BMC Pulmonary Medicine最新文献

{"title":"The first case of a solitary peripheral adenopapilloma of the lung with a risk of cancer.","authors":"Gui-Jiang Liu, Hu Chen, Chao Xu, Rui-Dong Ma, Xun Xia","doi":"10.1186/s12890-025-03541-z","DOIUrl":"10.1186/s12890-025-03541-z","url":null,"abstract":"<p><strong>Background: </strong>Solitary peripheral ciliated adenopapilloma of the lung (SPCAP) is a rare benign lung tumor, rarely located in the peripheral lung, and there is no report of canceration. Our case report suggests that it is likely to be cancerous. SPCAP classification remains inconclusion.Therefore, our case report can enrich the pathological database, improve clinicians' understanding of this disease and provide help for clinical diagnosis.</p><p><strong>Case presentation: </strong>A 41-year-old woman found a pulmonary nodule for 2 years by chest computed tomography (CT) and this chest -enhanced CT follow-up found that the wall of the nodule was slightly thickened, which could not rule out malignant tumor. Therefore, we recommend that patients be hospitalized for surgery.The patient had no notable habits such as a smoking history, drug dependence, or history of sexual misconduct. Physical examination and blood tumor markers were normal. Initially diagnosed with a benign lung tumor, SPCAP was finally diagnosed by thoracoscopic wedge resection of the right lower lobe, accompanied by a small area of atypical adenomatous hyperplasia of the alveolar epithelium.One week after the operation, the patient re-examined the chest CT, and was discharged without secondary lesions.</p><p><strong>Conclusions: </strong>SPCAP is a benign tumor with no previous reports of carcinoma in the literature, and the pathological manifestations of our case suggest atypical adenomatous hyperplasia and nuclear atypia.This may suggest the possibility of cancerous transformation of this tumor, and this case provides more knowledge about this tumor and it also provides a basis for surgical treatment.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"89"},"PeriodicalIF":2.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and clinical impact of coronary artery disease confirmed by coronary CT angiography in patients with interstitial lung disease.","authors":"Hyun Seok Kwak, Ho Cheol Kim, Hyun Jung Koo, Seung-Whan Lee, Pil Hyung Lee, Tae Oh Kim","doi":"10.1186/s12890-025-03554-8","DOIUrl":"10.1186/s12890-025-03554-8","url":null,"abstract":"<p><strong>Background: </strong>Patients with interstitial lung disease (ILD) who undergo routine chest computed tomography (CT) often have findings suggestive of coronary artery disease (CAD). However, the incidence and prognostic impact of significant CAD, confirmed by coronary CT angiography (CCTA), are not well established.</p><p><strong>Methods: </strong>From January 2013 to February 2024, we evaluated 215 patients from a retrospective ILD registry at our institute, who underwent CCTA as part of ILD management. Using the CAD-Reporting and Data System, we investigated the incidence of significant CAD and evaluated its impact on 5-year mortality and rehospitalization for respiratory or cardiovascular causes through multivariable Cox proportional hazards regression.</p><p><strong>Results: </strong>During a median follow-up of 2.3 years, CCTA was performed at a median of 5 months postdiagnosis of ILD in the cohort. Significant CAD was identified in 92 patients (42.8%), with 27 (12.6%) undergoing coronary revascularization. The presence of significant CAD was significantly associated with an increased risk of mortality (adjusted hazard ratio [HR]: 2.31; 95% confidence interval [CI]: 1.07 - 5.01; P = 0.03) and a higher risk of rehospitalization (adjusted HR: 2.03; 95% CI: 1.23 - 3.34; P = 0.01). Key clinical variables associated with significant CAD included older age (≥ 63 years), hypertension, and coronary calcification observed on non-gated chest CT.</p><p><strong>Conclusions: </strong>CCTA-identified CAD was associated with a worse clinical prognosis in patients with ILD, with significant risk factors including older age, hypertension, and coronary calcification observed on non-gated chest CT. These findings suggest that obtaining CCTA may be beneficial for managing patients with ILD, particularly those with identified risk factors.