separately on the DL network. The mean absolute error (MAE), mean squared error (MSE), and Pearson correlation coefficient (r) were used as evaluation indices, and the consistency between the predicted and actual values was analyzed using the Bland-Altman plot. The interpretability of the model's prediction process was analyzed using the Grad-CAM visualization technique.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 2408 subjects were included (average age 66 ± 12 years; 1479 males). Among these, 822 cases were used for encoder training to extract image features, and 1,586 cases were used for the development and validation of a multimodal feature fusion model based on a multilayer perceptron (MLP). The MAE, MSE, and r predicted between PFT and model estimates for FEV1 were 0.34, 0.20, and 0.84, respectively. For FVC, the MAE, MSE, and r were 0.42, 0.31, and 0.81, respectively. For FEV1/FVC, the MAE, MSE, and r were 6.64, 0.73, and 0.77, respectively. For FEV1%, the MAE, MSE, and r were 13.42, 3.01, and 0.73, respectively. For FVC%, the MAE, MSE, and r were 13.33, 2.97, and 0.61, respectively. It was observed that there was a strong correlation between the measured and predicted indices of FEV1, FVC, FEV","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"484"},"PeriodicalIF":2.8,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12542279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive value analysis of diaphragmatic ultrasound evaluation for mechanical ventilation outcomes in patients with acute exacerbation of chronic obstructive pulmonary disease. 膈超声评价慢性阻塞性肺疾病急性加重期机械通气预后的预测价值分析。
IF 2.8 3区 医学
BMC Pulmonary Medicine Pub Date : 2025-10-17 DOI: 10.1186/s12890-025-03567-3
Leilei Qu, Wenping Zhao, Wei Zhang, Jiping Li
{"title":"Predictive value analysis of diaphragmatic ultrasound evaluation for mechanical ventilation outcomes in patients with acute exacerbation of chronic obstructive pulmonary disease.","authors":"Leilei Qu, Wenping Zhao, Wei Zhang, Jiping Li","doi":"10.1186/s12890-025-03567-3","DOIUrl":"10.1186/s12890-025-03567-3","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) exacerbations often necessitate mechanical ventilation. Weaning from ventilation poses challenges, especially due to diaphragmatic dysfunction. We evaluated the predictive value of diaphragmatic ultrasound for mechanical ventilation outcomes in COPD patients during acute exacerbations.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 200 patients experiencing acute COPD exacerbations between June 2020 and September 2023. We identified these patients using the ICD-10 codes for COPD (J44.x) and acute exacerbations from our electronic medical record system.Patients underwent diaphragmatic ultrasound assessments and were then grouped based on weaning success or failure. The study investigated parameters such as the E-T index, diaphragmatic displacement (DD), and diaphragmatic thickening fraction (DTF), correlating them with weaning outcomes. Correlation and receiver operating characteristic (ROC) analyses were employed to ascertain predictive values.</p><p><strong>Results: </strong>The E-T index, DD, and DTF were significantly higher in the success group, indicating these parameters as predictors of successful weaning. The E-T index (rho = -0.254, P < 0.001), DD (rho = -0.269, P < 0.001), and DTF (rho = -0.201, P = 0.004) negatively correlated with weaning failure. Conversely, the diaphragmatic Rapid Shallow Breathing Index (D-RSBI) positively correlated with failure (rho = 0.179, P = 0.011). Higher LUS scores predicted weaning failure (P = 0.029). Combined analysis of ultrasound indicators demonstrated an area under the curve (AUC) of 0.905, highlighting the model's predictive utility.Additional correlations showed that higher PaCO₂ before weaning was linked with lower DD, suggesting an association between impaired diaphragmatic mechanics and elevated CO₂ levels.</p><p><strong>Conclusion: </strong>Diaphragmatic ultrasound was a valuable tool for assessing readiness for mechanical ventilation weaning in COPD exacerbations, enhancing the precision of clinical decisions.Our findings also suggest that a threshold E-T index of ∼ 1.915 and DTF of ∼ 42.475% may have clinical relevance in identifying successful weaners.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"478"},"PeriodicalIF":2.8,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12535007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical lung volume reduction eligibility in an emphysema patient pool referred for endoscopic treatment. 肺气肿患者池中的手术肺体积缩小资格转介内镜治疗。
IF 2.8 3区 医学
BMC Pulmonary Medicine Pub Date : 2025-10-17 DOI: 10.1186/s12890-025-03954-w
Christelle M Vandervelde, Jorine E Hartman, Karin Klooster, Wim Janssens, Stephanie Everaerts, Sofian Bouneb, Walter Weder, Dirk-Jan Slebos, Laurens J Ceulemans
{"title":"Surgical lung volume reduction eligibility in an emphysema patient pool referred for endoscopic treatment.","authors":"Christelle M Vandervelde, Jorine E Hartman, Karin Klooster, Wim Janssens, Stephanie Everaerts, Sofian Bouneb, Walter Weder, Dirk-Jan Slebos, Laurens J Ceulemans","doi":"10.1186/s12890-025-03954-w","DOIUrl":"10.1186/s12890-025-03954-w","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"479"},"PeriodicalIF":2.8,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12534989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaping versus smoking: a quest for long-term impact in a mouse model. 电子烟与吸烟:对小鼠模型的长期影响的探索。
IF 2.8 3区 医学
BMC Pulmonary Medicine Pub Date : 2025-10-17 DOI: 10.1186/s12890-025-03943-z
