BMC Nephrology最新文献

{"title":"Development and validation of a nomogram for predicting CRBSI in hemodialysis: a retrospective cohort study.","authors":"Shan Wu, Fan Dai, Yanhong Wen, Chang Luo, Chuanfang Wu","doi":"10.1186/s12882-025-04172-6","DOIUrl":"10.1186/s12882-025-04172-6","url":null,"abstract":"<p><strong>Objectives: </strong>To develop and validate of a nomogram for predicting Catheter related bloodstream infection(CRBSI) in patients with maintenance hemodialysis.</p><p><strong>Methods: </strong>This was a retrospective cohort study.A total of 756 patients underwent hemodialysis between January 2017 to December 2021 in purification center of the Affiliated Hospital of Changsha Central Hospital, University of South China were enrolled in this research.The demographic data, hemodialysis data, laboratory indexes of the patients were analyzed. Univariate analysis and multivariate Logistic regression were used to analyze the influencing factors of CRBSI in hemodialysis patients and a nomogram model was established.Area under the receiver operating characteristic curve(AUC) and Hosmer-Lemeshow(H-L)test were used to verify the discrimination and calibration of the model.</p><p><strong>Results: </strong>Among the 756 hemodialysis patients,64 patients developed CRBSI, with an incidence rate of 8.5%(64/756).The results of multivariate analysis showed that combined with diabetes mellitus、dialysis age、catheter retention time、C-reactive protein and procalcitonin were independent risk factors for CRBSI in hemodialysis patients(P < 0.05).The receiver operating characteristic curve analysis showed that the AUC of the model was 0.88 and the H-L test results showed that the model had good goodness of fit(χ² = 5, P = 0.7).The internal validation of the prediction model showed an AUC of 0.82, and the H-L results showed (χ² = 11, P = 0.2), indicating that the model has a good prediction performance and high accuracy.</p><p><strong>Conclusion: </strong>An easy-to-use nomogram for prediction of CRBSI in hemodialysis patients is well developed.This risk assessment tool can effectively identify patients at high risk of CRBSI and may be useful for optimizing catheter management.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"255"},"PeriodicalIF":2.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between alcohol consumption and renal function in patients with diabetes mellitus and hypertension: insights from the Taiwan Biobank.","authors":"Fa-Chen Lin, Shih-Kai Luo, Hung-Pin Tu, Hung-Yi Chuang, Chen-Cheng Yang, Chih-Hsing Hung","doi":"10.1186/s12882-025-04174-4","DOIUrl":"10.1186/s12882-025-04174-4","url":null,"abstract":"<p><strong>Background: </strong>Alcohol consumption is linked to varied health outcomes. While alcohol appears to have a protective effect on renal function, the impact on patients with diabetes mellitus (DM) and hypertension (HTN) remains unclear. This cross-sectional observational study aims to explore the association between alcohol use and renal function, particularly for individuals with these comorbidities.</p><p><strong>Methods: </strong>Data from participants in the Taiwan Biobank were analyzed. Participants were divided into drinkers and non-drinkers. Drinkers were defined as an alcohol intake of 150 mL or more per week for at least six months. Renal function was assessed using creatinine levels and 2021 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine for estimated glomerular filtration rate (eGFR). Multivariate multiple regression models were used to examine the relationships between alcohol consumption, DM, HTN, and renal function.</p><p><strong>Results: </strong>Drinkers had better renal function than non-drinkers, with higher eGFR values and lower creatinine levels. Alcohol consumption was linked to better renal function in DM patients but not HTN patients. A three-way interaction (drinking/DM/HTN) also revealed improved renal function.</p><p><strong>Conclusions: </strong>This study suggests that alcohol consumption may be associated with better renal function outcomes, particularly in patients with DM and HTN. However, these findings should be interpreted cautiously given the cross-sectional nature of the study. Further longitudinal and mechanistic research is warranted to validate the findings.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"256"},"PeriodicalIF":2.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of acute kidney injury in children with diabetic ketoacidosis.","authors":"Naseem Alyahyawi, Dalal Alghamdi, Ahlam Almahmoudi, Ibrahim Sandokji, Shatha Bokhari, Osama Y Safdar, Mohammad Shalaby, Mohamed Shazly, Jameela A Kari","doi":"10.1186/s12882-025-04178-0","DOIUrl":"10.1186/s12882-025-04178-0","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Acute kidney injury (AKI) in pediatric patients has been linked to unfavorable short-term and long-term health outcomes. Despite the significance of AKI awareness in children with diabetes mellitus type 1 (T1D), the incidence of AKI in children admitted with diabetic ketoacidosis (DKA) has been under looked.