BMC Complementary Medicine and Therapies最新文献

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Simple Sitting Baduanjin mind-body exercise: randomized controlled trial protocol for advanced cancer patients with the fatigue-sleep disturbance symptom cluster. 简易八段锦坐姿身心锻炼:针对晚期癌症患者疲劳-睡眠障碍症状群的随机对照试验方案。
IF 3.3 2区 医学
BMC Complementary Medicine and Therapies Pub Date : 2024-10-02 DOI: 10.1186/s12906-024-04652-6
Huina Zou, Xiaoyan Lin, Tingjin Duan, Jianwei Zheng, Huimin Xiao
{"title":"Simple Sitting Baduanjin mind-body exercise: randomized controlled trial protocol for advanced cancer patients with the fatigue-sleep disturbance symptom cluster.","authors":"Huina Zou, Xiaoyan Lin, Tingjin Duan, Jianwei Zheng, Huimin Xiao","doi":"10.1186/s12906-024-04652-6","DOIUrl":"10.1186/s12906-024-04652-6","url":null,"abstract":"<p><strong>Background: </strong>Advanced cancer patients commonly suffer from a fatigue-sleep disturbance symptom cluster. Baduanjin is considered a promising mind-body exercise for relieving the fatigue-sleep disturbance symptom cluster. However, few studies have investigated a tailored Baduanjin for advanced cancer patients. The proposed study will create an optimized Baduanjin exercise program to adapt to advanced cancer patients and evaluate the effect of a Simple Sitting Baduanjin (SSBDJ) mind-body exercise on the fatigue-sleep disturbance symptom cluster among advanced cancer patients.</p><p><strong>Methods: </strong>The study will be a prospective, assessor-blinded, two-arm, randomized controlled trial, involving a 12-week intervention and 4-week follow-up. A total of 108 advanced cancer patients experiencing the fatigue-sleep disturbance symptom cluster will be recruited from two tertiary general hospitals in China. Participants will be randomized to an experimental group (n = 54) or a control group (n = 54). The experimental group will receive a 12-week SSBDJ intervention plus the usual care, and the control group will receive only the usual care. Outcomes including fatigue-sleep disturbance symptom cluster, fatigue, sleep disturbance, and quality of life will be measured before the intervention, at the 4th, 8th, and 12th weeks of the intervention, and 4 weeks after the intervention. The intention-to-treat principle and a generalized estimating equation will be used to analyze data.</p><p><strong>Discussion: </strong>This study may produce a new Baduanjin exercise prescription that is user-friendly, simple to execute, more targeted, and adaptable. If proven effective, this approach may be integrated into routine cancer care to manage the fatigue-sleep disturbance symptom cluster and improve QOL in advanced cancer patients.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registry, ChiCTR-2,300,072,331. Registered on 9 June 2023.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"24 1","pages":"348"},"PeriodicalIF":3.3,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11448021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioassay-guided isolation and structure elucidation of anti-mycobacterium tuberculosis compounds from Galatella grimmii (Regel & Schmalh.) Sennikov. 生物测定指导下从 Galatella grimmii (Regel & Schmalh.) Sennikov 中分离抗结核分枝杆菌化合物并阐明其结构。
IF 3.3 2区 医学
BMC Complementary Medicine and Therapies Pub Date : 2024-10-01 DOI: 10.1186/s12906-024-04632-w
Abolfazl Shakeri, Mehrangiz Tajvar, Ghazaleh Tabriznia Tabrizi, Saman Soleimanpour, Javid Davoodi, Javad Asili, Mohammad Sadegh Amiri, Seyed Ahmad Emami
{"title":"Bioassay-guided isolation and structure elucidation of anti-mycobacterium tuberculosis compounds from Galatella grimmii (Regel & Schmalh.) Sennikov.","authors":"Abolfazl Shakeri, Mehrangiz Tajvar, Ghazaleh Tabriznia Tabrizi, Saman Soleimanpour, Javid Davoodi, Javad Asili, Mohammad Sadegh Amiri, Seyed Ahmad Emami","doi":"10.1186/s12906-024-04632-w","DOIUrl":"10.1186/s12906-024-04632-w","url":null,"abstract":"<p><strong>Background: </strong>Galatella is a genus in the family Asteraceae, represented by 35-45 species. Considering the high effectiveness of the ethyl acetate (EtOAc) fraction of G. grimmii against Mycobacterium tuberculosis (MIC = 0.5 µg/mL), a bioassay-directed fractionation of this extract was carried out.