Layal Massara, Anais Ollivier, Romain Dusautoir, Gwenola Kervoaze, Muriel Pichavant, Anne Platel, Jérôme Kluza, Jean-Marc Lo-Guidice, Sebastien Antherieu, Philippe Gosset
{"title":"Vaping versus smoking: a quest for long-term impact in a mouse model.","authors":"Layal Massara, Anais Ollivier, Romain Dusautoir, Gwenola Kervoaze, Muriel Pichavant, Anne Platel, Jérôme Kluza, Jean-Marc Lo-Guidice, Sebastien Antherieu, Philippe Gosset","doi":"10.1186/s12890-025-03943-z","DOIUrl":"10.1186/s12890-025-03943-z","url":null,"abstract":"<p><p>Smokers consider that electronic cigarettes are safer than tobacco and are marketed as safe products. Nevertheless, reports show the exposure to high levels of electronic cigarette aerosols (ECA) activates lung cells and triggers inflammation and structural alterations after chronic exposure. In order to assess the potential harmful long term effect of exposure to ECA, we investigated in mice, its effect on lung and systemic inflammation as well as on lung function. To reproduce closely the situation frequently encountered in human, we exposed mice during 1 h/day during 3 or 6 months with two levels of electronic cigarette power in comparison with mice exposed to cigarette smoke (CS). Lung and systemic inflammation was evaluated by measuring cell recruitment and activation or cytokine concentrations. Respiratory function and lung transcriptome and structure were also measured. Our data revealed that chronic exposure to moderate levels of ECA increased specifically lung inflammation, these effects being characterized by the mobilization of conventional dendritic cells in the BAL and the recruitment of T cells in the lungs and by the early secretion of IL-22. Surprisingly, there is no strong overlap between the impact of both ECA and CS exposure on lung transcriptome. Modulation of pro-inflammatory pathways are limited to mice exposed to low power e-cigarette. In contrast, alteration of respiratory function is observed in high-power ECA-exposed mice with a different profile than with CS. Subchronic exposure to ECA might alter the respiratory function independently of the inflammatory response and in a different manner than CS.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"477"},"PeriodicalIF":2.8,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12535149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends of asthma mortality in china: a comprehensive analysis by population, region, and sex with future projections. 中国哮喘死亡率趋势:人口、地区和性别的综合分析及未来预测。
IF 2.8 3区 医学
BMC Pulmonary Medicine Pub Date : 2025-10-15 DOI: 10.1186/s12890-025-03930-4
Hang Su, Wen Hua, Wuping Bao, Zichong Xu, Xue Zhang, Lei Zhao, Lei Han, Yishu Xue, Huahao Shen, Min Zhang
{"title":"Trends of asthma mortality in china: a comprehensive analysis by population, region, and sex with future projections.","authors":"Hang Su, Wen Hua, Wuping Bao, Zichong Xu, Xue Zhang, Lei Zhao, Lei Han, Yishu Xue, Huahao Shen, Min Zhang","doi":"10.1186/s12890-025-03930-4","DOIUrl":"10.1186/s12890-025-03930-4","url":null,"abstract":"<p><strong>Background: </strong>Asthma prevalence in China has risen due to rapid industrialization, environmental changes, and improved diagnostics. While efforts in asthma control have expanded nationwide, research on asthma-related mortality remains limited. Understanding death patterns from asthma is important to identify key regions and populations at risk, and to support more effective prevention and treatment strategies suitable for China's population and healthcare system.</p><p><strong>Methods: </strong>We conducted a retrospective study using China CDC's DSPs data, stratifying asthma mortality by sex, region, urban-rural residence, and age. This is a nationwide population and mortality survey study, including data on the total surveyed population and deaths from 2008 to 2021, covering approximately 25% of the total population. Trend analysis was conducted on the total surveyed population stratified by age, sex, and region to explore patterns of mortality changes. Based on mortality trend changes, decomposition analysis of asthma mortality and future trend projections considering population changes were performed to further identify key regions and populations.</p><p><strong>Results: </strong>Asthma mortality in China showed significant regional variation, with higher rates in the southwestern region and lower rates in northern and coastal regions. The crude mortality rate of asthma in China (2008-2021) generally decreased, especially in the older population (33.8% decline), but increased in individuals aged 15-19 in recent years. Mortality rates peaked around 2015 and then declined annually. Geographically, the most substantial decline rate was observed in the eastern region (10.5% decline), followed by the central region (8.1% decline). However, the decline rate in the western region was less pronounced and even displayed an upward trend, particularly in urban areas. Both decomposition analysis and BAPC analysis revealed an unclear mortality trend in urban areas of the western region, while mortality declined in the eastern and central regions.</p><p><strong>Conclusion: </strong>The asthma mortality rate in China has experienced a comprehensive decline over the past decade. However, rates in certain groups, like the older population and those in western China, remained higher than the global average, while in the youth population a slight upward trend was observed. Addressing these disparities is crucial for future efforts.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"475"},"PeriodicalIF":2.8,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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