BMC Complementary Medicine and Therapies最新文献

{"title":"Antioxidant and hepatoprotective effect of Jatropha dioica against the valproic acid-induced damage in an in vivo model.","authors":"Paula Cordero-Pérez, Ramiro Tijerina-Márquez, Veronica Mayela Rivas-Galindo, Liliana Torres-González, Diana Raquel Rodríguez-Rodríguez, Oscar Humberto Mendoza-Hernández, César Bigran Espinosa-Cantú, Guadalupe Yazmín Solís-Cruz, Linda E Muñoz-Espinosa, Edelmiro Pérez-Rodríguez, Idalia Cura-Esquivel, Gabriela Alarcón-Galván, Diana Patricia Moreno-Pena","doi":"10.1186/s12906-025-04914-x","DOIUrl":"10.1186/s12906-025-04914-x","url":null,"abstract":"<p><strong>Background: </strong>Understanding liver diseases is important worldwide due to their prevalence. Apart from liver disease arising from hepatitis C viral infection, most chronic liver diseases currently have no cure. Several therapeutic alternatives, including some natural products, have been proposed to treat liver diseases. The natural product Jatropha dioica has been reported to possess antioxidant activity and, by extension, could have hepatoprotective activity. Accordingly, our aim was to test the hypothesis that an extract of J. dioica is protective against liver damage induced by valproic acid (VPA).</p><p><strong>Methods: </strong>Twelve male and twelve female Wistar rats were sorted into four groups: control, non-toxicity, valproic acid control (VPA-C), and J. dioica + VPA (JdVPA). J. dioica (300 mg/kg, given orally) was used as treatment, followed by a concomitant injection of VPA (500 mg/kg, i.p.) for the first 4 days to induce liver injury. To evaluate the severity of the injury, liver function tests were performed. In addition, oxidative stress biomarkers were quantified, as well as measures of the expression of the genes Actb, Il6, and Nfkb1.</p><p><strong>Results: </strong>The VPA-C group showed a significant increase in alanine aminotransferase (ALT), aspartate aminotransferase (AST), and malondialdehyde (MDA), a decrease in superoxide dismutase (SOD), and a reduction in glutathione (GSH) vs the control group. The JdVPA group showed a significant decrease in ALT, AST, and MDA and an increase in GSH and SOD vs the VPA-C group. Gene expression of Il6 and Nfkb1 did not show any statistically significant differences between study groups. Histologically, VPA presented an inflammatory infiltrate, which decreased in the JdVPA group.</p><p><strong>Conclusion: </strong>The extract of J. dioica at the administered dose did not display toxicity and was capable of ameliorating the liver injury generated by VPA in biochemical and oxidative stress biomarkers, which suggests its potential hepatoprotective activity.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"207"},"PeriodicalIF":3.3,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serotonin release mediates analgesia via opioidergic system and withdrawal symptoms in chronic kratom extract-treated mice.","authors":"Dwi Wahyu Indriani, Siti Irma Rahmawati, Asep Bayu, Peni Ahmadi, Anissa Nofita Sari, Zuraida Zuraida, Ni Luh Putu Indi Dharmayanti, Masteria Yunovilsa Putra","doi":"10.1186/s12906-025-04947-2","DOIUrl":"10.1186/s12906-025-04947-2","url":null,"abstract":"<p><strong>Background: </strong>Kratom alleviates pain by activating μu-opioid receptors (MOR), which trigger serotonin release to produce analgesia. Serotonin also interferes drug abuse effect. This study aimed to determine the role of serotonin in kratom-induced pain relief and withdrawal symptoms in mice.</p><p><strong>Methods: </strong>The analgesic effect was assessed using the hot-plate test. To induce withdrawal symptoms, mice received naloxone after being treated with kratom extracts for five days at increasing doses. Another group of morphine-dependent mice was treated with kratom extracts to ameliorate their withdrawal symptoms. A molecular docking study and molecular dynamics were conducted to predict the binding target of alkaloid kratom for increasing serotonin levels.