BMC Pulmonary Medicine最新文献

{"title":"Does asthma pay-for-performance program really improve the quality of asthma care: a nationwide retrospective cohort analysis in Taiwan.","authors":"Pin-Kuei Fu, Tsung-Hsien Yu","doi":"10.1186/s12890-025-03673-2","DOIUrl":"https://doi.org/10.1186/s12890-025-03673-2","url":null,"abstract":"<p><strong>Background: </strong>Asthma is a prevalent noncommunicable disease worldwide, imposing significant burdens and diminishing the quality of life for those affected. Pay-for-Performance (P4P) programs are reimbursement models that offer incentives to healthcare providers based on their performance metrics. While P4P initiatives have been implemented across various medical conditions, their specific impact on asthma care remains uncertain. This study aims to compare the characteristics and quality of asthma care between patients enrolled in the P4P program and those who are not. Additionally, we will examine trends in these characteristics and care quality over time.</p><p><strong>Methods: </strong>This study utilized a multiple cross-sectional design to analyze asthma patients diagnosed in 2010 and 2019, drawing data from Taiwan's National Health Insurance claims database. We collected information on demographic characteristics, P4P program enrollment, medication usage, healthcare service utilization, and attributes of both patients and their primary treatment hospitals. To address the study objectives, we employed logistic regression models and applied 1:1 propensity score matching to mitigate selection bias.</p><p><strong>Results: </strong>A total of 811,177 individuals diagnosed with asthma were identified, comprising 317,669 in 2010 and 493,508 in 2019. Our findings indicate that patients enrolled in the P4P program had higher prescription rates for inhaled corticosteroids (ICS) and experienced lower rates of hospital admissions and emergency department visits for acute asthma exacerbations compared to non-enrolled patients. We also observed that demographic characteristics influenced P4P enrollment, with these impacts evolving over time. Furthermore, the effects of the P4P program varied across different levels of hospital accreditation.</p><p><strong>Conclusion: </strong>This study demonstrates that the P4P program positively influences the quality of asthma care. However, variations between P4P and non-P4P enrollers persist and have widened over time. Health authorities should address these disparities to ensure equitable care for all asthma patients.</p><p><strong>Clinical trial number: </strong>Protocol #202203101RINC.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"199"},"PeriodicalIF":2.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-time ultrasound-guided laryngeal mask assisted percutaneous dilatational tracheostomy versus bronchoscopy-guided percutaneous dilatational tracheostomy in critically ill patients: a randomized controlled trial.","authors":"Sameh Taha, Jihad Mallat, Mohamed Elsaidi, Ashraf Al-Agami, Ahmed Taha","doi":"10.1186/s12890-025-03645-6","DOIUrl":"https://doi.org/10.1186/s12890-025-03645-6","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous dilatational tracheostomy (PDT) is a common procedure for mechanically ventilated patients in the intensive care unit (ICU). This study compared the real-time ultrasound-guided PDT using a laryngeal mask airway (LMA) with the standard bronchoscopy-guided PDT technique in ICU patients requiring elective tracheostomy.</p><p><strong>Methods: </strong>This randomized controlled study was conducted at Ain Shams University Hospital's Critical Care Department from December 4th, 2021, to December 3rd, 2022. The study population included 60 critically ill patients admitted to the ICU. Thirty patients were randomly assigned to the real-time ultrasound-guided LMA-assisted group, and 30 patients were randomly assigned to the bronchoscopy-guided technique. The primary study outcome was the procedure time, and the secondary outcomes included procedure-related complications rate and cost-effectiveness.</p><p><strong>Results: </strong>The real-time ultrasound-guided LMA-assisted group had significantly shorter procedure time (median 17 [IQR: 15-20] min vs. 35 [IQR: 28-39] min, p < 0.001) and lower equipment damage (0% vs. 20%, p = 0.024) during the procedure compared to the bronchoscopy-guided group. Additionally, the cost of tracheostomy was significantly lower in the real-time ultrasound-guided LMA-assisted group (median: 300 vs. 800 USD, p < 0.001). The real-time ultrasound-guided LMA group had a lower major complications rate than the bronchoscopy-guided group (36.7%) vs. 3.3%, p = 0.002).</p><p><strong>Conclusions: </strong>The study demonstrated that real-time ultrasound-guided LMA-assisted PDT had shorter procedure time, reduced equipment damage, lower costs, and was associated with lower complications when compared to the bronchoscopy-guided technique. These findings suggest that ultrasound guidance can enhance the efficiency and cost-effectiveness of PDT procedures.