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"88"},"PeriodicalIF":2.6,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel, rapid, and effective technique for whole lung lavage in patients with pulmonary alveolar proteinosis and silicosis: retrospective study.","authors":"Eviatar Naamany, Karam Azem, Shai M Amor, Safo Awad, Lev Freidkin, Dror Rosengarten, Shimon Izhakian, Mordechai R Kramer","doi":"10.1186/s12890-025-03540-0","DOIUrl":"10.1186/s12890-025-03540-0","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary alveolar proteinosis (PAP) presents a significant challenge due to its progressive and potentially fatal nature. Whole lung lavage (WLL) is a key treatment for primary PAP with respiratory failure. Despite its efficacy, the lack of standardised protocols has led to diverse practice techniques across different institutions. Our study introduces a novel approach, employing a cardiopulmonary bypass (CPB) system for infusing lavage fluid, a method not previously utilised. This paper will share our pioneering experience with this technique at a tertiary referral centre, focusing on its implementation and safety profile.</p><p><strong>Methods: </strong>This retrospective study included patients aged ≥ 18 who underwent WLL for PAP or silicosis. Pre-lavage preparations included chest X-rays and pulmonary function tests (PFT). Preprocedural empiric antibiotics were administered. During lavage, warm saline was infused using a CPB, with cycles of normal saline infusion and degassing until fluid clarity was reached. Positioning techniques facilitated saline drainage. The procedure concluded with intravenous furosemide administration.</p><p><strong>Results: </strong>Fifty-two WLLs were identified between 2010 and 2024; complete data was available for 33 procedures. Of these, 91% were due to PAP, and 9% to silicosis. Almost half of the patients did not require additional WLL, while 43% needed sequential contralateral WLL. Median operative and mechanical ventilation times were 65 [58.5, 67.5] and 118 [97, 195] minutes, respectively. The median length of hospital stay was two days [2, 3]. Although not statistically significant, O2 saturation and a 6-minute walk distance increase were observed after the WLL.</p><p><strong>Conclusion: </strong>This study outlines our novel approach to WLL, which incorporates rapid saline infusion via a CPB system. Our findings indicate reduced procedure time while maintaining safety and efficacy for treating PAP and silicosis. Despite promising results, the retrospective design and small sample size limit generalizability. Further high-quality studies are warranted to validate and refine this technique.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"87"},"PeriodicalIF":2.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence and pattern of post tuberculosis lung disease including pulmonary hypertension from an Australian TB service; a single-centre, retrospective cohort study.","authors":"Anthony Byrne, Yasmeen Al-Hindawi, Marshall Plit, Louis Yeung, Standish Rigava, Meredith King, Kenneth Ng, Sean F Mungovan","doi":"10.1186/s12890-025-03549-5","DOIUrl":"10.1186/s12890-025-03549-5","url":null,"abstract":"<p><strong>Introduction: </strong>Post Tuberculosis Lung Disease (PTLD) is increasingly recognised as a significant cause of morbidity internationally, but has not been described in an Australian setting. We aimed to determine the prevalence of PTLD among adult TB survivors from an Australian TB service and describe the pattens of lung function abnormalities and pulmonary disease, including pulmonary hypertension.</p><p><strong>Methods: </strong>We conducted a single-centre retrospective cohort study in Sydney, Australia, including all adults who successfully completed TB treatment between January 2013 and December 2022. Baseline characteristics, post treatment pulmonary function, and thoracic computed tomography (CT) data were analysed to determine the prevalence and patterns of PTLD, defined as any lung function and/or radiological abnormality attributable to TB.</p><p><strong>Results: </strong>Among 119 confirmed TB patients (mean age 46 ± 21 years, 61% males) PTLD was identified in 81/119 (68%). Pulmonary function testing was available for 51/119 (43%), of whom 38/51(75%) exhibited abnormalities. Obstructive deficits were found in 25/51 (49%), restrictive deficits in 11/51 (22%), and impaired gas transfer capacity in 26/51 (51%). Chest CT scans were completed in 76/119 (64%), with 70/76 (92%) demonstrating significant abnormalities, including pulmonary fibrosis 43/76 (57%), bronchiectasis 22/76 (29%), and emphysema 11/76 (15%). Pulmonary hypertension was suspected in 52/76 (68%) patients based on radiological findings.</p><p><strong>Conclusion: </strong>Despite successful treatment, PTLD was frequently observed among our cohort of Australian TB survivors. Further research into optimal screening practices to diagnose chronic pulmonary diseases and pulmonary hypertension could provide opportunities for earlier intervention and management.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"84"},"PeriodicalIF":2.