BMC Nephrology最新文献

{"title":"Hydroxychloroquine-induced renal phospholipidosis manifesting as proximal tubulopathy in systemic lupus erythematosus.","authors":"Shun Manabe, Momoko Seki, Yusuke Ushio, Moeko Ochiai, Rina Takahashi, Shizuka Kobayashi, Shiho Makabe, Naoko Ito, Hiroshi Kataoka, Sekiko Taneda, Kazuho Honda, Kosaku Nitta, Junichi Hoshino","doi":"10.1186/s12882-026-05021-w","DOIUrl":"https://doi.org/10.1186/s12882-026-05021-w","url":null,"abstract":"<p><strong>Background: </strong>Hydroxychloroquine (HCQ)-induced renal phospholipidosis typically manifests as glomerular \"zebra bodies\", \"myeloid bodies\", and \"curvilinear bodies\" and is generally considered a benign histological mimic of Fabry disease. We report a case of HCQ-induced renal phospholipidosis with proximal tubulopathy presenting as slowly progressive kidney dysfunction and Fanconi syndrome, challenging the notion that renal phospholipidosis is clinically silent.</p><p><strong>Case presentation: </strong>A 36-year-old woman with systemic lupus erythematosus (SLE) treated with HCQ for 18 months presented with slowly progressive kidney dysfunction. Urinalysis showed minimal proteinuria and no active sediment suggestive of a lupus nephritis flare; however, urinary markers of tubular injury were markedly elevated. She exhibited normoglycemic glycosuria, pan-aminoaciduria, hypophosphatemia, hypouricemia, and metabolic acidosis, consistent with mild but distinct Fanconi syndrome. Her estimated glomerular filtration rate (eGFR) slope rapidly declined at - 11.2 mL/min/1.73 m²/year during HCQ treatment. Kidney biopsy revealed glomerular z\"zebra bodies\", \"myeloid bodies\", and \"curvilinear bodies\" characteristic of HCQ-induced renal phospholipidosis, as well as lysosomes filled with electron-dense granules within glomeruli. Notably, lysosomes filled with electron-dense granules were also abundant in proximal tubular epithelial cells, resembling the \"lysosomal accumulation of light chains\" seen in light chain proximal tubulopathy (LCPT) without crystal formation and \"lysosomes containing dark electron-dense aggregates\" of chronic interstitial nephritis in agricultural communities (CINAC). Extensive clinical, biochemical, genetic, and histological evaluations excluded Fabry disease. Immunofluorescence demonstrated globotriaosylceramide (Gb3) minor and patchy positivity accumulation in both glomeruli and proximal tubules, suggesting that lysosomal metabolic dysfunction occurred similarly in glomerular cells and tubular epithelial cells. Based on these findings, a diagnosis of proximal tubulopathy secondary to HCQ-induced renal phospholipidosis was made. HCQ discontinuation resulted in the resolution of Fanconi syndrome and improvement of the eGFR slope to + 0.9 mL/min/1.73 m²/year.</p><p><strong>Conclusions: </strong>This case indicates that HCQ-induced renal phospholipidosis is not merely a silent histological finding but can manifest as clinically significant proximal tubulopathy. The pathophysiology likely involves active tubular secretion of HCQ causing rapid lysosomal and transporter dysfunction analogous to LCPT without crystal formation and CINAC. While standard monitoring for lupus nephritis focuses on glomerular markers, monitoring tubular function markers in HCQ-treated patients may enable early detection of this potentially underdiagnosed complication.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report of a child with kidney disease: consideration of the risk of a single APOL1 G2 allele with a protective N264K variant on the G0 parental chromosome.","authors":"Meidad Greenberg, Orly Tabachnikov, Dror Ben-Ruby, Asaf Vivante, Karl Skorecki","doi":"10.1186/s12882-026-05006-9","DOIUrl":"https://doi.org/10.1186/s12882-026-05006-9","url":null,"abstract":"<p><strong>Background: </strong>Apolipoprotein L1 (APOL1)-mediated kidney disease is causally associated with the G1/G2 risk alleles of the APOL1 gene, and shows incomplete penetrance shaped by environmental and genomic modifiers. A rare coding variant, N264K, observed on G0 or G2 variants, has been associated with protection in high-risk genotypes. Importantly, emerging data indicate that in some settings a single APOL1 risk allele can confer risk, including reports of end stage kidney disease in G0/G2 individuals, underscoring the need to determine whether N264K protection requires cis configuration with G2 allele (on the same polypeptide), or can also act in trans (on the opposite allele), an issue of potential future clinical diagnostic and therapeutic relevance when phase is unknown for certain genotypes.