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"197"},"PeriodicalIF":2.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculosis in children and adolescents using biological agents: a nationwide cohort study from Turkey.","authors":"Tugba Sismanlar Eyuboglu, Ayse Tana Aslan, Volkan Medeni, Sinem Can, Naim Ata, Mustafa Mahir Ulgu, Suayip Birinci","doi":"10.1186/s12890-025-03616-x","DOIUrl":"https://doi.org/10.1186/s12890-025-03616-x","url":null,"abstract":"<p><strong>Background: </strong>The use of biological agents in various diseases in children has been increasing and the risk of tuberculosis (TB) increases with them. We aimed to investigate the role of biological agents in children diagnosed with TB in a moderate level of TB country where TB screening is mandatory before and during biological agent treatment.</p><p><strong>Study design and methods: </strong>This was a retrospective cohort study. All patients who were 0-18 years old and diagnosed with TB-related ICD-10 in the national health database system between 2018 and 2023 were included in the study. The number of patients, demographic characteristics, treatments used by the patients, underlying diseases, and organ involvement of TB were recorded. Children using and not using biological agents were compared.</p><p><strong>Results: </strong>A total of 4351 children were diagnosed with TB, and 1.9% of them were treated with biological agents. The age of diagnosis was older (p = 0.001), and both pulmonary and extrapulmonary involvement was more frequent in children using biological agents (p = 0.001). Pulmonary involvement was more frequent in rheumatological diseases (p = 0.001), and naproxen usage was higher in children with pulmonary involvement (p = 0.014). Naproxen was found to increase the risk of pulmonary TB in children using biological agents (OR:3.824, p = 0.033).</p><p><strong>Conclusions: </strong>The low frequency of TB may be due to effective TB screening before and during the therapy. The age of diagnosis was older, pulmonary and extrapulmonary TB involvement was more common in children using biological agents, which may be related to the immunosuppressive effects. Children using biological agents who are also using naproxen should be closely followed up in terms of pulmonary TB.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"196"},"PeriodicalIF":2.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of asking a thorough social history; a case report of aluminum pneumoconiosis.","authors":"Taylor Caton, Jay Pescatore, Gerard Criner","doi":"10.1186/s12890-025-03662-5","DOIUrl":"https://doi.org/10.1186/s12890-025-03662-5","url":null,"abstract":"<p><p>Aluminum induced lung disease is associated with pulmonary fibrosis, granulomatous pneumonia, and pulmonary alveolar proteinosis. Recognizing aluminum pneumoconiosis remains important as demand for aluminum production continues to rise. The case presents a 53-year-old woman with incidentally noted lung nodules and hilar lymphadenopathy on CT imaging. Despite being asymptomatic, imaging findings prompted referral to a pulmonologist with CT chest demonstrating bulky mediastinal lymphadenopathy with dominant right paratracheal mass as well as several lung nodules in the bilateral lungs. The patient underwent PET scan revealing hypermetabolic lymph nodes bilaterally in the neck, bones, mediastinum, bilateral hila, retroperitoneal lymph nodes, and spleen. Transbronchial biopsy with nodal aspiration of the mediastium revealed granulomatous inflammation. Treatment was started with prednisone 40 mg daily for presumed sarcoidosis, however she had steroid induced hyperglycemia necessitating multiple hospital admissions. This therapy was then stopped. After eliciting a detailed history, it was noted she worked for 15 years as a powder metal laborer exposed to fine aluminum dust. The case highlights a rare presentation of aluminum pneumoconiosis with diffuse systemic manifestations. Though the exact mechanism of aluminum pathogenesis that produces a sarcoid-like granulomatous reaction remains unclear, metal elements have been implicated in acting as antigens stimulating the immune system. Imaging appearance varies, and CT findings can include alveolitis, small ill-defined centrilobular opacities, lung nodules, and pulmonary fibrosis. Unfortunately, no definitive treatment exists for aluminum pneumoconiosis and limiting ongoing exposure is paramount. Periodic lung function testing and thorax imaging remain staples for monitoring disease progression. Therefore, obtaining a thorough occupational history and awareness of possible manifestations of aluminum pneumoconiosis remains essential as aluminum production and manufacturing demand increases.