BMC Complementary Medicine and Therapies最新文献

{"title":"Assessing willingness and preference for body scan practices in ADHD: a survey study.","authors":"Burcu Göz Tebrizcik, Alexandra L Georgescu, Eleanor J Dommett","doi":"10.1186/s12906-025-04842-w","DOIUrl":"10.1186/s12906-025-04842-w","url":null,"abstract":"<p><strong>Background: </strong>Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental condition, but current treatment options are limited. Although medication is widely used, it does not fully address all challenges and can result in considerable side effects. One approach showing promise in alleviating symptoms is mindfulness. However, typical mindfulness-based stress reduction programmes require a significant time commitment, resulting in high attrition. Researchers have therefore started to focus on discrete components on mindfulness, including the body scan meditation.</p><p><strong>Methods: </strong>Before embarking on large-scale trials, it is helpful to understand the willingness and preferences for body scan practice. Using an online survey, we examined current mindfulness exercises and preferences, willingness, belief that it was feasible to engage in body scan practices in 157 individuals with ADHD.</p><p><strong>Results: </strong>We found that most were not currently practising mindfulness but were willing to do so and believed that it was feasible. Symptom severity and available space were predictors of willingness. Preferences were shown for professional classes and 1-2 body scan practices per week. These data indicate people with ADHD are willing to engage with body scan practices, supporting the implementation of large-scale studies.</p><p><strong>Conclusions: </strong>The result provides insights to support the co-development of an intervention based on body scan meditation to manage the difficulties and the design of future studies to investigate its efficacy.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"120"},"PeriodicalIF":3.3,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical profiling and mechanistic insights into the antibacterial efficacy of Melaleuca cajuputi leaf extract.","authors":"Musa Isah, Mohd Dasuki Sul'ain, Wan-Nor-Amilah Wan Abdul Wahab, Hasmah Abdullah, Shajarahtunnur Jamil, Nordina Syamira, Mahamad Shabudin, Ahmad Naqib Shuid, Wan Rosli Wan Ishak","doi":"10.1186/s12906-025-04790-5","DOIUrl":"10.1186/s12906-025-04790-5","url":null,"abstract":"<p><strong>Background: </strong>The emergence of antimicrobial resistance and the prevalence of bacterial infections have prompted the search for novel antimicrobials with diverse therapeutic potential from natural products. Thus, this study investigated the antibacterial efficacy of the leaf extracts of M. cajuputi. Additionally, the chemical composition and the mechanism of action of the most active extract (MAE) were evaluated.</p><p><strong>Methods: </strong>The antibacterial activity of leaf extracts of M. cajuputi was assessed using the broth microdilution assay. Scanning electron microscopy (SEM) was used to investigate the effects of MAE on the morphology of bacterial cells. Meanwhile, the chemical composition of the MAE was analyzed using Fourier transform infrared (FTIR) spectroscopy and gas chromatography-mass spectrometry (GC-MS). AutoDock Vina was used for molecular docking analysis to unveil the interactions between the ligands and the active sites of the target bacterial proteins.</p><p><strong>Results: </strong>The crude extracts were obtained through cold maceration. The methanolic extract demonstrated the most significant antibacterial activity, with minimum inhibitory concentration (MIC) values spanning 0.25 mg/mL to 2 mg/mL. After 12 h of treatment with 1 × MIC of the methanolic extract, the bacteria showed discernible morphological alterations, including disrupted cell wall and membrane integrity. Thirty compounds were identified in the MAE and subsequently subjected to molecular docking studies against target bacterial proteins. Amongst the compounds, methylanthracene, cycloisolongifolene, diphenyl imidazole, benzil monohydrazone, and trimethoxybenzoic acid showed pronounced binding affinities towards Klebsiella pneumoniae membrane protein (PDB ID: 5O79), peptide binding protein (PDB ID: 7RJJ), Streptococcus agalactiae cell wall surface anchor (PDB ID: 2XTL), pilin (PDB ID: 3PHS), Staphylococcus aureus transglycosylase (PDB ID: 3VMQ), and penicillin-binding proteins (PDB ID: 3VSK). The binding energy scores for these interactions varied between - 6.0 kcal/mol and - 7.5 kcal/mol. Molecular dynamics simulations validated the stability of these interactions, reinforcing the in vitro findings of cell wall and membrane disruption​.</p><p><strong>Conclusion: </strong>The findings of this study indicated that the methanolic extract of M. cajuputi leaves displayed potent antibacterial activity against Klebsiella pneumoniae, S. agalactiae, and S. aureus. The molecular docking analysis reveals significant binding interactions between the identified compounds and the target bacterial proteins, highlighting the potential of M. cajuputi as a novel source of anti-infectives targeting bacterial infections.