</p><p><strong>Case presentation: </strong>A previously healthy 10-year-old Muslim Arab male developed edema during laboratory-confirmed influenza. He had sub-nephrotic-range proteinuria with hypoalbuminemia, preserved kidney function, and normal blood pressure. Treatment with prednisone according to Kidney Disease: Improving Global Outcomes (KDIGO) pediatric guidelines did not induce remission. Kidney biopsy showed diffuse mesangial hypercellularity with prominent IgM deposition. In patients with steroid non-remitting disease, this finding is compatible with IgM nephropathy that can herald focal segmental glomerulosclerosis. Tacrolimus was started, and later pulse methyl-prednisolone was administered, achieving only transient reduction in proteinuria; therapy was complicated by reversible insulin-requiring hyperglycemia and subsequently withdrawn. Subsequent administration of Rituximab in combination with angiotensin-converting enzyme (ACE) inhibition resulted in significant reduction of proteinuria. Trio exome sequencing demonstrated APOL1 G0/G2 with N264K on the paternal G0 allele (trans to G2) and no other monogenic cause of steroid-resistant nephrotic syndrome. At follow-up, the child has preserved kidney function with normal plasma albumin level and without proteinuria. In human embryonic kidney (HEK-293) cultured cells co-transfection assays modeling heterozygosity, N264K reduced G2-dependent cytotoxicity only in cis (same construct as G2) and not in trans (on G0), despite comparable expression; the effect was stronger on an EIK than a KIK haplotype backbone.</p><p><strong>Conclusions: </strong>Taken together the clinical findings and the in vitro experimental laboratory results suggest that APOL1 allele phasing may be informative in selected cases where both G2 and N264K are reported, and support development of APOL1-mediated kidney disease biomarkers and genotype-informed therapies.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed graft function and its impact on short- and long-term outcomes after kidney transplantation.","authors":"Jehat Kiliç, Rengin Esen, Caner Varhan, Ömer Faruk Alakuş, Delyadil Karakaş Kiliç, Ramazan Daniş","doi":"10.1186/s12882-026-05029-2","DOIUrl":"https://doi.org/10.1186/s12882-026-05029-2","url":null,"abstract":"<p><strong>Introduction: </strong>Kidney transplantation is an effective treatment for end-stage renal disease, markedly improving survival and quality of life. However, delayed graft function (DGF) remains a notable early post-transplant complication. This study examine the impact of DGF on mortality, hypertension, graft survival, and other post-transplant complications.</p><p><strong>Methods: </strong>This retrospective study included adult recipients (≥ 18 years) who underwent kidney transplantation at the Organ Transplant Unit of Diyarbakır Gazi Yaşargil Training and Research Hospital between 1 January 2013 and 31 December 2023. A total of 285 patients with at least 12 months of follow-up were analyzed. Demographic characteristics, presence of post-transplant hypertension, immunosuppressive regimens, and laboratory parameters related to graft function were extracted from the Hospital Information Management System (HIMS) using a standardized abstraction form. Post-transplant hypertension was defined according to the KDIGO 2021 guideline; details of the analytic approach are described in the Statistics section.