BMC Complementary Medicine and Therapies最新文献

{"title":"In-vitro antioxidant and anti-proliferative activity of aerial parts of Senecio Laetus Edgew on breast cancer (MCF-7) and colon carcinoma (HCT116) cell lines.","authors":"Rukhsar Wadoo, Tabasum Ali, Ifat Jan, Suhail Ahmad Mir, Asif Amin, Raies Qadri, Sultan Alshehri, Faiyaz Shakeel, Ghulam Nabi Bader, Shahid Ud Din Wani","doi":"10.1186/s12906-025-04789-y","DOIUrl":"10.1186/s12906-025-04789-y","url":null,"abstract":"<p><p>The present study aimed to perform phytochemical investigation of various fractions of the aerial parts of Senecio laetus Edgew for its bio-constitution and to pharmacologically evaluate these fractions for antioxidant and antiproliferative activities against breast cancer (MCF-7) and colon carcinoma (HCT-116) cell lines. Phytochemical screening and characterization of compounds was carried out as per standard procedures. Extracts were subjected to GC-MS analysis for identification and characterization of constituents. The antioxidant activity was carried out using DPPH, ferric ion reducing power assay, and nitric oxide radical inhibition assays. In vitro antiproliferative activity of the extracts was carried out using MCF-7 (breast cancer) and HCT-116 (colon carcinoma) cancer cell lines by MTT assay, colony formation assay, and wound healing assay. Phytochemical screening showed the presence of alkaloids, flavonoids, carbohydrates, glycosides (cardiac and anthraquinone), tannins, triterpenoids, phenolic compounds, and phytosterols. GC-MS analysis showed the presence of 54 compounds. Ethyl acetate and methanolic extract exhibited the maximum amount of phenolic content compared to dichloromethane and hexane fractions. Antioxidant capacities were shown highest in ethyl acetate and methanolic fractions. The antiproliferative activity was found to be concentration dependent, with dichloromethane fraction more effective than ethyl acetate and hexane fractions against both the MCF-7 and HCT-116 cancer cell lines. The results indicate that S. laetus Edgew has a promising antioxidant and antiproliferative potential as shown by its activity against MCF-7 (breast carcinoma) and HCT-116 (colon carcinoma) cancer cell lines.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"45"},"PeriodicalIF":3.3,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11816538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of HYYK formula for residual follicle revival in premature ovarian insufficiency: a multicenter, randomized, double-blind, placebo-controlled trial protocol.","authors":"Yin Peng, Jian Liu, Yang Li, Guangning Nie, Fangping Cheng, Daning Feng, Qiaolin Du, Jian Huang, Hongyan Yang","doi":"10.1186/s12906-025-04803-3","DOIUrl":"10.1186/s12906-025-04803-3","url":null,"abstract":"<p><strong>Background: </strong>Premature ovarian insufficiency (POI), a condition impacting women under 40, is rising globally, posing significant risks to fertility, bone health, and cardiovascular function. Conventional hormone replacement therapy (HRT) alleviates symptoms but fails to restore ovarian function. Our prior studies have demonstrated that the Huyang Yangkun (HYYK) formula effectively supports menstrual cycle frequency and alleviates menopause-related symptoms in POI patients. This study aims to evaluate the efficacy and safety of the HYYK formula, a traditional Chinese medicine (TCM) approach, in enhancing residual follicle activity in POI patients.</p><p><strong>Methods: </strong>This multicenter, randomized, double-blind, placebo-controlled trial will enroll 102 women with POI, who will be randomly assigned to receive either the HYYK formula or a placebo for 24 weeks. Primary outcomes will be assessed through Hoogland and Skouby scores (indicative of residual follicle activity) and menstrual cycle regularity. Secondary outcomes include hormone levels (AMH, FSH, LH, E2), ovarian volume, antral follicle count, and clinical symptom scales, such as the Greene Scale and the Female Sexual Function Index. Safety assessments will involve routine physical exams and adverse event monitoring.</p><p><strong>Discussion: </strong>This is the first multicenter, randomized, double-blind, placebo-controlled study to investigate the efficacy of TCM in stimulating residual follicle recovery in POI patients. The trial rigorously investigates the potential of the HYYK formula as a therapeutic alternative for POI, aiming to deliver high-quality evidence that supports the use of TCM in POI management. This study will concentrate on stimulating residual follicle development in POI patients, offering a viable approach to delaying ovarian decline and generating compelling clinical evidence.