BMC Nephrology最新文献

{"title":"Correction: Navigating the complexities of end-stage kidney disease (ESKD) from risk factors to outcome: insights from the UK Biobank cohort.","authors":"Debasish Kar, Richard Byng, Aziz Sheikh, Mintu Nath, Bedowra Zabeen, Shubharthi Kar, Shakila Banu, Mohammad Habibur Rahman Sarker, Navid Khan, Durjoy Acharjee, Shafiqul Islam, Victoria Allgar, José M Ordóñez-Mena, Aya El-Wazir, Soon Song, Ashish Verma, Umesh Kadam, Simon de Lusignan","doi":"10.1186/s12882-025-04151-x","DOIUrl":"https://doi.org/10.1186/s12882-025-04151-x","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"239"},"PeriodicalIF":2.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of CRP SNV rs2808630 and acute proinflammatory biomarkers in patients with CKD and PLHIV with CKD: a case-control study.","authors":"Andrea Torres-Rojas, Luz Alicia González-Hernández, Karina Sánchez-Reyes, Jonathan Samuel Chávez-Iñiguez, Jorge Fernando Topete-Reyes, Jaime Federico Andrade-Villanueva, Pedro Martínez-Ayala, Adriana Valle-Rodriguez, Vida Verónica Ruiz-Herrera, Jorge Hernández-Bello, Zyanya Reyes-Castillo, Monserrat Álvarez-Zavala","doi":"10.1186/s12882-025-04138-8","DOIUrl":"https://doi.org/10.1186/s12882-025-04138-8","url":null,"abstract":"<p><strong>Background: </strong>The CKD in PLHIV is highly prevalent in Jalisco. Despite its control with ART, HIV is characterized by generating low-grade inflammation events that contribute to the development and progression of CKD. Considering the importance of hs-CRP in the context of CKD, various genetic predisposition studies have been conducted to search for variants of the CRP gene, among which the SNV rs2808630 has been associated with serum hs-CRP concentrations and progression of CKD. Due to the above, there is interest in studying this SNV, addressing the limited information available on this topic in Mexico.</p><p><strong>Methods: </strong>The case-control study included 163 patients with CKD, 102 PLHIV with CKD under ART with undetectable viral loads from the Hospital Civil of Guadalajara \"Fray Antonio Alcalde\" and 115 controls. Clinical assessment and general laboratory studies were carried out. Also, serum quantification of inflammatory biomarkers was performed by ELISA method. The determination of CRP SNV rs2808630 by qPCR and the association with inflammatory biomarkers was evaluated. Statistical analysis was carried out considering significant values p < 0.05.</p><p><strong>Results: </strong>Lower prevalence of CC genotype was shown in our population. Of the 358 samples, 221 (61.7%) present the wild-type genotype. The results analyzed correspond with what has been reported worldwide in studies of CRP SNV rs2808630 in the development of CKD without having a relationship with inflammatory and kidney function biomarkers. However, higher creatinine and IL-6 concentrations were observed in the group with the CC genotype. A significant correlation between IL-6 and eGFR was identified in CKD patients, but not for PLHIV with CKD, highlighting a potential difference in inflammatory dynamics between these groups. Importantly, in PLHIV with CKD, we found a strong correlation between hs-CRP and IL-8, suggesting a possible association with a higher proportion of the inflammatory isoform of hs-CRP, which may have implications for disease progression and cardiovascular risk.</p><p><strong>Conclusions: </strong>The presence of the CRP SNV does not appear to contribute to the development of CKD and has no association with inflammatory biomarkers. Though, genetically independent manner, hs-CRP levels are slightly different between groups and are underrated when related to the CKD stage in PLHIV. Also, high IL-6 concentrations are related to CKD progression, while IL-8 seems to have a better relation to CKD in PLHIV.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"236"},"PeriodicalIF":2.