</p><p><strong>Results: </strong>Chronic administration of kratom alkaloid extract (20 mg/kg) produced analgesic effects comparable to morphine (10 mg/kg). In contrast, kratom crude extracts (10 mg/kg and 20 mg/kg) demonstrated lower analgesia activity. This analgesic effect was mediated by MOR activation, leading to decreased intracellular cAMP and increased serotonin transmission. Repeated and increasing doses of crude or alkaloid kratom extracts (8 mg/kg to 45 mg/kg) produced less severe withdrawal symptoms than morphine. Increased dopamine and serotonin levels contributed to the onset of withdrawal symptoms. In the morphine group, treatment with kratom extracts increased serotonin levels while reducing dopamine. Molecular docking and molecular dynamics result revealed that kratom alkaloids interacts more readily with tryptophan hydroxylase, the enzyme responsible for serotonin biosynthesis.</p><p><strong>Conclusions: </strong>Kratom extracts have the potential to provide analgesic effects and withdrawal symptoms, both of which are mediated by elevated serotonin release.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"205"},"PeriodicalIF":3.3,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of binaural beat therapy with different frequencies on autonomic nervous system regulation among college students.","authors":"Shang-Yu Yang, Jiun-Yi Wang, Cheng Liu, Pin-Hsuan Lin","doi":"10.1186/s12906-025-04922-x","DOIUrl":"10.1186/s12906-025-04922-x","url":null,"abstract":"<p><strong>Background: </strong>Although binaural beat therapy (BBT) has been demonstrated to alleviate symptoms of anxiety and depression, but the effects of BBT of different frequencies on college students have not been thoroughly explored. This study explored the effects of BBT with different frequencies on autonomic nervous system regulation (i.e., anxiety reduction) among college students.</p><p><strong>Methods: </strong>This was a quasiexperimental study. Participants were recruited from a university in southern Taiwan. Each of the participants received interventions with different frequencies (theta frequency, 6 Hz; alpha frequency, 10 Hz; and beta frequency, 25 Hz). For each intervention, participants were subjected to 20 min of natural sounds embedded with binaural beats of a specific frequency. A pretest and posttest were conducted to measure blood pressure (BP) and heart rate variability.</p><p><strong>Results: </strong>A total of 65 participants were recruited. The mean age of participants was 20.15 years. Heart rate and systolic and diastolic BP were significantly lower after intervention with theta-frequency binaural beats (p < 0.05). Systolic BP was significantly lower after intervention with alpha-frequency binaural beats (p < 0.05). Heart rate, systolic BP, and nLF were significantly lower and nHF was significantly higher after intervention with beta-frequency binaural beats (p < 0.01). No significant differences were observed between the effects of the three interventions on ANS regulation among the participants.</p><p><strong>Conclusion: </strong>BBT, in which participants were subjected to theta-frequency, alpha-frequency, and beta-frequency binaural beats for 20 min, contributed to reducing anxiety. No significant differences were observed between the effects of each frequency.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"206"},"PeriodicalIF":3.3,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the neuroprotective mechanisms of Jiawei Suanzaoren decoction in depression: insights from network pharmacology and molecular docking.","authors":"Ruiting Ma, Wenjing Zhang, Lixia Chen, Lijun Tong","doi":"10.1186/s12906-025-04939-2","DOIUrl":"10.1186/s12906-025-04939-2","url":null,"abstract":"<p><strong>Background: </strong>Depression is a prevalent and debilitating neuropsychiatric disorder, often associated with neuroinflammation, oxidative stress, and neuronal apoptosis. Jiawei Suanzaoren (JWSZR), a traditional Chinese medicine (TCM) formulation, has demonstrated potential in alleviating depressive symptoms. However, its precise molecular mechanisms remain unclear. This study aims to elucidate the neuroprotective effects of JWSZR in depression using network pharmacology, molecular docking, and in vitro experimental validation.</p><p><strong>Methods: </strong>Active compounds of JWSZR were identified using the TCMSP and HERB databases, and depression-related targets were retrieved from GeneCards, DisGeNET, and OMIM. A protein-protein interaction (PPI) network was constructed, followed by functional enrichment analyses, including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Molecular docking was employed to predict the interactions between JWSZR's active components and key target proteins. Furthermore, in vitro experiments were performed using corticosterone (CORT)-induced PC12 cell model to validate the neuroprotective effects of JWSZR, assessing cell viability and apoptosis rates.