BMC Pulmonary Medicine最新文献

{"title":"Association between the red cell distribution width-to-platelet ratio and 30-day all-cause mortality among patients with acute respiratory failure: a retrospective analysis of the MIMIC-IV database.","authors":"Yong You, Kengliang Rao, Hongjia Chen, Min Wang, Shuwei Chen, Li Chen","doi":"10.1186/s12890-025-03894-5","DOIUrl":"10.1186/s12890-025-03894-5","url":null,"abstract":"<p><strong>Background: </strong>The importance of the red cell distribution width (RDW)-to-platelet ratio (RPR) in clinical practice has been described in various diseases. However, the prognostic importance of the RPR in patients with acute respiratory failure (ARF) remains unclear. The aim of the present study was to investigate the association of the RPR with 30-day all-cause mortality among ARF patients in the intensive care unit (ICU).</p><p><strong>Methods: </strong>Data were obtained from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database (version 3.1). The study population was divided into different groups based on RPR quartiles (Q1-Q4). The outcome of interest was all-cause mortality within 30 days. Cox proportional regression analysis was performed to determine the relationship between the RPR and 30-day mortality, and Kaplan‒Meier (K‒M) analysis was conducted to obtain survival curves. Additionally, restricted cubic spline (RCS) analysis was utilized to determine whether there was a nonlinear correlation between the RPR (as a continuous variable) and 30-day mortality in ARF patients. Subgroup analysis was subsequently performed to determine whether the association between the RPR and 30-day mortality in ARF patients was stable across the subgroups.</p><p><strong>Results: </strong>A total of 10,912 ARF patients were enrolled in this study. The 30-day mortality rate was 27.2%. Cox proportional regression analysis revealed that an elevated RPR was associated with an increased risk of 30-day mortality in ARF patients. Furthermore, K‒M survival analyses revealed that patients with higher RPR levels demonstrated significantly higher all-cause mortality rates within 30 days of admission than patients with lower RPRs. The RCS model illustrated the linear relationship between a higher RPR and increased risk of mortality in this specific patient population. The final subgroup analysis indicated no significant interaction effect of the RPR in most of the subgroups.</p><p><strong>Conclusions: </strong>This study demonstrated that RPR levels were significantly associated with short-term prognosis in patients with ARF and that a high RPR could serve as an independent predictor of all-cause mortality at 30 days in patients with ARF.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"433"},"PeriodicalIF":2.8,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal study of the influence of obesity, C-reactive protein, and smoking on FEV1 decline in young adulthood.","authors":"Ana Carolina Cunha, Milton Faria-Jr, Heloisa Bettiol, Marco Antonio Barbieri, Cecilia Claudia Costa Ribeiro, Elcio Oliveira Vianna","doi":"10.1186/s12890-025-03913-5","DOIUrl":"10.1186/s12890-025-03913-5","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is a disease with a high socioeconomic burden for the global population. Identifying those individuals with a higher potential to develop the disease is essential for reducing its incidence.</p><p><strong>Methods: </strong>This is an observational, longitudinal study that uses data from the 1978/1979 Ribeirão Preto City birth cohort (São Paulo State, Brazil). The study included 895 individuals who participated at the age of 23-25 and 37-38 years. Asthmatics were diagnosed by methacholine bronchial challenge test and were excluded from the analysis. A multiple linear regression was performed to evaluate the association of active smoking, passive smoking, body mass index (BMI), C-reactive protein (CRP) levels, and respiratory symptoms with FEV1 variation between ages.</p><p><strong>Results: </strong>The analysis showed an association between BMI, CRP levels, and active smoking with FEV1 fall. Active smoking increased FEV1 decline by 1.95%. For each 1 kg/m² increase in BMI, there was a 0.28% loss in FEV1, while an increase in CRP level of 1 mg/dL was associated to a 0.76% additional FEV1 decline.</p><p><strong>Conclusion: </strong>In addition to the well-known relationship between smoking and pulmonary function decline, there was also an association with BMI and CRP levels, suggesting the hypothesis that a metabolic process may contribute to the development of COPD.