Archives in cancer research最新文献

{"title":"Anti-cancer effect of L-Glutaminase on acute lymphoblastic leukemia (Raji), breast cancer (MCF7) and colorectal cancer (A549) cell lines","authors":"Elaheh Madadi Hiyagh, Sah, M. Ravasan, F. Darvishi, A. Mokhtarzadeh, B. Baradaran","doi":"10.21767/2254-6081-C1-021","DOIUrl":"https://doi.org/10.21767/2254-6081-C1-021","url":null,"abstract":"Cancer Science & Pediatrics 2019 Background: There are lots of treatments for cancer but always enzymes are the most efficient. Glutamine can be used to support proliferation in multiple ways. It is a proteinogenic amino acid, and can be act as a nitrogen donor for the synthesis of amino acids as well as nucleotides biosynthesis in cellular processes. The presence of L-glutaminase has been reported in various organisms, including animals, plants, and microorganisms except humans. It’s a treatment enzyme for ALL and L-glutaminase also has proved ineffectual for treatment solid tumours such as breast cancer and colorectal. In following research Yarrowia yeast glutaminase is used.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68127649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polycystic Ovarian Syndrome and infertility","authors":"pRuhi Yasminp","doi":"10.4172/2167-0420-C5-020","DOIUrl":"https://doi.org/10.4172/2167-0420-C5-020","url":null,"abstract":"Quality of Life (QoL) surveys are important tasks in health management for oncological patients. Ability to perform daily activities, patient satisfaction and levels of functionality are essential for evaluating QoL in breast cancer survivors. Hot flashes on tamoxifen treatment have been reported to decrease general quality of life in women with breast cancer. Long-term, disease-free survivors of breast cancer have an excellent QOL, many years after their breast cancer diagnosis. According to the World Health Organization???s International Classification of Functioning, Disability and Health (ICF), function is defined as the interactions between an individual, their health condition and the social and personal context in which they live. Breast cancer patients experience physical symptoms and psychosocial distress that adversely affect their quality of life. Healthcare providers and patients think that QoL assessments acceptable in helping breast cancer patients to overcome areas of QoL that have been affected by the disease.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70799612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crucial Role of Curcumin, Piperine and Taurine on Immunological Criteria in Hepatocellular Carcinoma Patients","authors":"S. Abdeen, M. El-Houseini, F. Kashwaa, M. El-Sherbiny, Ezz-Al Am, M. Kamel, O. AbdEl-Hameed, A. Salah","doi":"10.21767/2254-6081.100193","DOIUrl":"https://doi.org/10.21767/2254-6081.100193","url":null,"abstract":"Introduction: Hepatocellular carcinoma is the fifth most common cancer worldwide. The majority of HCC patients are diagnosed at advanced stage, and curative therapeutic options for HCC are very limited. Therefore, searching for additional therapy is strongly recommended. It has been shown that, curcumin and taurine revealed therapeutic role against hepatocarcinoma cells propagated ex-vivo and in vivo using experimental animal model in addition to piperine was found to increase the absorption and the bioavailability of curcumin. Patients and methods: Mononuclearleukocytes(MNLs) and serum were obtained from HCC patients (N=15) before and after treatment with 4 g curcumin mixed with 0.02 gm piperine and 0.5 gm taurine taken daily for three weeks, and six weeks compared to untreated healthy control (N=30). Sera Cytokines levels and immunophenotypic characterization of MNL were determined. Clinical data for the patients were also performed. Results: Regarding, cytokine evaluation in sera of the patient’s post-treatment did show that, IL-10 was significant decrease, on contrary there was significant increase in IFN-γ level. On contrast, levels of IL-6, IL-8, TNF-α, and TGF-α did not show significant difference compared to baseline (before treatment). As for immunophentyping of MNL of the patients under investigation; there were highly significant differences in CD4+%, CD8+%, CD4+CD25+%, and CD8+CD25+% after treatment compared to baseline (untreated patients). Conclusion: Curcumin, piperine and taurine open novel avenue as promising therapeutic natural derived agents in treatment of patients suffering from hepatocellular Carcinoma.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.100193","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68126404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to reconcile the microRNA-200 family with different tumour sites?","authors":"M. Almaghrabi","doi":"10.21767/2254-6081-C1-020","DOIUrl":"https://doi.org/10.21767/2254-6081-C1-020","url":null,"abstract":"","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68127924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blue Faery helps liver cancer patients spread their wings","authors":"A'ndrea J. Wilson","doi":"10.21767/2254-6081-C1-019","DOIUrl":"https://doi.org/10.21767/2254-6081-C1-019","url":null,"abstract":"","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68127597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Target Definition for Stereotactic