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil extracellular traps-related genes contribute to sepsis-associated acute kidney injury.","authors":"Tang Shaoqun, Yu Xi, Wang Wei, Luo Yaru, Lei Shaoqing, Qiu Zhen, Yang Yanlin, Sun Qian, Xia Zhongyuan","doi":"10.1186/s12882-025-04126-y","DOIUrl":"https://doi.org/10.1186/s12882-025-04126-y","url":null,"abstract":"<p><strong>Background: </strong>Neutrophil extracellular traps (NETs) and oxidative stress (OS) may be involved in sepsis-associated acute kidney injury (SA-AKI). The aim of this study was to identify potential regulators which modulate NETs and OS in SA-AKI, and to find potential therapeutic agents.</p><p><strong>Methods and materials: </strong>SA-AKI-related datasets GSE255281 and GSE225192 were downloaded from Gene Expression Omnibus. Molecular subtypes associated with NETs were identified by unsupervised clustering. The OS-related genes were obtained by weighted gene co-expression network analysis. Differentially expressed genes were screened by \"limma\" package in R. Least absolute shrinkage and selection operator algorithm was applied to identify the hub genes. Additionally, the biological functions of the hub genes were analyzed with single sample gene set enrichment analysis. NetworkAnalyst database was searched to screen the drugs targeting the hub targets. qRT-PCR was used to analyze the expression of key genes in the peripheral blood mononuclear cells (PBMCs) of the patients with SA-AKI and healthy controls. HK-2 cells and human umbilical vein endothelial cells (HUVECs) were induced by lipopolysaccharide (LPS) to construct a SA-AKI model, and the effects of estradiol and (+)-JQ1 on HK-2 cells and HUVECs were evaluated by CCK-8 assays, flow cytometry and OS indices.</p><p><strong>Results: </strong>Based on NETs-related genes, SA-AKI samples could be divide into two subgroups, and the differentially expressed genes between two subgroups were associated with OS. In silico analyses identified 13 hub targets. The expression of ECT2 and CHRDL1 in PBMCs of SA-AKI patients was significantly lower than that in control group, and the expressions of PTAFR, CSF3 and FOS were significantly higher. Estradiol and (+)-JQ1, which targeted more of the hub targets with good binding affinity, could increase the viability of HK-2 cells and HUVECs induced by LPS and inhibit apoptosis and OS.</p><p><strong>Conclusion: </strong>Formation of NETs, contributes to OS and pathogenesis of SA-AKI. Estradiol and (+)-JQ1, targeting multiple regulators in the formation of NETs, may be potential therapeutic agents for the treatment of SA-AKI.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"235"},"PeriodicalIF":2.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NR3C1 variants and glucocorticoid response in childhood nephrotic syndrome in North India.","authors":"Sarranya Paranthaman, Priyanka Srivastava, Anu Kumari, Chitra Bhardwaj, Pratibha Bawa, Anupriya Kaur, Inusha Panigrahi, Lesa Dawman, Karalanglin Tiewsoh","doi":"10.1186/s12882-025-04173-5","DOIUrl":"https://doi.org/10.1186/s12882-025-04173-5","url":null,"abstract":"<p><strong>Background: </strong>Nephrotic syndrome (NS) is a common kidney disorder in children, characterized by significant proteinuria, hypoalbuminemia, and peripheral edema. While glucocorticoids (GCs) are the first-line treatment for pediatric nephrotic syndrome (NS), a subset of patients exhibit steroid resistance, leading to poor prognosis and a higher risk of long-term kidney damage. The glucocorticoid receptor gene (NR3C1) plays a pivotal role in mediating the effects of GCs, and its polymorphisms have been implicated in variable GC responses.</p><p><strong>Methods: </strong>This study investigates the association between NR3C1 single nucleotide polymorphisms (SNPs) (rs6877893 and rs10482634) in 50 patients with steroid-sensitive nephrotic syndrome (SSNS) and 50 steroid-resistant nephrotic syndrome (SRNS) individuals by Kompetitive Allele Specific Polymerase Chain Reaction (KASP) assay and altered GC receptors (GRα and GRβ) expression by Real-Time PCR (RT-PCR). Adverse effect of steroid therapy was also assessed.