BMC Pulmonary Medicine最新文献

{"title":"Improved quality of life, reduced quantitative lung fibrosis in a trial of inhaled pirfenidone for idiopathic pulmonary fibrosis.","authors":"Grace Hyun J Kim, Felix A Woodhead, Deepthi Nair, Hao Bao, Howard M Lazarus, Craig S Conoscenti, Jonathan G Goldin","doi":"10.1186/s12890-026-04234-x","DOIUrl":"10.1186/s12890-026-04234-x","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13130782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thiamine supplementation is associated with lower in-hospital and ICU mortality in patients with acute respiratory failure: a retrospective cohort study based on the MIMIC-IV database.","authors":"Ming Yin, Xushu Jing, Qian He, Min Li","doi":"10.1186/s12890-026-04243-w","DOIUrl":"10.1186/s12890-026-04243-w","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long term health outcomes for patients with E-cigarette or Vaping, Associated Lung Injury (EVALI) compared to matched control subjects who vape.","authors":"Denitza P Blagev, Jacqueline Eve, Dave S Collingridge, Dixie Harris, Sean J Callahan, Michael J Lanspa","doi":"10.1186/s12890-026-04238-7","DOIUrl":"10.1186/s12890-026-04238-7","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception of e-cigarette as a harmful product delays initiation by two years among Mexican students aged 14-29 years.","authors":"Esperanza Figueroa-Hurtado, Camila Nereyda Alvarez-Torres, Diana Lizbeth Ortiz-Farias, Julio Vega-Cauich, Arturo Cortes-Telles","doi":"10.1186/s12890-026-04246-7","DOIUrl":"10.1186/s12890-026-04246-7","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When BAL meets CT scan: enhancing noninvasive diagnosis of acute cellular rejection after lung transplantation.","authors":"Elena Pordon, Marco Guerrieri, Felice Perillo, Elisa Salvadori, Matteo Fanetti, Laura Bergantini, Claudia Ghiribelli, Luca Luzzi, Chiara Catelli, Elena Bargagli, Antonella Fossi, Cristiana Bellan, Chiara Piscitello, Maria Antonietta Mazzei, David Bennett","doi":"10.1186/s12890-026-04153-x","DOIUrl":"10.1186/s12890-026-04153-x","url":null,"abstract":"<p><strong>Background: </strong>Acute cellular rejection (ACR) is a common complication after lung transplantation (LTX) and it is considered a risk factor for chronic lung allograft dysfunction (CLAD). Lung transbronchial biopsy is still the gold standard for a correct diagnosis of ACR. The aim of the present study was to evaluate the predictive role of bronchoalveolar lavage (BAL) cellular composition in combination with CT scan features for the diagnosis of ACR.</p><p><strong>Method: </strong>We retrospectively evaluated all LTX recipients who underwent transbronchial biopsies combined with BAL procedures and CT scan at a single Institution between January 2019 and October 2024 (n = 169). ACR histological diagnosis was made according to current guidelines, BAL analysis included percentage of cellular composition, lymphocytes' typing and microbiology. A qualitative analysis of specific CT was conducted by an expert thoracic radiologist.</p><p><strong>Results: </strong>Among the 169 biopsies analyzed, 34% showed acute cellular rejection (ACR), predominantly grade A1 (68%). Patients with ACR exhibited significantly higher lymphocyte percentages in BAL (p = 0.025), and the cutoff of 25% showed 22% sensibility and 92% specificity for the diagnosis of ACR. Combing BAL findings with CT features, patients with lymphocyte ≥ 25% in BAL and concomitant pleural effusion showed 95.7% specificity of ACR. Infections were associated with elevated neutrophil levels in BAL (p = 0.026); eosinophil levels were significantly higher in patients with significant ACR (grade ≥ 2) and concomitant infection than those with infection only (p = 0.0014).</p><p><strong>Conclusion: </strong>BAL cellular composition proved to be a strong predictive tool for the diagnosis of ACR. The lymphocyte threshold of 25% was able to distinguish patients with ACR, while the combination of increased BAL lymphocytes with ACR associated CT scan abnormalities especially pleural effusion significantly enhanced diagnostic accuracy. Elevated eosinophil levels were associated to more severe rejection and concomitant infection, highlighting their crucial role in the alloreactive immune response. These findings suggest the role of BAL and CT scan in combination as a valuable diagnostic tool in ACR diagnosis, although histological confirmation remains the gold standard.