Breastfeeding Medicine最新文献_第5页

Influence of Race and Ethnicity on Meeting Intention to Exclusively Breast Milk Feed at Postpartum Hospital Discharge. 种族和民族对产后出院时满足纯母乳喂养意愿的影响

IF 1.8 3区医学

Breastfeeding Medicine Pub Date : 2025-08-01 Epub Date: 2025-03-26 DOI: 10.1089/bfm.2024.0392

Sarah Costello, Donna Santillan, Tope Awelewa, Noelle Bowdler

{"title":"Influence of Race and Ethnicity on Meeting Intention to Exclusively Breast Milk Feed at Postpartum Hospital Discharge.","authors":"Sarah Costello, Donna Santillan, Tope Awelewa, Noelle Bowdler","doi":"10.1089/bfm.2024.0392","DOIUrl":"10.1089/bfm.2024.0392","url":null,"abstract":"Background: Racial/Ethnic disparities in breastfeeding practices exist despite strong evidence for significant health benefits of breastfeeding for the mother-newborn dyad. Breastfeeding intentions are known to predict breastfeeding practices at hospital discharge and breastfeeding retention in the long term. Interventions during postpartum hospitalization can help mothers achieve breastfeeding intentions and reduce racial/ethnic gaps in breastfeeding on discharge. This study aims to identify racial/ethnic disparities in meeting intentions to exclusively breast milk feed (EBMF) on hospital discharge. Methods: This was a retrospective cohort study of mothers who intended to EBMF and their newborns delivered at term at a single academic medical center during 2022. The primary outcome was EBMF at discharge. Results: Participants included non-Hispanic Black (NHB) (n = 96), Hispanic (n = 97), and non-Hispanic White (NHW) (n = 955) mothers who intended to EBMF. Mothers who identified as NHB (40.6%) or Hispanic (64.9%) were significantly less likely to EBMF compared with NHW (87.5%) mothers (odds ratio [OR] = 0.14, 95%CI [0.08, 0.23] and OR = 0.37, 95%CI [0.22, 0.61], respectively) at newborn hospital discharge. Rurality, insurance type, gravidity, parity, gestational diabetes, and birth weight were not associated with breast feeding choice/practices at discharge, but increasing age was associated with an increased likelihood of EBMF (OR = 1.07, 95%CI [1.03, 1.11]), as was neonatal intensive care unit admission (OR = 2.93, 95%CI [1.18, 7.31]). Cesarean birth was associated with decreased likelihood of EBMF (OR = 0.57, 95%CI [0.38, 0.85]). Conclusion: Significant racial/ethnic disparities in EBMF at hospital discharge exist among those who intended to EBMF, which are not explained by differences in other examined covariates.","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":"546-553"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antipsychotics and Breastfeeding. 抗精神病药物和母乳喂养。

IF 1.8 3区医学

Breastfeeding Medicine Pub Date : 2025-08-01 Epub Date: 2025-04-17 DOI: 10.1089/bfm.2025.0086

Philip O Anderson

引用次数: 0

Pharmacokinetics and Breast Milk Transfer to Infants of Subcutaneous Extended-Release Buprenorphine for the Treatment of Individuals with Opioid Use Disorder. 丁丙诺啡皮下缓释治疗阿片类药物使用障碍的药代动力学和婴儿母乳转移。

IF 1.8 3区医学

Breastfeeding Medicine Pub Date : 2025-08-01 Epub Date: 2025-05-13 DOI: 10.1089/bfm.2025.0045

Antoinette Nelson-Rodriguez, Kelley Saia, Xin Xie, Jeremiah Momper, Davida M Schiff, Elisha M Wachman

