Metabolism and target organ damage最新文献_第3页

Exploring the role of testosterone upon adiposity and cardiovascular risk markers in men with severe obesity 探究睾酮对重度肥胖男性脂肪和心血管风险指标的作用

Metabolism and target organ damage Pub Date : 2024-01-08 DOI: 10.20517/mtod.2023.40

Eleni Armeni

{"title":"Exploring the role of testosterone upon adiposity and cardiovascular risk markers in men with severe obesity","authors":"Eleni Armeni","doi":"10.20517/mtod.2023.40","DOIUrl":"https://doi.org/10.20517/mtod.2023.40","url":null,"abstract":"A prominent endocrine disorder linked to unhealthy lifestyle behaviors and increased visceral adiposity is Male Obesity Secondary Hypogonadism (MOSH). The pathogenesis of MOSH remains under investigation. However, recent evidence supports a direct role of leptin in affecting Leydig cells, reducing testosterone production, and increasing appetite. Conversely, testosterone deficiency is associated with comorbidities like hypertension, diabetes, and nonalcoholic fatty liver disease. A recently published study entitled “Relationship between sex hormones, markers of adiposity and inflammation in male patients with severe obesity undergoing bariatric surgery” describes evidence supportive of an inverse association between testosterone and serum leptin as well as levels of c-reactive protein (CRP) and IL-6, as well as a correlation between body mass index and CRP. The same study also provides novel insight retrieved from their in vitro findings, which reveal that testosterone exposure influences the expression of genes associated with adiposity, like fatty acid binding protein 4, peroxisome proliferation-activated receptor γ (PPARγ), leptin, and adiponectin, as well as von Willebrand factor, in human-derived adipocytes. Overall, the latest evidence highlights the importance of early identification of hypogonadism in obese males and the potential benefits of testosterone supplementation in alleviating complications associated with obesity, particularly chronic inflammation. These observations underscore the need for a holistic approach to managing severe obesity, addressing hormonal and inflammatory factors to reduce its overall burden on health.","PeriodicalId":91001,"journal":{"name":"Metabolism and target organ damage","volume":"55 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139447037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between hyperuricemia and hypertension: a short review of current evidence 高尿酸血症与高血压之间的关系：现有证据简评

Metabolism and target organ damage Pub Date : 2024-01-03 DOI: 10.20517/mtod.2023.41

Zhiwei Wang, Guiping Yao, Bing Yan, Chenghao Zhanghuang

{"title":"The relationship between hyperuricemia and hypertension: a short review of current evidence","authors":"Zhiwei Wang, Guiping Yao, Bing Yan, Chenghao Zhanghuang","doi":"10.20517/mtod.2023.41","DOIUrl":"https://doi.org/10.20517/mtod.2023.41","url":null,"abstract":"The investigation of the relationship between hyperuricemia and hypertension is a captivating field in hypertension research. The final product of purine metabolism is uric acid (UA), and the elevation of serum UA (SUA) levels directly contributes to the development of hypertension. Numerous studies have substantiated that hyperuricemia is a significant risk factor for hypertension. Furthermore, initial clinical trials have demonstrated that therapeutic interventions aimed at reducing SUA levels lower blood pressure (BP) in individuals with hypertension attributed to hyperuricemia. Recent research has demonstrated that hyperuricemia can facilitate the onset of hypertension via multiple mechanisms, including oxidative stress, inflammation, diminished nitric oxide (NO) synthesis, activation of reactive oxygen species (ROS), insulin resistance, vascular smooth muscle proliferation, and renal impairment. Given the interconnectedness between hyperuricemia and hypertension, it is advantageous to identify potential therapeutic approaches for timely intervention in order to impede the advancement of hypertension in individuals with hyperuricemia. This article reviews the research progress on the pathogenesis of hyperuricemia-induced hypertension.","PeriodicalId":91001,"journal":{"name":"Metabolism and target organ damage","volume":"19 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139389433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical frontiers of metabolic bone disorders: a comprehensive review 代谢性骨病的临床前沿：综述

Metabolism and target organ damage Pub Date : 2023-12-29 DOI: 10.20517/mtod.2023.38