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"121"},"PeriodicalIF":3.3,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contextualising implementation interventions for promoting outpatient integrative Chinese-western oncology service delivery and utilisation in Hong Kong: a Delphi study.","authors":"Leonard Ho, Ming Hong Kwong, Angus S C Li, Fai Fai Ho, Claire C W Zhong, Charlene H L Wong, Vincent C H Chung","doi":"10.1186/s12906-025-04779-0","DOIUrl":"10.1186/s12906-025-04779-0","url":null,"abstract":"<p><strong>Introduction: </strong>The rapidly rising incidence and prevalence of cancer pose a financial burden on Hong Kong's health system. This study aimed to co-create an outpatient integrative oncology (IO) service delivery model for the territory that bridges the District Health Centres (DHCs; local coordinators for medical and social service providers), private traditional Chinese medicine practitioners (TCMPs), and private oncologists and to establish stakeholder-recommended implementation interventions (IIs) for promoting service delivery and utilisation.</p><p><strong>Methods: </strong>We conducted individual semi-structured contextual interviews to develop a preferred outpatient model that would enable DHC-based IO interprofessional collaborations and to refine relevant IIs developed for facilitating the implementation of the model. Then, we conducted a Delphi survey to contextualise and finalise the IIs using the APEASE criteria.</p><p><strong>Results: </strong>After interviewing 11 local stakeholders, a model was proposed that IO specialist nurses in DHCs would coordinate referrals between private TCMPs and oncologists and evaluate service delivery. Thirty-six IIs were refined to support model implementation. This model presented the possible role of cancer nurse specialists in leading and coordinating interprofessional cancer care between traditional and conventional medicine. In the Delphi study, 21 local stakeholders achieved positive consensus on 35 IIs (agreement 76.2-100%). Affordability was the most critical criterion in determining the recommendation of IIs.</p><p><strong>Conclusions: </strong>Along with the 35 local stakeholder-recommended IIs, our proposed nurse-led model provided insights into forging the partnership between the nurse specialists, private TCMPs, and oncologists to provide outpatient IO services. Further research is expected to seek opinions from policymakers regarding the potential administrative implementation determinants.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"118"},"PeriodicalIF":3.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of music on patient anxiety undergoing bronchoscopy: a randomized controlled trial.","authors":"Kacem Amani, Aissa Sana, Jomaa Wassim, Chebil Dhekra, Ben Jazia Rahma, Kharrat Imen, Benzarti Wafa, Knaz Asma, Ben Bedira Baraa, Gargouri Imen, Maatallah Anis, Abdelghani Ahmed","doi":"10.1186/s12906-025-04861-7","DOIUrl":"10.1186/s12906-025-04861-7","url":null,"abstract":"<p><strong>Background: </strong>Bronchoscopy is a fundamental diagnostic and therapeutic examination with rare complications which is often associated to anxiety and discomfort. The aim of our study is to evaluate the effect of music on anxiety levels among patients undergoing bronchoscopy in the pneumology department.</p><p><strong>Methods: </strong>We conducted a prospective, randomized, investigator-blinded, controlled trial performed in two university hospitals. The patients were randomized into two groups: experimental group who had preselected classic Tunisian music during bronchoscopy and control group who had bronchoscopy without music. we assessed anxiety level using Spilberger's State Anxiety inventory (S-STAI) and comfort level using visual analogic scale (VAS). Vital signs and side effects during bronchoscopy were also assessed.</p><p><strong>Results: </strong>One hundred thirty-six patients were equally assigned into the two groups. the anxiety levels before and after bronchoscopy were similar into the two groups. The music had no effect on anxiety level using the S-STAI . There was no significant difference between the two groups regarding side effects and vital signs during bronchoscopy. There was a significant effect of music on mean change of VAS score (p = 0.018).</p><p><strong>Conclusion: </strong>The music improved comfort level of patients undergoing bronchoscopy.</p><p><strong>Trial registration: </strong>This study was retrospectively registered in the pan African Clinical Trial Registry with the trial number PACTR202309620440045 on 3 September 2023.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"119"},"PeriodicalIF":3.