{"title":"Overexpression of plasmalemmal vesicle-associated protein-1 in patient with cyanotic nephropathy: a case report.","authors":"Yusuke Ushio, So Hirata, Shun Manabe, Mayuko Suyama, Ayano Tanaka, Momoko Seki, Haruka Kato, Kana Nomura, Anna Nakai, Hitoko Sumori, Yuki Kawaguchi, Shizuka Kobayashi, Shiho Makabe, Hiroshi Kataoka, Naoko Itoh, Sekiko Taneda, Kazuho Honda, Junichi Hoshino","doi":"10.1186/s12882-025-04046-x","DOIUrl":"10.1186/s12882-025-04046-x","url":null,"abstract":"<p><strong>Background: </strong>Cyanotic nephropathy (CN) is a known complication of cyanotic congenital heart disease (CCHD). However, many aspects of its pathophysiology remain unclear.</p><p><strong>Case presentation: </strong>We report the case of a 29-year-old male with a history of tetralogy of Fallot. Renal biopsy revealed glomerular hypertrophy and focal segmental glomerulosclerosis. Electron microscopy revealed extensive endothelial cell damage. To investigate the etiology of endothelial cell damage, PAL-E staining was conducted, revealing staining along the glomerular capillary wall.</p><p><strong>Conclusion: </strong>This is the first report of PAL-E staining in CN, suggesting potential overexpression of PV-1. The association of PV-1 expression with endothelial cell damage indicates its role in the pathogenesis of CN.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"109"},"PeriodicalIF":2.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC NephrologyPub Date : 2025-03-03DOI: 10.1186/s12882-025-04031-4
Sarwar Noori Mahmood, Shakhawan Hama, Amin Said, Rawa O Mohammed, Mzhda Sahib Jaafar
{"title":"Safety and efficacy of mini-percutaneous nephrolithotomy in management of renal stones in pediatric age group.","authors":"Sarwar Noori Mahmood, Shakhawan Hama, Amin Said, Rawa O Mohammed, Mzhda Sahib Jaafar","doi":"10.1186/s12882-025-04031-4","DOIUrl":"10.1186/s12882-025-04031-4","url":null,"abstract":"<p><strong>Background: </strong>Currently, kidney stones are frequently observed in children and teens.</p><p><strong>Objectives: </strong>To evaluate the safety and efficacy of mini-percutaneous nephrolithotomy (MPCNL) in managing renal stones in pediatric patients.</p><p><strong>Patients and methods: </strong>This retrospective case series study included 115 consecutive patients aged < 11 years old who underwent MPCNL at Sulaimani Teaching Hospital and Mercy Medical City, Sulaimaniyah, Iraq, from January 2016 to March 2021. MPCNL was done on all patients through 16-20 Fr tracts. The stone-free rate, perioperative complications, tract number, operative time, postoperative hemoglobin change, and hospitalization time were assessed.</p><p><strong>Results: </strong>The mean patients' age was 6.53 ± 1.3 years, and the mean stone burden was 2.073 ± 1.03 cm<sup>2</sup>. After a single session of MPCNL, 93.25% of patients attained a complete stone clearance through a single tract in 109 patients (94%) and two tracts in 6 patients (5.2%). Hospitalization time, operative time, postoperative hemoglobin drop, and perioperative complications were 2.23 ± 0.93 days, 39.26 ± 8.22 min, 0.51 ± 0.34 g/dL, and 25.21%, respectively. No major complications (Clavien grade III and IV) were found. Most complications were minor, including Clavien grade I (n = 18, 15.6%) and II (n = 11, 9.56%), which were managed conservatively.</p><p><strong>Conclusions: </strong>MPCNL is an effective and potentially safe procedure for treating complex renal stones in pediatric patients aged < 11 years, yielding an excellent stone-free rate and acceptable complications.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"111"},"PeriodicalIF":2.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC NephrologyPub Date : 2025-03-03DOI: 10.1186/s12882-025-04012-7
Mohamed E H Elzeky, Rash Hafez Ramadan El-Shaboury, Basma Salameh, Emad Samaan, Noha F M Shahine, Awatef Abdelhamid
{"title":"Effects of gamified versus pedometer-based walking intervention on physical activity, fatigue, and sleep quality among hemodialysis patients: a quasi-experimental study.","authors":"Mohamed E H Elzeky, Rash Hafez Ramadan El-Shaboury, Basma Salameh, Emad Samaan, Noha F M Shahine, Awatef Abdelhamid","doi":"10.1186/s12882-025-04012-7","DOIUrl":"10.1186/s12882-025-04012-7","url":null,"abstract":"<p><strong>Objectives: </strong>Exercise is a promising approach for symptom management in hemodialysis patients who are typically very sedentary. This study evaluated the effects of gamified versus pedometer-based walking interventions on these patients' physical activity, physical function, fatigue, sleep quality, and hemodynamics.