</p><p><strong>Trial registration: </strong>Chinese Clinical Trials.gov ChiCTR2100049604 Registered on August 6, 2021 ( http://www.chictr.org.cn ).</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"46"},"PeriodicalIF":3.3,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11817039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Vitis vinifera nanoemulgel and evaluation of its potential anticancer, antimicrobial and anti-inflammatory.","authors":"Ahmad M Eid, Haneen Al-Hawari, Shahd Nazzal, Samera Khudarieh","doi":"10.1186/s12906-025-04804-2","DOIUrl":"10.1186/s12906-025-04804-2","url":null,"abstract":"<p><strong>Background: </strong>Since ancient times, plants with medicinal properties have played a crucial role in the prevention and treatment of various diseases. The current study focuses on the formulation and assessment of Vitis vinifera (V. vinifera) oil nanoemulgel, exploring its potential antimicrobial, anticancer, and anti-inflammatory properties.</p><p><strong>Method: </strong>The incorporation of Vitis vinifera oil into a nanoemulsion was achieved through the self-nanoemulsifying technique, utilizing Tween 80 and Span 80 as emulsifying agents. The addition of Carbopol hydrogel to the nanoemulsion resulted in the formation of a nanoemulgel. The subsequent evaluation focused on the following properties: rheology, polydispersity index (PDI), zeta potential, and antimicrobial potentials against seven microbial strains, as well as anticancer activities involving B16-F1, Hep-3B, LX-2, and HeLa cell lines, along with anti-inflammatory activities.</p><p><strong>Result: </strong>The optimal nanoemulsion formulation had a particle size of 173.19 nm and a low PDI of 0.129. Similarly, the nanoemulgel had a particle size of less than 200 nm and a PDI below 0.15. Its zeta potential was less than - 35 mV, and it exhibited pseudoplastic rheological behavior. V. vinifera oil nanoemulgel demonstrated notable antimicrobial activity against MRSA, P. vulgaris, and K. pneumoniae, with inhibition zones of 27 ± 1.6 mm, 39 ± 2.2 mm, and 24 ± 1.3 mm, respectively. Additionally, it showed enhanced anticancer activity against HeLa, LX-2, B16-F1, and Hep-3B cancer cell lines, with IC₅₀ values of 28.84, 56.23, 151.35, and 66.06 µg/mL, respectively.</p><p><strong>Conclusion: </strong>These findings show that the nanoemulgel had enhanced activity compared to the oil. Additionally, the nanoemulgel inhibited both COX-1 and COX-2, showing selectivity towards COX-1. This shows the potential of using nanotechnology in the development of pharmaceutical dosage forms.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"47"},"PeriodicalIF":3.3,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11816773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astragaloside IV attenuates glucocorticoid-induced osteoclastogenesis and bone loss via the MAPK/NF-κB pathway.","authors":"Chun Guo, Yangyang Li, Ruijuan Yang, Mingzhang Xie, Xiangfeng Chen, Zhiqun Che, Zhixia Wang, Bin Zhong, Yanhong Luo, Xiao-Min Leng","doi":"10.1186/s12906-025-04793-2","DOIUrl":"10.1186/s12906-025-04793-2","url":null,"abstract":"<p><strong>Background: </strong>Astragaloside IV (AS-IV) is a bioactive saponin extracted from Radix Astragali, and it is reported to promote osteoblast differentiation while inhibiting osteoclastogenesis. However, the mechanism of AS-IV in glucocorticoid-induced osteoclastogenesis (GIO) remains undetermined. Herein, we examined the influence of AS-IV on GIO and bone loss.</p><p><strong>Methods: </strong>RAW264.7 cells were incubated with dexamethasone (Dex) alone or Dex and receptor activator of nuclear factor-B ligand (RANKL) (Dex and RANKL) for 2 days, and then treated with Dex or Dex and RANKL through AS-IV for the timeframes indicated. Following, mice were intraperitoneally administered with an intermediate-acting glucocorticoid, methylprednisolone (MP), or MP and AS-IV for 6 weeks.</p><p><strong>Results: </strong>AS-IV significantly decreased Dex-induced osteoclast nucleus and area, however, it did not impact the number of Dex-induced osteoclasts in RAW264.7 cells. AS-IV also significantly decreased the osteoclastic marker protein expressions in Dex-induced RAW264.7 cells with concentration of dose dependent fashion. Additionally, AS-IV promoted p38 phosphorylation (p-) and p-p65 translocation to the nucleus, while inhibiting phosphorylation of extracellular signal-regulated kinase (ERK) (p-ERK) and inhibitor of Nuclear factor κB (NF-κB) (p-IκB) levels. However, the AS-IV-mediated action on p-MAPK, p-NF-κB, and osteoclastic marker expressions were reversed by MAPK or IκB inhibitor in Dex-induced RAW264.7 cells. Furthermore, our in vivo evaluation revealed that AS-IV also attenuated the MP-mediated bone loss, and suppressed osteoclastogenesis.