Metabolism and target organ damage最新文献_第7页

Nonalcoholic fatty liver disease in type 2 diabetes: A bad omen. But can we do something to change it? 2型糖尿病的非酒精性脂肪肝:一个不好的预兆。但我们能做些什么来改变它吗?

Metabolism and target organ damage Pub Date : 2021-08-18 DOI: 10.20517/mtod.2021.06

F. Bril

引用次数: 1

Risk of cardio-nephro-metabolic disease from NAFLD to MAFLD: fact or fiction? 从NAFLD到MAFLD的心肾代谢疾病风险：事实还是虚构？

Metabolism and target organ damage Pub Date : 2021-08-17 DOI: 10.20517/mtod.2021.07

R. Hassouneh, M. Siddiqui, C. Bhati

引用次数: 1

Precision medicine approaches in metabolic disorders and target organ damage: where are we now, and where are we going? 代谢紊乱和靶器官损伤的精准医学方法：我们现在在哪里，我们要去哪里？

Metabolism and target organ damage Pub Date : 2021-07-26 DOI: 10.20517/mtod.2021.03

A. Lonardo, C. Byrne, G. Targher

引用次数: 17

Nonalcoholic fatty liver disease on Twitter: a sentiment analysis 推特上的非酒精性脂肪肝:情绪分析

Metabolism and target organ damage Pub Date : 2021-01-01 DOI: 10.20517/mtod.2021.09

A. Mantovani, Giorgia Beatrice, C. Zusi, A. Dalbeni

{"title":"Nonalcoholic fatty liver disease on Twitter: a sentiment analysis","authors":"A. Mantovani, Giorgia Beatrice, C. Zusi, A. Dalbeni","doi":"10.20517/mtod.2021.09","DOIUrl":"https://doi.org/10.20517/mtod.2021.09","url":null,"abstract":"Sentiment analysis is a technique for exploring a piece of text with the aim to investigate sentiments hidden within it. The use of sentiment analysis in health care could assist in understanding how individuals discuss and feel about a specific topic. Currently, there are scarce data regarding the use of sentiment analysis related to nonalcoholic fatty liver disease (NAFLD), which is the most common chronic liver disease worldwide and is associated with hepatic and extra-hepatic complications. Hence, the aim of this report was to assess the sentiments of NAFLD expressed in messages posted on Twitter, one of the most popular social media platforms worldwide. We chose the hashtags #FattyLiver, #NAFLD, #NASH, and #MAFLD as terms to identify the messages related to NAFLD on Twitter. Messages containing at least one of these hashtags were collected using the standard Application Programming Interface provided by Twitter. The sentiment analysis revealed that sentiments hidden within messages related to NAFLD were substantially neutral and that “breastcancer” and “cancer” were two of the most common words used, suggesting that a large part of messages focused on the relationship between NAFLD and extra-hepatic cancers. Conversely, the association between NAFLD and cardiovascular disease seems to be less relevant for Twitter community. These observations might be useful for developing better public health strategies and for promoting a constructive attitude among subjects that read and discuss about NAFLD (and its complications) on social media. Page 2 of Mantovani et al. Metab Target Organ Damage 2021;1:6 https://dx.doi.org/10.20517/mtod.2021.09 5","PeriodicalId":91001,"journal":{"name":"Metabolism and target organ damage","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67659032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What should we advise MAFLD patients to eat and drink? 我们应该建议mald患者吃什么和喝什么?

Metabolism and target organ damage Pub Date : 2021-01-01 DOI: 10.20517/mtod.2021.11

M. Machado

引用次数: 4

The Fatty liver Index (FLI) 15 years later: a reappraisal 脂肪肝指数(FLI) 15年后:重新评估

Metabolism and target organ damage Pub Date : 2021-01-01 DOI: 10.20517/mtod.2021.08