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"439"},"PeriodicalIF":2.8,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary calcified nodules and cysts as the initial presentation of Sjögren's syndrome secondary nodular pulmonary amyloidosis: a rare case report.","authors":"Yingming Jin, Chaoying Zhang, Xiyan Zhu, Zhi Fang","doi":"10.1186/s12890-025-03876-7","DOIUrl":"10.1186/s12890-025-03876-7","url":null,"abstract":"<p><strong>Background: </strong>Secondary pulmonary amyloidosis due to Sjögren's syndrome (SS) is an uncommon disease. However, pulmonary amyloidosis detected before the diagnosis of SS is exceedingly rare. Herein, we report a unique case of a 40-year-old female who presented with pulmonary calcified nodules and cysts as an initial manifestation of pulmonary amyloidosis. Further diagnostic evaluation revealed SS.</p><p><strong>Case presentation: </strong>A 40-year-old non-smoking female presented with a cough, whose chest computed tomography (CT) scan revealed many lung cysts along with calcified nodules. Pathology revealed nodular pulmonary amyloidosis. Subsequent investigations excluded common related lymphoproliferative disorders and plasma cell dyscrasias. Combined with elevated levels of antinuclear antibody (1:640), positivity for the anti-Sjögren's syndrome A (SS-A)/Ro antibody, abnormal tear break-up time (BUT) and Schirmer test, the diagnosis of SS was established.</p><p><strong>Conclusions: </strong>Pulmonary amyloidosis is a rare pulmonary manifestation of SS, especially with atypical early clinical symptoms, which can render diagnosis challenging. This case highlights that amyloidosis diagnosis precedes SS diagnosis. Moreover, it aims to alert clinicians that when multiple calcified nodules and cystic lesions are observed on chest CT, secondary pulmonary amyloidosis should be considered, and further investigations into related diseases such as SS should be conducted to avoid missed diagnoses.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"427"},"PeriodicalIF":2.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of antifibrotics on the progression of pulmonary hypertension in patients with interstitial lung disease listed for lung transplantation.","authors":"Christopher Thomas, Abhimanyu Chandel, Mira Zineddin, Charles Tang, Ho Cheol Kim, Vikramjit Khangoora, Christopher King, Oksana Shlobin, Steven D Nathan","doi":"10.1186/s12890-025-03897-2","DOIUrl":"10.1186/s12890-025-03897-2","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"428"},"PeriodicalIF":2.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The distribution and the clinical importance of MUC5B and TERT variants in Turkish patients with idiopathic pulmonary fibrosis.","authors":"Ayşe Ödemiş, Aliye Candan Öğüş, Aslı Toylu, Hülya Dirol, Aykut Çilli, Ömer Özbudak, Özden Altıok Clark, Tülay Özdemir","doi":"10.1186/s12890-025-03903-7","DOIUrl":"10.1186/s12890-025-03903-7","url":null,"abstract":"<p><strong>Background: </strong>The role of genetic variants in Mucin-5B (MUC5B) and telomerase reverse transcriptase (TERT) in idiopathic pulmonary fibrosis (IPF) pathogenesis, as well as their associations with clinical characteristics, remain uncertain and may exhibit ethnic variations.</p><p><strong>Methods: </strong>This single-center, cross-sectional study aimed to investigate the distribution of MUC5B rs35705950 and TERT rs2736100 variants among Turkish IPF patients. Additionally, we assessed associations between these genetic variants and clinical parameters including gender-age-physiology (GAP) score, percent predicted forced vital capacity (FVC%), percent predicted diffusing capacity for carbon monoxide (DLCO%), and the presence of honeycombing on high-resolution computed tomography (HRCT).</p><p><strong>Results: </strong>The allele frequency of the TERT rs2736100 variant showed no significant difference between IPF patients and healthy controls (41.7% vs. 43.7%, OR = 0.92, p = 0.73). Conversely, the allele frequency of the MUC5B rs35705950 variant was significantly higher in IPF patients compared to controls (39.6% vs. 12%, OR = 4.81, p = 0.0001). IPF patients carrying the homozygous MUC5B variant (TT) exhibited significantly higher mean FVC% values than those without the variant (GG) (82.2% vs. 71.7%, respectively; p = 0.004). Furthermore, the mean age at diagnosis was significantly older in IPF patients carrying at least one T allele of the MUC5B variant (GT + TT) compared to non-carriers (GG) (67.7 years vs. 62.3 years, respectively; p = 0.013).</p><p><strong>Conclusions: </strong>Our findings indicate that the MUC5B rs35705950 variant is significantly associated with increased IPF susceptibility among Turkish patients. In contrast, the TERT rs2736100 variant was not linked to IPF risk. Additionally, the presence of the MUC5B rs35705950 variant correlated with later disease onset and relatively preserved pulmonary function in this patient population.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"429"},"PeriodicalIF":2.