Breastfeeding Medicine最新文献

{"title":"Possible Association Between Etanercept Use During Breastfeeding and Infant Somnolence, Hypotonia, and Feeding Difficulties: A Case Report and Literature Review.","authors":"Burak Eskiyurt, Ersan Horoz, Deniz Ceyda Bakırlı, Mesut Gungor, Baris Karadas, Yusuf Cem Kaplan","doi":"10.1177/15568253261446227","DOIUrl":"https://doi.org/10.1177/15568253261446227","url":null,"abstract":"<p><strong>Background: </strong>Etanercept is a tumor necrosis factor inhibitor frequently used to control ankylosing spondylitis (AS) in women of reproductive age, yet data on its safety during breastfeeding are limited. We report a case of an infant who developed somnolence, hypotonia, feeding difficulties, and a concomitant infection temporally associated with maternal etanercept therapy during lactation and discuss implications for breastfeeding.</p><p><strong>Case: </strong>A 33-year-old woman with AS delivered a healthy female infant by cesarean section at 36 + 5 weeks' gestation and began exclusive breastfeeding. At 11 weeks postpartum, she initiated etanercept 25 mg subcutaneously once weekly for her active disease. During treatment, the infant developed prolonged sleep, somnolence, feeding difficulty, and hypotonia, followed within a week by low-grade fever, cough, and nasal congestion. After three doses, etanercept was discontinued, and she was referred to our teratology information service. Approximately 2 weeks after the last dose, the infant's respiratory symptoms worsened, and diarrhea developed, prompting emergency admission. Laboratory evaluation showed leukocytosis, elevated C-reactive protein, and a nasopharyngeal swab, which was positive for rhinovirus/enterovirus. Symptoms resolved with supportive care and azithromycin by treatment days 4-5. At 9 months of age, the infant has had no other health issues.</p><p><strong>Conclusions: </strong>This case illustrates the difficulty of interpreting adverse events in breastfed infants exposed to maternal biologic medications. Although current evidence suggests no clinically severe adverse effects, minimal infant exposure, and a low risk of clinically relevant immunosuppression with etanercept during breastfeeding, individualized counseling and careful monitoring of exposed infants remain essential.</p>","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":"15568253261446227"},"PeriodicalIF":1.8,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Origins.","authors":"Julie Ware","doi":"10.1177/15568253261445910","DOIUrl":"https://doi.org/10.1177/15568253261445910","url":null,"abstract":"","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":"15568253261445910"},"PeriodicalIF":1.8,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celebrate Our Families and Providers-They Are All Olympic (Liquid) Gold Medalists!","authors":"Julie Ware","doi":"10.1177/15568253261437784","DOIUrl":"https://doi.org/10.1177/15568253261437784","url":null,"abstract":"","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":"15568253261437784"},"PeriodicalIF":1.8,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Do No Harm.","authors":"Julie Ware, Elien Rouw, Casey Rosen-Carole","doi":"10.1177/15568253261432106","DOIUrl":"https://doi.org/10.1177/15568253261432106","url":null,"abstract":"","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":"15568253261432106"},"PeriodicalIF":1.8,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease-Modifying Therapy and Breastfeeding.","authors":"Philip O Anderson","doi":"10.1177/15568253251413184","DOIUrl":"https://doi.org/10.1177/15568253251413184","url":null,"abstract":"","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":"21 4","pages":"239-241"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Feeding Breast Milk at Different Temperatures on Newborns: A Systematic Review and Meta-Analysis.","authors":"Çiğdem Gök, Türkan Turan","doi":"10.1177/15568253251413231","DOIUrl":"10.1177/15568253251413231","url":null,"abstract":"<p><strong>Background: </strong>Breast milk is the optimal source of nutrition for newborns, especially preterm infants, and its temperature during feeding may influence both physiological stability and clinical outcomes. Although individual studies suggest potential benefits of warmed milk, evidence remains inconsistent and has not been comprehensively synthesized.</p><p><strong>Objective: </strong>To systematically review and analyze the effects of administering breast milk at different temperatures on physiological responses, feeding tolerance, and clinical outcomes in newborns.