BMC Nephrology最新文献

{"title":"Mercury poisoning-associated membranous nephropathy and autoimmune encephalitis.","authors":"Caihong Liu, Yongxiu Huang, Wei Wei, Xinyu Hu, Jing Yang, Yuliang Zhao","doi":"10.1186/s12882-025-04082-7","DOIUrl":"10.1186/s12882-025-04082-7","url":null,"abstract":"<p><p>Mercury intoxication is not uncommon and often presents with diverse symptoms of multiple systems. While neurological disorders and renal impairments have been examined in isolation, the concurrent occurrence of systemic symptoms linked to immune dysregulation is infrequently observed. Here, we report an unusual case that a 55-year-old male patient, who is a scrap merchant, was admitted to our center for neuropsychiatric disturbances, including incoherent speech and hallucinations. He was initially diagnosed with autoimmune encephalitis (AE) because of double positivity for CASPR2 and LGl1 antibodies in serum. The patient later presented with pruritus and nephrotic syndrome, where renal biopsy revealed membranous nephropathy (MN). In view of the mercury exposure history and elevated urinary mercury level, AE and MN were suspected to be related to mercury poisoning. The patient achieved a full recovery following a four-month treatment regimen comprising immunosuppressants and mercury-chelating agents, underscoring the significance of recognizing environmental toxins such as mercury in the coexisting diseases of different systems such as AE and MN.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"148"},"PeriodicalIF":2.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding kidney involvement in mycosis fungoides: T-cell clonality as a guide for targeted therapy - a case report and literature review.","authors":"Jelena Filipović, Eve Maubec, Clelia Previtali, Milica Višić, Beatrice Villette, Gregory Lazarian, Remi Letestu, Joel Cucherousset, Michael Soussan, Antoine Martin","doi":"10.1186/s12882-025-04014-5","DOIUrl":"10.1186/s12882-025-04014-5","url":null,"abstract":"<p><strong>Background: </strong>Mycosis fungoides (MF) is a common T-cell lymphoma that primarily affects the skin. Renal involvement is rare and has never been reported as the initial extracutaneous site. T-cell clonality testing is essential for confirming systemic involvement. We report identical T-cell clonality in both the skin and renal involvement of MF, accompanied by a review of the literature on MF involvement in the kidneys.</p><p><strong>Case presentation: </strong>A 58-year-old man with folliculotropic MF had asymptomatic bilateral kidney lesions incidentally detected on a routine magnet resonance imaging (MRI) 15 years after primary diagnosis. Immunohistochemistry (IHC) and polymerase chain reaction (PCR) confirmed clonal T-cell populations in skin and kidney biopsies, verifying systemic involvement. A Positron Emission Tomography (PET) scan showed a 50% reduction in kidney lesions after four months of therapy with Liposomal doxorubicin (20 mg/m²). However, despite this initial response, the disease spread to the lungs and pancreas, and the patient passed away eight months after kidney infiltration.</p><p><strong>Conclusion: </strong>This is the first documented confirmation of MF involvement to the kidneys through specific IHC and T-cell PCR-confirmed clonality testing. It highlights advances in therapy for localized disease and underscores the importance of confirming T-cell clonality, especially in atypical sites like the kidneys, illustrating its potential to enhance targeted therapy in disseminated MF.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"147"},"PeriodicalIF":2.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe acute kidney injury with anuria induced by hypokalemia requiring hemodialysis: a case study.","authors":"Seong-Wook Lee, Man-Hoon Han, Mee-Seon Kim, Yong-Jin Kim, You Hyun Jeon, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jeong-Hoon Lim","doi":"10.1186/s12882-025-03973-z","DOIUrl":"10.1186/s12882-025-03973-z","url":null,"abstract":"<p><strong>Background: </strong>Hypokalemia can result from various causes, with diarrhea being one of the most common. Although rare, chronic hypokalemia can lead to severe acute kidney injury (AKI) that requires dialysis. Therefore, this case study aims to investigate a patient with rectal cancer who, after concurrent chemoradiotherapy and ileostomy, developed chronic hypokalemia owing to prolonged diarrhea, leading to severe AKI with anuria.</p><p><strong>Case presentation: </strong>A 64-year-old man with a history of rectal cancer, ileostomy, and hypertension was admitted for severe AKI with anuria. He had developed severe hypokalemia due to chronic diarrhea. Despite having no prior kidney disease, his serum creatinine increased to 4.8 mg/dL, and potassium dropped to 2.2 mmol/L. Initial treatment included hemodialysis for anuric AKI with metabolic acidosis. A kidney biopsy revealed renal tubular vacuolization and With-no-lysine kinase (WNK) bodies in the distal tubules, which are characteristic of hypokalemic nephropathy. Potassium replacement therapy led to a gradual recovery of potassium levels and kidney function.</p><p><strong>Conclusion: </strong>This case highlights the importance of timely diagnosis and management of hypokalemic nephropathy through kidney biopsy.