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights from the European Nontuberculous mycobacterial pulmonary disease PAtient Disease Experience (ENPADE) survey- exploring disease burden and impact.","authors":"Michal Shteinberg, Marko Obradovic, Roald van der Laan, Christian Hoenig, Roger J Legtenberg, Andreas L G Reimann, Natalie Lorent","doi":"10.1186/s12890-025-03553-9","DOIUrl":"10.1186/s12890-025-03553-9","url":null,"abstract":"<p><strong>Background: </strong>Nontuberculous mycobacterial pulmonary disease (NTM-PD) poses substantial diagnostic and management challenges, particularly among individuals with pre-existing lung conditions and/ or immunodeficiencies. NTM-PD can severely impair lung function and quality of life, potentially leading to both increased healthcare costs and mortality. There is a lack of comprehensive understanding of the disease burden and healthcare gaps from the patients' perspective. The European NTM-PD Patient Disease Experience (ENPADE) survey aimed to collect insights into these aspects.</p><p><strong>Methods: </strong>The survey aim was addressed by several methods. First, an online questionnaire was carried out from July 2021 to February 2022 across eight European countries for quantitative data collection. Additionally, semi-structured qualitative patient interviews were conducted with a subset of patients, eliciting their insights on the aspects surveyed. Descriptive statistics were used for quantitative analysis and interview outcomes were categorised along the online questionnaire for qualitative analysis.</p><p><strong>Results: </strong>A total of 543 patients participated in the survey and 23 patients were interviewed. Satisfaction with care received before and after diagnosis was scored, on average, moderate with 32% \"highly satisfied\" patients and 25% \"highly dissatisfied\" patients across the aspects surveyed. Dissatisfaction was expressed particularly regarding referral and access to expert care, and information received on their disease and its management. Patients reported high restrictions in daily life (49%), work (31%), and social activities (43%), often leading to substantial emotional distress, such as experiencing an increase in feeling depressed or anxious (82%). Interviews with patients highlighted a need for improved disease information, faster diagnosis, and enhanced physician-patient relationships.</p><p><strong>Conclusions: </strong>The ENPADE survey outcomes revealed dissatisfaction among patients with care and restrictions in daily life, work, and social activities, often leading to emotional distress. These findings underscore the need for improved disease information, standardised care, and enhanced physician-patient relationships with appropriate support measures.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"85"},"PeriodicalIF":2.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of neutrophil percentage-to-albumin ratio with lung function in American adults: a population study.","authors":"Xiaolin Zhang, Fan Bai, Haibin Ni, Shiyuan Chen, Dan Fu, Haiyan Ren, Bin Hu","doi":"10.1186/s12890-025-03537-9","DOIUrl":"10.1186/s12890-025-03537-9","url":null,"abstract":"<p><strong>Background: </strong>Chronic respiratory diseases pose a significant threat to global health, underscoring the urgent need for effective preventative and therapeutic interventions. The neutrophil-to-albumin ratio (NPAR), an emerging biomarker for inflammation and nutritional status, has shown promising associations with respiratory health, necessitating an investigation into its potential for predicting lung function decline.</p><p><strong>Objective: </strong>This study aimed to delineate the relationship between the NPAR and pulmonary function within a sample of the American adult population and assess the viability of the NPAR as a prognostic indicator for compromised lung function.</p><p><strong>Methods: </strong>With data available from the National Health and Nutrition Examination Survey (NHANES) for the years 2007 to 2012, 10,055 American adults who met the exclusion criteria were included in the current study. Multivariate linear regression, smoothed curve fitting, and subgroup analyses were applied to evaluate the associations observed between the NPAR and lung function indicators.</p><p><strong>Results: </strong>Even after accounting for all potential confounding factors, a significant inverse relationship persisted between the NPAR and key lung function indicators, including forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and peak expiratory flow rate (PEF). This association remained robust even after potential confounding factors were considered. Subgroup analysis revealed that the negative correlation was more pronounced in certain demographic groups, such as young individuals, males, and current smokers. The study also revealed an \"N-shaped\" relationship between the NPAR and fractional exhaled nitric oxide (FENO), suggesting that the NPAR may play a role in promoting airway inflammation.