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between geriatric nutritional risk index (GNRI) and asthma in elderly individuals aged 60 and above: a cross-sectional study of the NHANES 2005-2018.","authors":"Jue Wang, ZiMeng Wang, Qi Zhang, Shiting Yu","doi":"10.1186/s12890-025-03830-7","DOIUrl":"10.1186/s12890-025-03830-7","url":null,"abstract":"<p><strong>Objective: </strong>The geriatric nutritional risk index (GNRI) is a promising tool for predicting nutrition-related complications in older adults. This study aimed to explore the association between GNRI and asthma in individuals aged 60 and above.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted using the National Health and Nutrition Examination Survey (NHANES) database. Propensity score matching was used to manage observational data to minimize clinical data bias and confounding variables. Weighted logistic regression with subgroup and sensitivity analyses was used to analyze the potential relationship between GNRI and asthma in elderly individuals aged 60 and above.</p><p><strong>Results: </strong>The study population consisted of individuals aged 60 and above. After adjusting for race, education, emphysema, and chronic bronchitis, the odds ratio (OR) for asthma in relation to the GNRI was 1.021 (95% confidence interval [CI]: 1.016-1.026, P < 0.001), indicating that a lower GNRI is associated with a higher risk of asthma in elderly individuals.The GNRI quartile analysis revealed a significant upward trend (Q4 versus Q1, OR: 1.666, 95% CI: 1.41-1.972, P < 0.001). The significance of the selected factors was assessed using the XGBoost machine learning model, which demonstrated that the GNRI was one of the top five variables influencing the risk of asthma in elderly individuals. Subgroup analysis confirmed the association between GNRI and factors such as gender, race, smoking, alcohol consumption, education level, poverty income ratio, emphysema, and chronic bronchitis. Furthermore, GNRI levels were associated with increased eosinophils, basophils, white blood cells, red blood cells, neutrophils, monocytes, and albumin levels.</p><p><strong>Conclusion: </strong>This study demonstrates that GNRI levels are significantly associated with asthma in the elderly.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"426"},"PeriodicalIF":2.8,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged in vitro anti-bacterial, anti-inflammatory, and surfactant-promoting effects of volatile anesthetics.","authors":"Claudia Scheffzük, Johanna Lührmann, Robin Brinkmann, Dominika Biedziak, Kristina Gloystein, Patrick Kellner, Cordula Stamme","doi":"10.1186/s12890-025-03849-w","DOIUrl":"10.1186/s12890-025-03849-w","url":null,"abstract":"<p><strong>Background: </strong>Volatile anesthetics are gaining recognition for their benefits in long-term sedation of mechanically ventilated patients with bacterial pneumonia and acute respiratory distress syndrome. In addition to their sedative role, they also exhibit anti-bacterial and anti-inflammatory properties, though the mechanisms behind these effects remain only partially understood. In vitro studies examining the prolonged impact of volatile anesthetics on bacterial growth, inflammatory cytokine response, and surfactant proteins - key to maintaining lung homeostasis - are still lacking.</p><p><strong>Methods: </strong>Using an anaerobic chamber setup, we evaluated the effects of the most commonly used volatile anesthetics, Sevoflurane and Desflurane, at clinically relevant concentrations on the growth of Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus. Bacterial growth was monitored over 24 h, assessing OD₆₀₀, CFU/ml, and growth rate during the log phase. In the same setup, but with aerobic conditions, we investigated the immunomodulatory properties of both anesthetics on human A549 cells, either with or without bacterial lipopolysaccharide (LPS, 1 µg/ml) stimulation. Over 48 h, we analyzed pro-inflammatory chemokine release using ELISA and assessed surfactant protein expression with Western blot analysis.</p><p><strong>Results: </strong>Sevoflurane and Desflurane significantly reduced Pseudomonas aeruginosa growth as expressed consistently in OD₆₀₀ and CFU/ml starting after 12 h. Both volatile anesthetics also significantly reduced Staphylococcus aureus OD₆₀₀ starting after 21 h. Sevoflurane (p < 0.01) and Desflurane (p < 0.001) counteracted LPS-induced interleukin-8 release by A549 cells after 48 h and significantly ( p < 0.01 and p < 0.05) enhanced the expression of the propeptide of surfactant protein C after 24 h.</p><p><strong>Conclusions: </strong>Prolonged anti-bacterial and anti-inflammatory effects of Sevoflurane and Desflurane include both the reduction of Pseudomonas aeruginosa and Staphylococcus aureus growth as well as the inhibition of LPS-induced chemokine release by A549 epithelial cells paralleled by an increase of surfactant protein expression. These effects highlight the potential of volatile anesthetics beyond sedation in supporting lung function in ventilated patients with respiratory failure.