</p><p><strong>Methods: </strong>A quasi-experimental single-blind study was conducted in three groups (two intervention and one control groups). It was carried out at the hemodialysis department in Mansoura University Hospital, Egypt, from October 2022 to 2023. A total of 94 patients were divided randomly into gamified (n = 31), pedometer (n = 31), and control (n = 32) groups. Randomization was done by dialysis scheduled time (first shift: pedometer group, second shift: gamified group, and third shift control group) rather than at the individual level, and the allocation ratio was approximately 1:1:1. The gamified group received a twelve-week smartphone-based gamified walking intervention, while the pedometer group received a twelve-week pedometer-based walking intervention. The control group did not receive any intervention. Step count, fatigue, sleep quality, physical function, and hemodynamic parameters were evaluated at baseline and after 12 weeks of intervention.</p><p><strong>Result: </strong>Post-intervention results indicated that patients in the gamified group significantly improved their step count, fatigue, and sleep levels compared to both the pedometer and control groups (P < 0.001). However, the groups had no statistically significant differences in physical function or hemodynamics.</p><p><strong>Conclusion: </strong>Hemodialysis patients who participated in a short-term, smartphone-based gamified walking intervention experienced increased step counts, reduced fatigue, and improved sleep quality.</p><p><strong>Trial registration: </strong>Prospectively registered with ClinicalTrials.gov on 28/10/2022; registration number NCT05599646.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"108"},"PeriodicalIF":2.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC NephrologyPub Date : 2025-03-03DOI: 10.1186/s12882-025-04025-2
Raihanah Nalubega, Anthony Batte, Sarah Kiguli
{"title":"Prevalence and predictors of stunting in children and adolescents aged 1-18 years with nephrotic syndrome attending Mulago Hospital, Uganda.","authors":"Raihanah Nalubega, Anthony Batte, Sarah Kiguli","doi":"10.1186/s12882-025-04025-2","DOIUrl":"10.1186/s12882-025-04025-2","url":null,"abstract":"<p><strong>Background: </strong>Nephrotic syndrome is the predominant glomerulopathy in children worldwide, particularly in low-income countries. One of the key complications of nephrotic syndrome is stunting. Stunting is the most prevalent form of undernutrition globally; which leads to early and long-term consequences. In this study, we determined the prevalence and predictors of stunting among children and adolescents with nephrotic syndrome at a tertiary nephrology clinic in Uganda.</p><p><strong>Methods: </strong>Between February and August 2022, we conducted a cross-sectional study that enrolled children and adolescents aged 1 to 18 years with nephrotic syndrome. Participants had been undergoing steroid treatment for a minimum of three months and were registered at the paediatric renal clinic of Mulago National Referral Hospital in Kampala, Uganda. Medical history, physical examination and anthropometric assessment were conducted on the enrolled children. The World Health Organisation (WHO) growth reference standards were used to evaluate stunting in the enrolled children. Multivariable logistic regression analysis was performed to determine independent predictors of stunting and a p-value < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Ninety-four participants were enrolled, with a median age (IQR) at diagnosis of six years (IQR 3-9). Among the participants, 48 (51.1%) were male. The prevalence of stunting was observed in 15 (15.9%) participants (95% confidence interval [CI]: 15.88 - 16.04). Regarding severity, 12 (12.8%) participants were moderately stunted, and 3 (3.2%) were severely stunted. Participants with persistent proteinuria exhibited higher odds of stunting than those without. (OR: 4.11, 95% CI: 1.05 - 15.98, p < 0.041).</p><p><strong>Conclusions: </strong>There is a high prevalence of stunting among children with nephrotic syndrome, particularly among those with on-going proteinuria. This underscores the importance of regular growth monitoring and screening for early identification and eventual management of stunting among children receiving care for nephrotic syndrome. Providing nutritional counselling and other interventions is thus crucial in addressing stunting among this specific group of children and adolescents.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"110"},"PeriodicalIF":2.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC NephrologyPub Date : 2025-03-03DOI: 10.1186/s12882-025-04029-y
Jipeng Li, Mengting Wu, Lijie He