</p><p><strong>Methods: </strong>The methanolic extract of the aerial parts of G. grimmii was obtained using maceration, then it was suspended in water and partitioned with petroleum ether, dichloromethane (CH<sub>2</sub>Cl<sub>2</sub>), EtOAc, and n-butanol (n-BuOH), successively. The most potent fraction (EtOAc), was selected for further isolation by Sephadex LH-20 and semi-preparative HPLC to obtain active compounds.</p><p><strong>Results: </strong>Fractionation of the EtOAc solvent fraction resulted in the characterization of five compounds, among them, compounds 1 and 2 showed the highest anti-mycobacterial effects with MICs of 0.062 and 1.00 µg/mL against H37Rv M. tuberculosis, respectively, which were higher than those of rifampin (MIC of 1.25 µg/mL) and isoniazid (MIC of 0.31 µg/mL), as positive controls. Also, compound 1 ​​inhibited all tested strains of drug-resistant Mycobacterium (MDR and XDR). Notably, the isolated compounds have been reported for the first time from G. grimmii.</p><p><strong>Conclusion: </strong>Due to the potent anti-mycobacterial effect of isolated compounds from G. grimmii, this study could pave the way for developing a novel class of natural anti-tuberculosis compounds.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"24 1","pages":"345"},"PeriodicalIF":3.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization, biological activity, and anticancer effect of green-synthesized gold nanoparticles using Nasturtium officinale L. 金莲花绿色合成金纳米粒子的特性、生物活性和抗癌作用
IF 3.3 2区 医学
BMC Complementary Medicine and Therapies Pub Date : 2024-10-01 DOI: 10.1186/s12906-024-04635-7
Ozlem Tonguc Yayintas, Neslihan Demir, Fadime Canbolat, Tülay Kiliçaslan Ayna, Melek Pehlivan
{"title":"Characterization, biological activity, and anticancer effect of green-synthesized gold nanoparticles using Nasturtium officinale L.","authors":"Ozlem Tonguc Yayintas, Neslihan Demir, Fadime Canbolat, Tülay Kiliçaslan Ayna, Melek Pehlivan","doi":"10.1186/s12906-024-04635-7","DOIUrl":"10.1186/s12906-024-04635-7","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Nanostructured materials used have unique properties and many uses in nanotechnology. The most striking of these is using herbal compounds for the green synthesis of nanoparticles. Among the nanoparticle types used for green synthesis, gold nanoparticles (AuNPs) are used for cancer therapy due to their stable structure and non-cytotoxic. Lung cancer is the most common and most dangerous cancer worldwide in terms of survival and prognosis. In this study, Nasturtium officinale (L.) extract (NO), which contains biomolecules with antioxidant and anticancer effects, was used to biosynthesize AuNPs, and after their characterization, the effect of the green-synthesized AuNPs against lung cancer was evaluated in vitro.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Ultraviolet‒visible (UV‒Vis) spectrophotometry, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDS), multiple analysis platform (MAP), and Fourier transform infrared (FT-IR) spectroscopy analyses were performed to characterize the AuNPs prepared from the N. officinale plant extract. Moreover, the antioxidant activity, total phenolic and flavonoid contents and DNA interactions were examined. Additionally, A549 lung cancer cells were treated with 2-48 µg/mL Nasturtium officinale gold nanoparticles (NOAuNPs) for 24 and 48 h to determine the effects on cell viability. The toxicity of the synthesized NOAuNPs to lung cancer cells was determined by the 3-(4,5-dimethylthiazol-2-il)-2,5-diphenyltetrazolium bromide (MTT) assay, and the anticancer effect of the NOAuNPs was evaluated by apoptosis and cell cycle analyses using flow cytometry.