</p><p><strong>Results: </strong>Network pharmacology and molecular docking revealed that JWSZR exerts neuroprotective effects through multiple targets, including estrogen receptor ESR2, HSP90AA1, and STAT1. These targets regulate immune responses, inflammatory pathways, and cell survival. In vitro, JWSZR significantly improved cell viability and reduced apoptosis in CORT-treated PC12 cells, indicating its potential to protect against depression-related neurodegeneration.</p><p><strong>Conclusion: </strong>This study provides novel insights into the neuroprotective mechanisms of JWSZR in depression, suggesting that it may act through multi-target interactions involving immune modulation and apoptosis inhibition.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"204"},"PeriodicalIF":3.3,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acetamiprid-induced testicular toxicity in mice: ameliorative effect and potential mechanisms of morin.","authors":"Nihal Turkmen Alemdar, Selim Demir, Esin Yulug, Ali Kulaber, Elif Ayazoglu Demir, Nadire Sevdenur Erdogan, Ahmet Mentese, Yuksel Aliyazicioglu","doi":"10.1186/s12906-025-04944-5","DOIUrl":"10.1186/s12906-025-04944-5","url":null,"abstract":"<p><strong>Background: </strong>Acetamiprid (ACP) is a novel chloronicotinyl insecticide that has been extensively utilized in agricultural, domestic, and public health contexts for nearly two decades. However, its potential to induce organ damage, including reproductive toxicity in mammals, has emerged as a significant concern. Morin is a naturally occurring flavonol that has gained prominence as a food supplement in recent years due to its antioxidant and anti-inflammatory properties. The objective of this study was to evaluate the protective effect of morin against testicular damage in mice subjected to ACP exposure.</p><p><strong>Methods: </strong>Thirty male Balb/c mice were randomly assigned to one of five groups, with the following treatment allocations: control, ACP (20 mg/kg), ACP + morin (15 and 30 mg/kg), and only morin (30 mg/kg). ACP and morin applications were conducted orally over a period of 14 days. Hormonal analyses were conducted on serum samples obtained from the mice, while biochemical and histological evaluations were performed on testicular samples.</p><p><strong>Results: </strong>The biochemical results demonstrated that ACP elevated oxidative stress, inflammation, and ER stress in testicular tissue by inhibiting the Nrf2 pathway, a finding that was corroborated by histopathological analyses. However, morin treatments eliminated ACP-induced Nrf2 inhibition and to activate antioxidant and anti-inflammatory mechanisms. These findings were also corroborated by the restoration of serum testosterone and inhibin B levels and the diminution of histopathological lesions.</p><p><strong>Conclusions: </strong>Overall, the findings indicated that morin may have potential protective properties against ACP-associated reproductive toxicity, however, further research is required to determine the detailed molecular mechanisms.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"203"},"PeriodicalIF":3.3,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of herbal medicine consumption and regulatory compliance in some selected districts of the Bono region, Ghana.","authors":"George Owusu, Meshack Antwi-Adjei, Jones Ofori-Amoah, Ransford Mawuli Tuekpe, Adjei Emmanuel Mainoo, Dorothy Kodua, Anatua Abigail, Oppong Millicent","doi":"10.1186/s12906-025-04953-4","DOIUrl":"10.1186/s12906-025-04953-4","url":null,"abstract":"<p><strong>Background: </strong>Though herbal medicine remains a vital component of healthcare in the Bono region of Ghana, knowledge of its prevalence, factors influencing the choice of herbal remedies, and compliance with quality control standards among the herbal medicine practitioners in the region is lacking. This situation adversely affects health outcomes, regulatory standards, and public trust in herbal medicines in the region.</p><p><strong>Aim: </strong>This study aimed at assessing the prevalence of herbal medicine use, factors that dictate the choice of herbal medicine, and adherence to quality control practices in the Bono region of Ghana.