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"200"},"PeriodicalIF":2.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational but not leisure-time physical activity associated with high-risk of obstructive sleep apnea status: a population-based study.","authors":"Han Chen, Lin Wang, Jisheng Zhang, Xudong Yan, Longgang Yu, Yan Jiang","doi":"10.1186/s12890-025-03672-3","DOIUrl":"https://doi.org/10.1186/s12890-025-03672-3","url":null,"abstract":"<p><strong>Purpose: </strong>Despite the well-documented benefits of physical activity, the distinct impacts of occupational physical activity (OPA) and leisure-time physical activity (LTPA) on the risk of obstructive sleep apnea (OSA) remain poorly understood. The objective of this study was to examine the relationship between OPA/LTPA and the risk of developing OSA within a nationally representative sample. We hypothesized that high-intensity OPA could potentially elevate the risk of OSA, whereas the effect of LTPA on OSA risk might be different.</p><p><strong>Methods: </strong>The cross-sectional study utilized data from the Korean National Health and Nutritional Examination Survey database (2019-2020), encompassing a total of 8093 participants. OSA risk was assessed using the STOP-BANG questionnaire, where a score of ≥ 3 signified high risk. Physical activity levels were evaluated using questions adapted from the Korean version of the Global Physical Activity Questionnaire. Participants were allocated based on their high or low levels of LTPA or OPA. Logistic regression analyses were conducted to unveil the associations between OSA and LTPA/OPA.</p><p><strong>Results: </strong>The multivariate regression analysis revealed that high-intensity OPA posed a risk factor for OSA (odds ratio [OR] = 1.738, 95% confidence interval [CI]: 1.134, 2.666), particularly among individuals with age ≥ 60 years old (OR = 1.321, 95% CI: 1.036, 1.682), those with a BMI ≥ 25 (OR = 1.967, 95% CI: 1.027, 3.767), and individuals with hypertension (OR = 3.729, 95% CI: 1.586, 8.768). Furthermore, a visible association was observed between high-intensity OPA and increased tiredness (OR = 1.447, 95% CI: 1.107, 1.891). However, no notable correlation was detected between LTPA and OSA prevalence in both overall and subgroup analyses (all P > 0.5).</p><p><strong>Conclusion: </strong>The study supported the link between high-intensity OPA and an elevated risk of OSA, suggesting the need to manage the duration and intensity of OPA.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"195"},"PeriodicalIF":2.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of hemothorax due to intrathoracic variceal rupture linked to Budd-Chiari syndrome.","authors":"Yue Hu, Zaichun Deng, Yongbin Chen, Tingting Wu","doi":"10.1186/s12890-025-03666-1","DOIUrl":"https://doi.org/10.1186/s12890-025-03666-1","url":null,"abstract":"<p><strong>Background: </strong>Budd-Chiari syndrome (BCS) is a hepatic venous system disease caused by obstruction of the hepatic blood flow outflow tract. The definition of hemothorax is that blood accumulates in the chest cavity, and the hematocrit value of the effusion exceeds 50%. Hemothorax caused by intrathoracic variceal rupture associated with BCS is rare.</p><p><strong>Case presentation: </strong>A 43-year-old female patient with just 69 g/L hemoglobin, complaining of shortness of breath for 2 days, was admitted to gastroenterology department. The chest computed tomography (CT) revealed right pleural effusion and contrast-enhanced CT in portal venous phase revealed portal hypertension and multiple tortuous veins. The ratio of red blood cells to white blood cells in bloody pleural effusion was about 500:1, and the neuron-specific enolase (NSE) and cytokeratin 19 fragment antigen 21 - 1 (CYFRA21-1) in the pleural effusion were significantly increased. Therefore, the patient was transferred to the respiratory medicine department to exclude malignant pleural effusion. The enhanced chest CT reexamination showed a continuous enhanced soft tissue-like lump in the thoracic cavity, which was a varicose vein. The vascular interventional physician reviewed the contrast-enhanced CT in portal venous phase to see a stenosis between the hepatic vein and the inferior vena cava, so BCS was suspected. Vascular interventional surgery was performed, and identified obstructed blood flow at the upper end of the inferior vena cava, which significantly improved after thrombolysis. Therefore, the intrathoracic variceal rupture linked to BCS was the source of the patient's pleural effusion.</p><p><strong>Conclusions: </strong>when there is unexplained bloody pleural effusion and the tumor index of pleural effusion increases, thoracoscopic pleural biopsy should not be blindly performed, and pleural effusion caused by vascular rupture should be further excluded.