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"425"},"PeriodicalIF":2.8,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Rhomboid intercostal block combined with sub-serratus plane block versus rhomboid intercostal block for postoperative analgesia after video-assisted thoracoscopic surgery: a prospective randomized-controlled trial.","authors":"Wei Deng, Xiao-Min Hou, Xu-Yan Zhou, Qing-He Zhou","doi":"10.1186/s12890-025-03601-4","DOIUrl":"10.1186/s12890-025-03601-4","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"424"},"PeriodicalIF":2.8,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for severe COVID-19 and development of a predictive model.","authors":"Ling Zhang, Xinran Li, Ziyan Wang, Lei Zhao, Huixia Gao, Conghui Liu, Jing Bai, Tiejun Liu, Weibin Chen, Wenqiang Li, Jingshan Bai, Aishuang Fu, Yanlei Ge","doi":"10.1186/s12890-025-03895-4","DOIUrl":"10.1186/s12890-025-03895-4","url":null,"abstract":"<p><p>A clinical case‒control study was conducted to identify risk factors for severe COVID-19 and to develop a predictive risk model to provide a reference for the dynamic assessment of the severity of disease in COVID-19 patients. A total of 410 patients with COVID-19 were included in the study, of whom 132 had severe or critical cases. The clinical data of the patients were collected, and the variables were subsequently screened via LASSO regression analysis and 10-fold cross-validation. The screened variables were subjected to multifactorial logistic regression analysis to screen out the independent risk factors for patients with severe or critical illnesses, and the independent risk factors were integrated to construct a nomogram. Model performance was evaluated using receiver operating characteristic (ROC) curve analysis, calibration curve analysis, and decision curve analysis (DCA), showing good predictive accuracy. Five variables, including the respiratory rate (R), systolic blood pressure (SBP), plasma albumin (ALB), lactate dehydrogenase (LDH), and C-reactive protein (CRP), were ultimately included to construct a clinical prediction model, with an area under the curve (AUC) of 0.86 (CI 0.82-0.90%). The clinical prediction model constructed in this study using simple clinical indicators can assist in the clinical prediction and identification of patients with heavy or critical COVID-19.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"422"},"PeriodicalIF":2.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of smoking on redox homeostasis and 8-OHdG levels in COPD patients: a cross-sectional comparative study.","authors":"Osman El Jundi, Pelin Uysal, Seyma Dumur, Aysen Kutan Fenercioglu, Hafize Uzun","doi":"10.1186/s12890-025-03907-3","DOIUrl":"10.1186/s12890-025-03907-3","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is a chronic and progressive condition that develops due to a genetic predisposition, with the dysfunction of antioxidants and anti-protease systems triggered by factors such as smoking. In this study, we aimed to determine the effects of smoking on serum 8-hydroxy-2' deoxyguanosine (8-OHdG) as a marker of oxidative DNA damage, malondialdehyde (MDA) to indicate lipid peroxidation, protein carbonyl (PCO) as a marker of protein damage, and paraoxonase (PON)1 levels as a measure of antioxidant activity involved in maintaining cellular redox balance in COPD patients.</p><p><strong>Methods: </strong>We conducted a cross-sectional study involving 141 patients with COPD (70 smokers, 71 non-smokers) and 140 healthy controls (70 smokers, 70 non-smokers) recruited from the Acibadem Mehmet Ali Aydinlar University outpatient clinic.</p><p><strong>Results: </strong>In the COPD-smokers group, significantly higher serum levels of 8-OHdG, MDA, and PCO, and a lower PON1 activity were found. A strong negative correlation was observed between 8-OHdG levels and both FEV1 and FEV1/FVC, as well as between 8-OHdG and PON1 activity in this group. ROC analysis demonstrated strong predictive power for 8-OHdG in the COPD-smokers group. However, given the study's cross-sectional design and limited adjustment for confounders, these findings should be interpreted cautiously.</p><p><strong>Conclusions: </strong>These findings emphasize the critical importance of smoking cessation and antioxidant-targeted strategies in the clinical management of COPD. A systemic oxidant-antioxidant imbalance leads to impairment in the cellular redox homeostasis in patients with COPD and smokers. This study revealed that increased oxidative damage and reduced antioxidant defense in smoking COPD patients are associated with disease severity.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"423"},"PeriodicalIF":2.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12406465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}