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teucrium Polium ameliorates amyloid β-induced brain network disorders in rats: electrophysiological and behavioral studies.","authors":"Karen Simonyan, Lilit Darbinyan, Lilia Hambardzumyan, Larisa Manukyan, Vergine Chavushyan","doi":"10.1186/s12906-024-04715-8","DOIUrl":"10.1186/s12906-024-04715-8","url":null,"abstract":"<p><p>Synaptic failure in specific cholinergic networks in rat brains has been implicated in amyloid β-induced neurodegeneration. Teucrium polium is a promising candidate for drug development against Alzheimer's disease (AD) and similar disorders. However, the protective effect of Teucrium polium against amyloid β-induced impairment of short-term synaptic plasticity is still poorly understood. In this study, we used in vivo extracellular single-unit recordings to investigate the preventive efficacy of Teucrium polium on Aβ(25-35)-induced aberrant neuronal activity in the hippocampus and basolateral amygdala of rats, in response to high-frequency stimulation of the cholinergic nucleus basalis magnocellularis (NBM). After 12 weeks of intracerebroventricular administration of Aβ(25-35), alterations such as decreased excitatory responses and increased inhibitory synaptic activity were observed in the NBM-hippocampus and NBM-basolateral amygdala cholinergic circuits. Treatment with Teucrium polium improved the balance of excitatory and inhibitory responses by modulating synaptic transmission strength and restoring short-term plasticity. Acute injection of a therapeutic dose of Teucrium temporarily inhibited spiking activity in single NBM neurons. Open field tests revealed that amyloid-injected rats displayed anxiety and reduced exploratory drive. Treatment with Teucrium polium improved these behaviors, reducing anxiety and increasing exploration. Teucrium polium mitigated amyloid β-induced alterations in cholinergic circuits by enhancing the adaptive capacity of short-term synaptic plasticity. These findings suggest that Teucrium polium could serve as a preventive strategy to delay the progression of cholinergic neurodegeneration.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"116"},"PeriodicalIF":3.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring antimicrobial properties and oral health benefits of salix subserrata willd: unveiling the potential beyond its use as traditional chewing stick.","authors":"Fekade Beshah Tessema, Tilahun Belayneh Asfaw, Mesfin Getachew Tadesse, Rakesh Kumar Bachheti, Yilma Hunde Gonfa, Dawit Sitotaw Addisie, Terefe Gebremariam Aregahegn, Tigist Getachew Tadesse, Megersa Aboneh","doi":"10.1186/s12906-025-04854-6","DOIUrl":"10.1186/s12906-025-04854-6","url":null,"abstract":"<p><strong>Background: </strong>Salix subserrata is one of the traditional chewing sticks used commonly in Ethiopia. It is also used traditionally against rabies and other infections. There has been no comprehensive research on the biological activity of this plant to demonstrate its role in maintaining oral health. Given the compounds previously isolated from this species, this study aims to predict which extracts among the four solvents are responsible for promoting oral health.</p><p><strong>Method: </strong>The phytochemical content and antioxidant activity of the leaves, stem, and stem bark extracted with four different solvents were evaluated using standard methods. The EC₅₀ of the extracts was tested with the DPPH assay, and the silicon content of the stem was determined by a gravimetric method. The antibacterial activity was tested using an agar well diffusion method at different test concentrations of (mg/ml) crude extracts and MIC/MBC were determined using the microdilution method. Physicochemical and ADME properties were determined using the SwissADME online server. PASS online was used to predict biological activities related to the oral health of the compounds previously isolated from the plant.</p><p><strong>Results: </strong>The antioxidant activity, in terms of EC₅₀, of the leaves of S. subserrata was comparable to that of the standard reference, ascorbic acid. The silicon content in the stem extract of the plant was found to be 0.24%. The leaves of S. subserrata exhibited higher levels of total phenolic and flavonoid contents compared to other parts of the plant. Hexane, chloroform, and ethyl acetate extracts of S. subserrata were found to be active against the Gram-positive bacteria (Listeria monocytogenes and Enterococcus faecalis) which are known to be responsible for foodborne infections. Among the previously reported compounds from S. subserrata, catechin, quercetin, saligenin, catechol, gallocatechin, salicin, and triandrin were found to be predicted for the strong antioxidant, anti-infection, and anti-mucositis activities.</p><p><strong>Conclusion: </strong>All phytochemical analysis and antimicrobial activity results underscore the significance of plants traditionally used as chewing sticks. The roles of previously isolated compounds in maintaining oral health were also predicted, though toxicity tests and comprehensive profiling of the extracts necessitate further investigation.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"117"},"PeriodicalIF":3.