</p><p><strong>Results: </strong>Genotyping revealed a significant association between GG genotype of SNP rs10482634 and steroid resistance, suggesting that it may contribute to the heterogeneity in GC response in this population. There is also a positive association of AA genotype of rs10482634 with short stature and AG genotype of rs10482634 with cushingoid habitus, as a side effect of steroid therapy. We have also found an enhanced expression of GRα in SSNS population. No significant association was found between the SNP rs6877893 and the response to steroid treatment in the study cohort. Our study revealed higher rates of drug-related complications in patients receiving larger cumulative doses of steroids.</p><p><strong>Conclusion: </strong>These findings highlight the importance of genetic screening of NR3C1 SNPs in predicting steroid responsiveness and tailoring personalized therapeutic strategies in pediatric NS.</p><p><strong>Clinical trial number: </strong>not applicable.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"237"},"PeriodicalIF":2.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy outcomes in C3 glomerulopathy: a retrospective review.","authors":"Lauren O Fergus, Meryl Waldmann, Monica D Hall, Lynn Vining, Jillian Hall, Tina Liu, Yuzhou Zhang, Patrick J Walker, Richard J H Smith, Carla M Nester","doi":"10.1186/s12882-025-04118-y","DOIUrl":"https://doi.org/10.1186/s12882-025-04118-y","url":null,"abstract":"<p><strong>Background: </strong>C3 Glomerulopathy (C3G) is an ultra-rare glomerular disease driven by dysregulation of the alternative pathway of complement. 30-50% of adult patients progress to end stage kidney disease (ESKD) within 10 years of diagnosis. Little is known of the impact of pregnancy on the natural history of C3G or whether a coincident diagnosis of C3G affects maternal-fetal outcomes.</p><p><strong>Methods: </strong>Female subjects from the University of Iowa's C3G Natural History Study who met consensus biopsy criteria were included if they had at least one pregnancy and available renal/obstetric data. Assessed data included clinical history, kidney function tests, and complement tests to identify genetic and/or acquired drivers of complement dysregulation. Appropriate t-tests or z-tests were used to compare outcomes and clinical biomarker changes pre-/post-pregnancy. Nonlinear regression and relative risk were used to estimate risk for preeclampsia, premature delivery, and progression to ESKD.</p><p><strong>Results: </strong>Amongst mothers whose C3G presented before or during pregnancy (C3G + P), there were 37 pregnancies and 27 deliveries. Non-live birth outcomes impacted 10 C3G + P and included 5 spontaneous miscarriages, 1 stillbirth, 1 ectopic pregnancy, and 3 elective abortions. Twelve deliveries (44%) were premature, while 16 (59%) were associated with antepartum preeclampsia: an elevated risk when compared to healthy pregnancies and pregnancies of mothers with other glomerular diseases. Risk factors for complications included preexisting hypertension, an identified driver of complement dysregulation, and an eGFR prior to pregnancy of < 60 ml/min/1.73m². These risk factors also predict progression to ESKD within 5 (5/32, 16%) and 10 years (6/32, 19%) following pregnancy. Compared to pre-pregnancy values, post-pregnancy serum creatinine levels trended upwards and eGFRs downwards, both by small but significant amounts. Individual pre-/post-pregnancy eGFRs were significantly worse in mothers who progressed to ESKD within 5-10 years of pregnancy.</p><p><strong>Conclusions: </strong>A C3G + P is associated with increased risk of preeclampsia and prematurity compared to healthy controls, but no excess risk of spontaneous miscarriage. A C3G + P was associated with a small but significant decrease in renal function as measured by change in creatinine and eGFR. The elevated risk of adverse renal and obstetric events supports the need for multidisciplinary care for expectant patients with C3G.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"238"},"PeriodicalIF":2.