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;The primary objective of this study was to investigate the incidence of acute kidney injury (AKI) in pediatric patients hospitalized for diabetic ketoacidosis (DKA), and to identify the clinical and biochemical markers associated with the development of AKI.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective medical record review was conducted at King Abdulaziz University Hospital, a tertiary hospital in Jeddah, Saudi Arabia. The study included 373 children aged 18 years or younger from 2012 to 2022 with complete medical records available for analysis. We collected baseline and diabetes characteristics, in addition to clinical variables at presentation. Acute kidney injury (AKI) was diagnosed using the serum creatinine criteria established by the kidney disease: Improving Global Outcomes (KDIGO) organization. Descriptive comparisons were performed. Uni- and multivariable logistic regression analyses were employed to identify potential risk factors associated with the development of AKI.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;299 patients (80.2%) developed AKI including 98 (26.3%) stage 1, and 118 (31.6%) stage 2 and 83 (22.3%) stage 3. The frequency of AKI was higher in patients with severe DKA (26.9% vs. 19.7%, p=0.01) while in mild DKA the percentage of AKI was less than non-AKI (31.9% vs. 45.1%, p&lt;0.01The median last HbA1C prior to DKA presentation was 12%, and majority (88.2%) had DKA episodes in past. children who developed AKI had a significantly higher median heart rate (120 bpm, IQR 104-138) compared to those without AKI (108 bpm, IQR 98-124, p&lt;0.01). A high percentage of children with AKI had low Glasgow coma scale (&lt;15) compared to non-AKI (5.7% vs. 1.7%) but the difference was not statistically significant (p=0.22). Half of the children presented with DKA had poor outpatient follow up visits. The proven infections were observed in 53 (14.2%) children in DKA. It was higher in non-AKI group compared to AKI group (15.1% vs. 10.8%, p=0.46). At the time of discharge 131 (44%) patients with AKI showed persistent acute kidney disease. We did not observe mortality. Children with AKI had longer hospital stay compared to non-AKI (4 days vs. 3 days, p=0.02). None of the study participant have died during the studied hospital encounters.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Our findings indicate that AKI is common in children admitted with DKA. Longer duration and poor controlled T1D; previous episodes of DKA, severe DKA, infection and higher heart rate are risk factors to develop AKI. At the time of discharge, 131 (44%) patients AKI showed persistent acute kidney disease (AKD). The longer","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"254"},"PeriodicalIF":2.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular insights and clinical implications of DNA methylation in sepsis-associated acute kidney injury: a narrative review.","authors":"Lili Liu, Saisai Ni, Lianna Zhang, Yingying Chen, Mengqi Xie, Xiaojing Huang","doi":"10.1186/s12882-025-04179-z","DOIUrl":"10.1186/s12882-025-04179-z","url":null,"abstract":"<p><p>Sepsis-induced acute kidney injury (S-AKI) is a life-threatening complication of sepsis, marked by dysregulated inflammation, metabolic derangements, and immune dysfunction, driving high mortality. Its multifactorial pathogenesis increasingly implicates DNA methylation-a core epigenetic mechanism-as a critical disease modulator. This review synthesizes current knowledge of DNA methylation in S-AKI, covering molecular mechanisms, cellular dysfunction, and translational potential. In immune cells, sepsis-induced aberrant DNA methylation promotes hypomethylation of pro-inflammatory genes and hypermethylation of anti-inflammatory loci, exacerbating cytokine storms and immunosuppression. In renal tubular epithelial cells, abnormal methylation disrupts apoptosis, oxidative stress responses, and mitochondrial bioenergetics, impairing repair and accelerating S-AKI progression. Renal vascular endothelial cells exhibit methylation-dependent dysregulation of vasoactive and inflammatory pathways, compromising microvascular homeostasis and renal hemodynamics. DNA methylation signatures offer promise as early S-AKI biomarkers, with cell-type-specific patterns reflecting severity, injury, and prognosis. Targeting DNA methyltransferases with epigenetic