BMC Pediatrics最新文献

{"title":"Prevalence and factors associated with neonatal hypothermia: a cross-sectional study among healthy term neonates in a peri-urban hospital in Northern Uganda.","authors":"Mary Grace Akao, Gorrette Nalwadda, Joshua Epuitai, Elizabeth Ayebare, Grace Ndeezi, Dricile Ratib, James K Tumwine","doi":"10.1186/s12887-025-06123-4","DOIUrl":"10.1186/s12887-025-06123-4","url":null,"abstract":"","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"786"},"PeriodicalIF":2.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of physical activity interventions on body composition and quality of life in adolescents with anorexia nervosa: a meta-analysis of randomized controlled trials.","authors":"Deng Fangquan, Ji Yin, Kong Haijun, Fu Yebiao, Zhang Hanqiao, Zhang Junting","doi":"10.1186/s12887-025-06077-7","DOIUrl":"10.1186/s12887-025-06077-7","url":null,"abstract":"<p><strong>Objective: </strong>This study systematically evaluated the effects of exercise interventions on adolescents diagnosed with anorexia nervosa (AN), focusing on key outcomes such as body composition, skeletal muscle metrics, and quality of life. Additionally, this study aimed to identify the most effective intervention protocol.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across multiple databases, including PubMed, Web of Science, Embase, Scopus, the Cochrane Library, the China Biomedical Literature Database, CNKI, the Wanfang Database, and the VIP Database. Eligible studies included randomized controlled trials (RCTs) examining the impact of exercise interventions on adolescents with AN. Meta-analyses and systematic reviews were performed via RevMan 5.4 and Stata 15 software.</p><p><strong>Results: </strong>A total of seven RCTs involving 211 adolescent patients were included. Compared with the control interventions, exercise interventions did not significantly affect body mass index (BMI), fat mass, or lean body mass compared to control groups (all P > 0.05). However, significant improvements were observed in weight, thigh muscle circumference, mid-thigh skinfold thickness, and overall quality of life (as measured by the SF-36 scale) (all P < 0.05). Subgroup analysis revealed that an 8-week exercise program, with three sessions per week lasting approximately 50 min each, significantly improved body weight (P < 0.05). Variations in frequency, duration, or intervention period did not significantly affect BMI (all P > 0.05). Notably, combining aerobic and anaerobic exercise had a significant effect on BMI (P < 0.05), although no significant improvements were found in the 10 subdimensions of the SF-36 quality of life scale (all P > 0.05).</p><p><strong>Conclusion: </strong>Exercise interventions benefit adolescents with AN, particularly by supporting weight recovery, increasing thigh muscle circumference, improving skinfold thickness, and enhancing quality of life. An 8-week programme combining aerobic and anaerobic exercise (three sessions per week, 50 min per session) significantly promoted weight recovery and improved BMI. These findings underscore the importance of personalized exercise interventions to optimize body composition, skeletal muscle health, and quality of life in adolescents with AN.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"783"},"PeriodicalIF":2.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Major gut microbiota perturbations in firstborn infants compared to those with older siblings soon after delivery.","authors":"Annika Ljung, Monica Gio-Batta, Bill Hesselmar, Henrik Imberg, Hardis Rabe, Forough L Nowrouzian, Susanne Johansen, Agnes E Wold, Ingegerd Adlerberth","doi":"10.1186/s12887-025-06015-7","DOIUrl":"10.1186/s12887-025-06015-7","url":null,"abstract":"","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"780"},"PeriodicalIF":2.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early outcomes of robotic versus laparoscopic splenectomy in pediatric population: a systematic review and meta-analysis.","authors":"Nada Osama Aboelmajd, Moaz Yasser Darwish, Mariam Ahmed Orabi, Abanoub Gamil Abdelmalek Ghabious, Taha Abd-ElSalam Ashraf Taha, Nada K Abdelsattar","doi":"10.1186/s12887-025-06198-z","DOIUrl":"10.1186/s12887-025-06198-z","url":null,"abstract":"<p><strong>Background: </strong>Laparoscopic splenectomy (LS) is currently well-established as a standard technique for splenectomy. Robotic splenectomy (RS) is being introduced as a new minimally invasive alternative. The current study aims to directly compare RS and LS specifically in the pediatric population undergoing splenectomy for non-traumatic indications.</p><p><strong>Methods: </strong>We performed a systematic search in four databases: PubMed, Web of Science, Scopus and Cochrane CENTRAL in November 2024. We included studies that compared outcomes of RS and LS in pediatric patients. We extracted the amount of blood loss, operation time, length of hospital stay, the number of patients who needed blood transfusion or were converted to open approach and post-operative complications. Finally, RevMan software was adopted for meta-analysis.