{"title":"Pharmacokinetics and Breast Milk Transfer to Infants of Subcutaneous Extended-Release Buprenorphine for the Treatment of Individuals with Opioid Use Disorder.","authors":"Antoinette Nelson-Rodriguez, Kelley Saia, Xin Xie, Jeremiah Momper, Davida M Schiff, Elisha M Wachman","doi":"10.1089/bfm.2025.0045","DOIUrl":"10.1089/bfm.2025.0045","url":null,"abstract":"Background: Extended-release buprenorphine (XR BUP) is commonly used for individuals with opioid-use disorder (OUD), however, with limited experience in pregnancy. N-methyl-2-pyrrolidone (NMP), an excipient of monthly XR BUP formulations, is a developmental toxicant. No information is available on pharmacokinetics or breast milk transfer in lactating individuals receiving XR BUP. Methods: Samples of maternal plasma, infant plasma, and breast milk were collected from lactating individuals between 0 and 6 months postpartum receiving monthly XR BUP. All samples were analyzed for BUP and NMP concentrations using a validated liquid chromatography-tandem mass spectrometry assay. Results: Three lactating individuals provided a total of nine maternal plasma, six infant plasma, and five breast milk samples. Mean BUP concentrations were 6.0 ng/mL (standard deviation [SD] 1.6) in maternal plasma, 8.9 ng/mL (SD 6.6) in breast milk, and below the lower limit of quantitation for all infant plasma samples. We estimated the relative infant dose (RID) of BUP to be 1%. NMP was detectable in maternal plasma (mean 5.43 μg/mL, SD 4.56) and breast milk (mean 3.83 μg/mL, SD 5.07) only from samples measured between 1 and 5 hours after dosing. NMP was not detected in infant plasma. Conclusions: Among lactating individuals receiving XR BUP, BUP was present in low levels in maternal plasma (similar to nonlactating individuals on XR BUP) and breast milk of lactating individuals receiving XR BUP (similar to lactating individuals on sublingual BUP), resulting in a low RID. NMP passes into breast milk, however, was not present in infant plasma. Additional data are needed before definitive conclusions can be made.","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":"588-592"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacillus Pre-Pasteurization Screening Protocol Reduces Donor Human Milk Loss. 芽孢杆菌巴氏灭菌前筛选方案减少供体母乳损失。

IF 1.8 3区医学

Breastfeeding Medicine Pub Date : 2025-08-01 DOI: 10.1177/15568253251364882

Sydney McCune, Lisa Stellwagen, Carrie L Byington, Alison Wolf, Nguyen Nguyen, Lars Bode

{"title":"Bacillus Pre-Pasteurization Screening Protocol Reduces Donor Human Milk Loss.","authors":"Sydney McCune, Lisa Stellwagen, Carrie L Byington, Alison Wolf, Nguyen Nguyen, Lars Bode","doi":"10.1177/15568253251364882","DOIUrl":"https://doi.org/10.1177/15568253251364882","url":null,"abstract":"Introduction: Human milk is the optimal source of nutrition and bioactives for infants, particularly preterm infants, who are at higher risk of morbidity and mortality. Many premature infants require pasteurized donor human milk (PDHM) to supplement their diet. Given the increased susceptibility of preterm infants to infections, PDHM is strictly regulated to ensure safety. Pasteurization of human milk eliminates most pathogens. However, spore-forming bacteria, notably Bacillus cereus and other Bacillus species, are capable of surviving pasteurization. These bacteria contribute significantly to PDHM discard rates, which average approximately 5-10% of the final donor milk products, making it a leading cause of contamination-related waste. Objective: The University of California Health Milk Bank adopted at their inception in 2020, a novel pre-pasteurization screening protocol with the aim to reduce discard rates. This study examines 3 years of data to assess the protocol's effectiveness and cost efficiency. Results: Ninety-eight percent of post-pasteurization positive cultures were Bacillus species. Following a pre-pasteurization screening protocol, the total discard rate due to Bacillus contamination was 3.1%-1.9% pre-pasteurization and 1.2% post-pasteurization. Without pre-pasteurization screening, 10.7% of PDHM could have potentially been discarded due to Bacillus contamination. The cost of pre-pasteurization screening of donor milk was $60,069 over 3 years, and the potential reduction in discard-related losses was 1,942,800 mL (64,760 ounces), with a value of approximately $323,800 for a return on investment of $4.39 per dollar spent. Conclusions: The findings highlight the role of pre-pasteurization screening cultures as a cost-effective method of reducing product loss.","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To Supplement or Not to Supplement-That Is the Question. 补充还是不补充——这是个问题。

IF 1.8 3区医学

Breastfeeding Medicine Pub Date : 2025-08-01 Epub Date: 2025-05-15 DOI: 10.1089/bfm.2025.0113

Elien Rouw

引用次数: 0

Association of Cytokines in Breast Milk with Otitis Media Infection and Fever Frequency in Infants: A Case-Control Study. 母乳中细胞因子与婴儿中耳炎感染和发热频率的关系：一项病例-对照研究。

IF 1.8 3区医学

Breastfeeding Medicine Pub Date : 2025-07-31 DOI: 10.1177/15568253251363255

Naoko Higuchi, Kento Sawane, Tomoko Tanaka, Hiroko Takumi, Chisato Hara, Masaya Koshizaka, Midori Yamamoto, Kenichi Sakurai