modifiers represents a novel therapy, though challenges arise from sepsis's complex epigenetic landscape-bidirectional methylation changes, histone crosstalk, and context-dependent responses. A key paradox lies in DNA methylation's dual traits: stability underpinning biomarker reliability and plasticity enabling dynamic inflammatory adaptation, yet introducing therapeutic heterogeneity. Future research should prioritize dissecting cell-specific methylation mechanisms, integrating multi-omics to identify epigenetic subnetworks, and developing real-time monitoring tools for precision diagnosis and tailored interventions. Advancing these frontiers may translate epigenetic insights into transformative strategies to improve outcomes for this devastating condition.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"253"},"PeriodicalIF":2.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring interventions to support life participation for adults with chronic kidney disease: a scoping review.","authors":"Mikaela Correa, Roaa Hussam, Janine Farragher","doi":"10.1186/s12882-025-04162-8","DOIUrl":"10.1186/s12882-025-04162-8","url":null,"abstract":"<p><strong>Background: </strong>Individuals with chronic kidney disease (CKD) can experience significant health-related challenges that affect their life participation. Recent studies have identified life participation as a top priority for adults with CKD. This scoping review aims to comprehensively identify studies of interventions that targeted life participation outcomes in adults with predialysis CKD, and identify gaps in the literature.</p><p><strong>Methods: </strong>This scoping review followed the Joanna Briggs Institute (JBI) methodology. Five electronic databases were searched with additional sources identified through backwards chaining. Title and abstract screening were conducted independently by four screeners after initial inter-rater calibration, and full text screening and data extraction were undertaken by two researchers in duplicate. Data analysis was completed using descriptive statistics and narrative synthesis.</p><p><strong>Results: </strong>This scoping review identified twenty-three studies that examined interventions to support life participation in the CKD population. No studies targeted life participation as a primary outcome. When categorizing studies via the Canadian Model of Occupational Performance and Engagement (CMOP-E) the majority (87%) of interventions targeted personal-physical mechanisms of disability, with a predominant focus on pharmacological (48%) or exercise (35%) interventions. Dedicated outcome measures for life participation were rarely used, with the role-physical, role-emotional and social functioning subscales of the SF-36 quality of life assessment being the most common life participation outcome measures.</p><p><strong>Conclusions: </strong>This scoping review highlights a lack of research and prioritization of life participation in CKD. It demonstrates the narrow scope of intervention approaches used to support life participation, and limitations in how studies assess life participation. These gaps indicate a need for further research to support this top priority health outcome for the CKD community.</p><p><strong>Clinical trial number: </strong>As this is a scoping review, no clinical trial number is provided.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"251"},"PeriodicalIF":2.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevailing insights into anastomotic angles of surgically created arteriovenous fistulas: a literature review.","authors":"Xinyang Li, Chong Liu, Haidi Hu","doi":"10.1186/s12882-025-04182-4","DOIUrl":"10.1186/s12882-025-04182-4","url":null,"abstract":"<p><strong>Objective: </strong>An arteriovenous fistula (AVF) is the most common type of vascular access, given its low infection rate, few complications, good patency potential, and long service life. Although preferred for most patients with chronic kidney disease (CKD), those undergoing dialysis continue to experience AVF surgical failures and complications, with 60% of AVFs failing to mature. The anastomotic angles chosen for AVF creation are usually ones that surgeons find easiest to manually control. At present, many sources have confirmed that variations in anastomotic angle culminate in differing geometric parameters of perianastomotic blood vessels, thus affecting the AVF maturation process.</p><p><strong>Methods: </strong>This publication was intended to highlight the progress achieved with respect to AVF anastomotic angle conventions through collective outcomes of clinical analyses, basic research, computational fluid dynamics (CFD) studies, and VasQ external stent trials. The insights gained may well fuel clinical efforts to implement more durable blood channels in patients with end-stage kidney disease (ESKD). For our purposes, we described anastomotic angles as acute (< 30°), intermediate (30-70°), or obtuse (> 70°), rather than invoking mathematical standards.