Breastfeeding MedicinePub Date : 2024-06-01Epub Date: 2024-05-03DOI: 10.1089/bfm.2024.0132
Philip O Anderson
{"title":"Immunosuppressants and Breastfeeding.","authors":"Philip O Anderson","doi":"10.1089/bfm.2024.0132","DOIUrl":"10.1089/bfm.2024.0132","url":null,"abstract":"","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":"396-398"},"PeriodicalIF":2.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Breastfeeding MedicinePub Date : 2024-06-01Epub Date: 2024-03-25DOI: 10.1089/bfm.2023.0325
Büşra Deniz, Arzu Sarıalioğlu
{"title":"The Effect of Breast Milk Odor on the Pain and Stress Levels of the Newborn During the Endotracheal Suction Procedure.","authors":"Büşra Deniz, Arzu Sarıalioğlu","doi":"10.1089/bfm.2023.0325","DOIUrl":"10.1089/bfm.2023.0325","url":null,"abstract":"<p><p><b><i>Objective:</i></b> The study aimed to determine the effect of the breast milk odor on the pain and stress levels of the newborn during the endotracheal suction procedure. <b><i>Method:</i></b> The study was conducted in the randomized-controlled experimental design at the neonatal intensive care unit of the hospital in eastern Turkey between March 2022 and December 2023. The study population included newborns at the 37th to 41st gestational weeks who were receiving mechanical ventilation treatment in the neonatal intensive care unit of a hospital in eastern Turkey. All newborns who met the inclusion criteria during the data collection phase were included in the study. The study was completed with 88 newborns (44 in the intervention group and 44 in the control group). The Newborn Introductory Information Form, ALPS-Neo Newborn Pain and Stress Assessment Scale, and follow-up form were used to collect the study data. The breast milk odor of the mothers of the newborns was used as the intervention group in the study. The mothers of the newborns were contacted to obtain breast milk, and the information was obtained from the mother on the day of the procedure. One milliliter of breast milk was taken and dropped into a sterile sponge, and it was held 10 cm away from the baby's nose from 5 minutes before to 5 minutes after endotracheal suction. A routine endotracheal suction process was performed in the control group. Ethical principles were followed in the study. <b><i>Results:</i></b> We found that the intervention group's pain and stress score averages were lower than the control group during and after the endotracheal suction procedure (<i>p</i> < 0.05). <b><i>Conclusion:</i></b> We found that the breast milk odor reduced the pain, stress levels, and crying duration of newborns during the endotracheal suction process.</p>","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":"459-466"},"PeriodicalIF":2.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Breastfeeding MedicinePub Date : 2024-06-01Epub Date: 2024-04-02DOI: 10.1089/bfm.2023.0309
Nuket Ekici, Filiz Süzer Özkan
{"title":"Effect of White Noise on Anxiety Levels and Breastfeeding Success of Primiparous Mothers Having Vaginal Delivery: A Randomized Controlled Trial.","authors":"Nuket Ekici, Filiz Süzer Özkan","doi":"10.1089/bfm.2023.0309","DOIUrl":"10.1089/bfm.2023.0309","url":null,"abstract":"<p><p><b><i>Objective:</i></b> In this study, it was aimed to determine the effect of white noise on anxiety levels and breastfeeding success of primipara mothers having vaginal delivery. <b><i>Design:</i></b> The research was conducted using a randomized controlled experimental design. <b><i>Setting:</i></b> The research was conducted at a public hospital located in western Turkey. <b><i>Participants:</i></b> Sixty primipara mothers, who were between 37 and 42 weeks of gestation, who had a vaginal delivery, and who gave birth to a healthy newborn weighing 2,500-4,000 g, were included in the study as participants. <b><i>İnterventions:</i></b> The mothers and their babies in the study group (30) were made to listen to white noise with a CD player during breastfeeding in the first hour after delivery and 24 hours after delivery. <b><i>Measurements:</i></b> Measurements were performed before, during, and after breastfeeding. A descriptive information form, the State Anxiety Inventory (STAI) Scale, and the \"LATCH Breastfeeding Diagnostic and Evaluation Scale\" were applied to the mothers by the researcher and the observer. In this way, breastfeeding success and anxiety levels were measured. <b><i>Results:</i></b> There was a statistically significant difference between the study group listening to white noise and the control group in terms of the mean STAI-I, observation 2, and observation 4 scores (<i>p</i> < 0.001). Also, it was found that the mean LATCH, observation 1, and observation 2 scores in the control group were significantly lower than the mean LATCH, observation 1, and observation 2 scores in the study group (<i>p</i> < 0.001). <b><i>Conclusions:</i></b> As a result of the research, it was determined that white noise was an effective method in increasing breastfeeding success and reducing anxiety levels. In this direction, white noise can be used by health care professionals as a supportive method for breastfeeding.</p>","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":"476-482"},"PeriodicalIF":2.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140334712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Breastfeeding MedicinePub Date : 2024-06-01Epub Date: 2024-04-05DOI: 10.1089/bfm.2023.0274
