BMC Complementary Medicine and Therapies最新文献

{"title":"The interaction of vitamin D supplementation with Omentin-1 gene polymorphism on metabolic factors and anthropometric indices in women with prediabetes: a study protocol for a double-blind randomized controlled trial.","authors":"Roghayeh Molani-Gol, Maryam Rafraf, Mohammad Asghari Jafarabadi, Dariush Shanehbandi","doi":"10.1186/s12906-025-05034-2","DOIUrl":"10.1186/s12906-025-05034-2","url":null,"abstract":"","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"299"},"PeriodicalIF":3.4,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isorhamnetin protects against D-GalN/LPS-induced acute liver injury in mice through anti-oxidative stress, anti-inflammation, and anti-apoptosis.","authors":"Li Long, Miao Zhang, Hui-Zhen Qin, Li-Ba Xu, Bing-Bing Wang, Wen-Yuan Wu, Hua Zhu, Si Lin","doi":"10.1186/s12906-025-04949-0","DOIUrl":"10.1186/s12906-025-04949-0","url":null,"abstract":"<p><strong>Background: </strong>Acute liver injury (ALI), which can progress to cirrhosis, hepatocellular carcinoma and acute liver failure, has become a global concern and a serious threat to human life and health. Isorhamnetin (ISO) is an O-methylated flavonol from the class of flavonoids. It has a protective effect on various organs, but its effect on ALI is still unclear in current studies.</p><p><strong>Purpose: </strong>This study aimed to investigate the protective effect of ISO against D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced ALI and to explore the underlying molecular mechanisms.</p><p><strong>Methods: </strong>Ninety-six male Kunming mice were randomly divided into six groups and given the appropriate drug administration for 14 days. The ALI mouse model was established by intraperitoneal injection of 700 mg/kg D-GalN and 10 µg/kg LPS. Hematoxylin-eosin (HE) staining was performed to observe the histopathological changes. Enzyme-linked immunosorbent assay (ELISA) and quantitative Real-time Polymerase Chain Reaction (qRT-PCR) were performed to detect the expression of genes related to oxidative stress and inflammation. Inflammation and apoptosis related factors were detected by western blot.</p><p><strong>Results: </strong>ISO alleviated D-GalN/LPS-induced ALI, reducing the alanine transaminase (ALT), aspartate transaminase (AST), and malondialdehyde (MDA) levels (P < 0.01), while improving histopathology (P < 0.05). Additionally, ISO elevated the superoxide dismutase (SOD) level, and improved the survival rate of mice (P < 0.01). Moreover, ISO reduced the nitric oxide (NO), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) levels (P < 0.05), while increasing the glutathione (GSH), and catalase (CAT) levels (P < 0.05). ISO also decreased the expression of nuclear factor-kappa B alpha (IκBα), Nuclear factor kappa-B (NF-κB) p65, IL-1β, IL-6, TNF-α, nitric oxide synthase (iNOS), and toll-like receptor 4 (TLR4) at the messenger ribonucleic acid (mRNA) level (P < 0.05). Furthermore, western blot showed that ISO decreased the expression of NF-κB p-p65, cysteine aspartate protease-3 (caspase-3), and B-cell lymphoma 2-associated X protein (Bax) proteins and elevated the expression of B-cell lymphoma 2 (Bcl-2) and B-cell lymphoma 2-like protein (Bcl-xL) proteins (P < 0.05).</p><p><strong>Conclusions: </strong>ISO could alleviate D-GalN/LPS-induced ALI by attenuating oxidative stress and inflammatory cytokines, enhancing the expression of anti-apoptotic proteins, reducing hepatocyte apoptosis, and inhibiting the activation of the NF-κB signaling pathway. Our study will provide some new references for treating ALI with ISO.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"297"},"PeriodicalIF":3.4,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A well-being promotion program increases self-compassion, active coping and emotion regulation among providers who work with children and families.","authors":"Liliana J Lengua, Rebecca Calhoun, Ignatius Balinbin, Robyn Long, Katie Malloy Spink, Marie Angeles","doi":"10.1186/s12906-025-05043-1","DOIUrl":"10.1186/s12906-025-05043-1","url":null,"abstract":"<p><p>This study examined the effects of the REsilient Attitudes and Living for Professionals (REAL Pro) prevention intervention on the well-being of professionals who work with children and families. The program combines mindfulness and self-compassion practices with cognitive-behavioral tools that aim to promote improved stress management, emotion regulation and well-being, and was evaluated with early childhood (n = 87) and K-12 educators (n = 40), staff serving youth in out-of-school or after-school settings (n = 31), and medical providers (n = 35). Participants completed pre- and post-test assessments, reporting on measures of stress management (perceived stress, self-compassion), emotion regulation (dysregulation, active coping, denial), and well-being (flourishing, resilience, burnout, secondary