</p><p><strong>Method: </strong>A cross-sectional study with 504 recruited herbal medicine consumers and 98 practitioners, selected across four districts of the Bono region, was used. Paper-pencil questionnaires were used to obtain respondents' sociodemographic data. The chi-square (χ2) test was used to assess associated factors, while logistic regression analysis was used to determine the factors associated with herbal medicine use.</p><p><strong>Results: </strong>It was revealed that 92.7% of the respondents had used herbal medicine within the past 24 months. Old age (P < 0.001), farming (P < 0.001), self-employment (P < 0.004), unemployment (P < 0.049), and no formal education (P < 0.044) were associated with herbal medicine usage. Of the 98 practitioners, 44.9% had active FDA licenses, and 59.2% had undergone formal training in quality control practices at recognized institutions. Of the 73 herbal products identified, 46.5% had no FDA registration certification, 42.5% had no information on unwanted effects and contraindications, and 26% had no expiry dates.</p><p><strong>Conclusion: </strong>The study highlighted a widespread use of herbal medicine and a significant regulatory compliance gap in the Bono region. As herbal medicine remains an essential remedy in this area, commitments from the government, regulatory bodies, practitioners, and the general public are required to improve regulatory adherence to safeguard public health.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"202"},"PeriodicalIF":3.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal plants traditionally used for management of malaria in rural communities of Uganda.","authors":"Lydia Bunalema, Moses Ocan, Francis Williams Ojara, Sam Nsobya, Charles Okot Odongo, Gordon Odia, Aloysious Lubega","doi":"10.1186/s12906-025-04946-3","DOIUrl":"10.1186/s12906-025-04946-3","url":null,"abstract":"<p><strong>Background: </strong>Malaria remains a major cause of morbidity and mortality especially in sub-Saharan Africa. Whereas herbal medicines have long been used for disease remedy in many African communities, there is limited evidence on the extent of use, their safety, and efficacy. This study, sought to identify herbal medicinal plants used by communities in low and high malaria transmission settings in Uganda for managing of malaria.</p><p><strong>Method: </strong>An Ethnobotanical survey was conducted across four geographical regions purposively selected to represent moderate-to-high (Apac, Arua and Tororo districts) and low (Kabale district) malaria transmission settings. One-hundred and two (102) traditional medicine practitioners (TMPs) in Ugandan local communities were included in the study. A checklist was used to collect data and covered the following areas; knowledge on malaria transmission, malaria symptoms, diagnosis, medicinal plants used, preparations, preservation methods and doses. Data was analyzed in MS Excel^®. Consensus factor, use value metrics and frequencies were calculated.</p><p><strong>Results: </strong>Ninety-seven plant species distributed across 45 families were mentioned by TMPs in management of malaria in Ugandan communities. Plant family Asteraceae, 15.5% (15/97) had the highest distribution of plants reported by TMPs. Vernonia amygdalina Delile, Aloe vera Burm. F., Artemisia annua L., Vernonia grantii Oliv. and Justicia betonica L. were the most mentioned, with use values of 0.4, 0.3, 0.2, 0.15 and 0.14 respectively. Leaves 64% and root barks 18% were the most harvested plant parts while decoctions (54%) and infusions 26% were the most common methods of preparing herbal products for individuals with malaria. Medicines were stored as dry powders for extended periods although some were prepared as fresh plants. Nearly all medicinal preparations were administered orally with varying dosage (5 ml-500 ml*3times a day) recommendations. Treatment duration varied between 3 and 7 days among practitioners. TMPs mentioned that malaria is transmitted by mosquitoes while others, said poor hygiene, stagnant water and body contact.</p><p><strong>Conclusion: </strong>A diverse number of plant species, use and preparation methods are documented in this study as a way of preserving traditional knowledge in Uganda. Vernonia amygdalina Del., Aloe vera (L) Burm. f, Vernonia grantii Oliv. and Justicia betonica L. were identified as important plant species that can be further studied to validate their safety, antiplasmodial and active bioactive phytochemicals that can provide novel lead compounds for malaria treatment. These plant species can also be conserved through cultivation for sustainable use.