{"title":"Association of Cytokines in Breast Milk with Otitis Media Infection and Fever Frequency in Infants: A Case-Control Study.","authors":"Naoko Higuchi, Kento Sawane, Tomoko Tanaka, Hiroko Takumi, Chisato Hara, Masaya Koshizaka, Midori Yamamoto, Kenichi Sakurai","doi":"10.1177/15568253251363255","DOIUrl":"https://doi.org/10.1177/15568253251363255","url":null,"abstract":"Introduction: Infants have an immature immune system, making them more susceptible to infectious diseases, including otitis media (OM). Breastfeeding is known to reduce OM risk. Although cytokines in breast milk regulate immune functions, their association with OM incidence is underexplored. This study investigated the breast milk cytokines associated with OM in infancy. Methods: A case-control study was conducted using mother-child pairs from the Chiba Study of Mother and Child Health (16 cases, 53 controls) with a history of OM. Breast milk samples were collected at three time points (colostrum, 1 month, and 4 months postpartum), and cytokine concentrations were measured. We compared cytokine levels between cases and controls and analyzed differences between primiparous and multiparous mothers, including subgroup analysis for multiparous mothers. Results: Children in the case group were more likely to have multiparous mothers. Cytokine concentrations were highest in colostrum and decreased over time, except for interleukin-7 (IL-7), which increased at 1 month postpartum. However, among multiparous mothers, IL-7 concentration was higher in the control group at 1 month postpartum (66.3 [45.7, 84.7] versus 14.1 [0.00, 42.5] pg/mL). Conclusions: IL-7 in mature breast milk significantly prevents OM, potentially in infants born to multiparous mothers. Trial Registration: This trial was registered in the University Hospital Medical Information Network (UMIN) Clinical Trials Registry (trial registration number: UMIN000046221, registration date: 29/11/2021).","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Breast Milk Temperature on Comfort and Physiological Parameters of Preterm Infants: A Randomized Crossover Study. 母乳温度对早产儿舒适度和生理参数的影响：一项随机交叉研究。

IF 1.8 3区医学

Breastfeeding Medicine Pub Date : 2025-07-31 DOI: 10.1177/15568253251363535

Seda Çağlar, Nihan Korkmaz, Merve Azak, Halime Dervişoğlu, Avidan Kızılelma Yiğit

{"title":"The Effect of Breast Milk Temperature on Comfort and Physiological Parameters of Preterm Infants: A Randomized Crossover Study.","authors":"Seda Çağlar, Nihan Korkmaz, Merve Azak, Halime Dervişoğlu, Avidan Kızılelma Yiğit","doi":"10.1177/15568253251363535","DOIUrl":"https://doi.org/10.1177/15568253251363535","url":null,"abstract":"Aim: In neonatal intensive care units (NICUs), the temperature of breast milk can significantly influence the comfort and physiological stability of preterm infants. The aim of this study was to compare the effects of breast milk warmed to different temperatures (traditional bain-marie method, 37°C using a milk warmer, and 32-34°C using a milk warmer) on the comfort and physiological parameters of preterm infants. Methods: This randomized crossover study included 24 preterm infants who were fed breast milk under three conditions as follows: warmed to 32-34°C, 37°C, and using the bain-marie method. Comfort was assessed using the Premature Infant Comfort Scale, and physiological parameters were evaluated before and after feeding. Nonparametric tests (Kruskal-Wallis and Friedman) were used for statistical analysis. Results: The infants had a mean gestational age of 30.48 weeks and a mean birth weight of 1353.25 grams. Postfeeding comfort scores were significantly higher in the 37°C and bain-marie groups compared with the 32-34°C group (p < 0.001). However, there were no significant differences in heart rate, oxygen saturation, or body temperature between the groups. Conclusion: Breast milk warmed to body temperature (37°C) improves infant comfort without adverse effects on physiological parameters. Standardization of warming protocols in NICUs may contribute to improved care practices for preterm infants.","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Pasteurization on Ghrelin and Resistin Hormone Concentrations in Human Breast Milk. 巴氏灭菌对人母乳中生长素和抵抗素激素浓度的影响。

