BMC Pulmonary Medicine最新文献

{"title":"Proteomic study of high-altitude pulmonary hypertension in the Xinjiang Pamir highlanders.","authors":"Zi-Yan Sun, Henry S Lynn, Ainiwaier Tuerxun, Maierhaba Xuereti, Kawsaray Memetimin, Dilinuer Maimaitiyiming","doi":"10.1186/s12890-026-04325-9","DOIUrl":"https://doi.org/10.1186/s12890-026-04325-9","url":null,"abstract":"<p><strong>Background: </strong>High-altitude pulmonary hypertension (HAPH), classified as Group 3 pulmonary hypertension, is a significant threat to the health of high-altitude populations. The scarcity of studies in diverse populations has become a research bottleneck, limiting diagnostic and therapeutic advances.</p><p><strong>Methods: </strong>In this first proteomic study focusing on the eastern Pamir Plateau (Kizilsu Kyrgyz Autonomous Prefecture, Xinjiang), plasma samples were analyzed using data-independent acquisition (DIA) mass spectrometry. Differential expression analysis in parallel with weighted gene co-expression network analysis was performed to identify core pathways and hub proteins, and gene set enrichment analysis was used for quality assessment. Integrative analysis of the two methods was used to select candidates for validation by enzyme-linked immunosorbent assay (ELISA) in an independent cohort.</p><p><strong>Results: </strong>Among > 1400 detected proteins, 123 were differentially expressed and 45 were identified as hub proteins significantly associated with HAPH. Extracellular matrix (ECM) remodeling- and angiogenesis-related proteins were upregulated, whereas proteins related to enzyme activity, iron metabolism, and inflammatory responses were downregulated. Integrative analysis identified 23 core proteins, with ECM-receptor interaction and TGF-β/Smad signaling identified as key pathways. ELISA confirmed that plasma levels of THBS2, LOXL1, and POSTN were significantly elevated in patients with HAPH (P < 0.05). Among these, THBS2 and LOXL1 levels were positively correlated with mPAP (THBS2: r = 0.389, 95% CI: 0.034-0.657, P = 0.033; LOXL1: r = 0.457, 95% CI: 0.115-0.701, P = 0.011).</p><p><strong>Conclusions: </strong>ECM remodeling is closely associated with HAPH in this indigenous high-altitude population. THBS2, LOXL1, and POSTN show potential as biomarkers and therapeutic targets.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental trajectories of frailty among Chinese elderly COPD patients: a prospective cohort study.","authors":"Qian Xu, Xiaoli Guo, Lijun Chen, Chong Chen, Yajing Liang, Yan Shi, Chunbo Liu","doi":"10.1186/s12890-025-03929-x","DOIUrl":"https://doi.org/10.1186/s12890-025-03929-x","url":null,"abstract":"<p><strong>Background: </strong>The trajectory of frailty in patients with COPD and its predictors have yet to be determined. Therefore, this study aims to explore the development trajectory and predictors of frailty in patients with COPD.</p><p><strong>Methods: </strong>This study is a prospective cohort study, ultimately including 378 participants. Among the 378 enrolled participants, 307 (81.2%) were male, with a mean age of 73 ± 8 years. Based on GOLD Classification, patients were distributed as follows: Group A (n = 104), Group B (n = 155), and Groups C/D (n = 119) .The Frailty Phenotypic Assessment Scale was employed to measure the frailty status of patients at admission, as well as at 1,6 and 12 months post-admission. Group-based trajectory modeling was utilized to analyze the frailty trajectories of COPD patients, and further analysis was conducted to identify the factors influencing these frailty trajectories.</p><p><strong>Results: </strong>The study identified distinct trends in the frailty of elderly patients with Chronic Obstructive Pulmonary Disease (COPD). The group trajectory model revealed three classifications: Group 1, Pre-frail Rapidly Developing Group\" (28.87%); Group 2, Pre-frail Sustainable Group\" (41.23%); and Group 3, High Frailty Persistent Group\" (29.90%). The results of the disordered multi-categorical logistic analysis indicated that, when comparing the Group1 and Group 2, a higher number of hospitalizations for acute exacerbations (≥ 2) was associated with older age, elevated IL-6 levels which increased the likelihood of a greater trajectory in the Pre-frail Sustainable Group (P < 0.05). In both the Group2 and Group3, a higher number of hospitalizations for acute exacerbations of COPD (≥ 2) correlated with lower frequency of social activities, older age, increased eosinophil percentage (EOS%), a smaller FEV1/FVC ratio, and higher IL-6 levels, all of which contributed to a greater likelihood of a High Frailty Persistent trajectory (P < 0.05).</p><p><strong>Conclusions: </strong>The observed frailty progression underscores the need for early screening and targeted interventions in high-risk COPD patients, particularly those with recurrent exacerbations or systemic inflammation. Future studies should explore whether attenuating frailty progression improves long-term outcomes.