Reirradiation of Recurrent Glioblastoma","authors":"M. Beyzadeoğlu, O. Sager, F. Dinçoğlan, S. Demiral","doi":"10.21767/2254-6081.100192","DOIUrl":"https://doi.org/10.21767/2254-6081.100192","url":null,"abstract":"Background and purpose: Glioblastoma multiforme (GBM) constitute the most prevalent brain tumor in adults. The prognosis of GBM is typically bleak, with eventual recurrence in an overwhelming majority of the patients despite multimodality management including surgery, radiation therapy (RT), and systemic treatment. Vast majority of patients develop recurrence within or in close vicinity of the initial RT field, which limits the reirradiation dose to be delivered for recurrent tumor. Accurate target definition is critical for stereotactic reirradiation of recurrent glioblastoma. Multimodality imaging with computed tomography (CT), magnetic resonance imaging (MRI) and molecular imaging techniques may be used for detection of recurrence. In this study, we assessed the utility of multimodality imaging in target volume determination for stereotactic reirradiation of recurrent glioblastoma. Patients and methods: Sixteen patients receiving radiosurgery at our institution for recurrent glioblastoma were identified for comparative evaluation of target definition based on CT imaging only and CT-MR fusion based imaging. Results: CT-only imaging and CT-MR fusion based imaging for radiosurgery target definition was comparatively evaluated for 16 patients treated with radiosurgery at our institution for recurrent glioblastoma. Comparative assessment revealed that target definition based on CT-MR fusion based imaging was optimal and identical to the consensus decision of treating physicians in majority of the treated patients. Conclusion: Incorporation of MRI may improve target definition for recurrent glioblastoma radiosurgery despite the need for further supporting evidence.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68126862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persisting Dilemmas in Etiology and Challenges in Screening and Diagnosis of Cervical Pre-cancer and Cancer","authors":"S. Chhabra","doi":"10.21767/2254-6081.100190","DOIUrl":"https://doi.org/10.21767/2254-6081.100190","url":null,"abstract":"Introduction: Cervical cancer is probably fifth amongst all cancers, third most common in women after breast, colorectal in some countries. Recent trends reveal resurgence in developed countries too. Dilemmas continue about which cervical dysplasia/ cervical intraepithelial neoplasms are precursors of cancer and after how much interval. Objectives: The objective is to look at dilemmas in ethology of cervical cancer, challenges in screening and diagnosis of pre-cancer, cancer. Methodology: Simple review of literature was done by various search engines and personal experience was added. Results: Geographic variations in cervical cancer rates reflect differences in presence or absence of etiological factors and screening of pre-cancer. Molecular studies revealed human papilloma viruses (HPV)16, 18 as most oncogenic, long-term hormonal contraceptives, high parity, early sexual activity, multiple sex partners, tobacco smoking, co-infection with HIV as identified cofactors, and co-infection with Chlamydia trachomatis, Herpes simplex virus type-2, immunosuppression, low economic status, poor hygiene, low dietary antioxidants probable cofactors. Genetic, immunological factors play some role. However, role of none seems to be clear. Dilemmas continued about many factors. Discussion: Cervical cytology most commonly used conventional screening has many limitations, danger of cells drying, poor quality, reporting problems. So, liquid based, thin layer cytology is advocated which has limitations. False negative/positive results continue. Histopathology is essential but necrosis in advanced cases creates problems. Visual inspection, visual inspection using acetic acid, lugol’s iodine has varying results. Point-of-care, affordable HPV tests are elusive. Standard cytology-based programs in high-resource countries have been colposcopic localization and biopsy in screen-positive. However false positivity and overtreatment continue. Many challenges limit utilily of screening with colposcopy. Research continues to search for useful biochemical, microbiological markers. Conclusion: Dilemmas in ethology of cervical cancer and challenges in screening, diagnosis still continue. Risk of overtreatment outweigh risk of high-grade lesions, invasive cancers untreated. Research needs to continue.