</p><p><strong>Results: </strong>In clinical research, two studies support the acute angle, three studies support the intermediate angle, three studies support the obtuse angle. In CFD research, one article supports the acute angle, six articles support the intermediate angle, and one article supports obtuse angles.</p><p><strong>Conclusions: </strong>Our analysis demonstrates an intermediate angle of 30-70° would be an optimal angle for AVF anastomosis, according to the existing research results. VasQ external stent devices have yielded superior AVF maturity and patency by maintaining anastomosed arteries and veins at angles of 40-50°, resulting in improved patient outcomes clinically, which supports the use of the device in the clinical practice.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"252"},"PeriodicalIF":2.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miRNAs in secondary hyperparathyroidism: literature review.","authors":"Ziyi Lu, Kexin Zhang, Junyue Huang, Shoukai Zhang","doi":"10.1186/s12882-025-04177-1","DOIUrl":"10.1186/s12882-025-04177-1","url":null,"abstract":"<p><p>Secondary hyperparathyroidism (SHPT) is a common complication of Chronic kidney disease (CKD), which is mainly manifested by the overproduction of Parathyroid hormone (PTH), leading to multi-system pathologies such as calcium and phosphorus metabolism disorders, skeletal lesions, and cardiovascular diseases, which seriously affects the quality of life of patients. In recent years, the role of microRNAs (miRNAs) in the pathogenesis of SHPT has been gradually revealed, providing new research directions for diagnosing and treating the disease. miRNAs play an important role in the development of SHPT by regulating genes related to calcium-phosphorus metabolism, influencing the stability and translational efficiency of PTH mRNAs, and regulating the proliferation and apoptosis of parathyroid cells. miRNA-based gene therapy strategies (e.g., miRNA antagonists or mimics) have shown promising therapeutic effects in animal models, but their clinical translation still faces challenges such as targeted delivery and safety. This review aims to summarize the mechanistic roles of miRNA and the progress of research in SHPT studies to provide a theoretical basis for diagnosing and treating SHPT.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"250"},"PeriodicalIF":2.2,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nomogram for predicting the risk of peritoneal dialysis-associated peritonitis in patients with end-stage renal disease undergoing peritoneal dialysis: model development and validation study.","authors":"Yuehong Wang, Zhimin Wu, Liuqi Huang, Dan Suo, Min Zhang, Meifen Dai, Tianhui You, Jing Zheng","doi":"10.1186/s12882-025-04165-5","DOIUrl":"10.1186/s12882-025-04165-5","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to develop and validate a nomogram to predict the risk of peritoneal dialysis-associated peritonitis (PDAP) in patients undergoing peritopreneal dialysis.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on clinical data from 376 patients at Nanhai District People's Hospital in Foshan City, Guangdong Province, between December 2017 and December 2024. The dataset was randomly divided into a training set (n = 244) and a validation set (n = 132). Risk factors for PDAP were identified using Least Absolute Shrinkage and Selection Operator (LASSO) regression and logistic regression, and a predictive nomogram was developed and validated using R4.1.3. The model's performance was evaluated through receiver operating characteristic (ROC) curves, the Hosmer-Lemeshow goodness-of-fit test, decision curve analysis (DCA), and clinical impact curves (CICs).</p><p><strong>Results: </strong>Eight potential predictors were selected by LASSO regression analysis. Multivariate logistic regression analysis confirmed that age, dialysis duration, albumin, hemoglobin, β₂-microglobulin, Potassium and lymphocyte count were independent risk factors for PDAP occurrence (P = 0.001). The nomogram's area under the curve (AUC) was 0.929 (95% CI: 0.896-0.962) in the training set and 0.905 (95% CI: 0.855-0.955) in the validation set. The Hosmer-Lemeshow goodness-of-fit test indicated a good model fit (training set χ² = 13.181, P = 0.106; validation set χ² = 8.264, P = 0.408). Both DCA and CIC revealed that the nomogram model had good clinical utility in predicting PDAP.