trauma symptoms). Dependent sample t-tests were conducted, showing significant improvement from pre- to post-test in self-compassion, emotion regulation, active coping, and a trend toward increased resilience. Three-month follow-up in a small subset of the sample (n = 11) suggested potential delayed reduction in burnout and secondary trauma symptoms. Satisfaction surveys and qualitative data indicated high participant satisfaction with the program and that participants made use of and perceived benefits from the skills for themselves and their clients. The preventive intervention shows promise for providing professionals with tools for stress management and emotion regulation, with the potential for reducing burnout in providers working with children and families who tend to experience substantial work-related stress.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"296"},"PeriodicalIF":3.4,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is sacred animal (Asian Elephant) can be a medicinal repository: a new approach for colon cancer treatment using the methanolic extracts of the dung samples and their valuation for antimicrobial, cytotoxic, and apoptotic actions.","authors":"Somashekara Rajashekara, Manyao Khampei Konyak, Ramakrishnappa Sarala, Kurubarahalli Siddamadegowda Poojashree, Pavithra Bai, Jampanna Nagabhushana","doi":"10.1186/s12906-025-05039-x","DOIUrl":"10.1186/s12906-025-05039-x","url":null,"abstract":"","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"295"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping evidence of spinal manipulation therapy for headaches in South Africa: a scoping review of grey literature.","authors":"Keseri Padayachy, Ismail Fatima, Morris Kahere, Alister du Rose, Katherine A Pohlman","doi":"10.1186/s12906-025-05044-0","DOIUrl":"10.1186/s12906-025-05044-0","url":null,"abstract":"<p><strong>Objective: </strong>Spinal manipulative therapy (SMT) has been demonstrated to be an effective management approach for primary headaches; however, current literature often excludes data from South Africa (SA). The use of grey literature provides a viable mechanism to address knowledge gaps. Understanding that Master's dissertations are a source of grey literature, this review's primary objective was to address the following question: What is the range of evidence, particularly regarding subjective and objective outcome measures, for the application of SMT in managing headache patients at chiropractic training facilities in SA?</p><p><strong>Methods: </strong>A scoping review methodology was adopted in compliance with the Joana-Briggs-Institute and the Arksey and O'Malley frameworks and reported following the preferred reporting items for systematic reviews and meta-analysis extended for scoping reviews checklist. The search was performed using the Durban University of Technology and University of Johannesburg Research Databases. All studies conducted from 1995 to May 2023 were retrieved. Trials conducted with SMT for the management of headaches were included and subjective (i.e., numerical rating scale, headache disability index, neck disability index) and objective (i.e., range of motions, pressure algometry) outcomes were extracted.</p><p><strong>Results: </strong>In total 25 dissertations with 921 headache patients were reviewed. Across most of the dissertations, combining SMT with additional modalities versus SMT alone or another modality alone yielded greater improvement in subjective outcome measures, although there were occasional exceptions where no clear pattern emerged. In terms of objective measures, there were both increases and decreases across the different interventions.</p><p><strong>Discussion: </strong>The findings align with existing literature, indicating that primary headache patients in SA who receive SMT in conjunction with other non-pharmacological treatments respond favourably. This study underscores the potential value of grey literature, particularly in regions where high-quality data is scarce. It highlights the significance of SMT for policymakers, funders, and other stakeholders involved in managing headache patients in SA. Although limitations related to the quality of the dataset are acknowledged, the standardization and robust design of clinical trial protocols at SA institutions reveal numerous strengths. Despite ongoing discussions in the literature regarding the use of SMT for headache management, there is a strong case for existing literature to be used in the SA context.