BMC Complementary Medicine and Therapies最新文献

{"title":"Patterns of complementary and alternative medicine use and factors influencing its utilization in thyroid cancer: findings from the MASTER study.","authors":"Han-Sang Baek, Mijin Kim, Kyungsik Kim, Woojin Lim, Kwangsoon Kim, Ja Seong Bae, Dong-Jun Lim, Eun-Jae Chung, Bon Seok Koo, Sung Yong Choi, Eun Kyung Lee, Eu Jeong Ku, Kyeong Jin Kim, Hee Kyung Kim, June Young Choi, Bo Hyun Kim, Sue K Park","doi":"10.1186/s12906-026-05428-w","DOIUrl":"10.1186/s12906-026-05428-w","url":null,"abstract":"<p><strong>Background: </strong>Complementary and alternative medicine (CAM) therapies are increasingly popular; however, comprehensive data on their usage patterns and types remain limited, especially in South Korea. We investigated the patterns and economic impact of CAM use in thyroid cancer after lobectomy.</p><p><strong>Methods: </strong>We utilized data from the MASTER study, a prospective, multicenter, randomized, controlled trial on patients with differentiated thyroid cancer post-lobectomy. Data on CAM usage in 1,166 patients at baseline and at 3, 6, and 12 months postoperatively were included. Logistic regression quantified the effect of levothyroxine treatment on CAM usage.</p><p><strong>Results: </strong>CAM use was reported by 58% of participants. Dietary nutritional products were the most used CAM modality, with usage rates of 42.5% at baseline, decreasing to 37.7% at 12 months. Exercise and physical therapies also showed significant differences, with 19.2% using these modalities at baseline, increasing to 27.1% at 12 months. The median cost for CAM varied, with dietary products consistently costing 144 USD (200,000 KRW) and exercise costs rising from 144 USD (200,000 KRW) to 288 USD (400,000 KRW) over time. Patients on levothyroxine were less likely to use CAM, with an odds ratio (OR) of 0.57 (95% confidence interval [CI] = 0.45-0.72, P < 0.001). However, levothyroxine users who did use CAM were more likely to use multiple CAM modalities, with an OR of 3.66 (95% CI = 1.88-7.14, P = 0.001) at baseline, though this association did not remain significant later.</p><p><strong>Conclusions: </strong>CAM is integrated into thyroid cancer treatment, indicating a need for healthcare professionals to discuss its safety and effective care integration.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148307022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Citrus aurantium capsules on peripartum anxiety and postpartum blues: a randomized triple -blind clinical trial.","authors":"Fatemeh Ahmadinia, Farangis Sharifi, Hourivash Ghaderi, Fatemeh Deris, Sheida Shabanian","doi":"10.1186/s12906-026-05437-9","DOIUrl":"10.1186/s12906-026-05437-9","url":null,"abstract":"<p><strong>Background and aim: </strong>Maternal anxiety and blue during pregnancy and postpartum can have significant negative effects on mother, child and family. In recent years, the people of Iran, like other countries in the world have paid special attention to the use of medicinal plants due to the side effects of chemical drugs, one of the medicinal plants with sedative and anti-anxiety effects is Citrus aurantium. The aim of this study was to investigate the effect of Citrus aurantium capsules on peripartum anxiety and postpartum blues.</p><p><strong>Methods: </strong>In the present clinical trial, 100 pregnant women with anxiety diagnosis were included in the study and randomly divided into control and case groups. The intervention group received 500 mg of Citrus aurantium capsule twice daily and the control group received placebo for 6 weeks (two weeks after delivery). Beck Anxiety Questionnaire was completed before the intervention, immediately after delivery and 2 weeks after delivery, and the postpartum blues checklist was completed immediately after delivery and 2 weeks after delivery. Data were analyzed by SPSS software.</p><p><strong>Results: </strong>The mean anxiety score of the control group at two weeks postpartum was significantly lower than before the intervention (P < 0.05) but at the time of delivery was not significantly different from before the intervention. The mean score of anxiety in the intervention group during delivery and two weeks after delivery was significantly lower than before the intervention (P < 0.05). The mean score of anxiety in the intervention group during the study period was significantly lower than the control group (P < 0.05). The frequency of labor grief during labor in the control and intervention groups did not show a significant difference (P > 0.05), but two weeks after delivery the frequency of labor grief in the intervention group with 28% was significantly lower than the control group with It was 54% (P < 0.05).</p><p><strong>Conclusion: </strong>Citrus aurantium capsule reduces anxiety during and after childbirth and is recommended for use in anxious patients.</p><p><strong>Trial number: </strong>IRCT20210926052594N1 Registration date: 2021-10-09.