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of resistance training, Yijinjing and Baduanjin exercise with oral caltrate D on bone mineral density and bone metabolism in older women: a randomised controlled trial.","authors":"Yi Yang, Heng Liu","doi":"10.1186/s12906-025-04849-3","DOIUrl":"10.1186/s12906-025-04849-3","url":null,"abstract":"<p><strong>Background: </strong>The literature lacks studies comparing the effects of traditional Chinese exercises, Qigong Yijinjing (YJJ) and Baduanjin (BDJ), with resistance training (RT) on bone mineral density (BMD) and bone metabolism in older adults.</p><p><strong>Objective: </strong>This study investigated the effects of regular RT, YJJ, and BDJ exercises training, combined with oral Caltrate D supplementation, on lumbar spine and proximal femur BMD and serum bone metabolism indices in older women.</p><p><strong>Methods: </strong>Eighty-four older women were randomly divided into the RT group (RG, n = 21), YJJ group (YG, n = 22), BDJ group (BG, n = 21) and control group (CG, n = 20). These groups performed the assigned exercises for 24 weeks (3 times/week, 60 min/time). The BMD of the lumbar L₂-₄ and proximal femur, as well as serum bone metabolism indices, were measured using dual-energy X-ray absorptiometry and an automatic chemiluminescence apparatus, respectively.</p><p><strong>Results: </strong>At week 24, compared to the CG, the RG, YG, and BG had significantly higher BMD and procollagen type I N-terminal propeptide (PINP) levels in the lumbar L_2-4 region (BMD: p = 0.049, p = 0.016, p = 0.040; PINP: p = 0.026, p = 0.029, p = 0.020), and lower β-carboxy-terminal cross-linked telopeptide of type 1 collagen (β-CTX) levels (p = 0.001, p = 0.012, p = 0.042). Intragroup comparison between baseline and week 24 data revealed that in RG, YG, and BG, lumbar L_2-4 BMD (RG: p = 0.036, YG: p = 0.002, BG: p = 0.022) and PINP (RG: p = 0.020, YG: p = 0.001, BG: p = 0.001) increased, whereas β-CTX (RG: p = 0.003, YG: p < 0.001, BG: p = 0.008) decreased.</p><p><strong>Conclusions: </strong>RT, YJJ and BDJ combined with Caltrate D for 24 weeks can increase lumbar BMD, increase the bone formation marker PINP and decrease the bone resorption marker β-CTX in older women but had no significant effect on the BMD of the proximal femur. YJJ and BDJ had the same effect on improving BMD in the older adults as RT with the same exercise cycle and frequency.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"115"},"PeriodicalIF":3.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the therapeutic impact of Salvia officinalis on lipid and oxidative stress markers in patients with polycystic ovary syndrome - a randomized placebo-controlled clinical trial.","authors":"Arezoo Maleki-Hajiagha, Faraz Mojab, Fardin Amidi, Leila Amini","doi":"10.1186/s12906-025-04858-2","DOIUrl":"10.1186/s12906-025-04858-2","url":null,"abstract":"<p><strong>Background: </strong>Salvia.officinalis (S. officinalis), is recognized for its antihyperlipidemic, metabolism-regulating, and antioxidant properties in diabetic and hyperlipidemic disorders. This study examining its effects on lipid and oxidative stress (OS) markers in patients with Polycystic Ovary Syndrome (PCOS), thereby substantiating its role in managing metabolic disorders.</p><p><strong>Methods: </strong>In this randomized placebo-controlled trial was performed in gynecology clinics affiliated to Iran University of Medical Sciences. Accordingly, 70 Iranian married women aged 15-40 years with newly diagnosed PCOS were included. They were randomized to receive either 330 mg of S. officinalis extract or placebo daily for eight weeks. The study outcomes included lipid profile and OS markers.</p><p><strong>Results: </strong>The study found a significantly lower triglyceride levels and malondialdehyde after eight weeks of S. officinalis extract intake compared to placebo. Also, the mean change of triglyceride, high-density lipoprotein cholesterol, malondialdehyde, and total antioxidant capacity were statistically significant in intervention group.</p><p><strong>Conclusion: </strong>The study demonstrates that S. officinalis extract can significantly reduce triglyceride levels and OS in patients with PCOS, suggesting its potential as an adjunctive natural therapy for managing metabolic and oxidative imbalances associated with this condition. While the extract did not significantly alter other lipid profile markers, the observed improvements highlight the therapeutic promise of S. officinalis. These findings support further investigation into the clinical applications S. officinalis for PCOS and its potential benefits for metabolic health.</p><p><strong>Trial registration: </strong>IRCT201504146917N2 on 2015-10-03 (registered while recruiting).</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"114"},"PeriodicalIF":3.3,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of Phellinus hartigii extracts: Biological activities, and phenolic content analysis.","authors":"Orhan Ünal, Ayşenur Gürgen, Tetiana Krupodorova, Mustafa Sevindik, Şanlı Kabaktepe, Ilgaz Akata","doi":"10.1186/s12906-025-04851-9","DOIUrl":"10.1186/s12906-025-04851-9","url":null,"abstract":"<p><strong>Background: </strong>Medicinal mushrooms are sources of natural substances with diverse biological functions. The study evaluated the biological activity of Phellinus hartigii (Allesch. & Schnabl) Pat. and optimized extraction conditions to the maximize its bioactive potential.