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"294"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of SH003 on immune function: study protocol for a randomized, double-blind placebo-controlled clinical trial.","authors":"Chunhoo Cheon, Seong-Gyu Ko","doi":"10.1186/s12906-025-05032-4","DOIUrl":"10.1186/s12906-025-05032-4","url":null,"abstract":"<p><strong>Background: </strong>The immune system is essential for defending the body against pathogens and maintaining homeostasis. Recent global public health challenges have increased interest in natural products that enhance immune function. SH003, a compound derived from Astragalus membranaceus, Angelica gigas Radix, and Trichosanthis Radix, has shown potential as an immunomodulatory agent. This study aims to evaluate the efficacy and safety of SH003 in improving immune function in individuals with a mildly weakened immune systems.</p><p><strong>Methods: </strong>This randomized, double-blind, placebo-controlled trial will be conducted over 8 weeks with 120 participants aged 19 to 75 years who have experienced two or more upper respiratory infections in the past year. Participants will be randomly assigned to receive either SH003 or a placebo. The primary outcome is the change in natural killer cell activity. Secondary outcomes include cytokines levels (IL-2, IL-12, IFN-γ, TNF-α), inflammation markers (CRP, ESR), and stress and respiratory symptoms. Safety outcomes will be monitored through vital signs and laboratory tests.</p><p><strong>Discussion: </strong>This study represents the first clinical trial to evaluate the immune-enhancing effects of SH003 in a general population with mild immune system impairment. The results could offer valuable insights into the potential of SH003 as a novel immune support intervention.</p><p><strong>Trial registration: </strong>Clinical Research Information Service (registration number: KCT0009424, May 10, 2024, https://cris.nih.go.kr ). Retrospectively registered.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"293"},"PeriodicalIF":3.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of turmeric products on knee osteoarthritis: a systematic review and network meta-analysis.","authors":"Han Su Wai, Thanika Pathomwichaiwat, Thanarat Suansanae, Surakit Nathisuwan, Wipharak Rattanavipanon","doi":"10.1186/s12906-025-05045-z","DOIUrl":"10.1186/s12906-025-05045-z","url":null,"abstract":"<p><strong>Background: </strong>Turmeric has traditionally been used to treat various inflammatory conditions, including knee osteoarthritis (OA). There are multiple turmeric preparations available. However, the comparative effectiveness of these products remains unknown. This study aimed to assess the comparative effectiveness of turmeric products for knee OA outcomes by conducting a systematic review and network meta-analysis of randomized, controlled trials (RCTs).</p><p><strong>Methods: </strong>PubMed, EMBASE, SCOPUS, and ClinicalTrials.gov databases were searched up to August 2024, identifying RCTs that compared turmeric preparations and/or active comparators versus placebo. The primary outcome measured pain reduction, using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), while secondary outcomes evaluated pain using other tools. Mean differences (MDs) were pooled using a random-effects model, and the concept of minimum clinically important difference (MCID) was considered.</p><p><strong>Results: </strong>Seventeen studies were included. All turmeric preparations significantly reduced WOMAC pain. The mean differences (MD, 95% CI) for WOMAC pain reduction were as follows: - 4.01 (-6.22, - 1.80) for conventional curcuminoid preparations (CT) plus active drug comparators (AC, defined as NSAIDs and acetaminophen), - 3.33 (-5.26, - 1.39) for AC, - 3.17 (-5.50, - 0.83) for CT, and - 2.47 (-3.27, - 1.67) for bioavailability-enhanced curcuminoid preparations (BE). The BE preparation also demonstrated a 30% reduction in WOMAC pain compared to placebo, reaching the MCID threshold. The BE + AC combination led to a 70% reduction in VAS pain compared to AC alone.</p><p><strong>Conclusions: </strong>All turmeric preparations appear to be effective in reducing knee OA pain when used as monotherapy compared to placebo. However, the certainty of evidence remains low, indicating a need for further research.</p><p><strong>Prospero registration number: </strong>CRD42023464749.</p><p><strong>Clinical trial number: </strong>not applicable.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"292"},"PeriodicalIF":3.4,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mobilization with movement plus exercise versus exercise alone for patients with central sensitization associated with chronic subacromial pain syndrome: a sham-controlled randomized clinical trial.","authors":"Volkan Deniz, Bayram Kelle","doi":"10.1186/s12906-025-05028-0","DOIUrl":"10.1186/s12906-025-05028-0","url":null,"abstract":"","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"289"},"PeriodicalIF":3.4,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144727945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Massage positively influences daytime brain activity and reduces arousal state in poor sleepers: a randomized controlled trial.","authors":"Ilias Ntoumas, Christina Karatzaferi, Fotini Boubougiatzi, Nefeli Manakou, Artemis Aslanidi, Christoforos D Giannaki, Fotini Papanikolaou, Efthimios Dardiotis, Eleftherios Lavdas, Giorgos K Sakkas","doi":"10.1186/s12906-025-05022-6","DOIUrl":"10.1186/s12906-025-05022-6","url":null,"abstract":"<p><strong>Background: </strong>Daytime napping is used as a strategy to complement insufficient night-time sleep and improve daytime mental and physical performance. Massage can play a crucial role in promoting relaxation and wellness at various settings including the work place. The purpose of the present study was to investigate the effect of two different types of manual massage sessions on day-time napping in poor sleepers.