</p><p><strong>Conclusions: </strong>This study demonstrates that AS-IV inhibits GIO and attenuates bone loss via the MAPK/NF-κB pathway. This also suggested that AS-IV could be a potential promising therapeutic agent for glucocorticoid-triggered bone loss.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"48"},"PeriodicalIF":3.3,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11818135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and perception of stroke management practices among middle-aged residents of Otolo community in Nnewi North Local Government Area, Nigeria.","authors":"Uchenna Prosper Okonkwo, Chidera Chibuikem Fortunate, Sochima Johnmark Obiekwe, Uchechukwu Martha Chukwuemeka, Christiana Nkiru Okafor, Augustine Asiduba Igwe, Jovita Ada Daniel","doi":"10.1186/s12906-025-04785-2","DOIUrl":"10.1186/s12906-025-04785-2","url":null,"abstract":"<p><strong>Background: </strong>Stroke is a leading cause of morbidity and mortality globally, with Nigeria having one of the highest stroke mortality rates in Africa. The burden of stroke is particularly high in middle-aged individuals, who are often the primary breadwinners and caregivers in their families. Despite the high burden of stroke in this community, there is a paucity of studies on the knowledge and perception of stroke management practices among middle-aged residents of Otolo community.</p><p><strong>Aim: </strong>This study investigated the knowledge and perception of middle-aged residents of Otolo community in Nnewi North Local Government Area to stroke management practices; and to identify certain sociodemographic factors that may influence the knowledge and perception of this residents.</p><p><strong>Method: </strong>A total of 191 middle-aged residents of Otolo community in Nnewi North Local Government Area, participated in this cross-sectional study. A self-reported questionnaire was distributed to the participants in the meeting venues, churches and market places with the help of research assistants after filling the consent forms. The data collection lasted for four weeks and it took the average of 12 min to complete each questionnaire. Analysis of the collected data was done using IBM Statistical Package for Social Sciences (SPSS) version 26.</p><p><strong>Result: </strong>The findings of this study revealed that the study participants had a better knowledge of medical stroke management 36 (19%) than traditional stroke care 19(10%). Majority of the participants had a positive perception of medical stroke care129 (68%) than traditional management practices110 (58%). Age, educational status and occupational status were found to have statistically significant association (p < 0.05) with the participants' knowledge, while the educational attainment and occupational status were the major demographic variables found to be associated (p > 0.05) with the respondents' perception of stroke management practice.</p><p><strong>Conclusion: </strong>The middle-aged residents of Otolo community had a fair knowledge of medical management of stroke and a poor knowledge of traditional stroke care. Majority of the study respondents had a more positive perception of medical management of stroke as compared to traditional management. Some of the sociodemographic factors found to impact knowledge and perception of this management practices includes age, educational attainment and occupation.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"44"},"PeriodicalIF":3.3,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of in vitro skin permeation and accumulation of phenolic acids from honey and honey-based pharmaceutical formulations.","authors":"Anna Nowak, Anna Muzykiewicz-Szymańska, Magdalena Perużyńska, Edyta Kucharska, Łukasz Kucharski, Karolina Jakubczyk, Paulina Niedźwiedzka-Rystwej, Justyna Stefanowicz-Hajduk, Marek Droździk, Juraj Majtan","doi":"10.1186/s12906-025-04786-1","DOIUrl":"10.1186/s12906-025-04786-1","url":null,"abstract":"<p><strong>Background: </strong>Honey has been successfully used in wound care and cosmetics because of its effective biological properties, including antibacterial, antioxidant, and anti-inflammatory activities. Polyphenols, particularly phenolic acids, are key honey components responsible for these beneficial effects. In recent years, there has been a growing demand for natural, ecologically friendly, and biodegradable products in the modern cosmetics and wound care market. This study aimed to identify and quantify phenolic acids in four Polish honey samples of different botanical origins (heather, buckwheat, linden and rapeseed) and to assess for the first time the permeation of the identified phenolic acids through the skin and their accumulation after the application of pure honey samples, as well as honey-based hydrogel and emulsion formulations.