</p><p><strong>Results: </strong>Six retrospective studies met our eligibility criteria and were included in the current systematic review and meta-analysis with a total of 248 patients, of which 123 and 125 children underwent RS and LS respectively. Blood loss was significantly lower in RS group (MD = -56.95, P = 0.01). Operation time, hospital stay, the need for blood transfusion and post-operative complications showed no significant difference between both RS and LS groups. Despite the overall good quality of the included studies, the GRADE quality of evidence was considered very low due to the observational nature of the included studies, small sample sizes and high variability between outcomes of different studies.</p><p><strong>Conclusion: </strong>Our study guides the existing literature towards a possible non-inferior status of robotic splenectomy compared to the well-established laparoscopic splenectomy in most clinical outcomes. Blood loss was significantly lower in children who underwent robotic splenectomy, but small sample size limits generatability of such finding. The challenge of higher costs of robotic splenectomy needs to be addressed in well-designed cost-effectiveness studies.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"781"},"PeriodicalIF":2.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Milk temperature reducing necrotizing enterocolitis in very preterm infants: study protocol for a randomized controlled trial.","authors":"Xuexiu Liu, Yuan Shi, Fang Li, Long Chen","doi":"10.1186/s12887-025-06159-6","DOIUrl":"10.1186/s12887-025-06159-6","url":null,"abstract":"<p><strong>Background: </strong>Necrotizing enterocolitis (NEC) is a common and serious gastrointestinal condition among preterm infants. Factors such as infection, inflammation, and improper feeding are believed to contribute to its onset, but its precise pathophysiology remains unclear. Cold exposure, including feeding at low temperatures, has been associated with increased risks of NEC, yet the direct relationship between feeding temperature and NEC development remains underexplored. This study aims to assess the impact of thermostatic versus standard feeding on the incidence of stage 2 or higher NEC in very preterm infants.</p><p><strong>Methods: </strong>This randomized controlled trial involves preterm infants (< 32 weeks gestational age) admitted to a neonatal intensive care unit. Participants are randomly assigned to receive either thermostatic feeding, with milk maintained at a set temperature throughout feeding, or standard feeding, where milk is allowed to reach room temperature. Both breast milk and formula are used based on clinical guidelines. Primary outcomes include the incidence of ≥ stage 2 NEC, while secondary outcomes involve the incidence of bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP) > 2nd stages, intraventricular hemorrhage (IVH) > 2nd grades, time to achieve total gastrointestinal nutrition, weekly weight growth, frequency of feeding intolerance, extrauterine growth restriction, and late-onset sepsis.</p><p><strong>Expected results: </strong>The study expects to identify a significant reduction in NEC incidence among infants receiving thermostatic feeding compared to those in the standard feeding group. Additionally, improvements in feeding tolerance, weekly weight growth, and time to achieve full gastrointestinal nutrition are anticipated.</p><p><strong>Conclusion: </strong>This study aims to clarify the relationship between feeding temperature and NEC risk, potentially influencing future neonatal care guidelines. By identifying optimal feeding practices, this trial aims to reduce the morbidity and mortality associated with NEC in very preterm infants.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"782"},"PeriodicalIF":2.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth impairment in glycogen storage disease type I versus types III/VI/IX: a cross-sectional study.","authors":"Xiaohui Wu, Yueyu Sun, Min Yang","doi":"10.1186/s12887-025-06053-1","DOIUrl":"10.1186/s12887-025-06053-1","url":null,"abstract":"<p><strong>Background: </strong>Growth retardation is common in glycogen storage disease (GSD), though the relative contributions of hormonal and metabolic factors remain unclear. We compared clinical and biochemical features between GSD I and non-GSD I patients and identified independent predictors of height standard deviation score (SDS).</p><p><strong>Methods: </strong>Thirty-eight children with GSD (24 with GSD I; 14 with GSD III/VI/IX; mean age: 7.5 years) underwent evaluation of height SDS, BMI SDS, IGF1 SDS, and metabolic parameters. After excluding three patients with inflammatory bowel disease (final n = 35), multiple regression was used to identify factors associated with height SDS. In GSD I (n = 24), Lasso regression selected variables, and 1,000 bootstrap resamples assessed coefficient stability.