</p><p><strong>Results: </strong>A total of 285 kidney transplant recipients were included, with DGF observed in 31 patients (10.9%). Baseline characteristics such as recipient age, sex, BMI, and pre-transplant hypertension were comparable between groups (p > 0.05). Patients with DGF had significantly older donors (p = 0.006), a higher proportion of non-related donors (p = 0.001), longer dialysis duration (p = 0.008), and more frequent deceased donor transplantation (35.5% vs. 5.9%, p < 0.001). Postoperative complications and mortality were also higher in the DGF group (p = 0.003 and p < 0.001, respectively). In univariate analysis, non-related donor status, postoperative events, discharge protein levels, and dialysis duration were associated with DGF. In multivariate analysis, deceased donor status (OR = 4.883, p = 0.015), postoperative events (OR = 3.336, p = 0.011), and discharge protein levels (OR = 1.007, p = 0.033) remained independent predictors.</p><p><strong>Conclusion: </strong>DGF was associated with adverse outcomes after kidney transplantation. Deceased donor status, postoperative events, and higher discharge protein levels were identified as independent predictors, underscoring the multifactorial nature of DGF. Early identification of high-risk patients and close post-transplant monitoring may improve clinical outcomes.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression inventory for maintenance hemodialysis patients: a cross-cultural adaptation and psychometric evaluation in Turkey.","authors":"Nurten Ozen, Ugur Ugrak, Baris Seloglu, Tugba Cepken, Clemente Neves Sousa, Vesile Unver","doi":"10.1186/s12882-026-04979-x","DOIUrl":"https://doi.org/10.1186/s12882-026-04979-x","url":null,"abstract":"<p><strong>Background: </strong>There is a clear need for more effective screening tools for patients undergoing hemodialysis, especially considering the wide variation in depression screening options and the lack of a gold standard assessment tool for this specific population. This study aims to examine the validity and reliability of the Turkish version of the Depression Inventory for Maintenance Hemodialysis Patients (DI-MHD).</p><p><strong>Methods: </strong>This was a methodological study of the translation, cultural adaptation, and psychometric validation of the DI-MHD. Two hundred eighty-three patients from two hemodialysis units in Turkey were recruited for the study using convenience sampling. The following data were collected from the participants: descriptive characteristics, DI-MHD scores, Beck Depression Inventory (BDI) scores, and inflammatory biomarkers. The BDI was used as a reference instrument to evaluate the concurrent validity of the DI-MHD. Exploratory and confirmatory factor analyses were implemented to test the construct validity. The test‒retest method was used to test the reliability and consistency of the scale over time. IBM SPSS version 22.0 and AMOS 24.0 were used for analysis.</p><p><strong>Results: </strong>Exploratory factor analysis revealed a dominant single factor explaining 37.21% of the total variance (extracted variance = 33.52%). Although confirmatory factor analysis demonstrated acceptable fit for the correlated four-factor and second-order models, high latent factor correlations (φ = 0.677-1.052) and strong higher-order loadings (0.708-1.041) indicated limited discriminant validity among dimensions. Therefore, the one-factor model was retained as the most parsimonious and theoretically coherent solution.</p><p><strong>Conclusion: </strong>The Turkish version of the DI-MHD is a valid and reliable tool that can be used to evaluate and classify the depression levels of patients in hemodialysis units.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov NCT. First registration date: 2025-02-20.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of renal AHL amyloidosis with marked complement deposition: clinicopathologic and proteomic findings.","authors":"Yoshihiro Yamamoto, Takahiro Shinzato, Shusuke Shishihara, Ken Matsuo, Arimi Ishikawa, Naomi Kuwahara, Akira Shimizu, Kojiro Nagai","doi":"10.1186/s12882-026-05017-6","DOIUrl":"https://doi.org/10.1186/s12882-026-05017-6","url":null,"abstract":"<p><strong>Background: </strong>Amyloidosis comprises a heterogeneous group of diseases characterized by extracellular deposition of β-pleated-sheet fibrillar proteins that cause progressive organ dysfunction. Among immunoglobulin-related amyloidosis, combined heavy- and light-chain (AHL) amyloidosis is extremely rare, which accounts for approximately 7%. Several studies have demonstrated that complement components can be detected in renal amyloidosis. We report a rare case of renal AHL amyloidosis with marked complement deposition with clinicopathologic and proteomic insights.