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"201"},"PeriodicalIF":3.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative investigation on Hippocratea africana root: insights from cardio-protective, anti-oxidative stress activities, isolation, GC/MS, and pharmacological significance profiling.","authors":"Edet Effiong Asanga, Kufre Uyo Noah, Jude Efiom Okokon, Chinedum Martins Ekeleme, Imaobong Etima Udoh, Augustine Bassey, Martin Osita Anagboso, Aniekeme Ndisa Inyang","doi":"10.1186/s12906-025-04941-8","DOIUrl":"10.1186/s12906-025-04941-8","url":null,"abstract":"<p><strong>Background: </strong>Hippocratea africana root is scientifically used in cardiotoxicity treatment; therefore, this study was designed to validate this claims through the evaluation of its cardioprotective activity, isolation, and characterization of its constituents, as well as in silico profiling of these ligands against antioxidant enzymes.</p><p><strong>Methods: </strong>Standard protocols were followed in the extraction, fractionation, isolation, characterization, evaluation of cardio-protective activity (marker enzymes, oxidative stress markers, and histological section), retrieval of target proteins (SOD, CAT, GPx, and GSH), ADMET, and docking studies. Column and thin layer chromatography as well as GC/MS aided the isolation and characterization of compounds; SWISSADME and ADMET lab 2 enhanced the evaluation of pharmacokinetic properties; PyRx for docking analysis; Biovia discovery studio and PyMol software for 2D and 3D visualization of the ligand-protein interactions.</p><p><strong>Results: </strong>The root extract administration significantly (p < 0.05) reduced the serum levels of CK-MB, LDH, and troponin I that were elevated after doxorubicin administration; however, the levels of GSH, GST, SOD, GPx, and CAT that were decreased after doxorubicin administration were significantly (p < 0.05) elevated whereas the raised MDA level was reduced after treatment with the extract and fractions of the plant. Also, the histological sections in the extract-treated rats showed reductions in pathological features as compared with the negative control group. Moreover, the chemical pathological changes were consistent with histopathological observations suggesting marked cardio-protective potentials. Furthermore, the chromatographic analyses yielded bulked fractions {D3 (11 mg), E6 (25 mg), and E8 (21 mg)} and their GC/MS analyses revealed dihydroartemisinin; retinoic acid, methyl ester; α-thujene; α-terpinolene; 9,12,15-octadecatrienal; α-terpineol etc. with already reported antioxidant activities. These ligands (dihydroartemisinin; retinoic acid, methyl ester) obeyed Lipinski's criteria, had remarkable pharmacokinetic profiles, and their docking analyses revealed that they modulated antioxidant enzymes with better binding affinities than vitamin C.</p><p><strong>Conclusion: </strong>Given the demonstrated antidotal and cardioprotective properties of the plant root, it presents a promising candidate for mitigating doxorubicin-induced toxicities and could be effectively utilized as a supportive therapy in such contexts.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"200"},"PeriodicalIF":3.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of pregnant and breastfeeding women's intention to use traditional Chinese medicine: a cross-sectional study from China.","authors":"Zanmei Li, Jiao Li, Yushan Lan, Liangkun Ma, Lei Xuan","doi":"10.1186/s12906-025-04952-5","DOIUrl":"10.1186/s12906-025-04952-5","url":null,"abstract":"<p><strong>Background: </strong>Traditional Chinese medicine (TCM) is widely used by pregnant and breastfeeding women in China, yet predictors of its use intention remain understudied in mainland China. This study applied an extended Theory of Planned Behavior (TPB) framework to identify factors influencing TCM use intention in this population.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted among 264 pregnant and breastfeeding women from diverse regions in mainland China between July and October 2023. Data were collected through an online questionnaire that included demographic information, TPB-based measures (attitudes, subjective norms, perceived behavioral control, intention), and past TCM use experiences. Structural Equation Modeling (SEM) was used to test hypothesized relationships.