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"149"},"PeriodicalIF":2.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and validation of a predictive model for malignant tumors in patients with membranous nephropathy.","authors":"Yaling Zhai, Shuaigang Sun, Wenhui Zhang, Huijuan Tian, Zhanzheng Zhao","doi":"10.1186/s12882-025-04053-y","DOIUrl":"10.1186/s12882-025-04053-y","url":null,"abstract":"<p><strong>Background: </strong>The association between membranous nephropathy (MN) and malignant tumors has long been focused. However, most existing studies have primarily concentrated on patients diagnosed with malignant tumors within a limited timeframe, typically defined as one year before or after the diagnosis of MN. This narrow focus only captures a subset of MN patients complicated by malignant tumors, leaving those diagnosed outside this timeframe understudied and largely unexplored. In the present study, we aim to comprehensively investigate the clinicopathological characteristics of MN patients complicated with malignant tumors and to develop an effective predictive model for identifying the risk of malignancy in MN patients.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the demographic, clinical, and pathological characteristics of 174 MN patients complicated with malignant tumors and 604 idiopathic membranous nephropathy (IMN) patients without malignant tumors. All patients were randomly allocated into a training cohort (n = 584) and a validation cohort (n = 194) in a 3:1 ratio. A predictive model was developed using regression analysis, and its performance was evaluated in terms of discrimination, calibration, and clinical utility through the area under the ROC curve (AUC), calibration curve, and decision curve analysis (DCA).</p><p><strong>Results: </strong>MN patients complicated with malignant tumors demonstrated significantly increased deposition rates of glomerular IgG1, IgG2, IgG3, and PLA2R, as well as decreased deposition rates of IgG4. Based on independent risk factors, a predictive model was developed, which exhibited excellent performance upon validation.</p><p><strong>Conclusion: </strong>In this largest cohort to date of MN patients with malignant tumors, a predictive model was constructed using pathological parameters to estimate the risk of malignancy effectively. This tool aims to assist clinicians in decision-making and improve the prognosis of high-risk MN patients by facilitating tumor screening at the time of initial diagnosis.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"146"},"PeriodicalIF":2.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and short term outcomes of childhood immune complex membranoproliferative glomerulonephritis and C3 glomerulopathy: a single centre retrospective study.","authors":"Irshad Ali Bajeer, Sabeeta Khatri, Pawan Kumar, Seema Hashmi, Mohammed Mubarak, Ali Asghar Lanewala","doi":"10.1186/s12882-025-04078-3","DOIUrl":"10.1186/s12882-025-04078-3","url":null,"abstract":"<p><strong>Background: </strong>Membranoproliferative glomerulonephritis, with its immune complex variety and C3 glomerulopathy, is a rare glomerular disease in children. The objective of this study was to determine the clinical features and short-term outcomes in children.</p><p><strong>Methods: </strong>This retrospective cohort study was conducted at the Department of Pediatric Nephrology, Sindh Institute of Urology and Transplantation, Karachi, from January 2020, to June 2022. All the children with membranoproliferative lesions identified via light microscopy and less than 18 years were included.</p><p><strong>Results: </strong>A total of 35 children were diagnosed MPGN, 7 (20%) with C3 glomerulopathy and 28 (80%) idiopathic immune complex MPGN. In the IC-MPGN group, 14 patients (50%) had crescentic glomerulonephritis. Induction therapy consisted of cyclophosphamide and methylprednisolone followed by steroids, azathioprine was prescribed for maintenance phase. At the 18-month follow-up, 9 (64%) patients were in complete remission (CR), 3 (21%) were in partial remission (PR), and 2 (15%) progressed to chronic kidney disease. The remaining 14 (50%) had non-crescentic idiopathic IC-MPGN and were prescribed steroids only, cyclophosphamide with steroids and angiotensin converting enzyme inhibitors. The outcomes at 18 months were relatively poorer than those with the crescentic variety. Four (28%) patients achieved CR, 8 (56%) PR, and 2 (14%) did not respond. In the C3 glomerulopathy cohort, 3 (43%) had crescentic glomerulonephritis, one child was in CR, and two were in PR. The non-crescentic C3G were kept on ACEI 3 (43%) and Mycophenolate mofetil 1 (14%). One child treated with ACEIs achieved a PR, two were in CR, and one child treated with MMF did not respond.</p><p><strong>Conclusions: </strong>The outcome of MPGN (immune complex and C3G) is quite variable, and aggressive therapy for crescentic glomerulonephritis may show a favourable response. Considering the similar clinical presentations and patient outcomes, C3G and IC-MPGN might represent two facets of the same disease.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"143"},"PeriodicalIF":2.