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoid pneumonia mimicking lung cancer: a retrospective case series and literature review.","authors":"Xiaotong Lin, Xiangling Lin, Yin Yin, Hongsen Liang, Ting Bao, Zheng Yang, Yun Li","doi":"10.1186/s12890-026-04209-y","DOIUrl":"https://doi.org/10.1186/s12890-026-04209-y","url":null,"abstract":"<p><strong>Background: </strong>Lipoid pneumonia (LP) is a rare inflammatory lung disease caused by lipid accumulation in alveolar spaces. Its nonspecific clinical and radiological features often lead to misdiagnosis as lung cancer, resulting in potentially avoidable surgical interventions.</p><p><strong>Methods: </strong>We conducted a retrospective case series of six patients who underwent surgical resection at our institution between 2019 and 2025 with a preoperative suspicion of lung cancer but were ultimately diagnosed with LP by postoperative histopathology. Clinical presentations, imaging features, tumor marker levels, and pathological findings were analyzed.</p><p><strong>Results: </strong>All six patients had pulmonary nodules or masses highly suggestive of malignancy on chest CT, including ground-glass opacities, spiculated margins, and cystic changes. Two patients had elevated tumor markers (CEA (carcinoembryonic antigen) or NSE (neuron-specific enolase)). Final pathological examination revealed intra-alveolar lipid-laden macrophages, cholesterol clefts, and chronic granulomatous inflammation, consistent with LP. Most patients denied a specific history of lipid aspiration, though one case had a habit of applying intranasal cooling oil.</p><p><strong>Conclusions: </strong>LP can closely mimic lung cancer both radiologically and biochemically. A high index of suspicion is required in patients with atypical pulmonary lesions, even when tumor markers are elevated. Pathological examination remains the gold standard for diagnosis. Early recognition may help avoid potentially avoidable surgery.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and predictive nomogram for postoperative intestinal fistula complicated by pulmonary infection in patients with acute intestinal obstruction.","authors":"Jun Gao, Hao Sun, Xiyan Qin, Lei Na","doi":"10.1186/s12890-026-04330-y","DOIUrl":"https://doi.org/10.1186/s12890-026-04330-y","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this research is to investigate risk factors for postoperative intestinal fistula combined with pulmonary infection in patients with acute intestinal obstruction and the construction of a predictive model.</p><p><strong>Methods: </strong>Two hundred twenty-seven patients with acute intestinal obstruction admitted to our hospital from January 2018 to December 2024 were selected. Patients were divided into two groups based on whether postoperative intestinal fistula complicated with pulmonary infection occurred: the intestinal fistula complicated with pulmonary infection group (78 cases) and the control group (149 cases). Clinical data of patients were collected and peripheral blood levels of NLR and SAA were measured. Logistic regression analysis was employed to investigate the risk factors for postoperative intestinal fistula complicated with pulmonary infection in patients with acute intestinal obstruction. A nomogram model was established to predict the occurrence of postoperative intestinal fistula complicated with pulmonary infection in patients with acute intestinal obstruction. The goodness of fit of the predictive model was evaluated using the Hosmer-Lemeshow (H-L) chi-square test. The predictive value of the model was analyzed using receiver operating characteristic (ROC) curves and calibration curves.</p><p><strong>Results: </strong>There were no statistical differences in age, gender ratio, intraoperative blood loss, operation duration, comorbidities, and smoking history between the two groups (all P>0.05); The postoperative hospitalization duration, BMI index, NLR and SAA levels in the intestinal fistula with pulmonary infection group were significantly higher than those in the control group (all P < 0.05). Logistic multivariate analysis indicated that BMI, NLR and SAA levels were independent factors for postoperative complications of intestinal fistula with pulmonary infection after acute intestinal obstruction surgery (all P < 0.05). The nomogram prediction model constructed based on the three factors showed acceptable calibration and moderate-to-high discriminative ability with AUC of 0.912, sensitivity and specificity of 0.890 and 0.897, respectively. After internal validation, the value of AUC was 0.853, with sensitivity and specificity being 0.872 and 0.864, respectively.