{"title":"Immunomodulatory effects of mesenchymal stem cell therapy in chronic kidney disease: a literature review.","authors":"Jipeng Li, Mengting Wu, Lijie He","doi":"10.1186/s12882-025-04029-y","DOIUrl":"10.1186/s12882-025-04029-y","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) has been a growing public medical concern in recent years which calls for effective interventions. Mesenchymal stem cells (MSCs) have garnered increased interest in past decades due to their potential to repair and regenerate damaged tissues. Many clinical trials have highlighted the safety and effectiveness of kidney disease with this novel cell therapy. MSC infusion can improve renal function indices such as glomerular filtration rate, urine protein, serum creatinine, and blood urea nitrogen, while inhibiting immune response by increasing regulatory T cells. The therapeutic mechanisms may be primarily attributed to a function combined with immunomodulation, anti-inflammation, anti-fibrosis, promoting angiogenesis, anti-oxidation, anti-apoptosis, or tissue healing produced by cell secretsome. However, CKD is a broad concept due to many pathological etiologies including diabetes, hypertension, heart disease, immunological damage, a family history of renal failure, and so on. Furthermore, the therapeutic efficacy of MSCs may be influenced by different cell sources, injection methods, medication dosage, or homing proportion. As a result, it is timely and essential to access recent advancements in the MSC application on CKD.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"107"},"PeriodicalIF":2.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC NephrologyPub Date : 2025-02-28DOI: 10.1186/s12882-025-03993-9
Alicia Alanis-Ocádiz, Svetlana V Doubova, José Manuel Arreola-Guerra, Adriana Monroy, Jannett Padilla-López, Carolina Quiñones-Villalobos, Carlos Alberto Prado-Aguilar
{"title":"Design and psychometric validation of a social capital questionnaire for adults with end-stage chronic kidney disease undergoing dialysis or hemodialysis.","authors":"Alicia Alanis-Ocádiz, Svetlana V Doubova, José Manuel Arreola-Guerra, Adriana Monroy, Jannett Padilla-López, Carolina Quiñones-Villalobos, Carlos Alberto Prado-Aguilar","doi":"10.1186/s12882-025-03993-9","DOIUrl":"10.1186/s12882-025-03993-9","url":null,"abstract":"<p><strong>Background: </strong>The effects of end-stage kidney disease (ESKD) can spill over into a patient's social life. Social capital (SC) is a determinant of health that can enhance patients' health through support and resources. However, no questionnaire is currently available to measure SC in ESKD patients. This study aimed to design and validate a questionnaire to measure SC in ESKD adults undergoing dialysis or hemodialysis.</p><p><strong>Methods: </strong>A mixed methods approach was used to generate the questionnaire and determine its content validity with a panel of nine experts and content validity index, face validity through cognitive interviews with patients, construct validity (exploratory and confirmatory factor analysis), criterion validity, reliability and the effect of known groups differences.</p><p><strong>Results: </strong>Content validity was confirmed by an expert panel, achieving a content validity index value > 0.85 for all items. Face validity was achieved through cognitive interviews with 20 patients over 18 years of age in a terminal stage of CKD, ensuring that the target population understood the questions. An exploratory factor analysis used the sample of 610 patients and tested the structure of the seven dimensions of the structural domain (participation in organizations, links to institutions, social network sizes, collective activities, diversity, bridging, and bonding) and explained 95.7% of the total variance with a reliability of 0.89, and criterion validity > 0.32 (p < 0.05) for the correlations between the indices of each dimension and the domain index. The structure of the cognitive domain was tested for six dimensions (norms of reciprocity, social harmony, feeling of belonging, perceived fairness, social support, and social trust) with a total variance of 80.7%, reliability of 0.94 and criterion validity for correlations > 0.68 (p < 0.05). The confirmatory factor analysis with 352 patients proved the factorial structure adequate for both questionnaire domains and all dimensions, with CFI and TLI values > 0.9, an RMSEA ≤ 0.06, and SRMR ≤ 0.05.</p><p><strong>Conclusions: </strong>We conclude that the questionnaire designed to measure social capital is valid and reliable for ESKD patients in Mexico.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"105"},"PeriodicalIF":2.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC NephrologyPub Date : 2025-02-28DOI: 10.1186/s12882-025-04023-4
Jenny Lindberg, Mats Johansson, Linus Broström