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"193"},"PeriodicalIF":2.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hsa-miR-21 promoted the progression of lung adenocarcinoma by regulating LRIG1 expression.","authors":"Li Liu, Xinhua Liu, Chengpeng Gao, Meijuan Liu, Mengmeng Peng, Leqiang Wang","doi":"10.1186/s12890-025-03620-1","DOIUrl":"https://doi.org/10.1186/s12890-025-03620-1","url":null,"abstract":"<p><p>Lung cancer is the foremost cause of cancer-related fatalities globally, and lung adenocarcinoma (LUAD) is one of the common types of lung cancer with significant molecular heterogeneity. Leucine rich repeats and immunoglobulin like domains 1 (LRIG1) has been demonstrated to be down-regulated in lung cancer and related to prognosis of patients. The purpose of this work is to explore the targeting miRNAs of LRIG1, and the related regulatory mechanisms in LUAD. The data of LUAD patients were collected from The Cancer Genome Atlas and Gene Expression Omnibus databases. The differential expression analysis and gene set enrichment analysis (GSEA) were performed using \"limma\" and \"clusterProfiler\" function package, respectively. The levels of hsa-miR-21 mRNA and LRIG1 mRNA and LRIG1 protein expressions were analyzed using RT-qPCR and western blot analysis. The infiltration of immune cells was determined using CIBERSORT software. In LUAD patients, hsa-miR-21 expression was observably related to LRIG1 expression. Hsa-miR-21 might negatively modulate the LRIG1 expression in LUAD. LUAD patients with hsa-miR-21 up-regulation exhibited inferior prognosis. In addition, those with LUAD who had high hsa-miR-21 expression but low LRIG1 expression had a worse prognosis, whereas those with low hsa-miR-21 expression but high LRIG1 expression had a better prognosis. Functional enrichment analysis indicated that metabolic related signaling pathways (EGFR tyrosine kinase inhibitor resistance) were significantly activated in LUAD patients with LRIG1 up-regulation. Finally, we found that relative content of naive B cells, plasma cells and resting CD4 + T cells were significantly increased and regulatory T cells and Macrophages M0 were decreased in LRIG1 high expression group and hsa-miR-21 low expression group. We firstly reported that hsa-miR-21 might regulate the LRIG1 expression in LUAD, thereby effecting the onset and progression of LUAD. Clinical trial number: Not applicable.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"189"},"PeriodicalIF":2.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of multivariate logistic regression analysis and amyloid A lactate monitoring in patients with severe pneumonia-associated sepsis.","authors":"Mengying Xie, Zuliang Min, Wei Jiang, Zhifang He, Xuexia Xia","doi":"10.1186/s12890-025-03648-3","DOIUrl":"https://doi.org/10.1186/s12890-025-03648-3","url":null,"abstract":"<p><strong>Background: </strong>Patients with severe pneumonia-associated sepsis often face high mortality rates, highlighting the need for simple and effective prognostic biomarkers. This study aimed to investigate the prognostic significance of serum amyloid A (SAA) and blood lactate (Lac) levels using multivariate logistic regression.</p><p><strong>Method: </strong>This was a retrospective study conducted from January 2021 to December 2023, which included 156 patients diagnosed with severe pneumonia. Of these, 54 developed sepsis (septic group) while 102 did not (non-septic group). Clinical data, SAA, and Lac levels were compared between the groups. Multivariate logistic regression was employed to identify factors influencing the onset of severe pneumonia-associated sepsis and to assess the prognostic significance of SAA and Lac.</p><p><strong>Result: </strong>Significant differences were found in APACHE II score, SOFA score, age, mechanical ventilation, SAA, and Lac levels between the septic and non-septic groups (P < 0.05). Logistic regression analysis identified age, SOFA score, APACHE II score, mechanical ventilation, SAA, and Lac as influencing factors for severe pneumonia-associated sepsis (P < 0.05). Patients with poor prognosis (PP) had significantly elevated SAA and Lac levels compared to those with good prognosis (GP) (P < 0.05). Among septic patients, those with PP had significantly higher SAA and Lac levels compared to those with GP (P < 0.05). Multivariate logistic regression revealed that advanced age, septic shock, elevated SAA levels, and increased Lac levels were predictors of PP (P < 0.05). The prognostic value of SAA and Lac was demonstrated by AUCs of 0.764 and 0.771, respectively. When combined, the AUC increased to 0.903 with a specificity of 95.00% and sensitivity of 80.25%.