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148300869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual antibacterial and pro-healing effects of thymoquinone in an experimental infected diabetic wound model.","authors":"Saffet Ulutas, Mehmet Mutaf, Sibel Cangi, Recep Dokuyucu","doi":"10.1186/s12906-026-05443-x","DOIUrl":"10.1186/s12906-026-05443-x","url":null,"abstract":"<p><strong>Background: </strong>Impaired wound healing and persistent infection are major challenges in diabetic wounds. This study aimed to investigate the therapeutic effects of topical thymoquinone formulated in peanut oil on wound healing and bacterial burden in an infected diabetic wound model.</p><p><strong>Methods: </strong>Diabetes was induced in rats using streptozotocin, followed by creation of standardized full-thickness excisional wounds that were subsequently infected with Staphylococcus aureus. Animals were randomly assigned to four groups: untreated negative control, vehicle (peanut oil), thymoquinone, and positive control (topical mupirocin). Treatments were applied topically once daily for 14 days. Wound closure was assessed at predefined time points, bacterial load was quantified as log₁₀ CFU/g tissue, and histopathological evaluation was performed using semi-quantitative scoring of re-epithelialization, inflammatory cell infiltration, granulation tissue formation, and collagen deposition.</p><p><strong>Results: </strong>Mean wound closure rates in the thymoquinone group were 27.6 ± 6.1% on day 3, 55.1 ± 8.4% on day 7, 72.4 ± 7.5% on day 10, and 88.2 ± 5.6% on day 14, which were significantly higher than those observed in the untreated negative control group (12.4 ± 4.6%, 28.7 ± 6.9%, 41.9 ± 8.1%, and 58.6 ± 9.3%, respectively) and the vehicle (peanut oil) group (18.9 ± 5.2%, 36.4 ± 7.3%, 52.7 ± 8.6%, and 69.8 ± 8.9%, respectively; p = 0.004 on day 3, p = 0.002 on day 7, p = 0.001 on day 10, and p = 0.001 on day 14), while remaining comparable to the positive control (mupirocin) group without demonstrating statistical superiority. Mean bacterial counts were 5.94 ± 0.46 log₁₀ CFU/g on day 3 and 4.73 ± 0.51 log₁₀ CFU/g on day 7 in the thymoquinone group, compared with 7.62 ± 0.41 and 6.89 ± 0.44 log₁₀ CFU/g in the negative control group and 7.18 ± 0.38 and 6.32 ± 0.40 log₁₀ CFU/g in the peanut oil group (p = 0.003 on day 3 and p = 0.002 on day 7). Histopathological evaluation revealed significantly improved re-epithelialization (3.8 ± 0.4 vs. 1.6 ± 0.5 in controls, p = 0.002), increased granulation tissue formation (4.0 ± 0.5 vs. 1.8 ± 0.6, p = 0.003), and enhanced collagen deposition (3.9 ± 0.4 vs. 1.5 ± 0.5, p = 0.002), together with reduced inflammatory cell infiltration (1.9 ± 0.4 vs. 4.1 ± 0.4, p = 0.001) in thymoquinone-treated wounds compared with controls.</p><p><strong>Conclusion: </strong>Topical thymoquinone formulated in peanut oil improved wound closure, reduced bacterial burden, and enhanced histopathological indicators of tissue repair in this experimental infected diabetic wound model. Further studies are warranted to confirm these findings and explore their translational relevance.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13531877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hesperidin attenuates gentamicin-induced testicular toxicity via modulation of the PI3K/AKT signaling pathway.","authors":"Murat Celebi, Cagla Celebi, Hasan Susar, Ibrahim Halil Gungor, Ozhan Karatas","doi":"10.1186/s12906-026-05441-z","DOIUrl":"10.1186/s12906-026-05441-z","url":null,"abstract":"<p><strong>Background: </strong>Gentamicin is an aminoglycoside antibiotic widely used in the treatment of Gram-negative infections; however, one of its major limitations is testicular toxicity. Oxidative stress is considered to play a central role in gentamicin-induced testicular damage. Hesperidin is a natural flavonoid with potent antioxidant and cytoprotective properties and may exert protective effects on the reproductive system.</p><p><strong>Methods: </strong>This study investigated the protective effects of hesperidin against gentamicin-induced testicular damage. Histopathological and immunohistochemical evaluations were performed alongside biochemical and hormonal analyses. In addition, sperm concentration, motility, and the rate of abnormal spermatozoa were assessed. To elucidate the underlying molecular mechanisms, the gene expression levels of PD-1, PI3K, and AKT-1 were analyzed.</p><p><strong>Results: </strong>Gentamicin administration was associated with lower Johnsen scores, decreased testosterone levels and sperm motility, increased sperm abnormalities, elevated MDA concentrations, reduced CAT, SOD, GPx, and GSH levels, increased Caspase-3 and 8-OHdG immunoreactivity, and reduced AKT expression. Hesperidin co-administration significantly attenuated many of these alterations, being associated with improved histopathological scores, enhanced antioxidant status, reduced immunoreactivity of oxidative stress- and apoptosis-related markers, improved sperm quality parameters, and increased PI3K and AKT gene expression compared with the gentamicin-treated group.