{"title":"In search of common ground - nephrologists' experiences in preparing and informing patients on the path to end-stage kidney disease.","authors":"Jenny Lindberg, Mats Johansson, Linus Broström","doi":"10.1186/s12882-025-04023-4","DOIUrl":"10.1186/s12882-025-04023-4","url":null,"abstract":"<p><strong>Background: </strong>Patient education and dialogue are important when choosing a future treatment strategy for patients with chronic kidney disease. To support patients in their decision-making process, it is critical to provide information in a way that patients can understand. This study was conducted to understand how nephrologists view the goals of information sharing, the challenges involved, and the strategies used as part of treatment planning.</p><p><strong>Methods: </strong>This study had a qualitative design using semi-structured interviews with 14 practicing nephrologists working in different hospitals in Sweden and with experience in providing information to patients approaching the need for dialysis. The interviews were conducted in 2022. The data were analyzed using qualitative content analysis.</p><p><strong>Results: </strong>The results are presented thematically under the headings Objectives, Content, Challenges, and Strategies. Participants tried to find common ground with patients, in terms of shared knowledge, shared views on the appropriate decision-making process, and ultimately also agreement on which treatment option was best. There was a tension between allowing patients to make their own decisions and guiding patients to make decisions with the best outcomes as judged by the nephrologist. Achieving common ground was not always possible, both because of factors related to the patient's preferences or limited capacity, and because of boundaries set by the physician to protect the patient from unwarranted or harmful information. Dealing with competing sources of information was seen as challenging. The nephrologists felt a professional responsibility for their treatment recommendations, combined with uncertainty about which patient would benefit from dialysis and when to start.</p><p><strong>Conclusions: </strong>Planning future treatment for patients with chronic kidney disease involves a complex information process that leaves room for both paternalism and respect for autonomy. Nephrologists face many competing challenges when discussing treatment options with patients. These challenges should be taken into account in the development of support for nephrologists in the area of information sharing.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"106"},"PeriodicalIF":2.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Self-control study of multi-omics in identification of microenvironment characteristics in calcium oxalate kidney stones.","authors":"Shang Xu, Zhi-Long Liu, Tian-Wei Zhang, Bin Li, Yuan-Chao Cao, Xin-Ning Wang, Wei Jiao","doi":"10.1186/s12882-025-04026-1","DOIUrl":"10.1186/s12882-025-04026-1","url":null,"abstract":"<p><strong>Background: </strong>Perform proteomic and metabolomic analysis on bilateral renal pelvis urine of patients with unilateral calcium oxalate kidney stones to identify the specific urinary microenvironment associated with stone formation.</p><p><strong>Methods: </strong>Using cystoscopy-guided insertion of ureteral catheters, bilateral renal pelvis urine samples are collected. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is employed to identify differential proteins and metabolites in the urine microenvironment. Differentially expressed proteins and differential metabolites are further analyzed for their biological functions and potential metabolic pathways through Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, Reactome pathway analysis and Biomolecular Interaction Network Database protein-protein interaction (PPI) network analysis.</p><p><strong>Results: </strong>In the urine from the stone-affected side, 36 differential proteins were significantly upregulated, 4 differential proteins were downregulated, and 10 differential metabolites were significantly upregulated. Functional and pathway analyses indicate that the differentially expressed proteins are primarily involved in inflammatory pathways and complement and coagulation cascades, while the differential metabolites are mainly associated with oxidative stress.</p><p><strong>Conclusion: </strong>The proteomic and metabolomic profiles of the urinary microenvironment in stone-affected kidneys provide a more precise reflection of the pathophysiological mechanisms involved in stone formation and development.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"104"},"PeriodicalIF":2.