</p><p><strong>Methods: </strong>The honey samples' antioxidant activity and total phenolic content were determined using the DPPH and ABTS assays and the Folin-Ciocalteu method, respectively. Phenolic acids and volatile compounds were identified and quantified in honey samples using the HPLC-UV and GC-MS method, respectively. The biocompatibility of the honey samples was evaluated using a murine fibroblast cell line (L929). A Franz-type vertical diffusion cell with porcine skin was used to assess phenolic acid's permeation and skin accumulation from different honey-based pharmaceutical formulations. The biodegradability of the prepared formulations was also characterised.</p><p><strong>Results: </strong>Gallic acid, 3,4-dihydroxybenzoic acid, 2,5-dihydroxybenzoic acid, coumaric acid, and 3-hydroxybenzoic acid were identified and quantified in the honey samples. Heather honey exhibited significantly higher antioxidant activity and total polyphenol content than the other honey samples. Heather, linden and buckwheat honey samples significantly decreased cell viability at concentrations of 5% and 2.5%, while rapeseed honey sample markedly reduced fibroblast viability only at 5%. Among the tested formulations - pure honey, hydrogel, and emulsion - higher skin permeation and accumulation rates of phenolic acids were observed with the prepared honey-based hydrogels than with the pure honeys and emulsions. Additionally, the prepared formulations were classified as partially biodegradable.</p><p><strong>Conclusions: </strong>The obtained results confirmed the effectiveness of two pharmaceutical formulations in the form of a hydrogel or emulsion containing honey after applied topically. The inclusion of honey in the vehicle, in particular hydrogel increased the penetration of phenolic acids through the skin.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"43"},"PeriodicalIF":3.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11796271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effects of Health Qigong and closed motor exercise on the physical and mental health of female drug rehabilitation participants: a randomized controlled trial.","authors":"Guang Yang, Deyu Meng, Shichun He, Meiqi Wei, Man Li, Lu Zhang, Zhendong Pan, Ziheng Wang","doi":"10.1186/s12906-025-04797-y","DOIUrl":"10.1186/s12906-025-04797-y","url":null,"abstract":"<p><strong>Background: </strong>Drug rehabilitation is a challenging process that impacts both the physical and mental health of individuals. Traditional martial arts, such as Health Qigong, and closed motor exercises, such as power cycling, have shown potential benefits in improving health outcomes. This study aims to compare the effects of Health Qigong, closed motor exercises, and their combination on the physical and mental health of female drug rehabilitation participants.</p><p><strong>Methods: </strong>In this randomized controlled trial, female participants from the Jilin Province Women's Compulsory Isolation Drug Rehabilitation Center were randomly assigned to three groups: Health Qigong (QigongG), Closed Motor Exercise (ClosedG), and Combined Health Qigong and Closed Motor Exercise (CombinedG). Measurements were taken at baseline, mid-intervention, and post-intervention and included resting heart rate, vital capacity, choice reaction time, sleep quality, and relapse tendency.</p><p><strong>Results: </strong>At the study's conclusion, the ClosedG group showed significant improvements in relapse tendency, vital capacity, and sleep quality compared to baseline. The QigongG showed significant improvements in relapse tendency, sleep quality, and choice reaction compared to baseline. The CombinedG group demonstrated significant improvements in relapse tendency, vital capacity, sleep quality, and choice reaction time, outperforming the ClosedG groups in reaction time, and outperforming QigongG groups in vital capacity. The CombinedG group exhibited the most notable overall improvements.</p><p><strong>Conclusion: </strong>The combined intervention of Health Qigong and closed motor exercises is more effective in improving physical and mental health metrics among female drug rehabilitation participants than either intervention alone. These findings suggest that incorporating a combination of traditional martial arts and closed motor exercises could enhance rehabilitation programs for drug rehabilitation.