</p><p><strong>Case presentation: </strong>A 76-year-old woman with a five-year history of microscopic hematuria developed mild renal dysfunction (serum creatinine 1.05 mg/dL) and proteinuria (0.95 g/day). Physical and serologic evaluations showed no evidence of systemic amyloidosis or autoimmune disease. Serum and urine immunofixation detected an IgG-κ M-protein, and bone marrow findings were consistent with monoclonal gammopathy of undetermined significance. Kidney biopsy demonstrated Congo red-positive fibrillar deposits with IgG1, κ, and complement (C3/C1q) staining. Electron microscopy revealed non-branching fibrils measuring 8 to 12 nm in diameter. Because marked complement deposition was observed, fibrillary glomerulonephritis (FGN) was considered in the differential diagnosis. However, negative Dna J heat-shock protein family B member 9 immunostaining raised suspicion for amyloidosis. Mass spectrometry identified IgG1 heavy and κ light chains together with serum amyloid P and apolipoprotein E, confirming IgG1-κ-type AHL amyloidosis.</p><p><strong>Conclusions: </strong>This case illustrates a presentation of AHL amyloidosis with marked complement deposition. Recent study reveals that complement components can be detected in a subset of amyloidosis cases. These features can complicate the differential diagnosis from FGN and highlight the importance of an integrated diagnostic approach combining histopathology, immunostaining, and proteomic analysis. Furthermore, clone-directed therapy targeting the pathogenic plasma cell clone may represent a rational therapeutic strategy for monoclonal immunoglobulin-associated renal disease.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contrast-free functional MRI for assessing renal involvement in patients with ANCA-associated vasculitis.","authors":"Marie Scheuer, Anna Kernder, Isabell Haase, Sara Bokonjic, Thomas Andreas Thiel, Eric Bechler, Charlotte Böttger, Helena Anne Peters, Gerald Antoch, Jörg H W Distler, Matthias Schneider, Alexandra Ljimani","doi":"10.1186/s12882-026-04981-3","DOIUrl":"https://doi.org/10.1186/s12882-026-04981-3","url":null,"abstract":"<p><strong>Background: </strong>Early detection of renal involvement in ANCA-associated vasculitis (AAV) is crucial, as functional changes often precede anatomical damage. Current diagnostic standards, such as the measurement of serum creatinine, renal biopsy and urinary analyses have limitations due to delayed detection and lack of specifity. Functional renal MRI (fMRI) techniques, including diffusion-weighted imaging (DWI), diffusion tensor imaging (DTI), arterial spin labeling (ASL) and blood oxygenation level dependent (BOLD) offer promising non-invasive alternatives for assessing renal function in AAV. The aim of this study was to evaluate the feasibility of non-invasive assessment of renal changes associated with AAV using mpMRI (multiparametric MRI).</p><p><strong>Methods: </strong>This study evaluated 7 patients and 10 healthy controls: patients with rapidly progressive glomerulonephritis (RPGN) due to AAV (n = 3), AAV patients without clinical signs of renal involvement (n = 4), and healthy controls (n = 10). All participants underwent functional renal MRI. Key parameters, including the apparent diffusion coefficient (ADC), fractional anisotropy (FA), and ASL-based renal perfusion and T2* parameter maps, were acquired and analyzed.</p><p><strong>Results: </strong>The following differences in renal imaging parameters were observed between RPGN patients and healthy controls: RPGN patients showed reduced ADC values in the renal medulla and increased FA values compared to controls. Additionally, ASL values in the renal cortex were lower in RPGN patients. T2* values were lower in RPGN patients compared to the healthy control group in the cortex, and higher in the medulla. Patients with AAV without confirmed renal involvement also showed alterations in ADC, T2* and FA values compared to healthy controls.