</p><p><strong>Conclusions: </strong>A significant correlation between the NPAR and the decline in lung function among American adults was revealed in this research, emphasizing the potential clinical relevance of the NPAR as a respiratory health biomarker, as well as the importance of considering systemic inflammation in the management and prevention of respiratory disorders.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"86"},"PeriodicalIF":2.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the psychosocial impact of Elexacaftor/Tezacaftor/Ivacaftor therapy in Cystic Fibrosis patients.","authors":"Marta Solís García, Adrián Peláez, Rosa Mar Gómez Punter, María Criado López, Claudia Madrid Carbajal, Julio Ancochea, Jose María Eiros Bachiller, Ana Sofía Martín Hernández, María Rodrigo-García, Marta García Clemente, Rosa Mª Girón Moreno","doi":"10.1186/s12890-024-03455-2","DOIUrl":"10.1186/s12890-024-03455-2","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to assess how Elexacaftor/Tezacaftor/Ivacaftor (ETI) influences lung function, Body Mass Index (BMI), Sweat Test (ST) and mental health of Cystic Fibrosis (CF) patients, emphasizing on depression and anxiety.</p><p><strong>Methods: </strong>We conducted an observational, prospective, multicentre study including 108 patients over 18 years old who initiated ETI therapy between December 2019 and December 2023. Patients underwent regular evaluations, including clinical, functional, and microbiological assessments, alongside completion of quality of life, anxiety, and depression questionnaires. We evaluated whether there was a difference in anxiety and depression levels over time.</p><p><strong>Results: </strong>After 12 months of treatment, significant improvements were noted in BMI, lung function (FEV1%), ST and various aspects of quality of life (CFQ-R). However, anxiety and depression levels did not differ significantly during the follow-up. When we stratified our sample by key groups, we observed that younger patients (under 28 years) and those with homozygous Phe508del mutations experienced significant higher anxiety with no differences on depression. Furthermore, anxiety and depression demonstrated a moderate correlation, strengthening over time.</p><p><strong>Conclusions: </strong>Treatment with ETI establishes significant improvements in lung function, BMI, ST and quality of life in patients with CF. However, despite these positive outcomes, there were no significant changes observed in levels of anxiety and depression, except for individuals with homozygous mutation type and those younger than 28 years old, who exhibited significant higher levels of anxiety.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"81"},"PeriodicalIF":2.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'Stuck in catch-22': a qualitative study of perceived work ability and decision-making about employment in severe asthma.","authors":"P Mackiewicz, H Hussein, A H Mansur, M T Krishna, G I Walters","doi":"10.1186/s12890-025-03499-y","DOIUrl":"10.1186/s12890-025-03499-y","url":null,"abstract":"<p><strong>Background: </strong>Severe asthma (SA) is characterised by persistent asthma symptomatology despite adherence to intensive treatment and control of asthma triggers. It is estimated that approximately 50% of individuals with SA have current employment, considerably less than rates in the general population. Poor physical and mental health status have been suggested as a potential explanation for this, but the relationship has not been investigated in depth. We investigated how bio-psycho-social and cultural factors influence work ability and employment in SA patients.</p><p><strong>Methods: </strong>Participants were recruited from the Birmingham Regional NHS Severe Asthma Service via opportunity sampling, with the exclusion criteria being individuals who had never been employed, currently in full-time education, or non-English speakers. Subsequently, men and those with minority-ethnic backgrounds were purposefully selected to gain a balanced sample. Interviews were performed either face-to-face, online or via telephone, transcribed using software and edited manually. Data were analysed using Reflexive Thematic Analysis.</p><p><strong>Results: </strong>The study included 12 participants (9 females and 3 males). Four major themes were constructed: impact of patients' asthma control on work, psychological burden of living with SA, costs and benefits of being in employment, and adaptations and strategies for remaining in employment.</p><p><strong>Conclusions: </strong>Our findings highlight the potential for physical, occupational, psychological, and social support to address the diverse job-related difficulties experienced by people with SA. Additionally, national policy reforms should be considered to improve work capacity and promote employment opportunities.