</p><p><strong>Results: </strong>GSD I patients had lower height SDS (-2.30 vs. - 1.17; p = 0.021) and higher lactate (3.94 vs. 1.48 mmol/L; p < 0.001), uric acid (431.04 vs. 283.79µmol/L; p < 0.001) and triglyceride levels (2.38 vs. 1.29 mmol/L, p = 0.002) compared to non-GSD I. In combined-cohort regression, lactate was the only independent negative predictor of height SDS (p = 0.011); glucose levels and IGF1 SDS did not reach statistical significance. In GSD I, Lasso retained lactate (β = - 0.682), glucose (β = - 0.625), and IGF1 SDS (β = 0.524), and bootstrap validation showed only IGF1 SDS remained consistently significant.</p><p><strong>Conclusions: </strong>Hyperlactatemia is significant predictor of growth impairment in GSD, while IGF1 is a stable predictor in GSD I. These findings highlight metabolic and hormonal targets for future hypothesis-driven research in this population.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"773"},"PeriodicalIF":2.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of low birth weight in newborns at a referral hospital in the western Nepal: an unmatched case-control study.","authors":"Ranjan Dhungana, Animesh Dhungana, Bernhard Fassl, Allison Judkins, Brandon Tomlin, Dhanendra Veer Shakya, Mala Chalise","doi":"10.1186/s12887-025-06158-7","DOIUrl":"10.1186/s12887-025-06158-7","url":null,"abstract":"<p><strong>Background: </strong>Low Birth Weight, birth weight of less than 2,500 g regardless of gestational age, is a significant public health issue globally. This study investigates risk factors of LBW in the western Nepal, a region that has not been extensively studied.</p><p><strong>Methods: </strong>A hospital-based unmatched case-control study was conducted at Bheri Hospital in the western Nepal from July 2020 to June 2021. Three hundred mothers delivering live singleton babies, with 150 of them having newborns weighing less than 2,500 g (cases) and 150 of them weighing 2,500-4,000 g (controls) were selected using simple random sampling method. Data were collected through face-to-face interviews using structured questionnaire and review of hospital record reviews. Data were analyzed using STATA version 17. Multivariable logistic regression was performed to analyze the association, and adjusted odds ratio with 95% confidence interval and P-value < 0.05 were considered to be statistically significant.</p><p><strong>Results: </strong>Mothers with a monthly income above Nepali Rupees15,000 had lower odds of having LBW infants (aOR: 0.2, 95% CI: 0.1-0.3). Lack of support from husbands and mothers-in-law during pregnancy significantly increased the odds of LBW, (aOR: 3.9, 95% CI: 1.2-12.3; aOR: 9.5, 95% CI: 4.6-19.5, rspectively). Maternal smoking during pregnancy also increased the odds of LBW significantly (aOR: 8.9, 95% CI: 1.9-40.2). Intended pregnancy was protective, reducing the odds of LBW (aOR: 0.2, 95% CI: 0.1-0.3). Women with a history of delivering LBW babies had a higher risk of recurrence (aOR: 12.2, 95% CI: 1.5-98.7), and those with a recent abortion exhibited increased odds of LBW (aOR: 5.6, 95% CI: 1.8-17.5). Attending four or more ANC visits and receiving nutritional counseling significantly lowered the odds of LBW (aOR: 0.2, 95% CI: 0.07-0.7 and aOR: 0.2, 95% CI: 0.1-0.4, respectively). Weight gain of 7 kg. or more during pregnancy also reduced LBW risk (aOR: 0.1, 95% CI: 0.01-0.14), whereas preterm birth increased the odds of LBW (aOR: 9.5, 95% CI: 4.5-20.2).</p><p><strong>Conclusions: </strong>Interventions to reduce LBW should address these modifiable risk factors, emphasizing maternal nutrition, promoting ANC coverage, integrating routine nutritional counselling into ANC services, smoking cessation and promoting family support in daily activities during pregnancy.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"778"},"PeriodicalIF":2.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and associated factors of anemia among newborns in Africa: a systematic review and meta-analysis.","authors":"Mengistu Abebe Messelu, Baye Tsegaye Amlak, Tadesse Yirga Akalu, Bekele Getenet Tiruneh, Mulualem Biazen Adugna, Abiyie Zeleke, Makda Fekadie Tewelgne, Aster Tadesse Shibabaw, Getnet Nibret, Salelign Amlaku, Temesgen Ayenew","doi":"10.1186/s12887-025-06103-8","DOIUrl":"10.1186/s12887-025-06103-8","url":null,"abstract":"","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"770"},"PeriodicalIF":2.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple phenotypic traits including developmental impairment in a Chinese family with infantile convulsion and choreoathetosis syndrome: a case study expanding the clinical spectrum of prrt2-related syndrome.","authors":"Ruohao Wu, Xiaojuan Li, Zhanwen He, Zhe Meng, Liyang Liang, Wenting Tang","doi":"10.1186/s12887-025-06180-9","DOIUrl":"10.1186/s12887-025-06180-9","url":null,"abstract":"<p><strong>Background: </strong>Pathogenic heterozygous variants in the gene encoding proline-rich transmembrane protein 2 (PRRT2) have been recently identified as the major cause of familial infantile convulsion and choreoathetosis syndrome (OMIM#602,066), a spectrum of autosomal dominant paroxysmal neurological disorders, including self-limited infantile epilepsy (SeLIE) and infantile convulsion that can be isolated (IC) or associated with paroxysmal kinesigenic dyskinesia (PKD/IC). Incomplete penetrance of PRRT2 variants and variable phenotypes without developmental impairment have been widely reported in previous studies of this syndrome, but no studies to date have documented global development delay (GDD) with growth retardation (GR) occurred in a family with multiple phenotypes of this syndrome.