</p><p><strong>Conclusion: </strong>These findings indicate that hesperidin possesses a protective potential against gentamicin-induced testicular damage, likely mediated through its antioxidant and anti-apoptotic effects.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13531793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical profiling and evaluation of in vitro antibacterial and antibiotic synergistic activities of Cleistanthus bracteosus Jabl. from Malaysian rainforests.","authors":"Mackingsley Kushan Dassanayake, Teng-Jin Khoo, Chien Hwa Chong, Christophe Wiart, Omar Ashraf Elfar, Rachael Symonds, Mohammed Tahir Ansari","doi":"10.1186/s12906-026-05439-7","DOIUrl":"10.1186/s12906-026-05439-7","url":null,"abstract":"<p><strong>Background: </strong>Plants are rich and valuable sources of phytochemical constituents that can contribute to a variety of biological activities. The research in discovering novel antimicrobial compounds from plants has been of increased interest due to the global rise of antibiotic resistance. The present study aims to evaluate the in vitro antibacterial, antibiotic synergistic potential and the chemical profile of plant extracts associated with Cleistanthus bracteosus Jabl. found in Malaysian rainforests for the first time.</p><p><strong>Methods: </strong>The antibacterial activity and synergistic antibacterial activity of chloroform, methanol and n-hexane crude extracts of C. bracteosus were determined against bacterial pathogens of Escherichia coli, Bacillus subtilis, Staphylococcus aureus, B. cereus, Pseudomonas aeruginosa, Salmonella typhi and Acinetobacter baumannii. The chloroform extracts were subjected to fractionation, chemical profiling, and field emission scanning electron microscopic (FE-SEM) analysis.</p><p><strong>Results: </strong>The chloroform stem extract exhibited the highest antibacterial activity which indicated a mean inhibition zone diameter (IZD) of 10 ± 0.26 mm against the Gram-positive bacterium B. cereus. The best synergistic activity was shown for chloroform wood extract when combined with ampicillin against A. baumannii, with a growth inhibitory index (GIIs) of 1.33. Potassium clavulanate actively synergised with chloroform stem extract against E. coli ATCC 10536 (IZD = 27 ± 0.56 mm) and chloroform bark extract against S. typhi (IZD = 28 ± 0.54 mm). C. bracteosus extracts showed the presence of secondary metabolites like flavonoids, phenols, tannins, alkaloids, coumarins, saponins and traces of terpenoids, with chloroform extracts of bark, stem and wood consisting of 20 bioactive phytochemical compounds according to gas chromatography-mass spectrometry analysis (GC-MS). Further analysis with high-performance liquid chromatography (HPLC) implied the presence of digoxigenin and lauric acid. The FE-SEM observations further elucidated the effects of C. bracteosus chloroform extracts on the morphology of susceptible organisms.</p><p><strong>Conclusion: </strong>The findings of this investigation justify that chloroform extracts of C. bracteosus can function as a novel antibacterial agent with synergistic potential.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical profile, anti-biofilm and antioxidant activities of Cymbopogon citratus (DC.) Stapf essential oil.","authors":"Asmaa M Arafa, Galal Yahya, Mahmoud Saad Abdel-Halim, Ali Osman, Shaimaa I Nazeih, Hisham A Abbas, Islam Mostafa","doi":"10.1186/s12906-026-05431-1","DOIUrl":"10.1186/s12906-026-05431-1","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The urgent need for novel antimicrobial agents arises from the escalating threat of antibiotic-resistant pathogens. Tackling the resistance mechanisms through the application of resistance modifying agents in combination to antimicrobials represents an effective strategy to combat antimicrobial resistance and to enhance the antimicrobial activity. Screening of plant extracts, essential oils and their active compounds for potential resistance modifying properties has proven effective on both a small and large scale. In this study, we define the metabolomic profile of essential oils extracted from different parts of Cymbopogon citratus (DC.) Stapf (lemongrass), and characterize their antioxidant and virulence attenuating activities.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The major active ingredients of essential oils extracted from different parts of Cymbopogon citratus (lemongrass) were identified by GC-MS analysis. The minimum inhibitory concentration (MIC) of the essential oils against P. aeruginosa PAO1, Staphylococcus aureus ATCC 6538, and Candida albicans ATCC 10,261 was determined using the broth microdilution assay. Antibiofilm and antiprotease activities were phenotypically evaluated for the extracted lemongrass essential oils for the same standard strains and clinical isolates for the same microbes. Also, the effects on microbial virulence were validated by RT-qPCR against a subset of genes regulating biofilm, quorum sensing, and stress response in P. aeruginosa, and S. aureus. Furthermore, the antioxidant activities of the different essential oils extracted were evaluated using DPPH, β-carotene/linoleic acid and FRAP methods.