Diagnostic accuracy of ultrasonography for the detection of hepatic steatosis: an updated meta-analysis of observational studies

Metabolism and target organ damage Pub Date : 2021-01-01 DOI:10.20517/mtod.2021.05

S. Ballestri, A. Mantovani, C. Byrne, A. Lonardo, G. Targher

引用次数: 21

Abstract

Aim: We examined the diagnostic accuracy of ultrasonography to detect any HS (defined as steatotic hepatocytes ≥ 5% on histology) and moderate-severe HS (defined as steatotic hepatocytes ≥ 30% on histology) by performing a systematic review and meta-analysis. Methods: We systematically searched PubMed, Web of Science, and Scopus databases, from January 2011 to February 2021, to identify studies conducted in adults investigating the diagnostic accuracy of ultrasonography vs . histology for detecting either ≥ 5% histologically defined HS or moderate-severe HS ( ≥ 30%). Meta-analysis was performed using random-effects modeling. Results: Twelve studies were included involving a total of 2921 individuals, 1710 (58.5%) of whom had HS ≥ 5% by histology. The overall sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of ultrasonography for the detection of ≥ 5% histologically defined HS, compared to histology, were 82% (95%

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超声诊断肝脏脂肪变性的准确性:一项观察性研究的最新荟萃分析

目的:我们通过系统回顾和meta分析，检查超声检查任何HS(定义为组织学上脂肪变性肝细胞≥5%)和中重度HS(定义为组织学上脂肪变性肝细胞≥30%)的诊断准确性。方法:从2011年1月到2021年2月，我们系统地检索了PubMed、Web of Science和Scopus数据库，以确定在成人中进行的研究，调查超声检查与组织学诊断≥5% HS或中重度HS(≥30%)的诊断准确性。采用随机效应模型进行meta分析。结果:12项研究共纳入2921例患者，其中组织学HS≥5%的患者1710例(58.5%)。超声检测≥5%组织学定义的HS的总体敏感性、特异性、阳性似然比和阴性似然比与组织学相比为82% (Ballestri et al.页2 95%)。Metab靶器官损伤2021;1:7 https://dx.doi.org/10.20517/mtod.2021.05 15置信区间分别为76%-86%，80%(72%-86%)，4.0(2.90-5.70)，0.23(0.18-0.30)。汇总分析7项研究，超声检查组织学定义≥30%的HS的总体敏感性为85%(72% ~ 92%)，特异性为85%(73% ~ 93%)，阳性似然比为5.72(3.06 ~ 10.7)，阴性似然比为0.18(0.10 ~ 0.33)。漏斗图未显示任何显著的发表偏倚。结论:与组织学检查相比，常规超声检查可可靠、准确地检测出≥5%的组织学定义的HS。这些发现要求在临床领域广泛使用常规超声检查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolism and target organ damage

CiteScore

3.00

自引率

0.00%

发文量