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metabolic syndrome and increased susceptibility to renal cell carcinoma - a meta-analysis.","authors":"Yanyu Zhou, Yujun Chen, Heng Yang, Zhiqi Xu, Jinbiao Zhuang, Qitao Bian, Gongxian Wang","doi":"10.1186/s12882-025-04013-6","DOIUrl":"10.1186/s12882-025-04013-6","url":null,"abstract":"<p><strong>Background: </strong>Metabolic syndrome (MetS) has been demonstrated to be associated with various types of cancer, but its specific relationship with kidney cancer remains inconclusive. Therefore, this study conducts a Meta-analysis to systematically evaluate the potential link between metabolic syndrome and the risk of kidney cancer development.</p><p><strong>Methods: </strong>Observational studies were retrieved from PubMed, Embase, Cochrane Library, and Web of Science. Two independent reviewers extracted study characteristics and assessed the quality of the studies. A random-effects model was employed to account for heterogeneity, and subgroup analyses were conducted to explore the impact of study characteristics on the results. Publication bias was evaluated using funnel plot symmetry and Egger's regression test.</p><p><strong>Results: </strong>Six studies were included, with 10 results extracted for the Meta-analysis. The findings indicated that MetS is an independent risk factor for kidney cancer (HR: 1.44, 95% CI: 1.31-1.59, P < 0.001). Heterogeneity between studies was significant (Cochran's Q test, P < 0.001; I<sup>2</sup> = 83.7%), indicating substantial variability. Subgroup analyses revealed consistent associations across gender, follow-up duration, and MetS diagnostic criteria (P > 0.05), but significant variations by race and study design (P < 0.05). The funnel plot appeared symmetrical, and Egger's regression test (P = 0.425) confirmed a low risk of publication bias.</p><p><strong>Conclusion: </strong>MetS is independently associated with an increased susceptibility to RCC in the adult population, although the strength of this association varies across different study designs and regions due to the observed heterogeneity.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"102"},"PeriodicalIF":2.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC NephrologyPub Date : 2025-02-26DOI: 10.1186/s12882-025-03999-3
Mohamed Mamdouh Elsayed, Mohamed Magdy Abdelkader, Amr Mohamed ElKazaz, Iman Ezzat Elgohary
{"title":"The impact of predialytic oral protein-based supplements on nutritional status and quality of life in hemodialysis patients: a randomized clinical trial.","authors":"Mohamed Mamdouh Elsayed, Mohamed Magdy Abdelkader, Amr Mohamed ElKazaz, Iman Ezzat Elgohary","doi":"10.1186/s12882-025-03999-3","DOIUrl":"10.1186/s12882-025-03999-3","url":null,"abstract":"<p><strong>Background: </strong>Administration of oral nutritional supplements (ONS) inside hemodialysis (HD) units before sessions is an increasingly adopted option. Our aim was to assess the effects of predialytic ONS on nutritional status and quality of life (QOL) in HD patients.</p><p><strong>Methods: </strong>One hundred HD patients were enrolled in this prospective, multicentric randomized clinical trial. Patients were assigned to receive ONS (25 gm protein powder) 1 h prior to the start of the HD session (predialytic) or maintained on their routine nutrition regimen for 3 months.</p><p><strong>Results: </strong>At study end, supplemented patients showed a significant increase in serum albumin (p < 0.001), and a non-significant decrease in the median subjective global assessment (SGA) score. While in the control group, serum albumin remained stable, and the median SGA score increased significantly (p < 0.001). Body mass index and anthropometric measures did not differ between both groups. The supplemented patients showed significant improvement in three subscales of the Kidney Disease Quality of Life-36, without a significant change in QOL in control patients. Supplemented patients had significantly higher blood pressure (BP) (p = 0.037), lower urea reduction ratio (p = 0.020) and Kt/V (p = 0.021), higher serum calcium, lower total cholesterol and lower CRP (p = 0.047) levels compared to controls. There was no significant difference between groups regarding serum sodium, potassium, or phosphorus or adverse events.</p><p><strong>Conclusions: </strong>Predialytic ONS administration may contribute to improvements in serum albumin, and QOL. The effects on BP, CRP, and the reduction in dialysis adequacy, should be carefully considered while adopting such strategy.</p><p><strong>Clinical trials registration: </strong>ClinicalTrials.gov NCT05952570.</p><p><strong>First registration date: </strong>2/07/2023.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"103"},"PeriodicalIF":2.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}