BMC Nephrology最新文献

{"title":"Correction: An explainable machine learning model for early warning of hypertensive and hypotensive anomalies in maintenance hemodialysis patients.","authors":"Zhuoyu Li, Siying Hao, Shujun Shi, Lin Li, Ziwei Tao","doi":"10.1186/s12882-025-04447-y","DOIUrl":"10.1186/s12882-025-04447-y","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"515"},"PeriodicalIF":2.4,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of dual glomerular pathology: Alport syndrome and immune complex-mediated MPGN.","authors":"Seyda Gul Ozcan, Eylul Koc, Ahmet Murt, Mevlut Tamer Dincer, Iclal Gurses, Nurhan Seyahi, Sinan Trabulus","doi":"10.1186/s12882-025-04400-z","DOIUrl":"10.1186/s12882-025-04400-z","url":null,"abstract":"<p><strong>Background: </strong>Immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) and Alport syndrome are distinct glomerular diseases with different pathophysiologic mechanisms. Their coexistence is extremely rare and may present diagnostic and therapeutic challenges.</p><p><strong>Case presentation: </strong>A 42-year-old woman presented with persistent proteinuria and hematuria. Initial laboratory evaluations showed a progressive increase in proteinuria. She had a family history of renal disease. A renal biopsy, which had initially been postponed on patient request, subsequently revealed diffuse mesangial and focal endocapillary proliferation, GBM thickening, periglomerular fibrosis, and immune complex deposition with IgM, C3, and C1q, thereby confirming the diagnosis of IC-MPGN. Genetic testing identified a heterozygous COL4A5 c.1871G > A (p.Gly624Asp) mutation consistent with X-linked Alport syndrome. The patient follows conservative management now.</p><p><strong>Conclusion: </strong>This case highlights the rare coexistence of IC-MPGN, chronic TIN and Alport syndrome. In patients with progressive glomerular disease, especially with a family history of renal disease or extrarenal findings, genetic evaluation should be considered. Early renal biopsy and genetic testing are essential to guide management in complex cases with overlapping features.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"514"},"PeriodicalIF":2.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significant proteinuria as a predictor of renal prognosis in malignant hypertension patients with thrombotic microangiopathy: a prospective cohort study.","authors":"Wanxin Shi, Xingji Lian, Wenchuan Li, Rong Lian, Shengyou Yu, Zefang Dai, Zhong Zhong, Yiqin Wang, Wei Chen, Jianbo Li, Feng He","doi":"10.1186/s12882-025-04407-6","DOIUrl":"10.1186/s12882-025-04407-6","url":null,"abstract":"<p><strong>Background: </strong>Malignant hypertension (mHTN) is the most severe form of hypertension. Thrombotic microangiopathy (TMA) serves as both a complication of mHTN and a contributor to its progression by exacerbating renal damage. Proteinuria is a common manifestation of mHTN. However, the impact of proteinuria on renal prognosis in mHTN patients with TMA is unclear.</p><p><strong>Methods: </strong>This observational cohort study included 276 mHTN-associated TMA patients based on renal biopsy from 2008 to 2023. Demographic characteristics, laboratory results, and histopathological findings were recorded and compared between the mild (< 1 g / 24 h) and significant (≥ 1 g / 24 h) proteinuria groups. Propensity score matching (PSM) was used to adjust for baseline differences. Cox regression model was employed to evaluate risk factors associated with renal prognosis.</p><p><strong>Results: </strong>Among the 276 patients included in the study, 185 (67.0%) had significant proteinuria, while 91 (33.0%) had mild proteinuria at baseline. After PSM, 83 pairs of patients with mHTN-associated TMA were matched. Patients with significant proteinuria exhibited lower serum albumin, and higher ratio of global sclerosis compared to patients with mild proteinuria. Moreover, mHTN-associated TMA with significant proteinuria was independently associated with receiving renal replacement therapy (RRT) (adjusted hazard ratio (aHR), 1.30; 95% confidence interval (CI), 1.16-1.46; P < 0.001) compared with mild proteinuria. This association remained significant after PSM (aHR, 1.29; 95% CI, 1.13-1.47; P < 0.001). Furthermore, mHTN-associated TMA patients with significant proteinuria had a lower incidence of renal function recovery with a reduction in creatinine levels than in patients with mild proteinuria in the absence of intensive blood pressure control.</p><p><strong>Conclusion: </strong>In mHTN-associated TMA patients, the presence of significant proteinuria serves as a strong predictor of poor renal outcome.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"513"},"PeriodicalIF":2.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12406467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the relationship between intravenous iron therapy and troponin T levels in hemodialysis patients: a cross-sectional study.","authors":"Marah Hunjul, Diana Owda, Bayan Sawaid, Heba Saadeh, Ahmad Enaya, Zakaria Hamdan, Zaher Nazzal","doi":"10.1186/s12882-025-04436-1","DOIUrl":"10.1186/s12882-025-04436-1","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"510"},"PeriodicalIF":2.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research and advances in mouse models of diabetic nephropathy: a narrative review.","authors":"Kang Xie, Yan Ma, Jingjing Din, Yujie Jin, Siwen Zhang, Shiqiang Liu, Cui Yu, Xu Wu, Chunyan Xing, Lizhuo Wang, Jialin Gao","doi":"10.1186/s12882-025-04432-5","DOIUrl":"10.1186/s12882-025-04432-5","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"511"},"PeriodicalIF":2.