</p><p><strong>Conclusion: </strong>BMI, NLR, and SAA are independent risk factors for postoperative intestinal fistula complicated with pulmonary infection in patients with acute intestinal obstruction. The predictive model constructed showed potentially useful predictive performance in this cohort for postoperative intestinal fistula complicated with pulmonary infection in such patients.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The systemic immune-inflammation index combined with the platelet-to-lymphocyte ratio demonstrates notable potential as a prognostic tool for older adults with pneumonia caused by influenza A virus infection: a retrospective cohort study.","authors":"PiaoPiao Wu, Jiadun Wang, Jingping Cheng","doi":"10.1186/s12890-026-04300-4","DOIUrl":"https://doi.org/10.1186/s12890-026-04300-4","url":null,"abstract":"<p><strong>Background: </strong>The clinical course of influenza A virus (IAV) pneumonia in elderly patients is highly variable and strongly influenced by immunosenescence and dysregulated inflammation. Despite the prognostic relevance of inflammatory markers, reliably stratifying high-risk patients remains challenging. We investigated the combined potential of the systemic immune-inflammation index (SII) and the platelet-to-lymphocyte ratio (PLR) as a novel, accessible composite prognostic tool for this susceptible population.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 160 patients aged ≥ 65 years with IAVP, who were divided into favorable prognosis (CURB-65 < 3, n = 71) and poor prognosis (CURB-65 ≥ 3, n = 89) groups based on their CURB-65 scores.</p><p><strong>Results: </strong>The poor prognosis group exhibited significantly higher levels of white blood cells, neutrophils, C-reactive protein (CRP), interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR), blood urea nitrogen (BUN), creatinine (Cr), PLR, and SII, as well as lower levels of prealbumin, albumin, total protein, and lymphocyte counts (all P < 0.05).</p><p><strong>Conclusion: </strong>Both PLR and SII are positively correlated with disease severity and serve as independent prognostic indicators in elderly IAVP patients. Their combination enhances the accuracy and generalizability of clinical risk stratification models.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity of prolonged air leak probability score in primary spontaneous pneumothorax.","authors":"Necati Çıtak, Servet Özdemir","doi":"10.1186/s12890-026-04305-z","DOIUrl":"https://doi.org/10.1186/s12890-026-04305-z","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of bronchoalveolar lavage in fibrotic and non-fibrotic interstitial lung diseases - a multicenter analysis.","authors":"Evgeni Gershman, Ophir Freund, Ori Wand, Sonia Schneer, Jazmin Bloch, Tzlil Hershko, Eyal Kleinhendler, Doron Cohn-Schwartz, Yitzhak Hadad, Galit Aviram, Yochai Adir, David Shitrit, Amir Bar-Shai, Avraham Unterman","doi":"10.1186/s12890-026-04321-z","DOIUrl":"https://doi.org/10.1186/s12890-026-04321-z","url":null,"abstract":"<p><strong>Background: </strong>Bronchoalveolar lavage (BAL) cellular analysis is recommended as part of the diagnostic workup of interstitial lung diseases (ILD) when diagnosis is unclear. In recent years, ILD have been classified based on the presence or absence of fibrosis. The objective of this study was to compare BAL cellular profiles across multiple ILDs, stratified by fibrosis status.</p><p><strong>Methods: </strong>A retrospective multicenter study of consecutive patients who underwent bronchoscopy, including BAL for ILD evaluation, between 2017 and 2022. BAL indices were chosen based on guidelines and prior research. Chest radiologists blinded to clinical data performed radiological assessment. ILD diagnoses were assigned by multi-disciplinary discussion.</p><p><strong>Results: </strong>In total, 238 patients with BAL results were included (mean age 60 years, 46% females, 50.4% with fibrotic ILD, 91% with concurrent transbronchial biopsy). BAL lymphocytes > 20% and > 30% were more prevalent in non-fibrotic compared to fibrotic ILD (36.4% vs. 17.5% and 25.4% vs. 9.2%, p < 0.01). In multivariate linear regression model, fibrotic disease was associated with lower lymphocyte counts (β=-6.15, p = 0.007). Rates of mixed BAL pattern, lymphocytosis, or isolated neutrophils > 3% did not distinguish between fibrotic diseases. On computed tomography, BAL lymphocytosis was not associated with ground-glass opacities or mosaic attenuation in both fibrotic and non-fibrotic groups, while honeycombing was associated with a lower rate of elevated (> 4.5%) BAL neutrophils (71% vs. 91%, p = 0.018).</p><p><strong>Conclusion: </strong>Specific patterns in BAL differential were uncommon in fibrotic ILD and were not different among its subtypes. As a stand-alone modality, BAL seems to have a limited utility in fibrotic ILD.