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renometabolic disorder in experimental rat model of polycystic ovarian syndrome is reversed by acetate-mediated inhibition of pyruvate dehydrogenase kinase 4.","authors":"Stephanie E Areloegbe, Chukwubueze L Atuma, Ayodeji Aturamu, Isaac O Ajadi, Oluseyi E Adelekan, Mary B Ajadi, Christopher O Akintayo, Gloria O Omoruyi, Samuel O Onyekweli, Omosola F Anifowose, Oluwatobi A Amusa, Kayode Ajayi, Paul A Oyewole, Tolulope E Adegoke, Kehinde S Olaniyi","doi":"10.1186/s12882-025-04157-5","DOIUrl":"10.1186/s12882-025-04157-5","url":null,"abstract":"<p><strong>Background: </strong>Chronic Kidney disorders is a global public health problem, including in women with polycystic ovarian syndrome (PCOS), and is characterized by renal fibrosis, nephrotoxicity and glomerulonephritis, which increases the possibility of renal failure and organ transplant. Pyruvate dehydrogenase kinase 4 (PDK4) has been implicated in mitochondria dysfunction, contributing to metabolic dysregulation in different organs, including kidney. Studies have shown that short chain fatty acids, particularly acetate, alleviates metabolic alterations in experimental models. Hence, the present study investigated the therapeutic potential of acetate on renometabolic disorders associated with experimental PCOS model. The study in addition elucidates the probable involvement of PDK4 in PCOS-associated renometabolic disorders.</p><p><strong>Methods: </strong>Eight-week-old nulliparous female Wistar rats were randomly allotted into four groups (n = 5). Letrozole (1 mg/kg bw) was used to induce PCOS for 3 weeks. Thereafter, acetate (200 mg/kg bw) was administered for 6 weeks, uninterruptedly. Biochemical parameters from the plasma and renal tissue, as well as histology of ovaries were performed with appropriate methods.</p><p><strong>Results: </strong>Experimental PCOS rats were characterized with elevated circulating testosterone and the presence of multiple ovarian cysts. In addition, rat with PCOS also manifested insulin resistance, increased plasma urea and creatinine levels, increased renal Gamma glutamyl transferase (GGT), malondialdehyde (MDA), Nuclear factor -kappa B (NF-kB), Tumor necrosis factor -alpha (TNF-a), Transforming growth factor -beta 1 (TGF-B1), caspase-6, Histone deacetylase 2 (HDAC2), while a decrease in glucose-6 phosphate dehydrogenase (G6PD), reduced glutathione (GSH), renal nitric oxide (NO) and endothelial nitric oxide synthesis (eNOS), when compared with animals in the control group. These were associated with elevated level of PDK4 in the renal tissue. However, administration of acetate ameliorates these renal/metabolic abnormalities.</p><p><strong>Conclusion: </strong>Altogether, the results from the present study suggests that acetate ameliorates renal dysfunction in PCOS via downregulation of PDK4.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"234"},"PeriodicalIF":2.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of proliferative lupus nephritis with thrombotic microangiopathy; An ambispective observational single-center study.","authors":"Ahmed Fayed, Rasmia Elgohary, Amr Mohamed Shaker, Karem Mohamed Salem, Eman El Desouky, Gehad Gamal Maghraby","doi":"10.1186/s12882-025-04154-8","DOIUrl":"10.1186/s12882-025-04154-8","url":null,"abstract":"<p><strong>Background: </strong>Thrombotic microangiopathy (TMA) represents a broad spectrum of diseases. The combination of TMA with lupus nephritis (LN) is associated with worse renal outcomes and a higher mortality rate. To date, there is no agreement on the therapeutic strategies that should be offered to TMA-LN patients.</p><p><strong>Objective: </strong>In this study, we compared the long-term outcomes of plasma exchange (PLEX) and cyclophosphamide (CYC) in a TMA-LN cohort.</p><p><strong>Methods: </strong>100 TMA-LN patients who received an induction of steroids and either PLEX or CYC less than 3 months from the start of the study, were selected from the medical records of Kasr Alainy hospitals, Cairo University. The patients were monitored for hematological and renal response at 3, 6, and 12 months.