</p><p><strong>Methods: </strong>Extraction was performed using a Soxhlet apparatus under varying conditions: temperatures (30, 50, and 70 °C), durations (1, 5.5, and 10 h), and ethanol/water ratios (0%, 50%, and 100%). Total antioxidant status (TAS) was analyzed across 17 experiments, and the optimal conditions were identified using response surface methodology (RSM). Extracts from optimal conditions were further analyzed for antioxidant capacity (Rel assay kits, DPPH, FRAP), anticholinesterase activity (acetyl- and butyrylcholinesterase inhibition), antiproliferative activity (A549 lung cancer cell line), total phenolic content (Folin-Ciocalteu method), and phenolic compound profile (LC-MS/MS).</p><p><strong>Results: </strong>Optimal extraction conditions were determined to be 48.22 ˚C, 9.04 h, and an ethanol/water ratio of 52.22%. The extract exhibited significant antiproliferative effects against the A549 lung cancer cells, with activity increasing in a concentration-dependent manner. The inhibition values (IC₅₀) of acetylcholinesterase and butyrylcholinesterase were 21.29 ± 0.41 and 35.51 ± 0.53 μg/mL, respectively. The TPC (total phenolic content) value of the optimized extract was determined as 88.21 ± 1.50 mg/g, FRAP value as 137.81 ± 1.72 mg/g, DPPH value as 106.07 ± 2.44 mg/g, TOS (total oxidant status) value as 9.27 ± 0.06 µmol/L, TAS value as 4.98 ± 0.03 mmol/L and OSI (oxidative stress index) value as 0.19 ± 0.002. LC-MS/MS analysis identified nine phenolic compounds, with gallic acid and catechin hydrate as the most abundant.</p><p><strong>Conclusions: </strong>The extract of P. hartigii obtained under optimal conditions demonstrated substantial antioxidant, anticholinesterase, and antiproliferative activities, highlighting its therapeutic potential.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"113"},"PeriodicalIF":3.3,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health information-seeking behavior among users of traditional, complementary and integrative medicine (TCIM).","authors":"Miriam Trübner, Alexander Patzina, Judith Lehmann, Benno Brinkhaus, Christian S Kessler, Rasmus Hoffmann","doi":"10.1186/s12906-025-04843-9","DOIUrl":"10.1186/s12906-025-04843-9","url":null,"abstract":"<p><strong>Background: </strong>The use of traditional, complementary, and integrative medicine (TCIM) is widespread among the German population and driven by various motives, including both supplementing and avoiding treatments with conventional medicine. The aim of this article is to examine how these motives relate to different health information-seeking behaviors.</p><p><strong>Methods: </strong>The study uses regression analysis based on data from a German online access panel, which explored the use and acceptance of TCIM in Germany in 2022. From this study, we use information on 1,696 individuals (aged 18-75 years) who vary in their motives for using TCIM (subjective statements on five-point Likert scales) and have used TCIM to treat health problems.</p><p><strong>Results: </strong>Overall, TCIM is considered more a health-promoting measure than it is driven by aversion towards conventional medicine. Our analysis of information-seeking behavior for certain therapeutic procedures reveals that, as respondents' propensity to use TCIM as a health-promoting measure rises, they are more likely to perceive themselves as being influenced by scientific studies (AME: 0.04, p = 0.004), personal advice (AME: 0.09, p = 0.000), and their social circle's experiences (AME: 0.08, p = 0.000). In contrast, respondents who use TCIM more due to aversion to conventional medicine are less likely to perceive themselves as being influenced by scientific studies (AME: -0.04, p = 0.004) and doctors (AME: -0.07, p = 0.000). When analyzing respondents' most important medical information source, our results reveal that the more individuals indicate using TCIM out of aversion, the more likely they are to consider (online) media outlets their most important medical resource (AME: 0.05, p = 0.000), while the likelihood of considering medical professionals most important decreases (AME -0.06, p = 0.000).</p><p><strong>Conclusion: </strong>Motives behind TCIM use vary and correspond to differences in individuals' health information-seeking behavior. Beyond these motive-related differences, TCIM users value sources of health information other than their medical practitioners. This calls for an intensification of TCIM training among medical professionals to provide high-quality consultation and the creation of reputable online portals to ensure the provision of trustworthy information about TCIM.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"111"},"PeriodicalIF":3.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}