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The average size of the NPs was 56.4 nm. The intensities of the Au peaks from EDS analysis indicated that the AuNPs were synthesized successfully. Moreover, the in vitro antioxidant activities of the NO and NOAuNPs were evaluated; these materials gave values of 31.78 ± 1.71% and 31.62 ± 0.46%, respectively, in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay at 200 g/mL and values of 25.89 ± 1.90% and 33.81 ± 0.62%, respectively, in the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay. The NO and NOAuNPs gave values of 0.389 ± 0.027 and 0.308 ± 0.005, respectively, in the ferrous ion reducing antioxidant capacity (FRAP) assay and values of 0.078 ± 0.009 and 0.172 ± 0.027, respectively, in the copper ion reducing antioxidant capacity (CUPRAC) assay. When the DNA cleavage activities of NO and the NOAuNPs were evaluated via hydrolysis, both samples cleaved DNA starting at a concentration of 25 g/mL in the cell culture analysis, while the nanoformulation of the NO components gave greater therapeutic and anticancer effects. We determined that the Au nanoparticles were not toxic to A549 cells. Moreover, after treatment with the half-maximal inhibitory concentration (IC&lt;sub&gt;50&lt;/sub&gt;), determined by the MTT assay with A549 cells, we found that a","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"24 1","pages":"346"},"PeriodicalIF":3.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11445868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: The healing effect of nano emulsified Plantago major L extract on oral wounds in a wistar rat model. 更正:纳米乳化大车前子提取物对wistar大鼠口腔伤口的愈合作用。
IF 3.3 2区 医学
BMC Complementary Medicine and Therapies Pub Date : 2024-10-01 DOI: 10.1186/s12906-024-04644-6
Fatemeh Jahanimoghadam, Amirhossein Javidan, Mehdi Ranjbar, Molook Torabi, Sina Kakooei, Fariba Sharififar
{"title":"Correction: The healing effect of nano emulsified Plantago major L extract on oral wounds in a wistar rat model.","authors":"Fatemeh Jahanimoghadam, Amirhossein Javidan, Mehdi Ranjbar, Molook Torabi, Sina Kakooei, Fariba Sharififar","doi":"10.1186/s12906-024-04644-6","DOIUrl":"10.1186/s12906-024-04644-6","url":null,"abstract":"","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"24 1","pages":"344"},"PeriodicalIF":3.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the potential mechanism of Radix Bupleuri in the treatment of sepsis: a study based on network pharmacology and molecular docking. 探索柴胡治疗败血症的潜在机制:基于网络药理学和分子对接的研究
IF 3.3 2区 医学
BMC Complementary Medicine and Therapies Pub Date : 2024-10-01 DOI: 10.1186/s12906-024-04637-5
Hao Wang, Wei Xiong, Yongchu Laram, Li Hu, Wu Zhong, Yingchun Hu
{"title":"Exploring the potential mechanism of Radix Bupleuri in the treatment of sepsis: a study based on network pharmacology and molecular docking.","authors":"Hao Wang, Wei Xiong, Yongchu Laram, Li Hu, Wu Zhong, Yingchun Hu","doi":"10.1186/s12906-024-04637-5","DOIUrl":"10.1186/s12906-024-04637-5","url":null,"abstract":"<p><strong>Aim: </strong>To explore, using network pharmacology and RNA-seq technologies, potential active targets and mechanisms underpinning Radix Bupleuri's effectiveness during sepsis treatment.</p><p><strong>Methods: </strong>Following the Sepsis-3.0 criteria, the research cohort, comprising 23 sepsis patients and 10 healthy participants, was obtained from public databases. Peripheral blood samples were collected and subjected to RNA-seq analysis. Active ingredients and potential targets of Radix Bupleuri were identified using the Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine 2.0 (BATMAN-TCM 2.0) database and TCMSP database. Subsequently, protein-protein interaction (PPI) network construction, Gene Ontology (GO) analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were conducted to explore cross-targets between disease and drugs. Survival analysis of key targets was performed using the GSE65682 dataset, and single-cell RNA-seq was employed for cellular localization analysis of key genes. Finally, molecular docking and Molecular dynamics simulation of the core target was conducted.</p><p><strong>Results: </strong>Differential expression analysis revealed 4253 genes associated with sepsis. Seventy-six active components and 1030 potential targets of Radix Bupleuri were identified. PPI, GO, and pathway enrichment analyses indicated involvement in the regulation of transmembrane transport, monatomic ion transport, and MAPK signaling. Survival curve analysis identified PIK3CD, ARRB2, SUCLG1, and SPI1 as key targets associated with lower mortality in the high expression group, while higher mortality was observed in the high PNP and FURIN expression groups. Single-cell RNA sequencing unveiled the cellular localization of PIK3CD, PNP, SPI1, and FURIN within macrophages, while ARRB2 and SUCLG1 exhibited localization in both macrophages and T-cells. Subsequent molecular docking and Molecular dynamics simulation indicated a potential binding interaction for Carvone-PIK3CD, Encecalin-ARRB2, Lauric Acid-SUCLG1, Pulegone-FURIN, Nootkatone-SPI1, and Saikogenin F-PNP.