</p><p><strong>Conclusion: </strong>The proposed nomogram exhibited excellent predictive performance and clinical utility, providing a valuable tool for early identification and intervention in PDAP. Further external validation and prospective studies are recommended.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"248"},"PeriodicalIF":2.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathological perspective reveals a novel hemodialyzer reaction: a case report.","authors":"Weijuan Lou, Yongchun Xi, Ya Liu, Xueling Cai, Junfang Gai, Jianyong Yin, Jiahui Ding, Yifang Yang, Yanjuan Teng, Tingfang Chen, Niansong Wang, Yongping Guo","doi":"10.1186/s12882-025-04180-6","DOIUrl":"10.1186/s12882-025-04180-6","url":null,"abstract":"<p><strong>Background: </strong>While the appearance of red clots in the dialyzer and the arterial and venous blood tubing lines is a common phenomenon in every hemodialysis unit, the occurrence of recurrent yellowish-white matter formation in the hemodialysis venous blood pot of a patient is rare.</p><p><strong>Case presentation: </strong>We describe a male 69-year-old male with recurrent yellowish-white matter formation in the hemodialysis venous blood pot and red clots in the dialyzer. This was associated with a significant decrease in his red blood cells count. He had no history of thrombus no pro-thrombotic risk factors could be identified. Light microscopic examination of the deposits revealed the presence of large aggregates of neutrophils, large amounts of fibrin. The yellowish-white matter recurred at the next dialysis session. The occurrence of this episode was completely resolved by switching the dialysis filter and could not be avoided by increasing low molecular weight heparin dosage.</p><p><strong>Conclusion: </strong>The yellowish-white matter and clotting within the dialyzer, as well as severe anemia, could be prevented by changing the type of dialyzer. Due to the rarity of this dialyzer reaction, it is important that awareness of this reaction by early identification be undertaken.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"246"},"PeriodicalIF":2.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender-specific sarcopenia screening in hemodialysis: insights from lower limb strength and physiological indicators.","authors":"Yujie Yang, Hualong Liao, Yang Chen, Ying Qiu, Fei Yan, Ping Fu, Jirong Yue, Yu Chen, Huaihong Yuan","doi":"10.1186/s12882-025-04176-2","DOIUrl":"10.1186/s12882-025-04176-2","url":null,"abstract":"<p><strong>Objective: </strong>Maintenance hemodialysis (MHD) patients often suffer from sarcopenia, affecting lower limb muscle strength and increasing the risk of falls and mortality. This study aims to develop an auxiliary screening model for sarcopenia in MHD patients based on machine learning methods, utilizing lower limb muscle strength indicators, while paying attention to the gender difference and exploring its value in sarcopenia screening.</p><p><strong>Methods: </strong>This cross-sectional study collected data from MHD patients at a hemodialysis center in China. Sarcopenia was assessed using the 2019 Asian Working Group for Sarcopenia update. A self-developed lower limb muscle strength testing device was used. Other physiological indicators, including basic information and lab findings, were collected. Participants were grouped into sarcopenia and control groups, with gender-specific binary classification models developed. Stratified shuffling and synthetic minority oversampling techniques were used to build screening classifiers.</p><p><strong>Results: </strong>Data from 164 MHD patients were ultimately collected, including 83 males (41 with possible sarcopenia or sarcopenia) and 81 females (53 with possible sarcopenia or sarcopenia). Gender-specific binary classification models were developed using lower limb muscle strength indicators, with the male model having an AUC of 79% and the female model an AUC of 80%, respectively. Combining lower limb muscle strength with other physiological indicators improved the female model's screening capability, achieving an AUC of 90%.</p><p><strong>Conclusion: </strong>This study demonstrates that the auxiliary screening model for sarcopenia, developed using machine learning methods, highlights the significant value of lower limb muscle strength indicators in identifying sarcopenia in MHD patients. The gender-specific screening models show good discriminatory ability across different genders, providing effective tools for the early screening and management of sarcopenia in MHD patients.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registry (ChiCTR2100051111), registered on 2021-09-13.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"247"},"PeriodicalIF":2.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}