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic significance of the ROX index in patients with acute exacerbation of interstitial lung disease treated with high-flow nasal cannula oxygen therapy: a retrospective cohort study.","authors":"Issei Katayama, Hideki Makino, Saki Sahara, Yuki Kayada, Kazuki Oshita, So Ueda, Takuyuki Koda, Kotaro Kajiwara, Takanori Kanematsu","doi":"10.1186/s12890-026-04323-x","DOIUrl":"https://doi.org/10.1186/s12890-026-04323-x","url":null,"abstract":"<p><strong>Background: </strong>The respiratory rate-oxygenation (ROX) index (calculated as [SpO₂/FiO₂ ratio] / respiratory rate) is reported to be associated with outcomes in patients with acute hypoxemic respiratory failure treated with a high-flow nasal cannula (HFNC). However, its prognostic utility in acute exacerbation of interstitial lung disease (AE-ILD) remains unclear.</p><p><strong>Methods: </strong>We conducted a single-center retrospective cohort study that included patients with AE-ILD who received HFNC between April 2016 and June 2023. The ROX index at HFNC initiation (0 h) and 12 h was recorded. The primary outcome was 30-day mortality. Logistic regression analysis was also performed.</p><p><strong>Results: </strong>In total, 92 patients were included in this study; their median age was 80 years, and 73% were male. Univariate analysis revealed that 30-day mortality was associated with the ROX index at 0 h (odds ratio [OR], 0.80; 95% confidence interval [CI]: 0.63-1.00; p = 0.048) and 12 h (OR, 0.66; 95% CI: 0.50-0.85; p = 0.001). Multivariate analysis revealed that the ROX index at 12 h was independently associated with 30-day mortality (OR, 0.67; 95% CI: 0.51-0.88; p = 0.003). The optimal cutoff value of the ROX index at 12 h for 30-day mortality was 5.82 (area under the curve: 0.76).</p><p><strong>Conclusions: </strong>The ROX index at 12 h after HFNC was associated with 30-day mortality in patients with AE-ILD and may serve as a simple bedside marker for short-term prognosis.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The associations between dynapenic abdominal obesity and new-onset asthma: a prospective cohort study from the English Longitudinal Study of Ageing.","authors":"Xiaolong Ji, Jinding Pu, Yuxiang Lu, Yuanmei Gao","doi":"10.1186/s12890-026-04308-w","DOIUrl":"https://doi.org/10.1186/s12890-026-04308-w","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High prevalence of previously undiagnosed COPD in individuals undergoing lung cancer screening in Korea.","authors":"Kyung-Hwa Cho, Ki-Eun Hwang","doi":"10.1186/s12890-026-04318-8","DOIUrl":"https://doi.org/10.1186/s12890-026-04318-8","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) remains substantially underdiagnosed, particularly in individuals with mild or early-stage disease. Individuals undergoing lung cancer screening represent a high-risk population due to significant smoking exposure; however, the burden of previously undiagnosed COPD in this real-world clinical setting remains insufficiently characterized.</p><p><strong>Methods: </strong>This retrospective observational study included individuals who underwent national lung cancer screening using low-dose computed tomography (LDCT) at a tertiary referral center between September 2019 and December 2022. The study population consisted of individuals referred for pulmonologist consultation after screening, reflecting real-world clinical practice. Participants without a prior diagnosis of COPD who underwent pulmonary function testing were included. Clinical characteristics, pulmonary function parameters, and CT findings were analyzed. Multivariable logistic regression analysis was performed to identify factors associated with previously undiagnosed COPD.</p><p><strong>Results: </strong>Among 279 individuals who underwent pulmonologist consultation, 170 had available spirometry and were included in the analysis. Of these, 63 individuals (37.1%) met spirometric criteria for COPD despite having no prior diagnosis. Participants with previously undiagnosed COPD were more likely to report dyspnea and demonstrated greater physiologic impairment and structural lung abnormalities, including a trend toward lower diffusion capacity and CT-defined emphysema. In multivariable analysis, dyspnea, reduced DLCO, and CT-defined emphysema were independently associated with COPD.</p><p><strong>Conclusions: </strong>A substantial proportion of individuals undergoing lung cancer screening were found to have previously undiagnosed COPD. These findings highlight a gap in real-world screening workflows and support the potential value of integrating spirometry or respiratory assessment into lung cancer screening programs to facilitate early detection and timely management of COPD in high-risk populations.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}