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68126614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Hepatocellular Carcinoma and Its Mortality Rate: A Multicenter Study in Indonesia","authors":"Jasirwan Com, I. Hasan, A. Sulaiman, R. Gani, Lesmana Cra, Juferdy Kurniawan, K. Kalista, S. H. Nababan","doi":"10.21767/2254-6081.100191","DOIUrl":"https://doi.org/10.21767/2254-6081.100191","url":null,"abstract":"Background: Hepatocellular carcinoma (HCC) is a rising cause of mortality and a significant burden. Therefore, a population-based cancer registry is an essential element to provide a baseline and comprehensive analysis of the patient's risk factors. We present a multicentre HCC registry at two hospitals in Indonesia. Methods: We performed a follow up on HCC patients admitted between January 2015 and November 2017 in Cipto Mangunkusumo National General Hospital and Dharmais Hospital, Jakarta, Indonesia. The primary outcome was the patient's death which also was the endpoint of the follow up evaluation. We conducted a multivariate analysis using logistic regression and calculated the odds ratio (OR) with 95% confidence intervals (CIs). Results: In this study, there were 282 HCC patients and the mean age was 55 ± 12.75 years. As many as 74.8% (211/282) patients were male and hepatitis B virus (HBV) was the most common etiology found (63.1%; 178/282). At the last follow up, 136 (48.2%) patients have died. Mortality rate was not significantly affected by the patient's sex, age, hepatitis etiology, cirrhotic status, nor HCC surveillance. Based on Child-Pugh (CP) classification, the odds increase progressively in CP C patients (OR 1.95; 95% CI 1.08-3.53; p=0.026). The progressive increase was also found in higher Barcelona Clinic Liver Cancer (BCLC) stage of HCC with odds ratio for C and D patients were 3.50 (95% CI 1.18-10.38; p=0.024) and 3.41 (95% CI 1.02-11.41; p=0.047) respectively. Supportive treatment was the most dominant treatment modality with odds ratio 2.17 (95% CI 1.14-4.16; p =0.019) and was found to be associated with HCC mortality rate. The median survival of all patients was 17 months from the date of diagnosis. Conclusion: Child-Pugh classification, BCLC stage and treatment modality might predict mortality in HCC patients. Other parameters need further evaluation.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.100191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68126631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity in cancer survivor: A study in Italy","authors":"J. F. Chagas, J. Aquino, Maria Beatriz Nogueira Pascoal, Luis Antonio Br, I. Filho, Fern, A. Fruet, D. Pereira","doi":"10.21767/2254-6081-C3-012","DOIUrl":"https://doi.org/10.21767/2254-6081-C3-012","url":null,"abstract":"","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46951302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KAPS-biomarker for early diagnosis of prostate cancer","authors":"K. Chadha, W. Underwood","doi":"10.21767/2254-6081-C3-011","DOIUrl":"https://doi.org/10.21767/2254-6081-C3-011","url":null,"abstract":"P cancer (CaP) is the most common non-skin cancer in men and third most common cause of cancer deaths in men. Black men experience a higher burden of incidence and mortality from CaP compared to White men. The prostatespecific antigen (PSA) test, a commonly used biomarker for early diagnosis and management of CaP, cannot alone accurately predict the presence of CaP, its aggressiveness, or the risk of post-treatment recurrence. The widespread use of PSA testing in CaP screening is controversial partially because patients with benign enlargement of the prostate often have elevated levels of PSA and many men with diagnosed CaP have a normal PSA. Consequently, a search for more effective prostate tumor biomarkers is overdue. Our studies thus far show that concurrent measurements of the levels of serum cytokines such as IL-8, TNF-α, and sTNF-R1 (KAPS biomarker) provide a significant advantage as a CaP biomarker over PSA measurements alone in differentiating men with CaP from men without CaP. Our working hypothesis is that both Black and White men with CaP have altered circulating levels of KAPS biomarker compared to men without CaP. Further, the extent to which these levels are altered will vary according to CaP risk factors and can be used as a tool to improve the early detection of CaP and CaP treatment decision-making. We tested our hypothesis in a retrospective study of men with elevated PSA but a negative prostate biopsy, patients diagnosed with localized prostate cancer and patients with castration resistant CaP (CRPC). The predictive accuracy of the markers was described using receiver operating characteristic (ROC) curves. In our analysis, AUC values greater than 0.8 were considered as useful in predicting CaP outcomes for individual patients. All the comparisons for KAPS biomarker were statistically significant at the p<0.05 level. The AUC for each of marker alone was statistically superior to PSA alone (p<0.01 for each pairwise comparison). Each of the KAPS-marker combination AUCs was significantly better than PSA alone (p<0.01 for all), but not statistically different from each other. Combining TNF-α with PSA resulted in a 3.0-fold decrease in the PSAalone false positive fraction (FPF), and a 3.7-fold decrease in the PSAalone false negative fraction (FNF). The PSA+sTNFR1 combination had a 5.9-fold decrease in the FPF, and a 2.5-fold decrease in FNF. Ability of KAPS-biomarker was also effective at distinguishing between localized CaP and metastatic CaP patients. AUC results (with 95% confidence intervals) for additive combinations of these biomarkers will also be discussed. The best predictor of localized CaP vs. metastatic CaP was KAPS combined with PSA 0.999 (0.998 to 1.000). Due to the reported significant racial differences in the diagnoses of and mortality from CaP, future CaP biomarker studies should include a racially diverse sample of men, especially Black men.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68128834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}