</p><p><strong>Conclusion: </strong>Our findings indicate that mpMRI parameter might detect renal changes in AAV. Therefore, mpMRI might offer novel opportunities for non-invasive detection of disease-associated changes.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"27 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obinutuzumab versus rituximab in refractory membranous nephropathy: a single-center retrospective cohort study.","authors":"Wenhui Lei, Hai-Ping Lai, Yihui Lv, Lie Jin, Jun Xin","doi":"10.1186/s12882-026-04932-y","DOIUrl":"https://doi.org/10.1186/s12882-026-04932-y","url":null,"abstract":"<p><strong>Background: </strong>Refractory membranous nephropathy (MN) remains challenging. We aim to compare the efficacy and safety of obinutuzumab versus rituximab in adults with refractory or relapsing MN, using a retrospective, single-center study design.</p><p><strong>Methods: </strong>This retrospective, single-center cohort study was conducted at the Fifth Affiliated Hospital of Wenzhou Medical University from January 2022 to January 2025. Eleven patients received obinutuzumab, and twenty-two matched controls received rituximab after propensity score matching (1:2). Inclusion criteria were biopsy-confirmed primary MN, age between 18 and 80 years, and a diagnosis of refractory disease. The primary endpoints were a composite measure of treatment response (including partial remission [PR] and complete remission [CR]); secondary endpoints included immunological remission and safety. Kaplan-Meier analyses were used to estimate time to response and time to CR; log-rank tests compared groups. Multivariate Cox regression identified factors associated with response.</p><p><strong>Results: </strong>Baseline characteristics were balanced. Obinutuzumab achieved higher overall response and CR rates (log-rank p = 0.0074 and p = 0.012, respectively). At 18 months, CR was 54.6% with obinutuzumab versus 9.1% with rituximab (p = 0.024). Obinutuzumab induced prolonged B cell depletion and faster attainment of immunological remission (anti-PLA2R < 14 RU/mL). Improvements in serum albumin and 24-hour proteinuria favored obinutuzumab at 6-12 months (p < 0.05). Safety was comparable between groups; adverse events were mostly infusion-related and manageable. Multivariate analysis showed that obinutuzumab independently predicted a better response (adjusted HR (95%CI) 2.86 (1.08 ~ 7.62); p < 0.05).</p><p><strong>Conclusions: </strong>In this preliminary retrospective analysis, obinutuzumab was associated with higher response rates than rituximab in refractory membranous nephropathy, with comparable safety.Nevertheless, given the small sample size and retrospective design, these findings should be interpreted as hypothesis-generating. Prospective randomized controlled trials are required to confirm these observations.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A near-miss: case of pseudo-foreign body in End Stage Renal Disease.","authors":"Han Hui Chuen, Charles Jun Han Ng","doi":"10.1186/s12882-026-04952-8","DOIUrl":"https://doi.org/10.1186/s12882-026-04952-8","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147761897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interdialytic weight gain, carotid intima media thickness, and cardiovascular profile in children undergoing chronic hemodialysis: a multicenter study.","authors":"Henny Adriani Puspitasari, Retno Palupi-Baroto, Anisa Rahmadhany, Eka Laksmi Hidayati, Indah Kartika Murni, Kristia Hermawan, Callen Zulkifli, Intan Dyah Puspitasari, Sudung O Pardede, Mulyadi M Djer","doi":"10.1186/s12882-026-04912-2","DOIUrl":"https://doi.org/10.1186/s12882-026-04912-2","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147761955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remote ischemic preconditioning for prevention of contrast-induced acute kidney injury in chronic kidney disease patients undergoing percutaneous vascular interventions: a systematic review and meta-analysis of randomized trials.","authors":"Wei Wei, Dongmei Wu, Binyu Yang, Caihong Liu, Yongxiu Huang, Jinglei Ren, Huawei Zhang, Bangsheng Jia, Ping Fu, Heng Zhang, Yuliang Zhao","doi":"10.1186/s12882-026-05013-w","DOIUrl":"https://doi.org/10.1186/s12882-026-05013-w","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}