</p><p><strong>Case presentation: </strong>Here, using family-based whole-exome sequencing, we identified a pathogenic heterozygous PRRT2 variant (NM_145239.3: c.718C > T, p.Arg240*) in a 3-generation Chinese family of infantile convulsion and choreoathetosis syndrome. The variant was detected in five family members, of which two (pedigree III.1 and III.3) were diagnosed with PKD/IC, one (pedigree III.2) presented uncontrolled generalized/focal seizures with GDD and GR; the GR of this patient was aggravated with the progression of the epileptic condition; she was then diagnosed with IC and developmental impairment, one (pedigree II.2) was diagnosed with SeLIE, and one (pedigree II.3) was phenotypically unaffected and recognized as an obligate carrier.</p><p><strong>Conclusions: </strong>In conclusion, we reported a PRRT2-related syndrome family harboring multiple phenotypic features, including uncontrolled seizures with developmental impairment, which may potentially expand PRRT2-related clinical spectrum. Moreover, our findings suggest that children with PRRT2-related seizures/convulsions, especially those who suffer from uncontrolled multiple seizure types, should be aware of potential risks of having developmental impairment aggravation and need timely and effective antiepileptic medications.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"769"},"PeriodicalIF":2.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of effect of massage or chicory bath on bilirubin levels in term newborns undergoing phototherapy: a randomized clinical trial.","authors":"Malihe Nourollahpour Shiadeh, Hajar Pasha, Ommolbanin Zare, Alireza Yahyaei Shahandashti, Fatemeh Haghshenas","doi":"10.1186/s12887-025-06170-x","DOIUrl":"10.1186/s12887-025-06170-x","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Neonatal hyperbilirubinemia is a frequent metabolic complication in newborns. The available treatment methods may bring about adverse consequences; therefore, finding new modalities to decrease the duration of treatment is a major concern. The aim of this study was to compare the effect of massage or chicory bath on bilirubin levels in term newborns undergoing phototherapy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This randomized clinical trial study was conducted on 90 newborns with hyperbilirubinemia at Imam Ali Hospital of Amol on October 26, 2024 to February 6, 2025. Two intervention groups received chicory bath or massage as an adjuvant intervention in addition to standard phototherapy treatment, and the control group only received phototherapy. A custom-designed data collection form was used in this study. All newborns who met the inclusion criteria were selected and informed consent was obtained from their parents. Then, using a computerized random number table, the newborns were randomly assigned to three groups. Sampling continued until the intended number was reached. Descriptive and analytical statistical tests including analysis of variance, chi-square, Tukey's post hoc test, and repeated measures ANOVA were used to analyze the data using SPSS software (version 26). A significance level of 0.05 was considered acceptable.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;There was no significant difference between the three groups in terms of neonatal age, gender, birth weight, gestational age, and type of delivery. There was no significant difference between the three groups regarding average bilirubin levels on the second, third, and fourth days of hospitalization. The change in bilirubin levels over time was significant regardless of the group (P=0.000), and the trend of bilirubin change over time was not significant among the three groups. There was no significant difference in the rate of complications including skin rashes, drug sensitivity, and phototherapy sensitivity among the three groups. There was a significant difference between the three groups in terms of the frequency of defecation on the third and fourth days (P=0.02), which was higher in the massage group. There was a statistically significant difference in the number of hospitalization days among the chicory (3 ±0. 91) (Length of stay: 2-5), massage (2.77±0.73) (Length of stay: 2-4), and control groups (3.37±0.93) (Length of stay: 2-5) (p=0.03). This significant difference was observed between massage and control groups (P=0.02) concerning the rate of hospitalization, and the newborns in the massage group were discharged earlier.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Based on the results of the present study, Field massage combined with phototherapy was more effective in increasing the frequency of defecation and reducing the length of hospitalization in infants with hyperbilirubinemia compared to those in the chicory bath group and the control group who received p","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"775"},"PeriodicalIF":2.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}