Mohd Danish Ansari, Haya Majid, Anas Khan, Yasmin Sultana

{"title":"Clinical frontiers of metabolic bone disorders: a comprehensive review","authors":"Mohd Danish Ansari, Haya Majid, Anas Khan, Yasmin Sultana","doi":"10.20517/mtod.2023.38","DOIUrl":"https://doi.org/10.20517/mtod.2023.38","url":null,"abstract":"Metabolic bone disease (MBD)encompasses various conditions that adversely impact bone health, such as osteoporosis, primary hyperparathyroidism, osteomalacia, and fluorosis disease. Effectively managing these disorders requires early detection and a focus on maintaining healthy nutritional habits. Dietary adjustments serve as a cornerstone, but supplementation of essential minerals like calcium, phosphate, and vitamin D is often necessary to support bone reabsorption and regeneration, and reduce fracture risk. Despite the effectiveness of these measures in many cases, hereditary bone diseases pose distinctive challenges due to genetic factors. Emerging technologies that provide higher-resolution insights into bone architecture and quality are now complementing traditional diagnostic tools like dual-energy X-ray absorptiometry (DXA). Moreover, the therapeutic landscape has transformed with the introduction of newer agents that not only halt bone loss but also stimulate bone formation. These agents promise better outcomes with reduced side effects, catering to a wider patient population. However, the management of MBDs remains multifaceted, necessitating individualized approaches based on the patient’s clinical profile. As the global prevalence of MBDs, especially osteoporosis, continues to soar, it becomes imperative for clinicians to stay abreast with the evolving paradigms. This review serves as a bridge between historical knowledge and recent discoveries, offering a holistic perspective on the challenges and opportunities in the domain of MBDs.","PeriodicalId":91001,"journal":{"name":"Metabolism and target organ damage","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139143493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic bone disease: from basic science to clinical frontier 代谢性骨病：从基础科学到临床前沿

Metabolism and target organ damage Pub Date : 2023-11-30 DOI: 10.20517/mtod.2023.39

Ling-Feng Zeng

引用次数: 0

Acute pancreatitis in pregnancy and familial chylomicronemia syndrome: case report and literature review 妊娠期急性胰腺炎和家族性乳糜泻综合征：病例报告和文献综述

Metabolism and target organ damage Pub Date : 2023-11-13 DOI: 10.20517/mtod.2023.12

Batoul Jaafar, Jessica Abou Chaaya, Shahed Ammar, Ibrahim Salti

{"title":"Acute pancreatitis in pregnancy and familial chylomicronemia syndrome: case report and literature review","authors":"Batoul Jaafar, Jessica Abou Chaaya, Shahed Ammar, Ibrahim Salti","doi":"10.20517/mtod.2023.12","DOIUrl":"https://doi.org/10.20517/mtod.2023.12","url":null,"abstract":"Acute pancreatitis rarely occurs in pregnancy, with hypertriglyceridemia being the fourth leading cause during pregnancy. Hypertriglyceridemia, of which Familial Chylomicronemia Syndrome is the most severe form, ranks among the four principal causes of pancreatitis in pregnancy. Total Plasma exchange (TPE) has been found to be an effective and safe intervention both as a therapeutic and a prophylactic act. A 22-year-old female with FCS presented at the 21st week of gestation with acute hypertriglyceridemia pancreatitis. Despite medical management, she was then started on TPE at the two-week follow-up after serum triglyceride level was out of control. The triglyceride dropped from 55.0 % to 77.5 % during these sessions. Despite these interventions, pancreatitis recurred in week 34. An emergency C-section was carried out after a drop in the fetal heart rate. Postpartum triglycerides dropped by 57 % but remained above 1,000 mg/dl. FCS is difficult to manage during pregnancy, and it frequently fails to respond to various pharmacologic lines. TPE can help prolong a pregnancy, but it is not a definite treatment. Novel therapies for hypertriglyceridemia in pregnancy await additional safety testing.","PeriodicalId":91001,"journal":{"name":"Metabolism and target organ damage","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139279049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fructose as a novel nutraceutical for acetaminophen (APAP)-induced hepatotoxicity 果糖作为对乙酰氨基酚(APAP)引起的肝毒性的一种新型营养保健品

Metabolism and target organ damage Pub Date : 2023-10-30 DOI: 10.20517/mtod.2023.28

Kyle Rodrigues, Rawdat Hussain, Sarah Cooke, Gary Zhang, Deqiang Zhang, Lei Yin, Xin Tong

引用次数: 0

Non-metabolic causes of steatotic liver disease 脂肪变性肝病的非代谢原因

Metabolism and target organ damage Pub Date : 2023-10-26 DOI: 10.20517/mtod.2023.20