</p><p><strong>Conclusion: </strong>Radix Bupleuri could modulate immune function by affecting PIK3CD, ARRB2, SUCLG1, FURIN, SPI1, and PNP, thereby potentially improving the prognosis of sepsis.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"24 1","pages":"347"},"PeriodicalIF":3.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Piperine, a black pepper compound, induces autophagy and cellular senescence mediated by NF-κB and IL-6 in acute leukemia. 黑胡椒化合物胡椒碱在急性白血病中诱导 NF-κB 和 IL-6 介导的自噬和细胞衰老。
IF 3.3 2区 医学
BMC Complementary Medicine and Therapies Pub Date : 2024-09-28 DOI: 10.1186/s12906-024-04641-9
Kantorn Charoensedtasin, Wasinee Kheansaard, Sittiruk Roytrakul, Dalina Tanyong
{"title":"Piperine, a black pepper compound, induces autophagy and cellular senescence mediated by NF-κB and IL-6 in acute leukemia.","authors":"Kantorn Charoensedtasin, Wasinee Kheansaard, Sittiruk Roytrakul, Dalina Tanyong","doi":"10.1186/s12906-024-04641-9","DOIUrl":"10.1186/s12906-024-04641-9","url":null,"abstract":"<p><p>Acute leukemia is characterized by abnormal white blood cell proliferation with rapid onset and severe complications. Natural compounds, which are alternative treatments, are widely used in cancer treatment. Piperine, an alkaloid compound from black pepper, exerts anticancer effects through the cell death signaling pathway. Autophagy and senescence signaling pathways are considered target signaling pathways for cancer treatment. In this study, we investigated the effects of piperine via autophagy and senescence signaling pathways in NB4 and MOLT-4 cells. The MTT assay results demonstrated that piperine significantly decreased the viability of NB4 and MOLT-4 cells. Piperine induced autophagy by increasing LC3, Beclin-1 and ULK1 and decreasing mTOR and NF-κB1 expression in NB4 and MOLT-4 cells. In addition, piperine increased senescence-associated beta-galactosidase fluorescence intensity by increasing p21 and IL-6 expression while decreasing CDK2 expression in NB4 and MOLT-4 cells. In conclusion, our study provides additional information about the induction of autophagy and senescence by piperine in acute leukemia.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"24 1","pages":"343"},"PeriodicalIF":3.3,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11438257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of infant abdominal massage on the parental stress level among Chinese parents in Hong Kong - A mixed clustered RCT. 婴儿腹部按摩对香港华裔父母压力水平的影响--一项混合分组 RCT。
IF 3.3 2区 医学
BMC Complementary Medicine and Therapies Pub Date : 2024-09-28 DOI: 10.1186/s12906-024-04636-6
Veronica S K Lai, Daniel Y T Fong
{"title":"The effects of infant abdominal massage on the parental stress level among Chinese parents in Hong Kong - A mixed clustered RCT.","authors":"Veronica S K Lai, Daniel Y T Fong","doi":"10.1186/s12906-024-04636-6","DOIUrl":"10.1186/s12906-024-04636-6","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effectiveness and the experience of infant abdominal massage on reducing the parental stress level.</p><p><strong>Methods: </strong>A clustered RCT was conducted, 160 parents were recruited from 10 mother groups. An infant abdominal massage class was given to those in the intervention group by a certified International Association of Infant Massage instructor. The Chinese Parenting Stress Index (PSI-SF) was used to measure parental stress levels at baseline and 4 weeks after the intervention. 8 parents from the intervention group were invited for an online interview to understand the experience of parents in participating the infant abdominal massage class. Thematic analysis was applied.