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into pediatric lupus nephritis: clinical features and short-term outcomes from a single center retrospective study.","authors":"Sabeeta Khatri, Irshad Ali Bajeer, Madiha Aziz, Mohammed Mubarak, Ali Asghar Lanewala, Seema Hashmi","doi":"10.1186/s12882-025-04059-6","DOIUrl":"10.1186/s12882-025-04059-6","url":null,"abstract":"<p><strong>Background: </strong>Pediatric lupus nephritis is a rare glomerular disease with paucity of data on short and long term outcomes. This single center study aims to assess the outcomes at 12 months and the last follow-up visit.</p><p><strong>Methods: </strong>This retrospective review of medical charts was done to include children diagnosed with lupus nephritis at Sindh Institute of Urology and Transplantation Karachi from July, 2015 to December, 2022.</p><p><strong>Results: </strong>Twenty five children included in the analysis had mean age of 11.5 ± 3.5 years with predominant 20 (80%) girls. The most common clinical presentation was nephrotic syndrome in 15 (60%). The means of estimated GFR and serum albumin improved from baseline to 12 months, however serum albumin showed statistically significant improvement (121 ml/min/1.73 m² ± 77 to 130 ml/min/1.73 m² ± 57, -9.2, p-value 0.53 and 2.1 gm/dl ± 0.81 to 3.5 ± 0.73, - 1.4 p-value 0.00). The choice of induction drug had no impact on composite outcome with similar complete remission rates in MMF versus Cyclophosphamide and Calcineurin inhibitors groups (4/10, 40% versus 6/15,40%; p-value 0.81). The failure of complete remission of proteinuria at 12 months was statistically associated with poor composite outcome at last follow-up visit (p-value 0.02).</p><p><strong>Conclusion: </strong>In our study, the choice of induction regimens had no impact on overall outcome. However, we identified the importance of targeting and reducing proteinuria to improve outcomes in pediatric patients with lupus nephritis.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"145"},"PeriodicalIF":2.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular mechanisms and therapeutic interventions in acute kidney injury: a literature review.","authors":"Jiajia He, Yanqin Chen, Yi Li, Yunlin Feng","doi":"10.1186/s12882-025-04077-4","DOIUrl":"10.1186/s12882-025-04077-4","url":null,"abstract":"<p><p>Acute kidney injury (AKI) is a clinical challenge characterized by elevated morbidity and a substantial impact on individual health and socioeconomic factors. A comprehensive examination of the molecular pathways behind AKI is essential for its prevention and management. In recent years, vigorous research in the domain of AKI has concentrated on pathophysiological characteristics, early identification, and therapeutic approaches across many aetiologies and highlighted the principal themes of oxidative stress, inflammatory response, apoptosis, necrosis, and immunological response. This review comprehensively reviewed the molecular mechanisms underlying AKI, including oxidative stress, inflammatory pathways, immune cell-mediated injury, activation of the renin-angiotensin-aldosterone (RAAS) system, mitochondrial damage and autophagy, apoptosis, necrosis, etc. Inflammatory pathways are involved in the injuries in all four structural components of the kidney. We also summarized therapeutic techniques and pharmacological agents associated with the aforementioned molecular pathways. This work aims to clarify the molecular mechanisms of AKI thoroughly, offer novel insights for further investigations of AKI, and facilitate the formulation of efficient therapeutic methods to avert the progression of AKI.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"144"},"PeriodicalIF":2.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A narrative review of acute post-streptococcal glomerulonephritis in Nepali children.","authors":"Ajaya Kumar Dhakal, Devendra Shrestha, Divya Kc, Shankar Prasad Yadav","doi":"10.1186/s12882-025-04073-8","DOIUrl":"10.1186/s12882-025-04073-8","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Acute post-streptococcal glomerulonephritis (APSGN) is the primary cause of acute glomerulonephritis in children in Nepal and contributes significantly to paediatric hospitalisations in the country. This review discusses the current status of streptococcal infections, epidemiological trends, and the challenges in diagnosing and managing APSGN in Nepalese children. This study aimed to develop local data on acute post-streptococcal glomerulonephritis to help compare epidemiological trends and patterns with regions where this disease is less prevalent.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A targeted literature review was conducted in PubMed, Google Scholar, and Nepal Journals Online (a local database) to identify relevant literature published between 1 January 2000 and 31 December 2024. Additional searches of conference abstracts and reviews were performed using Google. The collected literature was analysed to determine the kidney disease patterns, current status of Group A Streptococcal infection, epidemiological trends, clinical manifestations, management, and outcomes of APSGN in Nepali children aged &lt; 16 years.