Patrik Nasr, Cecilia Jönsson, Mattias Ekstedt, Stergios Kechagias

{"title":"Non-metabolic causes of steatotic liver disease","authors":"Patrik Nasr, Cecilia Jönsson, Mattias Ekstedt, Stergios Kechagias","doi":"10.20517/mtod.2023.20","DOIUrl":"https://doi.org/10.20517/mtod.2023.20","url":null,"abstract":"Hepatic steatosis is caused by exaggerated hepatic lipid accumulation and is a common histological and radiological finding. Non-alcoholic fatty liver disease (NAFLD), or metabolic dysfunction associated steatotic liver disease (MASLD), is highly associated with metabolic syndrome and represents the most common cause of hepatic steatosis. However, since several comorbidities, lifestyle factors, and drugs can cause hepatic steatosis, MASLD is, to some extent, a diagnosis of exclusion. Nevertheless, initiatives have been taken to encompass positive (instead of negative) criteria for diagnosis - such as the presence of cardiometabolic risk factors together with hepatic steatosis. Nonetheless, before confirming a patient with MASLD, it is essential to map and evaluate other causes of fatty liver disease or steatotic liver disease. Several causes of hepatic steatosis have been identified in studies; however, the study cohorts are scarce and often anecdotal. Additionally, many studies have shown correlation without proving causation, and many are retrospective without reporting relevant patient characteristics and comorbidities - making it difficult to draw conclusions regarding the underlying etiology or present comorbidity of hepatic steatosis. In this narrative review, we aimed to identify and summarize present studies evaluating the impact of the most common and often suggested causes of hepatic steatosis.","PeriodicalId":91001,"journal":{"name":"Metabolism and target organ damage","volume":"60 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136381363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PNPLA3 rs738409 polymorphism and kidney dysfunction: an association beyond nonalcoholic fatty liver disease? PNPLA3 rs738409多态性与肾功能障碍:非酒精性脂肪肝以外的关联?

Metabolism and target organ damage Pub Date : 2023-10-19 DOI: 10.20517/mtod.2023.24

Alessandro Mantovani, Giovanni Targher

{"title":"<i>PNPLA3</i> rs738409 polymorphism and kidney dysfunction: an association beyond nonalcoholic fatty liver disease?","authors":"Alessandro Mantovani, Giovanni Targher","doi":"10.20517/mtod.2023.24","DOIUrl":"https://doi.org/10.20517/mtod.2023.24","url":null,"abstract":"This commentary is primarily devoted to a recent observational study by Mantovani and colleagues (Aliment Pharmacol Ther. 2023; 57: 1093-102) examining the adverse effect of the patatin-like phospholipase domain-containing protein-3 (PNPLA3 ) rs738409 G allele on the kidney function in a cohort of 1,144 middle-aged Italian individuals with metabolic dysfunction. In this study, the authors found that the PNPLA3 rs738409 G allele was significantly associated with lower levels of estimated glomerular filtrate rate (eGFR), even after adjusting for not only common anthropometric and cardiometabolic risk factors but also ethnicity, serum liver enzymes, use of drugs against dyslipidemia and chronic kidney disease polygenic risk score. Additionally, in a subgroup of 144 patients followed for a median of 17 months, the authors also found that the PNPLA3 rs738409 G allele was independently associated with a faster eGFR decline. Commenting on the cohort study by Mantovani et al ., we also summarized the rapidly expanding evidence linking the PNPLA3 rs738409 variant with the risk of kidney disease. Furthermore, we discussed the potential research implications of these findings.","PeriodicalId":91001,"journal":{"name":"Metabolism and target organ damage","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135778451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concise review: Breastfeeding, lactation, and NAFLD. An updated view of cross-generational disease transmission and prevention 简明综述:母乳喂养、哺乳和NAFLD。疾病跨代传播和预防的最新观点

Metabolism and target organ damage Pub Date : 2023-09-21 DOI: 10.20517/mtod.2023.17

Amedeo Lonardo, Ayako Suzuki

{"title":"Concise review: Breastfeeding, lactation, and NAFLD. An updated view of cross-generational disease transmission and prevention","authors":"Amedeo Lonardo, Ayako Suzuki","doi":"10.20517/mtod.2023.17","DOIUrl":"https://doi.org/10.20517/mtod.2023.17","url":null,"abstract":"Evidence suggests that breastfeeding protects the mother-infant dyad against the development and progression of nonalcoholic fatty liver disease (NAFLD). In this context, we aim to provide insight into the most notable and representative epidemiological studies published in the literature. Furthermore, we will delve into the potential underlying pathomechanisms that might be involved in this relationship. The current definitions of breastfeeding, lactation, mother-infant dyad, and nonalcoholic fatty liver disease (NAFLD) are provided. Next, the epidemiological evidence supporting potential benefits for the (long-term) lactating mother in terms of protection from the development and progression of NAFLD is reviewed. The putative mechanisms underlying this protection are also analyzed. Similarly, clinical and epidemiological studies evaluating the benefits of breastfeeding for the offspring are examined, together with a discussion of the putative underlying mechanisms. In conclusion, our understanding of breastfeeding (for the offspring) and lactation (for the mother) as protective factors from NAFLD development and fibrotic progression will provide further insight into unprecedented disease mechanisms shared by the mother-infant dyad promising to interrupt the vicious cycle of NAFLD transmission across generations.","PeriodicalId":91001,"journal":{"name":"Metabolism and target organ damage","volume":"340 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136236201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasonographic fatty liver indicator (US-FLI): a reliable biomarker for non-invasive NAFLD stratification 超声脂肪肝指标(US-FLI):非侵入性NAFLD分层的可靠生物标志物

Metabolism and target organ damage Pub Date : 2023-08-29 DOI: 10.20517/mtod.2023.21

S. Ballestri, A. Lonardo

引用次数: 0