BMC Pulmonary Medicine最新文献

{"title":"The intra-breath changes of reactance at low frequency in impulse oscillometry: differentiating obstructive airway disease and Interstitial Lung Disease.","authors":"Parthasarathi Bhattacharyya, Sayanti Karmakar, Wrick Chakraborty, Rajat Pal","doi":"10.1186/s12890-025-03835-2","DOIUrl":"https://doi.org/10.1186/s12890-025-03835-2","url":null,"abstract":"<p><strong>Background: </strong>Impulse Oscillometry (IOS) helps understanding the mechanical properties of the respiratory system. Evaluating its role in distinguishing Obstructive Airway Disease (OAD) from Restrictive Lung Disease (RLD) remains underexplored.</p><p><strong>Methods: </strong>We included the consecutive patients of both OAD (asthma and COPD), ILD (representing RLD) observing guideline recommendations and a cohort of 'healthy' subjects (asymptomatic, no disease clinico-radiologically and on spirometry). They underwent spirometry and impulse oscillometry concurrently on the same sitting. The comparison between the three groups included IOS derived R5, R10, R15, R20, R5-10, R5-15, R5-20, R10-20, X5, Rin5 (R5 inspiration), Rex5 (R5 expiration), Xin5 (X5 inspiration) and Xex5 (X5 expiration), Fres and AX. We proposed Δintrabreath-X5 (Xin5-Xex5) and a 'reactance variance index' (RVI) [(Xin5-Xex5)/Xex5 × 100] in the effort. Those showing highly significant difference (p ≤ 0.0001) were analysed with the ROC curves to determine the best differentiating values.</p><p><strong>Results: </strong>We included 104 OAD (COPD: 53, Asthma: 51), 75 RLDs and 43 healthy controls. Multiple resistance (R5, R5-10, R5-15, R5-20, and Rex5 Xex5) and reactance related (X5, Fres and AX) parameters displayed significant difference (p < 0.0001). The Xex5 and R5 turned out to be the best discriminators, with areas under the curve of 0.9244 and 0.9292, showing sensitivities of 88.57% and 85.85%, and specificities of 95.35% and 100%, respectively, using cut-off values of -2.49 and 5.04 in differentiating OAD from healthy subjects. Of the resistance factors (R5, R10, R15, R20, R5-15, R5-20, R-in-5) significantly differed between ILD and healthy cohorts; the R5 had the highest discriminating power (sensitivity of 64% and specificity of 100% to differentiate them. The Δintrabreath-X5 could best distinguish ILD from OAD with 88.06% sensitivity and 80.95% specificity, closely followed by Xin5/Xex5 and the RVI.</p><p><strong>Conclusion: </strong>IOS can acceptably distinguish OAD from ILD using Δintrabreath-X5. The observation demands further validation.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"411"},"PeriodicalIF":2.8,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of radical resection of lung cancer combined with breathing training on lung cancer patients in thoracic surgery: a meta-analysis.","authors":"Biao Lu, Xiaobing Li, Hao Jiang","doi":"10.1186/s12890-025-03819-2","DOIUrl":"https://doi.org/10.1186/s12890-025-03819-2","url":null,"abstract":"<p><strong>Background: </strong>Its objective was to use meta-analysis (MA) to methodically assess the impact of perioperative breathing exercises on the postoperative rehabilitation of patients with lung cancer (LC) having radical resection.  METHODS: PubMed, and other databases were searched for randomized controlled trials on radical resection of LC combined with perioperative respiratory training from January 1995 to January 2024. After quality assessment, MA was performed using Review Manager 5.3 software.</p><p><strong>Results: </strong>A total of 14 studies involving 880 patients were included, of which 434 patients received perioperative breathing training (Intervention group, IG). The differences between the two groups in terms of MIP (MD = -13.31, 95% CI: [-24.43, -2.19]; Z = 2.35, P = 0.02), FVC (MD = -0.23, 95% CI = [-0.36, -0.11]; Z = 3.69, P = 0.0002), 6-minute walk test (6MWT) values (MD = 36.42, 95% CI: [4.37, 68.48]; Z = 2.23, P = 0.03), incidence of pneumonia (OR = 0.38, 95% CI = 0.20-0.72; Z = 2.95, P = 0.003), and complication rates (OR = 0.66, 95% CI = 0.46-0.94; Z = 2.29, P = 0.02) were statistically significant. However, there were no significant differences between the two groups in MEP (MD = -6.10, 95% CI: [-12.10, -0.11]; Z = 2.00, P = 0.05), FEV1 (MD = -0.25, 95% CI = [-0.58, 0.08]; Z = 1.47, P = 0.14), FEV1/FVC (MD = -3.78, 95% CI = [-7.65, 0.09]; Z = 1.91, P = 0.06), PEF (MD = -15.02, 95% CI = [-45.88, 15.83]; Z = 0.95, P = 0.34), atelectasis (OR = 0.52, 95% CI = 0.24-1.12; Z = 1.68, P = 0.09), pneumothorax (OR = 1.20, 95% CI = 0.63-2.29; Z = 0.57, P = 0.57), and mechanical ventilation incidence (OR = 0.99, 95% CI = 0.34-2.91; Z = 0.01, P = 0.99).