Martin M Mulinge, Hellen K Abisi, Hellen M Kabahweza, Lydia Okutoyi, Dalton C Wamalwa, Ruth W Nduati
{"title":"The Role of Maternal Secretor Status and Human Milk Oligosaccharides on Early Childhood Development: A Systematic Review and Meta-Analysis.","authors":"Martin M Mulinge, Hellen K Abisi, Hellen M Kabahweza, Lydia Okutoyi, Dalton C Wamalwa, Ruth W Nduati","doi":"10.1089/bfm.2023.0274","DOIUrl":"10.1089/bfm.2023.0274","url":null,"abstract":"<p><p><b><i>Background:</i></b> Breast milk is the gold standard of infant nutrition, delivering nutrients and bioactive molecules as needed to support optimal infant growth and cognitive development. Increasing evidence links human milk oligosaccharides (HMOs) to these early childhood development milestones. <b><i>Aims:</i></b> To summarize and synthesize the evidence relating to HMOs and infant brain development, physical growth, and cognitive development. In addition, HMO concentrations in secretor and nonsecretor mothers were compared via a meta-analysis. <b><i>Study Design:</i></b> A systematic review and meta-analysis were carried out in accordance with the PRISMA statement. This review used three databases (PubMed, Scopus, and Web of Science) and was limited to English-language articles published between 2000 and June 30, 2023. <b><i>Results:</i></b> The initial searches yielded 245 articles, 27 of which were included in the systematic review and 12 in the meta-analysis. The meta-analysis revealed a substantial between-study heterogeneity, <i>I</i><sup>2</sup> = 97.3%. The pooled effect was 0.21 (95% CI: -0.41 to 0.83; <i>p</i> = 0.484), indicating that secretors had higher HMO concentrations, although this difference was not statistically significant. At one month of age, 2'FL, 3FL, and 3'SL play an important role in brain maturation and thus play a critical role in cognitive development. Secretors produce higher concentrations of 2'FL and 3'SL, explaining the benefits to infants of secretor mothers. Growth velocity was correlated to fucosylated and sialylated HMO concentrations, with lower concentrations linked to stunting. <b><i>Conclusions:</i></b> According to evidence from the systematically reviewed articles, HMOs are essential for a child's early development, but the extent to which they have an impact depends on maternal secretor status.</p>","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":"409-424"},"PeriodicalIF":2.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Breastfeeding MedicinePub Date : 2024-06-01Epub Date: 2024-04-03DOI: 10.1089/bfm.2023.0284
Moira Donovan, Diane L Spatz
{"title":"Effects of a Person's Lactation History on Later-Life Development of Alzheimer's Disease: An Integrative Review.","authors":"Moira Donovan, Diane L Spatz","doi":"10.1089/bfm.2023.0284","DOIUrl":"10.1089/bfm.2023.0284","url":null,"abstract":"<p><p><b><i>Objective:</i></b> The purpose of this integrative review is to assess the existing evidence regarding the effects of a person's lactation history on later-life development of Alzheimer's disease. <b><i>Methods:</i></b> The authors searched the electronic databases PubMed, Cumulative Index to Nursing and Allied Health Literature, Scopus, and Excerpta Medica dataBASE, and performed backward reference searches using search terms such as, \"Alzheimer's disease, dementia,\" and \"breastfeeding, lactation.\" Authors selected relevant records through the application of inclusion and exclusion criteria and reading the titles, abstracts, or records in full. <b><i>Results:</i></b> In total, 400 articles were identified, and 10 articles meeting inclusion criteria were analyzed. Authors extracted data following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and scored levels of evidence according to Melnyk and Fineout-Overholt. Data were organized according to themes of <i>breastfeeding duration, ever having breastfed, and indirect effects of breastfeeding</i>. <b><i>Conclusions:</i></b> Breastfeeding may have neuroprotective effects for the lactating person and reduce the risk of later-life development of Alzheimer's disease. However, future research is necessary to determine the generalizability of this association.</p>","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":"399-408"},"PeriodicalIF":2.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140850451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Breastfeeding MedicinePub Date : 2024-06-01Epub Date: 2024-03-19DOI: 10.1089/bfm.2023.0258
Xinhui Guo, Junyan Han, Luyang Hong, Yihuang Huang, Shujuan Li, Lan Zhang, Weili Yan, Ping Dong, Yi Yang, Yun Cao