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov NCT06454565. The date of registration is 2024.07.11 (Retrospectively registered).</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"38"},"PeriodicalIF":3.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tangeretin offers neuroprotection against colchicine-induced memory impairment in Wistar rats by modulating the antioxidant milieu, inflammatory mediators and oxidative stress in the brain tissue.","authors":"Olalekan Bukunmi Ogunro, Mojisola Esther Karigidi, Gideon Ampoma Gyebi, Areej Turkistani, Ahmad H Almehmadi","doi":"10.1186/s12906-025-04769-2","DOIUrl":"10.1186/s12906-025-04769-2","url":null,"abstract":"<p><strong>Background: </strong>Tangeretin, a flavone compound (O-polymethoxylated) naturally present in tangerine and other citrus peels has demonstrated effectiveness as an anti-inflammatory and neuroprotective agent in several disease model. This study evaluated the impact of tangeretin in mitigating cognitive dysfunction and oxidative stress induced by colchicine in rats, comparing its efficacy with donepezil hydrochloride.</p><p><strong>Methods: </strong>Cognitive dysfunction was induced by administering colchicine (15 µg/rat) intracerebroventricularly (ICV) via a stereotaxic apparatus in male Wistar rats. Colchicine resulted in poor memory retention in acquiring and retaining a spatial navigation task, passive avoidance apparatus, and Morris water maze paradigms. Chronic treatment with tangeretin (at doses of 50, 100, and 200 mg/kg, p.o. once daily) and donepezil hydrochloride (at a dose of 10 mg/kg, p.o. daily) for 28 days, starting seven days before colchicine injection, significantly ameliorated colchicine-induced cognitive impairment.</p><p><strong>Results: </strong>The biochemical analysis showed that chronic administration of tangeretin effectively reversed the colchicine-induced increase in the level/activity of lipid peroxidation, hydrogen peroxide (H₂O₂), myeloperoxidase (MPO), nitrite, reactive oxygen species (ROS), tumour necrosis factor-α (TNF-α), nuclear factor kappa B (NF-κB), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-10 (IL-10), serotonin, dopamine, glutamate, amyloid beta (Aβ) peptide, and caspase-3. Tangeretin also reversed the colchicine-induced reduction in the level/activity of brain-derived neurotrophic factor (BDNF), amma-aminobutyric acid (GABA), acetylcholinesterase (AChE), glutathione S-Transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR), catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), and total thiol (T-SH) in rat brains. However, donepezil hydrochloride did not prevent oxidative stress.</p><p><strong>Conclusions: </strong>These findings suggest that chronic administration of tangeretin at 50, 100, and 200 mg/kg, p.o. once daily, was protective in mitigating colchicine-induced cognitive impairment and associated oxidative stress. At the same time, donepezil hydrochloride did not demonstrate similar effects.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"40"},"PeriodicalIF":3.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the cervical and thoracic \"Daoyin\" training on posture and pulmonary function in patients with upper crossed syndrome: a randomized controlled trial.","authors":"Yue Guo, Ming Li, Chaowei Xie, Xiaoyan Liu, Yushan Chen, Jun Yang, Yuxue Wu, Shaoqing Chen, Shizhong Wang, Jianping Lin","doi":"10.1186/s12906-025-04791-4","DOIUrl":"10.1186/s12906-025-04791-4","url":null,"abstract":"<p><strong>Objectives: </strong>With the growing ubiquity of electronic devices, the incidence of upper crossed syndrome (UCS) is increasing every year and tends to affect younger populations. The study was designed to assess the effect of cervical and thoracic \"Daoyin\" training on pain, posture, pulmonary function, cervical range of motion, and emotional state in college students with UCS.</p><p><strong>Design: </strong>We conducted a parallel-group randomized control study.</p><p><strong>Setting: </strong>The Fujian Medical University in China.</p><p><strong>Participants: </strong>74 patients with UCS fulfilled the study requirement and were assigned to the intervention group (IG) and the control group (CG).</p><p><strong>Intervention: </strong>Instructed cervical and thoracic \"Daoyin\" training was given to students in the IG for eight weeks, five days a week for 45 min, whereas students in the CG continued with their usual activities.