</p><p><strong>Conclusion: </strong>This MA demonstrates that perioperative respiratory training significantly improves MIP, FVC, and 6MWT in patients undergoing radical LC surgery, while effectively reducing the incidence of postoperative pneumonia and overall complications. However, its impact on MEP, certain pulmonary function parameters (FEV1, FEV1/FVC, PEF), and specific complications (atelectasis, pneumothorax, mechanical ventilation requirement) did not reach statistical significance. The findings support the inclusion of respiratory training in perioperative rehabilitation programs for LC patients to optimize postoperative recovery outcomes.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"410"},"PeriodicalIF":2.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12392598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asthma risk: the inseparable synergy of obesity and metabolism.","authors":"Ruiqi Zhao, Raobin Xu, Jiabo Yuan, Congyao Wang, Zhuying Li, Jingbo Wang","doi":"10.1186/s12890-025-03878-5","DOIUrl":"https://doi.org/10.1186/s12890-025-03878-5","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"409"},"PeriodicalIF":2.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12392569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the impact of pulmonary circulation, particularly pulmonary vascular resistance, in patients with idiopathic pulmonary fibrosis: an exploratory study.","authors":"Yosuke Tanaka, Ken Okamura, Shota Kaburaki, Toru Tanaka, Akihiko Miyanaga, Namiko Taniuchi, Koichiro Kamio, Kazuo Kasahara, Masahiro Seike","doi":"10.1186/s12890-025-03837-0","DOIUrl":"https://doi.org/10.1186/s12890-025-03837-0","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"407"},"PeriodicalIF":2.8,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of clinical outcomes between high-flow nasal cannula and non-invasive ventilation in acute exacerbation of COPD: a meta-analysis of randomized controlled trials.","authors":"Zhaoshuang Zhong, Long Zhao, Yan Zhao, Rongmei Li, Shuyue Xia","doi":"10.1186/s12890-025-03873-w","DOIUrl":"10.1186/s12890-025-03873-w","url":null,"abstract":"<p><strong>Background: </strong>High-flow nasal cannula (HFNC) has recently emerged as a promising alternative to non-invasive ventilation (NIV) for patients with chronic obstructive pulmonary disease (COPD). However, direct comparative evidence on the clinical efficacy of HFNC versus NIV in acute exacerbations of COPD (AECOPD) remains limited and inconclusive.</p><p><strong>Methods: </strong>A systematic search of PubMed, EMBASE, Cochrane Library, and Web of Science was conducted up to January 2025 for randomized controlled trials (RCTs) comparing HFNC and NIV in AECOPD patients. Outcomes included mortality, treatment failure, intubation rates, and treatment intolerance.</p><p><strong>Results: </strong>Nine RCTs involving 786 patients were included in the meta-analysis. No significant differences were observed in mortality (I² = 0.0%, P = 0.818; RR 1.000, 95% CI 0.638 to 1.569, P = 0.999) or intubation rates (I² = 22.1%, P = 0.253; RR 1.401, 95% CI 0.790 to 2.484, P = 0.249). Although HFNC significantly reduced treatment intolerance (I² = 0.0%, P = 0.976; RR 0.145, 95% CI 0.048 to 0.438, P = 0.001), it showed a non-significant trend toward a higher treatment failure rate compared to NIV (I² = 36.2%, P = 0.180; RR 1.553, 95% CI 0.955 to 2.524, P = 0.076).</p><p><strong>Conclusion: </strong>HFNC therapy showed a trend towards a higher treatment failure rate compared to NIV, though the difference was not statistically significant. No significant differences were found in mortality or intubation rates between the two groups.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"405"},"PeriodicalIF":2.8,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of SMARCA2-deficient and SMARCA4-preserved lung adenocarcinoma diagnosed by pleural effusion cytology.","authors":"Xiaoyue Feng, Ruixia Jie, Fang Peng, Huan Lei, Xiaomin Dai","doi":"10.1186/s12890-025-03891-8","DOIUrl":"https://doi.org/10.1186/s12890-025-03891-8","url":null,"abstract":"<p><strong>Background: </strong>The SWI/SNF (Switch/Sucrose Non-fermentable) chromatin remodeling complex plays a critical role in regulating cellular transcription, and its dysfunction has been associated with the development of aggressive lung adenocarcinoma. The SWI/SNF complex comprises a variety of potential subunit combinations, including the ATP-dependent catalytic subunits SMARCA4 and SMARCA2. Notably, SMARCA4 deletions are observed in approximately 5-10% of lung adenocarcinomas. Conversely, SMARCA2-deficient and SMARCA4-preserved lung adenocarcinoma are relatively rare.