A. Lonardo, S. Ballestri, G. Bedogni, S. Bellentani, C. Tiribelli

{"title":"The Fatty liver Index (FLI) 15 years later: a reappraisal","authors":"A. Lonardo, S. Ballestri, G. Bedogni, S. Bellentani, C. Tiribelli","doi":"10.20517/mtod.2021.08","DOIUrl":"https://doi.org/10.20517/mtod.2021.08","url":null,"abstract":"The Fatty Liver Index (FLI) is a non-invasive biomarker proposed, in 2006, by Bedogni’s group, to aid in identifying patients with suspected nonalcoholic fatty liver disease (NAFLD) to be submitted to liver ultrasonography to confirm steatosis. Criteria of Assessment of Narrative Review Articles, a scale for the assessment of quality of narrative review articles, inspired our review article, which aims at evaluating the scope of published articles on FLI issued over the last 15-year period. The analysis of retrieved data identified the following conclusions. First, given that FLI and NAFLD share the same risk factors, FLI can be used to identify NAFLD among populations at risk to be submitted to screening. Second, FLI is able to identify the hazard of atherosclerosis, both at a subclinical stage and as an overt disease. Third, FLI detects incident diabetes and chronic kidney disease. However, evidence supporting the notion that FLI also predicts the metabolic syndrome, some endocrine disorders, certain tumor types, and overall and cause-specific mortality appears to be more limited. In conclusion, 15 years after its first publication, FLI has been validated as a robust biomarker of both steatosis and NAFLD. Moreover, the scope of FLI has been expanded to previously unexpected areas. Finally, we discuss FLI limitations and a research agenda aimed at further improving the accuracy of FLI scores in predicting liver-related outcomes, endocrine-metabolic disorders, cancer risk, and survival. Page 2 of Lonardo et al. Metab Target Organ Damage 2021;1:10 https://dx.doi.org/10.20517/mtod.2021.08 20","PeriodicalId":91001,"journal":{"name":"Metabolism and target organ damage","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67658977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Diagnostic accuracy of ultrasonography for the detection of hepatic steatosis: an updated meta-analysis of observational studies 超声诊断肝脏脂肪变性的准确性:一项观察性研究的最新荟萃分析

Metabolism and target organ damage Pub Date : 2021-01-01 DOI: 10.20517/mtod.2021.05

S. Ballestri, A. Mantovani, C. Byrne, A. Lonardo, G. Targher

引用次数: 21

Editorial: Metabolism and Target Organ Damage 社论:代谢和靶器官损伤

Metabolism and target organ damage Pub Date : 2021-01-01 DOI: 10.20517/MTOD.2021.01

A. Lonardo

引用次数: 3

Male hypogonadism and pre-diabetes interplay: association or causal interaction? A systematic review 男性性腺功能减退与糖尿病前期相互作用:关联还是因果关系?系统回顾

Metabolism and target organ damage Pub Date : 2021-01-01 DOI: 10.20517/mtod.2021.14

C. Greco, R. Corleto, Riccardo Ebert, M. Simoni, V. Rochira, D. Santi

{"title":"Male hypogonadism and pre-diabetes interplay: association or causal interaction? A systematic review","authors":"C. Greco, R. Corleto, Riccardo Ebert, M. Simoni, V. Rochira, D. Santi","doi":"10.20517/mtod.2021.14","DOIUrl":"https://doi.org/10.20517/mtod.2021.14","url":null,"abstract":"Aim: The association between type 2 diabetes mellitus (T2DM) and male hypogonadism has been largely demonstrated. Testosterone (T) serum levels are often lower in men with T2DM compared to the general population, and, conversely, men with higher T serum levels have shown lower risk of T2DM. On the contrary, the association between pre-diabetes and male hypogonadism has been less investigated thus far. Pre-diabetes is a common clinical condition preceding T2DM and has been recognized as a potential risk factor for other metabolic disorders and cardiovascular diseases. Therefore, the aims of this review are to investigate the association between pre-diabetes and male hypogonadism and to evaluate the potential effect of T treatment on glucose metabolism and anti-diabetic therapy on T serum levels. Methods: We conducted this systematic review developing different literature searches, following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis protocol. Page 2 of Greco et al. Metab Target Organ Damage 2022;2:11 https://dx.doi.org/10.20517/mtod.2021.14 18 Results: In our analysis, male hypogonadism has a prevalence of around 24%-35% in pre-diabetic men. Moreover, we observed improvement of metabolic parameters in pre-diabetes with T treatment. On the contrary, antidiabetic therapy seems to have no particular effects on T serum levels. Conclusion: Overall, we demonstrated that, although T administration could be considered in pre-diabetic men, pre-diabetes-related treatments should be confined to the control glucose metabolism, since no evidence for a positive effect on total T serum levels is available. Future research should be oriented to study the role of new antidiabetic drugs in the sex hormonal status in hypogonadal men.","PeriodicalId":91001,"journal":{"name":"Metabolism and target organ damage","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67658682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0