</p><p><strong>Results: </strong>The parental stress level was significantly decreased among intervention group with a mean difference of -5.46 (95% CI = 0.72 to 10.2, p = .049). ITT analysis was adopted for compliance analysis. The overall compliance for the intervention was 66% and found to have a significant effect on parental stress level (p < .01). The total PSI-SF among fathers was slightly higher than that among mothers. Furthermore, no moderating factors were found to have a significant interaction effect on PSI-SF (p < .05).For qualitative data, an overarching theme was generated that infant abdominal massage brought a positive experience despite the uncertainties affecting the compliance. Four themes and nine sub-themes were identified. Which were: (1) receiving clear and informative infant abdominal massage classes; (2) The influence of uncertain conditions on compliance; (3) Improving parental satisfaction; and (4) feeling it was a worthwhile experience.</p><p><strong>Conclusion: </strong>This study provides a cost-effective method for parents to tackle their parental stress, the findings aid in the planning or adjustment of current postpartum depression screening while also helping to lower the risk of postpartum mood disorders.</p><p><strong>Trial registration: </strong>Clinical Trial Number (NCT05650424 || http://clinicaltrials.gov/study/NCT05650424 ), registered on December 1, 2022. and HKU Clinical Trails Registry (HKUCTR3008), registered on November 3, 2022.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"24 1","pages":"342"},"PeriodicalIF":3.3,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11437811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction Note: Curcumin inhibits the migration of osteoclast precursors and osteoclastogenesis by repressing CCL3 production. 撤稿说明:姜黄素通过抑制 CCL3 的产生,抑制破骨细胞前体的迁移和破骨细胞的生成。
IF 3.3 2区 医学
BMC Complementary Medicine and Therapies Pub Date : 2024-09-27 DOI: 10.1186/s12906-024-04647-3
Zhengeng Liang, Yan Xue, Tao Wang, Qi Xie, Jiafu Lin, Yu Wang
{"title":"Retraction Note: Curcumin inhibits the migration of osteoclast precursors and osteoclastogenesis by repressing CCL3 production.","authors":"Zhengeng Liang, Yan Xue, Tao Wang, Qi Xie, Jiafu Lin, Yu Wang","doi":"10.1186/s12906-024-04647-3","DOIUrl":"https://doi.org/10.1186/s12906-024-04647-3","url":null,"abstract":"","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"24 1","pages":"341"},"PeriodicalIF":3.3,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11438388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of complementary and alternative medicine in patients with chronic liver diseases in Germany- a multicentric observational study. 德国慢性肝病患者使用补充和替代医学的情况--一项多中心观察研究。
IF 3.3 2区 医学
BMC Complementary Medicine and Therapies Pub Date : 2024-09-23 DOI: 10.1186/s12906-024-04607-x
Fleur Sophie Gittinger, Anna Rahnfeld, Elena Lacruz, Alexander Zipprich, Frank Lammert, Cristina Ripoll
{"title":"Use of complementary and alternative medicine in patients with chronic liver diseases in Germany- a multicentric observational study.","authors":"Fleur Sophie Gittinger, Anna Rahnfeld, Elena Lacruz, Alexander Zipprich, Frank Lammert, Cristina Ripoll","doi":"10.1186/s12906-024-04607-x","DOIUrl":"10.1186/s12906-024-04607-x","url":null,"abstract":"<p><strong>Background: </strong>The use of Complementary and alternative medicine (CAM) in chronic liver disease (CLD) patients in Germany is unknown. This study investigated the frequency of CAM use and associated sociodemographic, clinical and personality factors in CLD patients in Germany.</p><p><strong>Methods: </strong>This is a cross-sectional multicenter study of CLD patients attending liver outpatient clinics of university hospitals in Halle(-Saale) and Homburg between 2015 and 2017. Dedicated questionnaires recorded CAM use, sociodemographic and personality factors (evaluated with the \"Big five\" model, \"Hospital Anxiety and Depression\"-, \"Multidimensional Health Locus of Control\"- score). Uni- and multivariate analyses assessed factors associated to CAM use.</p><p><strong>Results: </strong>Overall 378 patients were recruited, 92 (24.3%) reported to CAM use. On univariate analysis, female CAM users were older (p = 0.001) and more physically active (p = 0.002), male CAM users more often used homeopathy (p = 0.000), actively promoted their health (p = 0.010) or had UDC in their medication (p = 0.004). Logistic regression analysis adjusted for personality factors showed significant association of age, physical exercise (females) and satisfaction with alternative medicine (females, males) to CAM use.