</p><p><strong>Case presentation: </strong>A 52-year-old woman presented with the complaints of persistent cough and dyspnea lasting for one week. Chest computed tomography demonstrated an irregularly shaped mass in the dorsal segment of the left lower lobe, accompanied with left pleural effusion and atelectasis. Cytological examination and cell block analysis revealed markedly atypical epithelial tumor cells exhibiting poor cohesion and rhabdoid morphological features. Immunocytochemical staining demonstrated positivity for Claudin4, TTF-1 and SMARCA4, while SMARCA2 expression was absent. Following these results, the pathological diagnosis was poorly differentiated lung adenocarcinoma with isolated SMARCA2 deficiency. Subsequently, next-generation sequencing (NGS) analysis identified a non-frameshift deletion in exon 19 of the EGFR gene. Based on these findings, target therapy with osimertinib was initiated, and the patient remained clinical stability for a duration of seven months following the initial presentation.</p><p><strong>Conclusions: </strong>The understanding of isolated SMARCA2-deficient lung adenocarcinoma remains limited, and no cases of this subtype diagnosed via cytology have been reported in the literature. The preparation of cell blocks combined with appropriate immunocytochemical staining represents a valuable and reliable diagnostic approach.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"406"},"PeriodicalIF":2.8,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of patients diagnosed with chronic obstructive pulmonary disease in terms of treatment compliance and quality of life after follow-up with telemedicine: a randomized controlled trial.","authors":"Zeynep Sena Dogan, Nurdan Kokturk","doi":"10.1186/s12890-025-03854-z","DOIUrl":"10.1186/s12890-025-03854-z","url":null,"abstract":"<p><strong>Background: </strong>During the COVID-19 pandemic, telemedicine has emerged as an important alternative method. The investigation of the safety and effectiveness of telemedicine in the post-exacerbation follow-up of advanced-stage COPD patients and determining whether telemedicine-mediated healthcare service resulted in any differences in COPD assessment test (CAT) scores, inhaler treatment adherence, and technique compared to the face-to-face healthcare service.</p><p><strong>Methods: </strong>This was a prospective, randomized, controlled, method-based clinical research study. Patients who were hospitalized due to COPD exacerbation were included in the present study. The sealed envelope randomization method was adopted to divide these patients into 2 groups: the \"telemedicine group\" and the \"control group\". Both groups were then followed up for 3 months. The 0th visit was considered the initial visit, which was followed by the 1st visit on Day 10 post-initiation, the 2nd visit at 1 month, and the 3rd visit at 3 months, all assessed via teleconsultations. The COPD assessment questionnaire (CAT) scores, inhaler treatment adherence, and technique were compared between the groups.</p><p><strong>Results: </strong>No significant differences existed between the two groups in terms of demographic data and disease characteristics at baseline assessment. At the end of 3 months, the CAT score was 9 (0-30) in the telemedicine group and 18 (0-34) in the control group (p = 0.019). The inhaler treatment technique was correct in 32 patients (91.4%) in the telemedicine group and 23 patients (65.7%) in the control group (p = 0.02). Inhaler treatment adherence was observed in 70.6% of the patients in the telemedicine group and 55.9% of the patients in the control group at the 3-month time point (p > 0.05).</p><p><strong>Conclusions: </strong>Telemedicine has improved the quality of life of advanced-stage COPD patients and their inhaler techniques. It may, therefore, be considered a promising alternative to traditional face-to-face follow-ups, although various technical infrastructures and legal regulations are necessary.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov ID: NCT06477328, Registration Date: 21.06.2024.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"408"},"PeriodicalIF":2.8,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for pneumonitis after the combination treatment of immune checkpoint inhibitors and thoracic radiotherapy.","authors":"Yang Tang, Haifeng Yu, Siyu Guo, Yihan Yao, Jing Zhao, Binbin Zheng, Dang Wu, Yang Xia, Qichun Wei, Ting Zhang","doi":"10.1186/s12890-025-03871-y","DOIUrl":"https://doi.org/10.1186/s12890-025-03871-y","url":null,"abstract":"<p><strong>Background: </strong>The combination of immune checkpoint inhibitors (ICIs) and thoracic radiotherapy (TRT) has played a significant role in the improvement of tumor therapy, but the increased incidence of pneumonitis has greatly limited its application. To identify potential intervention targets, we analyzed risk factors for pneumonitis after combination therapy with ICIs and TRT.