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13123235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CircSPARC mediates an immunosuppressive tumor microenvironment by regulating the miR-199a-5p/LASP1 axis in non-small cell lung cancer.","authors":"Chengsheng Zhang, Jingru Luo, Xiaohong Zhuang, Qi Qin, Junnv Xu, Shu Lin, Wenjun Tang","doi":"10.1186/s12890-026-04239-6","DOIUrl":"10.1186/s12890-026-04239-6","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147473024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying effect modifiers of corticosteroids in acute respiratory distress syndrome: a meta-regression analysis of randomized controlled trials.","authors":"Naoki Fukunaga, Takuya Wada, Yusuke Naito, Satoshi Hokari, Satoshi Okamori, Shota Yamamoto","doi":"10.1186/s12890-026-04236-9","DOIUrl":"10.1186/s12890-026-04236-9","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147473046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complementary assessment of cardiopulmonary morphometric changes in COPD using 3D multidetector computed tomography: relationship with functional indices.","authors":"Neslihan Köse Kabil, Esin Erbek, Güneş Bolatlı","doi":"10.1186/s12890-026-04240-z","DOIUrl":"10.1186/s12890-026-04240-z","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147473017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of key influencing factors of health information literacy in COPD patients: a cross-sectional study using a random forest model.","authors":"Ji-Hong Wu, Ji-Mei Wu, Bing Huang, Lan-Lan Wei","doi":"10.1186/s12890-026-04237-8","DOIUrl":"10.1186/s12890-026-04237-8","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between PaO2/FiO2 trajectories and survival outcomes in patients with sepsis-associated acute respiratory failure under invasive mechanical ventilation: a retrospective cohort analysis based on MIMIC-IV database.","authors":"Ruiqi Qin, Xingchen Gao, Jing He","doi":"10.1186/s12890-026-04191-5","DOIUrl":"10.1186/s12890-026-04191-5","url":null,"abstract":"<p><strong>Background: </strong>Acute respiratory failure is common in sepsis. When severe conditions like refractory hypoxemia or persistent CO2 retention occur, invasive mechanical ventilation (IMV) is required. The PaO2/FiO2 ratio is a key indicator for assessing acute respiratory failure severity and sepsis prognosis. This study investigates the early ICU trajectory of PaO2/FiO2 in septic patients requiring IMV for acute respiratory failure and its association with 28-day mortality.</p><p><strong>Methods: </strong>This retrospective cohort study utilized the MIMIC-IV database to examine septic patients with acute respiratory failure receiving IMV. Group-based trajectory modeling (GBTM) classified PaO2/FiO2 trends over the first 96 h. Cox and logistic regression assessed associations between trajectory patterns and 28-day or ICU mortality.</p><p><strong>Results: </strong>Among 2270 patients, ICU mortality was 27.1% and 28-day mortality 31.2%. Five distinct PaO2/FiO2 trajectories were identified. Compared to the persistently low trajectory group, patients in trajectory 5 (initially low PaO2/FiO2 that improved and stabilized at a mildly reduced level) had significantly lower risks of 28-day mortality (HR 0.73, 95% CI 0.61-0.87) and ICU mortality (OR 0.64, 95% CI 0.50-0.81).</p><p><strong>Conclusion: </strong>In patients with sepsis-related acute respiratory failure receiving invasive mechanical ventilation, early dynamic patterns of PaO2/FiO2 in the ICU are closely associated with short-term outcomes. Compared to those with persistently low oxygenation levels, patients whose PaO2/FiO2 was initially low but improved and stabilized at a mildly reduced level within 96 h exhibited significantly lower risks of ICU and 28-day all-cause mortality. PaO2/FiO2 trajectories may serve as a valuable tool for early prognostic assessment in patients with sepsis.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147473043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}