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Thirty-four articles were selected for in-depth review. A synthesis of local hospital studies revealed significant differences in the application of diagnostic criteria for APSGN owing to the inaccessibility of serological tests and complement testing. Children over five years of age, particularly those aged 8 to 11 years and predominantly male, were more severely affected. The disease was present year-round, with pyoderma identified as the main route of preceding streptococcal infection rather than throat infection, particularly affecting economically disadvantaged children. The classical manifestations were oedema, hypertension, gross haematuria, and oliguria, whereas complications included acute kidney injury, rapidly progressive glomerulonephritis, hypertensive emergency, congestive cardiac failure, and the need for kidney replacement therapy. The anti-streptolysin O titre was positive in 34-72.7% of patients, while complement C3 levels were depressed in 61.9-100% of cases. Urinalysis showed haematuria in 67-100% of patients and pyuria in 7.9-37%. Kidney ultrasonography indicated increased echogenicity in 37-78% of the cases. Most patients were managed conservatively with diuretics and anti-hypertensives. Atypical cases and those with a progressive disease course were further managed with steroids, kidney biopsies, or kidney replacement therapy. Most patients exhibited favourable short-term kidney outcomes. There was low mortality among patients with rapidly progressive glomerulonephritis and those who required kidney replacement therapy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;This review highlights that acute post-streptococcal glomerulonephritis remains a common cause of hospitalisation in Nepal. It remains a diagnostic difficulty owing to the inaccessibility of serological and","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"142"},"PeriodicalIF":2.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of stress ball use on cannulation-related invasive pain in Hemodialysis patients: a randomized controlled, single-blind study.","authors":"Betül Tosun, Soner Berşe, Ezgi Dirgar, Nurten Özen","doi":"10.1186/s12882-025-04071-w","DOIUrl":"10.1186/s12882-025-04071-w","url":null,"abstract":"<p><strong>Background: </strong>Stress ball usage is one of the non-pharmacological methods that help reduce pain and anxiety by diverting an individual's attention elsewhere.</p><p><strong>Purpose: </strong>This study evaluates the impact of stress ball use on pain levels during cannulation in hemodialysis patients.</p><p><strong>Methods: </strong>A single-blind, randomized, controlled design was used. Sixty-four participants were divided into experimental (n = 32) and control groups (n = 32). The experimental group used a stress ball for 3 min before and during cannulation, while the control group received routine care without additional intervention. Pain was assessed using the Visual Analog Scale (VAS) after cannulation across 12 sessions. Statistical significance was set at p < 0.05.</p><p><strong>Results: </strong>The median VAS score in the intervention group was significantly lower than in the control group. The intervention group showed a significant decrease in VAS scores over 12 sessions (p < 0.01). Stress ball usage had an increasing effect over time (p = 0.016). Overall, median VAS scores differed significantly between groups (p < 0.01).</p><p><strong>Conclusion: </strong>Using stress balls during cannulation reduces pain intensity in hemodialysis patients, with increased effectiveness over multiple sessions. Nurses can recommend stress balls as a simple and cost-effective pain management method.</p><p><strong>Trial registration: </strong>This study was retrospectively registered at ClinicalTrials.gov (Registration No: NCT06237738) on 2024-01-12.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"140"},"PeriodicalIF":2.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"lncRNA TUG1 and kidney diseases.","authors":"Tong Chen, Jian Lu, Qiuling Fan","doi":"10.1186/s12882-025-04047-w","DOIUrl":"10.1186/s12882-025-04047-w","url":null,"abstract":"<p><p>Long noncoding RNAs (lncRNAs) cover a large class of transcribed RNA molecules that are more than 200 nucleotides in length. An increasing number of studies have shown that lncRNAs control gene expression through different mechanisms and play important roles in a range of biological processes including growth, cell differentiation, proliferation, apoptosis, and invasion. TUG1 was originally discovered in a genomic screen of taurine-treated mouse retinal cells. Previous evidences pointed out that lncRNA TUG1 could inhibit apoptosis and the release of inflammatory factors, improve mitochondrial function, thereby protecting cells from damage, and showing a protective role of TUG1 in diseases. Given that TUG1 has multiple targets and can interfere with multiple steps in the oncogenic process, it has been proposed as a therapeutic target. In this review, we summarize the research progress of lncRNA TUG1 in kidney diseases in the past 8 years, and discuss its related molecular mechanisms.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"139"},"PeriodicalIF":2.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}