</p><p><strong>Methods: </strong>This was a randomized, single blind, placebo-controlled, three arm, interventional clinical trial. Fifteen participants (aged 21.6 ± 1.3 years) participated in three different conditions over one week apart: 1) 30-min Sports massage condition (ACT), 2) 30-min Relaxation massage condition (REL) and 3) control condition with no massage. Brain activity was monitored using a polysomnography EEG system, while vitals and relaxation/stress state were assessed by validated questionnaires and functional tests. The Pittsburgh Sleep Quality Index Score > 5 was used as cut off for distinguishing poor sleeper.</p><p><strong>Results: </strong>Results showed significant differences between the three conditions, with muscle tone to be reduced by 7.2% after ACT session (p = 0.000) and relaxation scores to be increased by 23.4% after REL session (p = 0.008). In addition, Sleep Latency N1 was improved only after the REL session compared to other two conditions (p = 0.037).</p><p><strong>Conclusions: </strong>In conclusion, massage can positively impact the quality and quantity of daytime napping and may serve as a complementary intervention to enhance mental well-being, reduce work related stress, improve performance and promote overall a healthier living.</p><p><strong>Trial registration: </strong>Retrospectively registered (registration date: 16/01/2025; trial registration number at ClinicalTrials.gov: NCT06780072).</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"290"},"PeriodicalIF":3.4,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144727943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute and subacute toxicity of the aqueous extract of Cissus Polyantha Glig and Bradt (Vitaceae) on biochemical and hematological parameters in Wistar rats.","authors":"David Miaffo, Oulianovie Guessom Kamgue, Kilenma Kolefer, Elizé Dadaya, Talba Abba Mahamad, Barthelemy Maidadi, Albert Kamanyi","doi":"10.1186/s12906-025-05027-1","DOIUrl":"10.1186/s12906-025-05027-1","url":null,"abstract":"<p><strong>Background: </strong>Cissus polyantha (C. polyantha) Glig and Bradt is a climbing plant of the Vitaceae family generally distributed in tropical regions and used in traditional African pharmacopoeia for the treatment of conjunctivitis, pain, inflammation, microbial diseases and diabetes mellitus. The aim of this study was to evaluate the acute and subacute toxicity of the aqueous extract from leafy stems of C. polyantha (AECP) in rats.</p><p><strong>Methods: </strong>In acute toxicity, AECP was administered orally at a single dose of 2000 mg/kg. Clinical signs, general behavior and mortality were assessed for 14 days. In subacute toxicity, AECP at 111, 222 and 444 mg/kg was administered orally for 28 days. Body weight, internal organ weight, water intake, food consumption, biochemical parameters, hematological profile and histological examinations were evaluated.</p><p><strong>Results: </strong>Acute toxicity results showed no signs of poisoning and no mortality. The mean lethal dose (LD₅₀) of AECP was therefore greater than 2000 mg/kg. In subacute toxicity, a significant increase in body weight, water and food consumption, liver weight and lymphocyte counts as well as a decrease in ALT activity and creatinine levels were recorded in rats of both sexes treated at 222 and/or 444 mg/kg. AECP caused a notable reduction in uric acid, total cholesterol and triglycerides at all doses tested. Histopathological analysis of rat kidneys shows slight mesengial hyperplasia at 444 mg/kg. However, all other parameters evaluated did not experience significant variation after AECP administration at all doses.</p><p><strong>Conclusions: </strong>In acute toxicity, the LD₅₀ is greater than 2000 mg/kg, so AECP is of low toxicity. In subacute toxicity, only the dose of 444 mg/kg of AECP resulted in decreased body weight, water and food consumption, and increased liver weight, ALT activity, and lymphocyte counts. Doses below 444 mg/kg may therefore be safe.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"288"},"PeriodicalIF":3.4,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144727942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}