{"title":"Associations of Early Gut Microbiome and Metabolome with Growth and Body Composition of Preterm Infants Within the First 6 Months.","authors":"Xinhui Guo, Junyan Han, Luyang Hong, Yihuang Huang, Shujuan Li, Lan Zhang, Weili Yan, Ping Dong, Yi Yang, Yun Cao","doi":"10.1089/bfm.2023.0258","DOIUrl":"10.1089/bfm.2023.0258","url":null,"abstract":"<p><p><b><i>Objectives:</i></b> This study aimed to explore the associations of growth and body composition with gut microbiome and metabolome in preterm infants. <b><i>Materials and Methods:</i></b> A prospective cohort study including 73 human milk-fed very preterm infants was conducted. During hospitalization, fecal samples were collected to detect microbes and metabolites using 16S rRNA gene sequencing and liquid chromatography-mass spectrometry. Growth and body composition indices were measured at term equivalent age (TEA) and 6 months of corrected age (CA). Associations of the fecal microbiome and metabolome profiles with growth and body composition indices, as well as their changes, were analyzed. <b><i>Results:</i></b> A higher abundance of <i>Streptococcus</i> was associated with a lower fat-free mass (FFM) <i>z</i>-score at 6 months of CA (<i>p</i> = 0.002) and a smaller increase in FFM <i>z</i>-score from TEA to 6 months of CA (<i>p</i> = 0.018). Higher levels of 3'-sialyllactose and 6'-sialyllactose (6'-SL) in feces were correlated with a lower <i>z</i>-score of percentage body fat (PBF) (<i>p</i> = 0.018 and 0.020, respectively) and a lower z-score of fat mass (<i>p</i> = 0.044 and 0.043, respectively) at 6 months of CA. A higher level of 6'-SL in feces was correlated with a greater increase in FFM <i>z</i>-score from TEA to 6 months of CA (<i>p</i> = 0.021). <b><i>Conclusions:</i></b> This study sheds light on the role of specific microbial-host interactions in metabolic changes in preterm infants, indicating the potential role of sialylated human milk oligosaccharides in optimizing body composition.</p>","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":"435-444"},"PeriodicalIF":2.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140157488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Breastfeeding MedicinePub Date : 2024-06-01Epub Date: 2024-04-23DOI: 10.1089/bfm.2023.0290
Roisin Coyne, William Hughes, Helen Purtill, Deirdre McGrath, Colum P Dunne, Roy K Philip
{"title":"Influence of an Early Human Milk Diet on the Duration of Parenteral Nutrition and Incidence of Late-Onset Sepsis in Very Low Birthweight (VLBW) Infants: A Systematic Review.","authors":"Roisin Coyne, William Hughes, Helen Purtill, Deirdre McGrath, Colum P Dunne, Roy K Philip","doi":"10.1089/bfm.2023.0290","DOIUrl":"10.1089/bfm.2023.0290","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Human milk is the preferred source of enteral nutrition for very low birthweight (VLBW) infants, and it possibly decreases dependence on parenteral nutrition (PN) and reduces incidence of late-onset sepsis (LOS). No systematic review to date has specifically addressed the value of early versus late introduction of human milk diet (HMD) on duration of PN and incidence of LOS among VLBW infants. <b><i>Objective:</i></b> To review the evidence for an early versus late introduction of HMD on duration of PN and incidence of LOS in VLBW infants. <b><i>Method:</i></b> Preferred reporting items for systematic reviews and meta-analysis-guided search of EMBASE and PubMed/Medline databases was conducted for this systematic review using phrases addressing population, intervention, comparator, and outcome framework to identify articles published over the past two decades without language restrictions. Full-text articles (both observational and randomized) that studied an early versus late initiation of HMD were included. Mean difference (MD) and relative risk (RR) with 95% confidence intervals (CIs) were calculated for PN and LOS. Quality of evidence was analyzed using UK National Service Framework and the risk-of-bias was assessed using Robvis<sup>®</sup>. <b><i>Results:</i></b> One randomized controlled trial (RCT) and two observational studies (two English and one Chinese) recruited 474 VLBW infants (455 analyzed). Among an intrauterine growth-restricted cohort enrolled in the RCT (<i>n</i> = 72), early HMD resulted in statistically significant reduction in PN dependence. However, no statistically significant difference was found in LOS. Two observational studies found similar reductions in PN duration and LOS incidence among the early HMD cohort. One observational study reported significant PN reduction; however, the incidence of LOS did not reach statistical significance in either case. <b><i>Conclusion:</i></b> An early HMD may reduce the duration of PN for a growth-restricted VLBW cohort. Observational studies suggesting reduced PN and LOS from early HMD endorse the need for bioactivity-focused human milk research. Variations in feeding guidelines among VLBW infants have the potential to influence neonatal outcomes significantly.</p>","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":"425-434"},"PeriodicalIF":2.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Breastfeeding MedicinePub Date : 2024-06-01Epub Date: 2024-05-13DOI: 10.1089/bfm.2024.0145