</p><p><strong>Findings: </strong>In PLEX arm, the mean creatinine level was 1.4 ± 0.7 mg/dl at baseline, decreased to 1.1 ± 0.5 mg/dl after 3 months, and returned to 1.4 ± 1.4 mg/dl at 6 and 12 months (p = 0.748). Proteinuria levels significantly decreased from 2.9 ± 0.7 9 gm/24 hrs at baseline to 0.4 ± 0.5 9 gm/24 hrs after 12 months (p < 0.001). PLT significantly increased over time with a mean of 65.6 ± 19.0 (x10^₃)/L at baseline, increasing to 235.9 ± 54.3 (x10^₃)/L after 12 months (p < 0.001). In CYC arm, the mean creatinine level of 1.2 ± 0.6 mg/dl was maintained from baseline through 6 months but significantly increased at 12 months with a mean of 1.9 ± 2.2 mg/dl (p = 0.005). Proteinuria levels significantly decreased with means of 3.3 ± 0.6 gm/24 hrs at baseline to 0.7 ± 0.9 gm/24 hrs after 12 months (p < 0.001). The PLT increased from 49.5 ± 19.0 (x10^₃)/L to 198.9 ± 71.5 (x10^₃)/L after 12 months (p < 0.001). At 3- and 12-month intervals, PLEX achieved sustained lower proteinuria (p < 0.001 and p = 0.047, respectively), higher PLT (p < 0.001 and p = 0.005, respectively), and higher complement 4 (p = 0.001 and p < 0.001, respectively), compared to CYC.</p><p><strong>Conclusion: </strong>Both groups demonstrated significant improvements in renal and hematological outcomes with better long-term renal outcomes in the PLEX arm and comparable improvements in the hematological measures in both groups.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"233"},"PeriodicalIF":2.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and financial impacts of nursing education programs on recurrent urinary tract infections after kidney transplant: a cohort study.","authors":"Hany M El Hennawy, Omar Safar, Mahmoud Z El Madawie, Jayson Gopiechand, Ibrahim Tawhari, Weam El Nazer, Mohammad F Zaitoun, Abdullah S Al Faifi","doi":"10.1186/s12882-025-04153-9","DOIUrl":"https://doi.org/10.1186/s12882-025-04153-9","url":null,"abstract":"<p><strong>Background: </strong>Urinary tract infections (UTIs) are the most prevalent infections among kidney transplant recipients, with recurrent cases imposing a significant financial burden due to increased hospitalizations and treatment costs.</p><p><strong>Objective: </strong>This study aims to investigate the incidence of recurrent UTIs and evaluate the financial impact of a comprehensive nursing education initiative.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted with kidney transplant patients, divided into two groups: a control group prior to the intervention and a study group following the implementation of the education program. The intervention consisted of weekly training sessions focusing on infection prevention, catheter care, and hygiene. Patient outcomes were monitored for one year post-transplant, with a focus on UTI rates, patient adherence, knowledge, and healthcare costs.</p><p><strong>Results: </strong>The nursing education program resulted in a 26% reduction in UTI incidence and decreased average hospital stays from 8 days to 4 days. Healthcare costs per admission fell from $10,000 to $6,000, leading to total savings of $700,000 based on 175 admissions. The program resulted in a net saving of $650,000. Additionally, significant improvements were observed in patient knowledge, satisfaction, and compliance.</p><p><strong>Conclusions: </strong>Nursing education on UTI prevention for kidney transplant patients effectively enhances clinical outcomes and reduces healthcare costs. These findings underscore the importance of integrating structured education programs into transplant care protocols to achieve sustainable health and economic benefits.</p><p><strong>Clinical trial number: </strong>Not Applicable.