</p><p><strong>Conclusions: </strong>CAM use is prevalent among CLD patients in Germany and is significantly associated to satisfaction with alternative medicine (females, males), physical exercise and older age (females). Doctors should actively inquire CLD patients about CAM use, as hepatotoxicity or interaction with medication can occur.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"24 1","pages":"340"},"PeriodicalIF":3.3,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11421120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gegen Qinlian decoction alleviates depression-like behavior by modulating the gut microenvironment in CUMS rats. 葛根秦连煎剂通过调节肠道微环境缓解CUMS大鼠的抑郁样行为
IF 3.3 2区 医学
BMC Complementary Medicine and Therapies Pub Date : 2024-09-20 DOI: 10.1186/s12906-024-04638-4
Yaqin Peng, Yao Du, Yuanyuan Zhang, Ze Wang, Tao Hu, Yuning Mai, Hongxiu Song, Weichao Pan, Qinglong Cai, Feifei Ge, Yu Fan, Hee Young Kim, Dekang Liu, Xiaowei Guan
{"title":"Gegen Qinlian decoction alleviates depression-like behavior by modulating the gut microenvironment in CUMS rats.","authors":"Yaqin Peng, Yao Du, Yuanyuan Zhang, Ze Wang, Tao Hu, Yuning Mai, Hongxiu Song, Weichao Pan, Qinglong Cai, Feifei Ge, Yu Fan, Hee Young Kim, Dekang Liu, Xiaowei Guan","doi":"10.1186/s12906-024-04638-4","DOIUrl":"https://doi.org/10.1186/s12906-024-04638-4","url":null,"abstract":"<p><strong>Background: </strong>Gegen Qinlian Decoction (GQD) is a classical traditional Chinese medicine (TCM) formula primarily utilized for treating gut disorders. GQD showed therapeutic effects on several diseases in clinical and animal studies by targeting gut microbes. Our recent studies also found that GQD efficiently alleviated anxiety in methamphetamine-withdrawn mice via regulating gut microbiome and metabolism. Given that various studies have indicated the link between the gut microbiome and the development of depression, here we endeavor to explore whether GQD can manage depression disorders by targeting the gut microbiome.</p><p><strong>Methods and materials: </strong>The depression-like model was induced in rats through chronic unpredictable mild stress (CUMS) and the depression levels were determined using the sucrose preference test (SPT). To address the depression-like behavior in rats, oral administration of GQD was employed. The colon microbiome and metabolite patterns were determined by 16s rRNA sequencing and untargeted metabolomics, respectively.</p><p><strong>Results: </strong>We found 6 weeks of CUMS can induce depression-like behavior in rats and 4 weeks of GQD treatment can significantly alleviate the depression-like behavior. GQD treatment can also ameliorate the histological lesions in the colon of CUMS rats. Then, CUMS increased the abundance of gut microbes, while GQD treatment can restore it to a lower level. We further discovered that the abundances of 19 bacteria at the genus level were changed with CUMS treatment, among which the abundances of Ruminococcus, Lachnoclostridium, Pygmaiobacter, Bacteroides, Pseudomonas, and Pseudomonas Family_XIII_AD3011_group were stored by GQD treatment. Besides, we identified the levels of 36 colon metabolites were changed with CUMS treatment, among which the levels of Fasciculic acid B, Spermine, Fludrocortisone acetate, alpha-Ketoglutaric acid, 2-Oxoglutaric acid, N'-(benzoyloxy)-2-(2,2-dichlorocyclopropyl) ethanimidamide, N6-Succinyl Adenosine Oleanolic acid, KQH, Ergosta-5,7,9(11),22-Tetraen-3-beta-Ol, Gentisic acid, 4-Hydroxyretinoic Acid, FAHFA (3:0/16:0), Leucine-enkephalin and N-lactoyl-phenylalanine can be restored by GQD treatment.</p><p><strong>Conclusion: </strong>Our findings provide evidence supporting the therapeutic efficacy of GQD in alleviating depression-like behavior in CUMS rats, potentially being targeted on colon bacteria (especially the abundance of Ruminococcus and Bacteroides) and metabolites (especially the level of Oleanolic acid).</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"24 1","pages":"339"},"PeriodicalIF":3.3,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11416015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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