Arthur I Eidelman
{"title":"The Analgesic Effect of Breast Milk.","authors":"Arthur I Eidelman","doi":"10.1089/bfm.2024.0145","DOIUrl":"10.1089/bfm.2024.0145","url":null,"abstract":"","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":"395"},"PeriodicalIF":2.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Breastfeeding MedicinePub Date : 2024-06-01Epub Date: 2024-04-08DOI: 10.1089/bfm.2023.0241
Lina Nguyen, Stephanie Stokes, Kendall Alsup, Jennifer Allen, Carolyn Zahler-Miller
{"title":"Dysphoric Milk Ejection Reflex: Characteristics, Risk Factors, and Its Association with Depression Scores and Breastfeeding Self-Efficacy.","authors":"Lina Nguyen, Stephanie Stokes, Kendall Alsup, Jennifer Allen, Carolyn Zahler-Miller","doi":"10.1089/bfm.2023.0241","DOIUrl":"10.1089/bfm.2023.0241","url":null,"abstract":"<p><p><b><i>Background:</i></b> Dysphoric milk ejection reflex (D-MER) is a phenomenon that occurs before milk letdown and is described as a wave of negative or devastating emotions, ranging from mild to severe and lasting for seconds to minutes. To date, there has been little research regarding this phenomenon. This study aims to determine the prevalence of D-MER in our population as well as its association with postnatal depression scores and breastfeeding self-efficacy. <b><i>Methods:</i></b> Lactating persons between 4 and 12 weeks postpartum at our institution were invited to complete an anonymous 59-question survey via an online platform. Questions asked included patient demographics, presence of symptoms of dysphoria (including timing, duration, and frequency), the Edinburgh Postnatal Depression Scale (EPDS), and the Breastfeeding Self-Efficacy Scale Short Form (BSES-sf). <b><i>Results</i></b><i>:</i> In total, 201 women completed the survey. Twelve women were classified as likely having D-MER (6%). Symptom resolution primarily occurred within a minute to 5 minutes (58%). Mean EPDS scores differed significantly between those with likely D-MER and those without (12.2 vs. 5.4, <i>p</i> = 0.002). BSES-sf scores differed significantly between the two groups (43.1 vs. 52.5, <i>p</i> = 0.009). Preexisting depression or anxiety was not associated with D-MER (<i>p</i> = 0.133), other reported mood disorders differed significantly between those with D-MER and those without (<i>p</i> = 0.004). Demographic characteristics of women with and without D-MER were similar. <b><i>Conclusion</i></b><i>:</i> D-MER prevalence may be lower than previously reported. Patients with likely D-MER appear to have lower breastfeeding self-efficacy and higher depression scores. Those with preexisting mood disorders may be at higher risk of experiencing D-MER.</p>","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":"467-475"},"PeriodicalIF":2.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Breastfeeding MedicinePub Date : 2024-06-01Epub Date: 2024-03-12DOI: 10.1089/bfm.2024.0047
Emily F Kaplan, Courtney N Link, Scott Schmalzried, Amanda Rosenblatt, Ann Kellams, Eliza Holland
{"title":"Association of Cannabis with Apneic Episodes in a Breastfed Infant: A Case Study.","authors":"Emily F Kaplan, Courtney N Link, Scott Schmalzried, Amanda Rosenblatt, Ann Kellams, Eliza Holland","doi":"10.1089/bfm.2024.0047","DOIUrl":"10.1089/bfm.2024.0047","url":null,"abstract":"<p><p><b><i>Background:</i></b> The use of cannabis and its perceived safety among pregnant and breastfeeding women has increased in the context of expanding legalization. Current guidelines recommend abstaining from the use of cannabis while pregnant or breastfeeding due to the potential for harm, although there is still much that is unknown in this field. <b><i>Case Presentation:</i></b> A 5-week-old infant presented with recurrent apneic episodes and a positive urine delta-9-tetrahydrocannabinol (THC) screening test. The infant's mother reported regular cannabis use for treatment of depression and anxiety while pregnant and breastfeeding. The infant was subsequently transitioned to formula feedings, and the infant's condition improved. <b><i>Conclusion:</i></b> Cannabis and its active metabolites can be transferred into breast milk and may have deleterious neurologic effects on infants. However, a causal relationship between cannabis exposure and short- or long-term neurologic sequelae has not yet been definitively established. Further studies are warranted to assess the safety of maternal cannabis use for breastfed infants.</p>","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":"490-493"},"PeriodicalIF":2.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140100965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}