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;GC-MS analysis of the essential oils of Cymbopogon citratus revealed the presence of 47 different compounds distributed in the different plant organs. Active constituents such as geranial, neral, myrcene, nerolic acid, linalool, iso-citral, trans iso-citral, and neryl acetate were more abundant in the essential oil extracted from leaves (89.77%), followed by stems (82.92%) and finally roots (52.02%). S. aureus, and C. albicans were more sensitive to C. citratus essential oils than Gram negative P. aeruginosa. Incorporation of sub-MIC doses of essential oils into the culture media was sufficient to disrupt the formation of microbial biofilms in P. aeruginosa, S. aureus, and C. albicans, and to inactivate the proteolytic activities of microbial proteases. The essential oils of C. citratus showed promising and broad-spectrum biofilm eradicating activity. Sub-MIC doses of lemongrass oil dramatically reduced the expression of relA, pslA, and spoT in P. aeruginosa, and agrA, icaA, and sigB in S. aureus indicating a broad-spectrum anti-virulence activity.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Our study identifies C. citratus essential oils as potential virulence-attenuating agents. Essential oils extracted from the leaves, stems, and roots of C. citratus exhibited signi","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13282879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-energy spontaneous fabrication of quercetin-loaded orange oil nanoemulsion for induction of colorectal cancer cell apoptosis.","authors":"Ahmed A Abd-Rabou, Amr E Edris","doi":"10.1186/s12906-026-05424-0","DOIUrl":"10.1186/s12906-026-05424-0","url":null,"abstract":"<p><strong>Background: </strong>Phytochemicals showed potential application as anticancer agents. In the current investigation, quercetin, cold-pressed orange peel oil, and their mixture in their natural state and in micellar dispersion and nanoemulsions were examined for their activity to induce HCT116 and Caco-2 colorectal cancer cells to apoptosis.</p><p><strong>Materials and methods: </strong>Gas chromatographic analysis was used to characterize orange oil composition. Different solubilization systems were developed in order to incorporate these phytochemicals into a self emulsifyable concentrate that spontaneously forms micellar dispersions and nanoemulsions upon titration into water. Different evaluations were performed to characterize the nanoemulsions. Some biological evaluations including cytotoxicity, apoptosis, protein expression, and reactive oxygen species were also performed.</p><p><strong>Results: </strong>Gas chromatographic analysis showed that d-limonene is the major constituent contained (89%) of orange oil. Systems composed of a single surfactant and a mixture of two surfactants and a cosurfactant were able to incorporate 500 mg quercetin and 5% orange oil in 100 ml nanoemulsions. The particle size of the nanoemulsions ranges between 12 ± 0.09 nm and 27 ± 0.1 nm, depending on the incorporated phytochemical, with z-potential value in the range of -0.9 mV. Encapsulation efficiency for both quercetin and orange oil was > 93% and the release from the formulations exhibited a controlled, time-dependent profile for both quercetin and orange oil. Quercetin and orange oil in their natural state showed cytotoxic and apoptotic activity against the tested colorectal cancer cells, which is enhanced upon combining these phytochemicals. The micellar dispersions and nanoemulsion form of these phytochemicals showed enhanced cytotoxicity, apoptotic activity, and ROS levels compared to their unformulated natural states indicating the powerful effect of nanoparticles. Moreover, nanoemulsion fabricated with a mixture of two surfactants showed the best cytotoxic and late apoptotic activity through downregulation of CDC25A, PI3k, and Bcl-2 expression levels and upregulation of Bax expression compared to nanoemulsion made using a single surfactant.</p><p><strong>Conclusions: </strong>Combining quercetin and orange oil in a co-fabricated nanoemulsion could be considered a promising formula that could be examined as an adjuvant to the protocol-prescribed drugs to enhance their activity against colorectal cancer cells.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13274026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional wisdom unveiled: an ethnobotanical exploration of medicinal bath plants for postpartum and infant healthcare among the Hakka people in Guangdong, China.","authors":"Donglin Li, Zhicheng Wu, Shuying Lv, Yuelan Meng, Zhendong Xie, Chongjian Ma, Xilong Zheng","doi":"10.1186/s12906-026-05432-0","DOIUrl":"10.1186/s12906-026-05432-0","url":null,"abstract":"<p><strong>Background: </strong>Medicinal baths are an important component of traditional Chinese medicine and are widely used for postpartum recovery, neonatal care, and general health maintenance. Although medicinal bathing practices among ethnic groups such as the Yao and Tibetan have been relatively well documented, ethnobotanical research on Hakka medicinal baths in Guangdong remains limited, despite their widespread use among postpartum women and newborns.