IF 1.8 3区医学

Breastfeeding Medicine Pub Date : 2025-07-30 DOI: 10.1177/15568253251363563

Stephanie Q Zhang, Alyssa Sproles, Ting Ting Fu

{"title":"Effect of Pasteurization on Ghrelin and Resistin Hormone Concentrations in Human Breast Milk.","authors":"Stephanie Q Zhang, Alyssa Sproles, Ting Ting Fu","doi":"10.1177/15568253251363563","DOIUrl":"https://doi.org/10.1177/15568253251363563","url":null,"abstract":"Background: Donor breast milk (DBM) is often used to supplement maternal milk, especially for very low birth weight infants, a population vulnerable to suboptimal postnatal growth. The Holder pasteurization process used to ensure DBM safety reduces bioactive components, with unclear impact on preterm infant growth. Ghrelin and resistin are two hormones found in breast milk that may play roles in infant growth. This study aimed to evaluate changes in ghrelin and resistin concentrations in breast milk following pasteurization. Methods: Forty frozen, deidentified pooled expressed breast milk samples were heated to 63°C for 30 minutes and then rapidly cooled. Ghrelin and resistin were measured using enzyme-linked immunosorbent assays. Wilcoxon signed-rank tests assessed differences in hormone levels before and after pasteurization. Macronutrient composition was measured using a mid-infrared human milk analyzer, and associations with hormone levels were assessed using linear regression. Results: One paired sample was excluded due to unquantifiable assay results. Among the remaining 39 pairs, median prepasteurization concentrations were 11.05 pg/mL for ghrelin and 311 pg/mL for resistin. Pasteurization significantly reduced hormone levels, with median decreases of 36.7% for ghrelin and 24.3% for resistin (both p < 0.001). A moderate association was observed between resistin and protein content (R2 0.3399, p < 0.0001). Conclusions: Pasteurization significantly reduces ghrelin and resistin concentrations in breast milk. Further investigation is warranted to determine the clinical relevance of these hormonal changes, particularly in relation to growth outcomes in preterm infants.","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Why We Should Attend a Breastfeeding Medicine Conference. 为什么我们应该参加母乳喂养医学会议。

IF 1.8 3区医学

Breastfeeding Medicine Pub Date : 2025-07-30 DOI: 10.1177/15568253251364370

Elien Rouw, Julie Ware

引用次数: 0

Reducing Racial, Ethnic, and Socioeconomic Disparities in Frenotomy Practice. 减少截骨术中种族、民族和社会经济差异。

IF 2.1 3区医学

Breastfeeding Medicine Pub Date : 2025-07-16 DOI: 10.1177/15568253251360779

Annemarie Kelly, Scott Wexelblatt, Laura Ward, Nichole Nidey, Jennifer McAllister

{"title":"Reducing Racial, Ethnic, and Socioeconomic Disparities in Frenotomy Practice.","authors":"Annemarie Kelly, Scott Wexelblatt, Laura Ward, Nichole Nidey, Jennifer McAllister","doi":"10.1177/15568253251360779","DOIUrl":"https://doi.org/10.1177/15568253251360779","url":null,"abstract":"Objective: Surgical correction of ankyloglossia through frenotomy has increased over 10-fold in the past decade, despite not seeing any significant improvement in breastfeeding rates. Due to heightened attention to this diagnosis and lack of consensus on treatment, we sought to evaluate our regional practice and standardize the screening for ankyloglossia. Materials and Methods: A retrospective cohort study of frenotomy practice within the birth hospital stay was conducted from June 1, 2019, to June 30, 2021. Patients were identified through billing data and grouped according to race, ethnicity, and health insurance status. The Tongue-tie and Breastfed Babies pictorial tool was then implemented regionally to test for differences. Post-intervention data was analyzed from June 1, 2023, to December 31, 2024. Chi-squared analysis was performed to test for differences. Results: Pre-intervention, there were significant disparities in frenotomy rates, with privately insured patients 2.75 times more likely than those with public insurance to receive a frenotomy during their birth hospitalization (OR 2.75, 95% CI: 2.43-3.12, p < 0.0001). Non-Hispanic White infants were 2.3 times more likely than non-Hispanic Black patients (OR 2.31, 95% CI: 1.94-2.74, p < 0.0001) and 3.9 times more likely than Hispanic infants to undergo the procedure (OR 3.87, 95% CI: 2.19-6.86, p < 0.0001). After the standardization, there were no longer any statistically significant disparities in frenotomy rates by insurance payor status as well as those between non-Hispanic White and non-Hispanic Black patients. Non-Hispanic White infants were still slightly more likely than Hispanic patients to undergo the procedure, but the odds ratio decreased significantly to just 1.37 (OR 1.37, 95% CI: 1.04-1.80, p = 0.0265). Conclusion: These findings suggest that standardizing the assessment of ankyloglossia can improve disparities among those who receive a frenotomy.","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0