</p><p><strong>Conclusion: </strong>Severe pneumonia-associated sepsis is influenced by age, SOFA score, APACHE II score, mechanical ventilation, SAA, and Lac levels. Elevated SAA and Lac levels are associated with PP and can provide prognostic information for adverse outcomes. While SAA and Lac show potential as biomarkers for predicting the prognosis of severe pneumonia-associated sepsis, their clinical utility should be considered in conjunction with other diagnostic and clinical factors for effective patient management and risk stratification.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"191"},"PeriodicalIF":2.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereotactic body radiation therapy and thermal ablation for treatment of patients with pulmonary metastases: a systematic literature review and meta-analysis.","authors":"Paul Laeseke, Calvin Ng, Nicole Ferko, Andrada Naghi, George W J Wright, Di Wang, Alyshia Laidlaw, Iftekhar Kalsekar, Tony Amos, Balaji Laxmanan, Sudip K Ghosh, Meijia Zhou, Philippe Szapary, Michael Pritchett","doi":"10.1186/s12890-025-03561-9","DOIUrl":"https://doi.org/10.1186/s12890-025-03561-9","url":null,"abstract":"<p><strong>Objective: </strong>To compare local tumor progression (LTP) and overall survival (OS) after image-guided thermal ablation (IGTA; microwave/radiofrequency ablation) versus stereotactic body radiation therapy (SBRT) in patients with pulmonary metastases.</p><p><strong>Methods: </strong>A systematic literature review was performed to capture studies that used IGTA or SBRT for patients with pulmonary metastases and studies that reported one, two, and threeyear LTP/OS were included. Patients with pulmonary metastases, and a subgroup with metastases from colorectal or renal cell carcinoma, or sarcoma (termed subgroup) which are considered more radioresistant, were analyzed. Single-arm pooled analyses, univariable, and multivariable random-effects meta-regressions were conducted to compare LTP and OS between IGTA and SBRT treated patients.</p><p><strong>Results: </strong>Analyses included 3,264 IGTA and 5,486 SBRT patients. IGTA patients with pulmonary metastases had higher LTP than SBRT patients at one year, 13% and 9% respectively. At two years, the LTP for IGTA patients was 14% compared to 16% for SBRT patients. Three-year LTP remained lower for IGTA patients compared to SBRT patients (14% and 22% respectively). In the subgroup, SBRT patients had higher LTP than IGTA patients across all timepoints. OS was similar across analyses/subgroups in the single-arm pooled analyses. The multivariable analyses showed that SBRT was associated with significantly lower OS at one year; however nonsignificant differences were observed at years two and three.</p><p><strong>Conclusions: </strong>In patients with pulmonary metastases, IGTA had lower LTP than SBRT at later timepoints. In patients with colorectal, renal cell carcinoma, or sarcoma pulmonary metastases, LTP was similar to overall LTP for IGTA, while it was higher for SBRT.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"188"},"PeriodicalIF":2.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impostor of chest pain: a case of lung cancer mimicking angina.","authors":"Dingshan Zhang, Mingtai Chen, Xin Zhou, Yanneng Xu, Yiwei Zeng, Xiaoqin Luo, Ping Liu, Lingling Liang, Yunmei Qian, Gang Luo, Yan Jiang, Mengnan Liu","doi":"10.1186/s12890-025-03663-4","DOIUrl":"https://doi.org/10.1186/s12890-025-03663-4","url":null,"abstract":"<p><p>Chest pain is a common symptom with a complex etiology involving multiple organs and systems. Cardiovascular, digestive and respiratory diseases can cause chest pain. A single condition usually reformulates and can cause this symptom, but a combination of conditions can also cause it. This case reports a 69-year-old male suffered from recurrent chest pain. Coronary heart disease, gastroesophageal reflux disease and left lung adenocarcinoma were diagnosed successively for nearly 1 year. The patients focus on one disease, and the medical staff neglects to deal with multiple diseases simultaneously. Ambiguous evidence and patients' unmotivated attitudes towards treatment make early diagnosis of lung cancer difficult. Treatment for coronary heart disease and gastroesophageal reflux disease masks the symptoms of lung cancer to some extent, resulting in a skewed diagnostic focus. This report highlights the need for clinicians to improve communication with patients to enhance treatment adherence and provide comprehensive screening, identification, and treatment of chest pain etiologies to prevent delays in patient treatment. The findings also suggest that awareness of the therapeutic and prognostic impact of interstitial lung disease on lung cancer should be improved, which is essential for the development of clinical treatment protocols.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"194"},"PeriodicalIF":2.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}