Encapsulating peritoneal sclerosis outcomes: a retrospective study on the significance of nutritional parameter variations.

IF 2.4 4区医学 Q2 UROLOGY & NEPHROLOGY

BMC Nephrology Pub Date : 2025-09-01 DOI:10.1186/s12882-025-04111-5

Chih-Ying Chien, Ming-Tsun Tsai, Jinn-Yang Chen, Chiao-Lin Chuang, Jiu-Yun Tian, Hsin-Ling Tai, Chih-Ching Lin, Szu-Yuan Li

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引用次数: 0

Abstract

Background: Encapsulating peritoneal sclerosis (EPS) can result in abdominal organ encasement, and bowel obstruction, and is associated with a high mortality rate. While various risk factors have been identified for the development of EPS, the factors influencing patient outcomes in EPS are less well-studied. This study aims to investigate the prognostic factors that affect the clinical course and survival of EPS patients.

Methods: In this retrospective study, we examined a cohort of 1406 peritoneal dialysis (PD) patients over an 18-year study period. Among them, 35 individuals were diagnosed with EPS. We collected data encompassing demographic characteristics, comorbidities, PD-related parameters, clinical symptoms, computed tomography scores, laboratory results, and treatment modalities. The survival analysis incorporated both univariate and multivariate Cox regression models, as well as the Kaplan-Meier method.

Results: Patients with EPS exhibited a spectrum of clinical symptoms, with intestinal obstruction occurring in 88.6% and ultrafiltration failure in 42.9%. The five-year survival rate was 26.3%, and malnutrition and gastrointestinal infections contributed to three-fourths of the deaths. A notable finding was the one-month drop in albumin levels as a marker of ongoing malabsorption, demonstrating its predictive value for both overall (HR 2.01, p = 0.042) and EPS-related (HR 2.79, p = 0.017) mortality.

Conclusions: This study emphasizes the crucial role of monitoring the one-month albumin drop after EPS diagnosis, providing valuable insights for the improvement of clinical management and patient care.

Abstract Image

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包膜性腹膜硬化结局：营养参数变化意义的回顾性研究。

背景：包裹性腹膜硬化（EPS）可导致腹部器官包裹和肠梗阻，并伴有高死亡率。虽然各种危险因素已被确定为EPS的发展，但影响EPS患者预后的因素研究较少。本研究旨在探讨影响EPS患者临床病程及生存的预后因素。方法：在这项回顾性研究中，我们对1406名腹膜透析（PD）患者进行了为期18年的研究。其中35人被诊断为EPS。我们收集的数据包括人口统计学特征、合并症、pd相关参数、临床症状、计算机断层扫描评分、实验室结果和治疗方式。生存分析采用单变量和多变量Cox回归模型以及Kaplan-Meier方法。结果：EPS患者表现出一系列临床症状，其中肠梗阻发生率为88.6%，超滤功能衰竭发生率为42.9%。5年生存率为26.3%，营养不良和胃肠道感染占死亡人数的四分之三。一个值得注意的发现是白蛋白水平在一个月内下降，作为持续吸收不良的标志，证明了它对总体死亡率（HR 2.01, p = 0.042）和eps相关死亡率（HR 2.79, p = 0.017）的预测价值。结论：本研究强调了监测EPS诊断后1个月白蛋白下降的重要作用，为改善临床管理和患者护理提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Nephrology UROLOGY & NEPHROLOGY-

CiteScore

4.30

自引率

0.00%

发文量

375

审稿时长

3-8 weeks

期刊介绍： BMC Nephrology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.