</p><p><strong>Results: </strong>The results showed that 37.5% of participants reported using TCM during pregnancy or lactation. The extended TPB model explained 84.5% of variance in intention, with subjective norms having the strongest impact (β = 0.435; p < 0.001), followed by attitudes (β = 0.304; p < 0.001) and perceived behavioral control(β = 0.294; p < 0.001). Past experience with TCM also significantly influenced both attitudes and intentions. The model demonstrated excellent fit (χ²/df = 1.53; CFI = 0.99; RMSEA = 0.04).</p><p><strong>Conclusions: </strong>This study demonstrates that TCM use during pregnancy and lactation is common in China, and that subjective norms, attitudes, perceived behavioral control, and prior experience are key predictors of intention to use TCM. These findings underscore the importance of integrating cultural and social considerations into healthcare practices. Healthcare providers should be aware of the significant role of family in decision-making and incorporate culturally sensitive counseling into maternal care. Policymakers should strengthen regulatory oversight of TCM to ensure its safe and effective use during pregnancy.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"199"},"PeriodicalIF":3.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The first record of biological activities and chemical constituents of different extracts and semi-purified fractions of Bidens aurea (Aiton) Sherff (Asteraceae).","authors":"Shaimaa S Shoman, Randa S Hasan, Rim Hamdy, Emad A Shalaby","doi":"10.1186/s12906-025-04924-9","DOIUrl":"10.1186/s12906-025-04924-9","url":null,"abstract":"<p><p>Bidens aurea is a flowering plant known for its yellow or white flowers rich with various bioactive chemical compounds that possess or have proven high medicinal values, This research aimed to investigate the in vitro antioxidant and antimicrobial abilities of individual polar extracts and semi-purified fractions of Bidens aurea. In this study, three different extracts (cold water, hot water, and ethanol) and 6 isolated fractions of ethanolic extract (as the most potent sample) were assessed for their antiradical and antioxidant properties in comparison with ascorbic acid a natural standard with 2,2-diphenyl- 1-picrylhydrazyl (DPPH^•) and 2,2-azinobis (3-ethylbenzothiazoline- 6-sulfonic acid) (ABTS) radical scavenging assays, in addition to, GC-MS/MS identification of fractions and biochemical compounds. The findings revealed that, both methods were correlated in which the ethanolic extract showed the highest antioxidant effect with 61.71 ± 0.22 and 87.29 ± 0.56% in comparison with ascorbic acid as the natural standard (95.12 ± 0.29 and 99.32 ± 0.08%) at 1000 µg/ml against DPPH and ABTS, respectively. The fraction no. 6 (ethanol 100%) recorded the highest antioxidant activity by 90.40 ± 0.13 and 94.34 ± 0.18% at 1000 µg/ml respectively followed by fraction no. 5 (ethyl acetate: ethanol 20:80) by 82.61 ± 0.19 and 87.00 ± 0.48% at 1000 µg/ml, respectively. The antimicrobial effect revealed that the ethanolic extract of Bidens aurea was effective against all tested microorganisms with growth inhibition zones (IZ) diameters ranging from 21 to 33 mm (mm). Also, the crude ethanolic extract recorded the highest antimicrobial potential against all tested microorganisms except Bacillus cereus when compared with the extract fractions and antimicrobial standards (Fluconazole and gentamycin). The GC-MS/MS analysed of different Bidens fractions revealed the presence of various phyto-components. Totally 26 constituents were identified in Bidens aurea from all the four analysed fractions. Ethyl acetate: ethanol (60:40) fraction has a recorded the highest number of (10) phyto-constituents, while Ethyl acetate: ethanol (20:80) fraction has lower number of (3) phytoconstituents. Based on these findings, the ethanolic extract and its fractions of Biden aurea exhibit promising antioxidant, antiradical, and antimicrobial activities, suggesting their potential for further investigation in biomedical application.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"198"},"PeriodicalIF":3.3,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}