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"232"},"PeriodicalIF":2.2,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma concentrations of neurofilament light, p-Tau231 and glial fibrillary acidic protein are elevated in patients with chronic kidney disease and correlate with measured glomerular filtration rate.","authors":"Torunn Axelsson, Henrik Zetterberg, Kaj Blennow, Burak Arslan, Nicholas J Ashton, Markus Axelsson, Maria K Svensson, Aso Saeed, Gregor Guron","doi":"10.1186/s12882-025-04130-2","DOIUrl":"https://doi.org/10.1186/s12882-025-04130-2","url":null,"abstract":"<p><strong>Background: </strong>Patients with chronic kidney disease (CKD) have a high prevalence of cerebrovascular disease and cognitive impairment. The objective was to analyse whether plasma concentrations of neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP) and phosphorylated Tau231 (p-Tau231) are elevated in patients with CKD and to identify independent predictors of these biomarkers, with an emphasis on the role of measured glomerular filtration rate (mGFR).</p><p><strong>Methods: </strong>In this cross-sectional cohort study, we included 110 patients with CKD stages 3 and 4 (estimated GFR 15-59 ml/min/1.73 m²) without manifest cerebrovascular disease or dementia, and 55 healthy controls. Biomarkers of neurological disorders were measured with ultrasensitive single molecule array methods.</p><p><strong>Results: </strong>Plasma concentrations (median [IQR]) of NfL (37.5 [22.1-47.5] vs. 13.4 [10.5-16.7] ng/L, p < 0.001), p-Tau231 (25.7 [19.1-38.7] vs. 13.9 [10.5-16.3] ng/L, p < 0.001) and GFAP (190 [140-281] vs. 153 [116-211] ng/L, p < 0.001) were elevated in patients with CKD vs. controls. Measured GFR was negatively correlated with NfL (r = - 0.706, p < 0.001), p-Tau231 (r = - 0.561, p < 0.001), and GFAP (r = - 0.385, p < 0.001). In multivariable linear regression models, mGFR was an independent predictor of log-transformed plasma concentrations of NfL (standardized beta coefficient [β] = - 0.439, p < 0.001) and GFAP (β = - 0.321, p < 0.001).</p><p><strong>Conclusion: </strong>Patients with CKD had elevated plasma concentrations of NfL, p-Tau231 and GFAP compared with controls, and these biomarkers were inversely correlated with mGFR. Measured GFR was a significant, independent predictor of plasma concentrations of NfL and GFAP in patients with CKD. The mechanisms underlying this association need further investigation. Plasma levels of NfL and GFAP should be interpreted cautiously in patients with marked reductions in GFR.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"231"},"PeriodicalIF":2.2,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of exosomes in pathogenesis, diagnosis, and treatment of diabetic nephropathy.","authors":"Shaimaa I Barr, Eman M Abd El-Azeem, Sahar S Bessa, Tarek M Mohamed","doi":"10.1186/s12882-025-04120-4","DOIUrl":"https://doi.org/10.1186/s12882-025-04120-4","url":null,"abstract":"<p><p>Diabetic nephropathy (DN) is a serious microvascular complication that can progress to end-stage renal disease, with its prevalence and associated mortality increasing globally. However extensive research, the precise mechanisms underlying DN pathogenesis remain unclear, and the current treatment options for DN are limited to dialysis or renal replacement therapy, although several experimental approaches have shown potential, they remain investigational and lack clinical translation. Exosomes play a pivotal role in disease diagnosis and prognosis. Urinary exosomes, originating from various kidney cells, reflect the kidney's pathological condition and are involved in cell-to-cell communication through autocrine or paracrine signaling; therefore, they could contribute to the pathogenesis of DN and potential therapeutic approaches. Additionally, due to their diverse cargo, which depend on cellular origin and pathological state, exosomes may act as biomarkers for the early prediction of DN. This review presents a comprehensive overview of the latest findings on the role of exosomes in the diagnosis, pathogenesis, and treatment of DN.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"230"},"PeriodicalIF":2.2,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}