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12406435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a nomogram for predicting hyperphosphatemia in non-dialysis patients with chronic kidney disease.","authors":"Xianhui Zhao, Caiyun Zheng, Qitong Su, Dongli Lu, Shiqin Wu, Zhenghua Jiang, Zhaochun Wu","doi":"10.1186/s12882-025-04445-0","DOIUrl":"10.1186/s12882-025-04445-0","url":null,"abstract":"<p><strong>Background: </strong>Elevated serum phosphate levels are strongly associated with an increased risk of all-cause mortality in patients with chronic kidney disease (CKD). The aim of this study was to identify independent risk factors for hyperphosphatemia in patients with non-dialysis CKD and use the findings to develop and validate a predictive model for assessing hyperphosphatemia risk.</p><p><strong>Methods: </strong>Data of patients with CKD discharged from the Department of Nephrology between January 2021 and December 2023 were retrospectively analyzed. Potential predictors were screened from an array of clinical variables using least absolute shrinkage and selection operator regression in conjunction with 10-fold cross-validation. A multivariate logistic regression model was constructed to identify independent risk factors for predicting hyperphosphatemia. The C-index, receiver operating characteristic curve, calibration curve, and decision curve analysis were used to evaluate model predictive power, discriminability, accuracy, and clinical utility. Internal validation was implemented through a comparison of results from a validation set and the entire dataset.</p><p><strong>Results: </strong>This study included 216 patients, with 134 (62.04%) individuals who developed hyperphosphatemia. Logistic regression revealed that hemoglobin, blood urea nitrogen, serum creatinine, and parathyroid hormone were independently correlated with hyperphosphatemia. The nomogram C-index was 0.916 (95% confidence interval [CI]: 0.872-0.961). The model demonstrated excellent discriminative ability in the independent validation set (area under the curve [AUC] = 0.953, 95% CI: 0.909-0.998), with the full dataset analysis showing concordant results (AUC = 0.923, 95% CI: 0.889-0.958). The decision and clinical impact curves showed the clinical value of our nomogram for patients with CKD and hyperphosphatemia.</p><p><strong>Conclusions: </strong>The nomogram model was highly accurate in identifying CKD subpopulations at an elevated risk of serum phosphorus metabolic disorders. Our model can be utilized for prospective monitoring and preventive intervention. Furthermore, through individualized risk assessments, the model can contribute to the development of customized treatment strategies that have the potential to markedly improve long-term prognosis.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"512"},"PeriodicalIF":2.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12406407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical presentation of post-streptococcal glomerulonephritis in a child with genetically confirmed susceptibility to C3-glomerulopathy: a case report and brief review of the literature.","authors":"Charalampos Kapogiannis, Anastasios Kapogiannis, Diagoras Zarganis, Harikleia Gakiopoulou, Andreas Fretzayas","doi":"10.1186/s12882-025-04437-0","DOIUrl":"10.1186/s12882-025-04437-0","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"505"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encapsulating peritoneal sclerosis outcomes: a retrospective study on the significance of nutritional parameter variations.","authors":"Chih-Ying Chien, Ming-Tsun Tsai, Jinn-Yang Chen, Chiao-Lin Chuang, Jiu-Yun Tian, Hsin-Ling Tai, Chih-Ching Lin, Szu-Yuan Li","doi":"10.1186/s12882-025-04111-5","DOIUrl":"10.1186/s12882-025-04111-5","url":null,"abstract":"<p><strong>Background: </strong>Encapsulating peritoneal sclerosis (EPS) can result in abdominal organ encasement, and bowel obstruction, and is associated with a high mortality rate. While various risk factors have been identified for the development of EPS, the factors influencing patient outcomes in EPS are less well-studied. This study aims to investigate the prognostic factors that affect the clinical course and survival of EPS patients.</p><p><strong>Methods: </strong>In this retrospective study, we examined a cohort of 1406 peritoneal dialysis (PD) patients over an 18-year study period. Among them, 35 individuals were diagnosed with EPS. We collected data encompassing demographic characteristics, comorbidities, PD-related parameters, clinical symptoms, computed tomography scores, laboratory results, and treatment modalities. The survival analysis incorporated both univariate and multivariate Cox regression models, as well as the Kaplan-Meier method.</p><p><strong>Results: </strong>Patients with EPS exhibited a spectrum of clinical symptoms, with intestinal obstruction occurring in 88.6% and ultrafiltration failure in 42.9%. The five-year survival rate was 26.3%, and malnutrition and gastrointestinal infections contributed to three-fourths of the deaths. A notable finding was the one-month drop in albumin levels as a marker of ongoing malabsorption, demonstrating its predictive value for both overall (HR 2.01, p = 0.042) and EPS-related (HR 2.79, p = 0.017) mortality.</p><p><strong>Conclusions: </strong>This study emphasizes the crucial role of monitoring the one-month albumin drop after EPS diagnosis, providing valuable insights for the improvement of clinical management and patient care.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"509"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiopulmonary recirculation in patients with chronic heart failure and preserved left ventricular ejection fraction: the \"Monday Morning Phenomenon\".","authors":"Alexey Zulkarnaev, Ekaterina Parshina, Ilya Dmitriev, Vadim Stepanov, Natalia Fominykh","doi":"10.1186/s12882-025-04431-6","DOIUrl":"10.1186/s12882-025-04431-6","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"506"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taming renal inflammation: signaling pathways and therapeutic advances in lupus nephritis.","authors":"Marsela Braunstein","doi":"10.1186/s12882-025-04434-3","DOIUrl":"10.1186/s12882-025-04434-3","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"507"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}