</p><p><strong>Methods: </strong>Overall, 335 patients who received TRT and ICI therapy concurrently or sequentially were included in our study. Pneumonitis was assessed and the related factors were analyzed.</p><p><strong>Results: </strong>After combined TRT and ICI therapy, among the 335 patients, 219 (65.4%) patients had no pneumonitis or Grade 1 pneumonitis, 77 (23.0%) patients had Grade 2 pneumonitis, and 39 (11.6%) patients had Grade 3 or above pneumonitis. The incidence of Grade 2 or above pneumonitis was significantly related to the patients' age at diagnosis, sex, time interval and ipsilateral or bilateral lung dose‒volume parameters.</p><p><strong>Conclusion: </strong>We first showed that older, male patients are more likely to suffer from pneumonitis of Grade 2 and above. We also found that, numerically, patients who received ICIs before radiotherapy (RT) were more likely to have pneumonitis than those who received RT before ICIs. Moreover, a longer interval between treatments, lower mean lung dose (MLD) and smaller ipsilateral or bilateral lung dose‒volume parameters are correlated with a lower incidence of pneumonitis of Grade 2 or above.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"404"},"PeriodicalIF":2.8,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12376604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global trends and future projections of COPD burden under low-temperature risk: a 1990-2041 analysis based on GBD 2021.","authors":"Xuyuan Wang, Aiping Gou, Jiangbo Wang, Jing Li, Chunyan Gou","doi":"10.1186/s12890-025-03811-w","DOIUrl":"https://doi.org/10.1186/s12890-025-03811-w","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"403"},"PeriodicalIF":2.8,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12376480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voice problems in chronic cough: prevalence and implications for health and sick leave in a Northern European population.","authors":"Sofia Ögefeldt, Greta Öhlund Wistbacka, Ellika Schalling, Henrik Johansson, Andrei Malinovschi, Christer Janson, Lars Modig, Mathias Holm, Rain Jögi, Christine Cramer, Thorarinn Gislason, Ane Johannessen, Össur Ingi Emilsson","doi":"10.1186/s12890-025-03877-6","DOIUrl":"https://doi.org/10.1186/s12890-025-03877-6","url":null,"abstract":"<p><strong>Background: </strong>Voice problems have been reported in individuals with chronic cough, but population-based prevalence data are not yet available. While both conditions independently affect health and sick leave, their combined effects have not been studied. This study investigated the prevalence of voice problems in individuals with chronic cough and whether a cough duration of over 10 years is associated with a higher prevalence. Additionally, the relationship between chronic cough, voice problems, general health, and sick leave was explored.</p><p><strong>Method: </strong>Cross-sectional and longitudinal data from the Respiratory Health In Northern Europe, RHINE III (n = 7,372) and RHINE IV (n = 10,101) surveys were analyzed. Logistic regression was used to analyze associations between chronic cough, voice problems, general health, and sick leave.</p><p><strong>Results: </strong>Voice problems were reported by 30% of individuals with dry cough and 51% with productive cough, compared to 17% without cough. Among those with dry cough, prevalence increased from 24% (< 10 years) to 37% (> 10 years), with no significant difference for productive cough. Poor health was reported by 7.5% with dry cough and voice problems, 10% with productive cough and voice problems, and 1.7% without either condition. Chronic cough and voice problems were independently associated with poorer health, with an additive effect when co-occurring (adjusted Odds Ratio (95% CI): Dry cough 1.78 (1.34-2.37), Productive cough 2.03 (1.56-2.63), Voice problems 1.73 (1.54-1.94)). Chronic cough, but not voice problems, was linked to increased sick leave.</p><p><strong>Conclusion: </strong>Voice problems are common among individuals with chronic cough, especially in productive cough. Both chronic cough and voice problems are independently associated with poorer general health, with additive effects when co-occurring. Chronic cough, but not voice problems, was associated with more sick leave. These findings highlight the need to address the combined burden of chronic cough and voice problems to improve patient outcomes and well-being.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"402"},"PeriodicalIF":2.8,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}