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"82"},"PeriodicalIF":2.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related quality of life in sarcoidosis patients and the effect of occupational exposures: a cross-sectional study.","authors":"Denis Vinnikov, Leonid Strizhakov, Tatsiana Rybina, Sergey Babanov","doi":"10.1186/s12890-025-03552-w","DOIUrl":"10.1186/s12890-025-03552-w","url":null,"abstract":"<p><strong>Background: </strong>Health-related quality of life (HRQL) in patients with sarcoidosis has been related to treatment, symptoms, organ involvement and disease severity, but little is known about its association with occupation. The aim was to quantify HRQL in occupationally exposed sarcoidosis patients compared to their nonexposed counterparts.</p><p><strong>Methods: </strong>A total of 221 sarcoidosis patients (median age 49 years, interquartile range (IQR) 37-60 years) with a histologically confirmed diagnosis were recruited from university hospitals and outpatient centers in Belarus, Kazakhstan, and the Russian Federation. General (with SF-8) and specific (with K-BILD) HRQL were compared between patients who were ever exposed to 24 occupational factors and nonexposed patients in adjusted multivariable models.</p><p><strong>Results: </strong>Work in the office and office equipment (beta - 3.60 (95% confidence interval (CI) -6.91;-0.29)) was significantly associated with a poorer SF-8 physical component score (PCS) independent of sex, whereas exposure to irritant gases was strongly associated with a worse mental component score (MCS), adjusted for sex and smoking beta - 7.11 (95% CI -12.83;-1.39). Irritant gas (beta - 17.2 (95% CI -29.3;-5.1)) and work in the office (beta - 7.9 (95% CI -14.7;-1.0)) were associated with worse K-BILD total scores, while only the latter was associated with breathlessness and activities (BA) scores. Exposure to flour, irritant gas and office work were associated with the psychological (P) domain. Exposure to flour, irritant gas and work in the office could predict chest symptom (CS) scores.</p><p><strong>Conclusions: </strong>In patients with sarcoidosis and occupational exposure, patients may exhibit worse HRQL, but further research is needed to ascertain the interplay of individual and occupational factors.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"83"},"PeriodicalIF":2.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relation between vitamin D deficiency and Pseudomonas aeruginosa colonization in patients with bronchiectasis.","authors":"Yu-Hua Wen, Ruo-Xuan Dai, Heng Yang, Jie-Lu Lin, Ru-Jia Tao, Ling Yang, Jin-Fu Xu, Hai-Wen Lu","doi":"10.1186/s12890-025-03548-6","DOIUrl":"10.1186/s12890-025-03548-6","url":null,"abstract":"<p><strong>Background: </strong>The relationship between vitamin D deficiency and Pseudomonas aeruginosa (P. aeruginosa) colonization in bronchiectasis patients is not well understood.</p><p><strong>Methods: </strong>This study was conducted at Shanghai Pulmonary Hospital from June 2014 to May 2018. Serum 25-hydroxyvitamin D levels were measured in patients with bronchiectasis, and clinical data including sputum culture results were collected. To investigate the relationship between vitamin D levels and P. aeruginosa colonization, we conducted correlation analysis and logistic regression. Additionally, in vitro experiments with bone marrow-derived macrophages (BMDMs) infected with P. aeruginosa strain PAO1 were performed to further explore the influence of vitamin D on the bacterial infection and inflammatory response.</p><p><strong>Results: </strong>Among the 195 patients with bronchiectasis, 83.1% (162/195) were vitamin D deficient. A significant negative correlation was observed between serum vitamin D levels and the BSI (Bronchiectasis Severity Index) score. Patients with vitamin D deficiency showed higher rates of P. aeruginosa colonization compared to those with adequate vitamin D levels. Female gender and vitamin D deficiency were identified as risk factors for P. aeruginosa colonization in patients with bronchiectasis. Additionally, serum interleukin (IL)-1β levels were significantly elevated in the vitamin D-deficiency group. In vitro experiments, 1,25-dihydroxyvitamin D [1,25D] was shown to inhibit PAO1 phagocytosis in BMDMs and to suppress IL-1β secretion.</p><p><strong>Conclusions: </strong>Vitamin D deficiency was strongly associated with an increased risk of P. aeruginosa colonization in patients with bronchiectasis. Furthermore, vitamin D demonstrated protective effects by reducing P. aeruginosa survival in cells and modulating the inflammatory dysregulation induced by the bacterium.</p>","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"25 1","pages":"77"},"PeriodicalIF":2.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}