</p><p><strong>Methods: </strong>This systematic review and meta-analysis followed the Cochrane Handbook (version 6.0) and PRISMA guidelines. A comprehensive search of nine databases (CINAHL, CENTRAL, Web of Science, PubMed, Scopus, ScienceDirect, ERIC, EBSCO, OVID) was conducted for studies published between 2010 and 2025 in English. Data extraction and risk of bias assessment were performed independently by two reviewers using RoB-2 and ROBINS-I tools. Meta-analyses were conducted using Stata 16.0, applying fixed- or random-effects models based on <i>I</i>² heterogeneity values.</p><p><strong>Results: </strong>Five studies involving 373 infants met the inclusion criteria. Meta-analyses revealed no statistically significant effects of breast milk temperature on heart rate, oxygen saturation, or body temperature at 5 or 30 minutes after feeding. A small short-term decrease in body temperature (5 minutes post-feeding) was noted in the intervention group, but this was not sustained. Time to achieve full enteral feeding was also not significantly different between groups. Heterogeneity was substantial for several outcomes (<i>I</i>² > 85%). Risk of bias ranged from low to serious across included studies.</p><p><strong>Conclusions: </strong>Current evidence indicates that administering breast milk at different temperatures does not produce clinically meaningful differences in short-term physiological parameters or clinical outcomes in newborns. Milk at room temperature, near-body temperature, or alternative warming methods appears to be equally well tolerated.</p>","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":"265-274"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146028310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Safety of Taking Brexpiprazole During the Lactation Period.","authors":"Akari Fukuda, Gen Oyanagi, Saya Kikuchi, Chihiro Iwasaki, Miyu Okubo, Aoi Noda, Kei Morishita, Nao Okabe, Riko Iwabuchi, Yuji Sato, Erika Kimura, Natsuko Kobayashi, Hasumi Tomita, Shinichi Sato, Noriyuki Iwama, Takushi Hanita, Masatoshi Saito, Hiroaki Tomita, Taku Obara, Nariyasu Mano","doi":"10.1177/15568253251408037","DOIUrl":"10.1177/15568253251408037","url":null,"abstract":"<p><strong>Introduction: </strong>Brexpiprazole (BPZ), an antipsychotic drug introduced in 2018, is often used to manage psychiatric conditions. However, the effect of its use on infants whose mothers are receiving BPZ during lactation remains uncertain. Given the limited data on its effects on infants, this study evaluated the safety of its use by mothers during lactation.</p><p><strong>Materials and methods: </strong>Three mother-infant pairs were assessed between 2018 and 2023 at Tohoku University Hospital. Each mother continued BPZ monotherapy (1-2 mg/day) during pregnancy and lactation within the first month postpartum, and data on maternal and infant health, as well as withdrawal symptoms or adverse events in newborns and infants, were collected from medical records.</p><p><strong>Results: </strong>No withdrawal symptoms or severe adverse events were noted in any of the three newborns or infants. Mild cases of neonatal jaundice and acne were observed in all three newborns and infants; however, they were considered unrelated to BPZ exposure. Nonetheless, it appears that the drug might have decreased milk supply, as supplemental formula feeding was occasionally necessary.</p><p><strong>Conclusion: </strong>This study suggests that BPZ monotherapy (1-2 mg/day) during lactation does not lead to withdrawal symptoms or serious adverse events in newborns or infants within the first month postpartum. This initial evidence may help inform breastfeeding decisions among mothers receiving BPZ monotherapy.</p>","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":"275-279"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Two Midwife-Supported Breastfeeding Positions After Cesarean: A Pilot Randomized Controlled Study.","authors":"Benay Oğuz, Nursen Bolsoy","doi":"10.1177/15568253261415604","DOIUrl":"https://doi.org/10.1177/15568253261415604","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to compare the effectiveness of two different breastfeeding positions (routine cradle hold and modified football hold) with midwife support during the first breastfeeding session after cesarean section. The modified football hold is defined as an innovative position designed to increase maternal comfort and support effective breastfeeding by protecting the incision site.