</p><p><strong>Main outcome measures: </strong>Primary outcomes, including forward head and shoulder angles, pain and cervical spine function, as well as secondary outcomes, such as pulmonary function, cervical range of motion and emotional state, were measured at baseline and a follow-up of 8-week. These measurements were conducted using photogrammetry, visual analog scale (VAS), Neck Disability Index (NDI), pulmonary function, cervical range of motion test and Self-rating Anxiety Scale (SAS), respectively. The statistical analysis used the change value between the baseline and the 8-week intervention measurements.</p><p><strong>Results: </strong>74 patients (IG = 37; CG = 37) were randomized. All participants were included in the analysis. There were significant differences of the change values between groups in Forward Head Angle (FHA) (d = 1.113, P < 0.001), Forward Shoulder Angle (FSA) (d = 1.052, P < 0.001), VAS (d = 0.854, P < 0.001), NDI (d = 0.754, P = 0.005), pulmonary function (Forced Expiratory Volume in 1 s/Forced Vital Capacity (FEV1/FVC) (d = 0.516, P = 0.002), maximal voluntary ventilation (MVV) (d = 0.504, P = 0.033), cervical range of motion in Left Rotation (LR) (d = 0.647, P = 0.014) and emotional state (d = 0.587, P = 0.014). No side effects were observed in this study.</p><p><strong>Conclusion: </strong>Cervical and thoracic \"Daoyin\" training can improve the abnormal posture of head forward and round shoulders, reducing pain and anxiety, improving cervical spine function, and improving lung function to a certain extent.</p><p><strong>Trial registration: </strong>ChiCTR2300072669 (20/06/2023), Prospective registration, www.chictr.org.cn .</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"41"},"PeriodicalIF":3.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the antibacterial and anti-biofilm activity of two Iranian medical-grade kinds of honey on multidrug-resistant Pseudomonas aeruginosa.","authors":"Mustafa Riyadh Alshaybawee, Shahrzad Asgari, Paria Ghadersoltani, Ahmadreza Mehrabian, Parastoo Saniee","doi":"10.1186/s12906-025-04778-1","DOIUrl":"10.1186/s12906-025-04778-1","url":null,"abstract":"<p><strong>Introduction: </strong>Pseudomonas aeruginosa is a prominent multidrug-resistant and biofilm-forming bacteria. Mono-floral honey, enriched with a variety of biological compounds, can be categorized as medical-grade honey due to its notable pharmacological benefits. In this study, two types of Iranian honey were thoroughly characterized, and the antimicrobial and anti-biofilm properties were examined against three clinical strains of multidrug-resistant P. aeruginosa.</p><p><strong>Methods: </strong>Citrus and Thyme honey from Alborz were selected based on physicochemical, phytochemical, and melissopalynological tests conducted from a medical perspective. The antibacterial activity of the honey samples against three clinical strains of multidrug-resistant P. aeruginosa isolated from wound infections was evaluated using both the well-diffusion and broth microdilution methods. Additionally, an antibiofilm assay was performed using the crystal violet method in microplates.</p><p><strong>Results: </strong>Both medical grade honey samples exhibited considerable antibacterial activity against the three P. aeruginosa isolates at 75-100% v/v concentrations with inhibition zones measuring between 15 and 30 mm. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) values for both types of honey were 6.25% v/v (final concentration). The antibiofilm assay indicated that both types of honey demonstrated varying levels of antibiofilm activity. Citrus honey at 9% concentration was the most effective, showing an average inhibition rate of 59%, while Citrus honey at 2.3% final concentration exhibited the least effectiveness with an average inhibition rate of 23%.</p><p><strong>Discussion: </strong>A thorough analysis of the honeys studied confirmed their authenticity and the presence of medicinal compounds. The results of honey tests correspond to the normal range (natural Honey) in the Council of the European Union. Based on the evaluation and compliance with the medical grade criteria including authenticity, health, qualities well botanical origin mentioned honey is classified in medical grade. The antibacterial results indicated that both Thyme and Citrus honeys effectively inhibit the growth and biofilm formation of P. aeruginosa. Therefore, these honeys may serve as natural and safe alternatives or adjuncts to conventional antibiotic therapy for wound healing and infection management.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"39"},"PeriodicalIF":3.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}