</p><p><strong>Methods: </strong>Field investigations were conducted in 19 Hakka settlements in northern Guangdong from 2023 to 2024. Data were collected through semi-structured interviews, individual consultations, and field observations involving 138 Hakka informants. Fidelity Level (FL) and Informant Consensus Factor (FIC) were used to evaluate the cultural importance of medicinal bath plants and the degree of agreement among informants.</p><p><strong>Results: </strong>A total of 108 medicinal bath plant species were documented, most of which were herbaceous. The most frequently used plant parts were the whole plant, leaves, and stems. Knowledge of medicinal bath practices was mainly concentrated among older women, who play a central role in postpartum and neonatal care. These plants were reported to be used for the prevention and management of more than 30 health conditions. FIC values ranged from 0.61 to 0.87, with the highest agreement observed for postpartum recovery, respiratory diseases, and skin diseases. Ten plant species had a Fidelity Level (FL) of 100%, indicating high cultural recognition and importance. Compared with the medicinal bath practices of neighboring Yao communities, Hakka practices are characterized by milder remedies, simpler formulations, and a stronger emphasis on family-based healthcare, particularly for mothers and infants.</p><p><strong>Conclusion: </strong>Hakka medicinal baths reflect intergenerational knowledge transmission, practical healthcare strategies, and culturally embedded healing practices. This study systematically documents the medicinal bath plants used by the Hakka in Guangdong and provides a basis for the conservation of traditional knowledge and the sustainable use of medicinal plant resources. The findings also highlight the relevance of Hakka medicinal bath practices in postpartum care, infant healthcare, and community-based complementary healthcare.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13508430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148270255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: The wound healing effects of Citrus latifolia extracts: phytochemical profiling and in silico investigations.","authors":"Mona T M Ghanem, Zeinab A Elshahid, Wael M Elsayed, Heba D Hassanein, Shaimaa A Gouhar","doi":"10.1186/s12906-026-05408-0","DOIUrl":"10.1186/s12906-026-05408-0","url":null,"abstract":"","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"26 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13274018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148270233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of nurses' knowledge on maggot debridement therapy: influence of demographic, professional, and educational factors in a Malaysian teaching hospital.","authors":"Soon Lean Keng, Wong Mong Khim, Azlina Yusuf","doi":"10.1186/s12906-026-05435-x","DOIUrl":"10.1186/s12906-026-05435-x","url":null,"abstract":"<p><strong>Background: </strong>Maggot debridement therapy (MDT) is a biotherapeutic approach that uses sterile larvae to remove necrotic tissue and promote wound healing. Although its effectiveness in managing chronic wounds is well established, clinical adoption remains limited. Nurses are central to wound care, yet little is known about their MDT knowledge in Malaysia. This study assesses nurses' knowledge of MDT and examined the influence of demographic, professional, and educational factors within a tertiary teaching hospital setting.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among 165 nurses selected through random sampling. Data were collected using a validated self-administered questionnaire assessing sociodemographic data, professional experience, and MDT knowledge. Descriptive statistics were used to summarize data, and Pearson chi square and Fisher's Exact test were applied to determine associations between knowledge levels and key variables.</p><p><strong>Results: </strong>The mean age of participants was 32.72 years. Of these, 41.8% had 6-10 years of experience, 89.7% held a nursing diploma, and 87.9% had heard of MDT. Only 26.1% demonstrated high knowledge, while 52.7% showed low knowledge. A significant association was found between knowledge level and having heard of MDT (p = 0.040) and having performed MDT (p = 0.025).</p><p><strong>Conclusion: </strong>Nurses demonstrated limited knowledge and practical experience in Maggot Debridement Therapy despite general awareness of its clinical value. Knowledge was significantly associated with prior exposure and hands-on experience, underscoring the importance of experiential learning. Incorporating MDT into nursing curricula, continuous professional development, and institutional protocols is crucial to enhance evidence-based wound care and clinical adoption.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13495225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}