</p><p><strong>Method: </strong>The study is a randomized controlled, exploratory pilot study conducted at a public hospital in Türkiye between July 2021 and January 2022. The study included 90 postpartum women in total (45 in the experimental group and 45 in the control group). The groups were randomized using the block randomization method. The experimental group received a modified football hold with midwife support, while the control group received a routine cradle hold. The \"Mother and Newborn Information Form\" and the \"Infant Breastfeeding Assessment Tool (IBFAT)\" were used as data collection tools.</p><p><strong>Findings: </strong>The sociodemographic and obstetric characteristics of the experimental and control groups did not differ significantly (<i>p</i> > 0.05). In the experimental group, breastfeeding satisfaction was significantly higher (very satisfied: 68.9%; control: 22.5%) (<i>p</i> < 0.001). There was a statistically significant difference (<i>p</i> < 0.001) between the experimental group's mean IBFAT scores of 9.48 ± 1.85 and the control group's 5.95 ± 2.09. The effect size (Cohen's <i>d</i> = 1.78) was determined to be large.</p><p><strong>Conclusion: </strong>During the first breastfeeding session following a cesarean section, the modified football hold was found to be an effective method for increasing maternal satisfaction and promoting breastfeeding success. The effectiveness of breastfeeding and mother-baby bonding is thought to be enhanced by midwives' use of it in clinical settings. Nevertheless, further research using larger sample sizes and in various centers is required to validate the efficacy of this method.</p>","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":"21 4","pages":"250-257"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Codeine and Breastfeeding.","authors":"Philip O Anderson","doi":"10.1177/15568253261429410","DOIUrl":"10.1177/15568253261429410","url":null,"abstract":"","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":"242"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147316313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Effects of Breast Milk and <i>Hamamelis virginiana</i> (Witch Hazel) on the Healing of Diaper Dermatitis in Infants: A Randomized Trial.","authors":"Döndü Sevimli Güler, Gülşen Vural, Zekiye Turan, Filiz Ünal Toprak, Hacer Efnan Melek Arsoy","doi":"10.1177/15568253251406258","DOIUrl":"10.1177/15568253251406258","url":null,"abstract":"<p><strong>Background: </strong>Diaper dermatitis (DD) is a very common problem in infants between 1 and 6 months. While it rarely causes long-lasting problems, it can cause serious short-term problems for both infants and parents. Accordingly, this study compared the effect of breast milk and diaper rash cream containing <i>Hamamelis virginiana</i> (12 mg/100 g) on the healing process in 0-6 month-old infants with DD.</p><p><strong>Methods: </strong>This randomized, single-blinded trial was conducted with 60 infants aged 0-6 months diagnosed with DD. Participants were assigned to either the breast milk group (BG) or the comparison group (CG) receiving <i>Hamamelis virginiana</i> cream. Demographic characteristics and DD severity were assessed using a structured demographic questionnaire and the validated Assessment of the Severity of Uncomplicated DD in Infants Scale. Statistical analyses included Shapiro-Wilk, Mann-Whitney <i>U</i>, Wilcoxon signed rank, Chi-square, and Fisher's exact tests. Significance was set at <i>p</i> < 0.05.</p><p><strong>Results: </strong>Before the intervention, the mean scale score was 5.17 ± 0.46 in the BG, 2.83 ± 1.37 in the CG, which was a statistically significant difference. After the intervention, there was a significant decrease in the mean scale score in the BG to 0.03 ± 0.18, whereas the mean decrease was smaller in the CG (1.53 ± 1.11). The difference in the mean scale scores between the groups was statistically significant (<i>p</i> < 0.001). Furthermore, the postintervention mean scale score of the BG was significantly lower than that of the CG. However, baseline severity differences limit direct comparison of treatment efficacy.</p><p><strong>Conclusions: </strong>Topically applied breast milk appears to be a safe, accessible, and cost-effective option for treating uncomplicated DD, with greater improvement than cream containing <i>Hamamelis virginiana</i>. However, baseline severity differences limit direct comparison. Further studies using block randomization are recommended.</p>","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":"258-264"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145853366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}