BMC Nephrology最新文献

{"title":"Association of autosomal dominant polycystic kidney disease (ADPKD) with cardiovascular disease and mortality in patients with treated kidney failure.","authors":"Julia Jefferis, Andrew J Mallett, Gopi Rangan, Yeoungjee Cho, Andrea K Viecelli, Venkat Vangaveti, David W Johnson, Carmel M Hawley","doi":"10.1186/s12882-025-04185-1","DOIUrl":"10.1186/s12882-025-04185-1","url":null,"abstract":"<p><strong>Introduction: </strong>Autosomal dominant polycystic kidney disease (ADPKD) is a multisystem syndrome associated with significant morbidity and mortality, particularly kidney failure. This study sought to evaluate mortality and transplant outcomes in Australian and New Zealand patients with ADPKD commencing kidney replacement therapy (KRT).</p><p><strong>Methods: </strong>A retrospective review of all patients with kidney failure over 18 years of age commencing KRT between 1963 and 2020, stratified across eras, using Australia and New Zealand Transplant (ANZDATA) Registry data. People with ADPKD were compared to those with other causes of kidney failure (non-ADPKD). The primary outcome was mortality on dialysis. Secondary outcomes included post-kidney transplant patient survival and graft survival (both death-censored and with death as a competing risk). Outcomes were compared using multivariable Cox proportional hazards models.</p><p><strong>Results: </strong>During the study period, 63,875 patients commenced KRT, including 2,466 (3.9%) with ADPKD. Compared to patients without ADPKD, those with ADPKD had generally fewer comorbidities at KRT initiation. ADPKD was independently associated with a lower risk of mortality on dialysis (adjusted hazard ratio [aHR], 0.71, 95% CI 0.67-0.75, p < 0.001). Causes of death were similar between the ADPKD and non-ADPKD cohorts including for cardiovascular disease (27.5% vs. 27.6%, respectively), infection (7.9% vs. 8.5%) and cancer (3.4% vs. 3.5%). Kidney transplant recipients had fewer comorbidities across both cohorts, with a similar incidence of coronary artery disease (ADPKD 7.2% vs. non-ADPKD 8.0%). Compared with non-ADPKD, ADPKD was associated with a similar mortality risk in kidney transplant recipients (aHR, 0.96, 95% CI 0.88-1.05) and slightly improved graft survival (aHR, 0.87; 95% CI 0.77-0.97, p < 0.05), although there was no difference in death-censored graft survival (aHR, 0.92, 95% CI 0.79-1.07).</p><p><strong>Conclusions: </strong>Compared to other causes of kidney failure, ADPKD is associated with better patient survival on dialysis, similar patient survival post-kidney transplantation and similar death-censored graft survival.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"542"},"PeriodicalIF":2.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the triglyceride-glucose index and brachial artery flow-mediated dilation function in non-diabetic patients receiving maintenance hemodialysis.","authors":"Li Xu, Hong Ding, Ying Tian, Lei Song, Ying Shi, Dongxing Mu, Hong Liu, Jinhua Zhu","doi":"10.1186/s12882-025-04384-w","DOIUrl":"10.1186/s12882-025-04384-w","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the relationship between brachial artery flow-mediated dilation (FMD) function and the triglyceride-glucose (TyG) index in non-diabetic individuals receiving maintenance hemodialysis (MHD).</p><p><strong>Methods: </strong>Data, including clinical factors, biochemical indicators, and FMD assessments, were obtained from non-diabetic patients undergoing MHD at our hospital. Vascular endothelial dysfunction (VED) was defined as FMD < 10%. Linear regression was used to assess factors associated with FMD, and logistic regression was applied to evaluate the relationship between the TyG index and VED. The predictive value of the TyG index for FMD was evaluated using receiver operating characteristic (ROC) curves. Furthermore, subgroup and restricted cubic spline (RCS) analyses were employed to verify the robustness of the findings.</p><p><strong>Results: </strong>A total of 190 patients were enrolled and assigned to three groups according to the tertiles of the TyG index. It was found that FMD decreased significantly as the TyG index increased (p < 0.001). Multivariate linear regression revealed a significant inverse association between the TyG index and FMD (β = -0.200, p=-0.026), while logistic regression showed a significant relationship between the TyG index and VED (adjusted OR = 3.323, p < 0.001). The area under the ROC curve was 0.651 (p = 0.001), indicating the utility of the TyG index in predicting FMD in asymptomatic non-diabetic individuals undergoing MHD. Further subgroup analyses demonstrated that the significant association between the TyG index and VED persisted across most subgroups, except in females, where no statistically significant relationship was observed (p interaction for sex = 0.017). RCS analysis confirmed the linear relationship between the TyG index and FMD (p overall = 0.0024, p nonlinearity = 0.2068).</p><p><strong>Conclusions: </strong>An elevated TyG index was found to be significantly correlated with an increased likelihood of endothelial dysfunction in non-diabetic individuals undergoing MHD, and the TyG index demonstrated predictive significance for VED in this population.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"523"},"PeriodicalIF":2.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delphi study on evidence-based CKD prevention strategies for nurses in resource-limited settings: focus on e-learning implementation.","authors":"Fatema Ahmed, Qingyuan Ye, Li Li, Waleed Ksebe, Chen Wu, Kefang Wang","doi":"10.1186/s12882-025-04461-0","DOIUrl":"10.1186/s12882-025-04461-0","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Interactive e-learning modules are increasingly being used to educate nurses about preventing and detecting chronic kidney disease (CKD). These modules aim to improve knowledge, screening practices, skills, and self-management behaviours. This Delphi study aims to provide a prioritized list of strategies, content, and delivery methods to guide future implementation efforts and improve primary and secondary prevention of conservative CKD care in Syria.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A second-round Delphi study was performed using the input of 15 CKD clinical content experts (nephrologist-scientist & medical educator) involved in education and clinical practice from March to the end of April 2025. Eligible participants sent an e-mail containing an information sheet and an invitation to participate in the study. Consent is obtained before participants proceed to the survey. In the first round, we identified several potential strategies for CKD prevention education. However, consensus was not reached on all of them. We modified and refined these strategies based on the CKD clinical content experts ' opinions. We asked them to re-evaluate and re-rank these modified strategies in the second round via e-mail. Experts use predefined statements to score the effectiveness of CKD prevention strategies and delivery methods based on existing best practices specified in clinical guidelines, systematic reviews, and research studies. Descriptive statistics such as the median, interquartile range (IQR), and percentage agreement are used to assess consensus. Inferential statistics were used to measure participant agreement using Kendall's coefficient, and for stability between rounds, the Wilcoxon rank-sum test was used.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;We identified (9 primary and 32 secondary strategies) evidence-based CKD prevention strategies to implement within Syria and limited resource areas. Three strategies were deleted as not feasible and related to the Syrian context, and nine strategies were modified based on expert feedback on rationale and suggestions related to culture availability and cost-effectiveness. We added one strategy to replace the Genetic screening strategies with early and regular screening for high-risk populations. Challenges to implementing evidence-based CKD prevention strategies seem to exist in professional, organizational, and external contexts, which should all be considered to increase implementation success within resource-limited areas such as Syria.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Using the Delphi approach to tailor the e-learning module content to the specific needs of nurses, depending on the realities of the Syrian context, by synthesizing clinical work with evidence-based CKD prevention strategies and an obvious need to create a common foundation for nurses' knowledge of CKD prevention. This study offers actionable strategies to strengthen CKD prevention in resource-limited settings like","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"535"},"PeriodicalIF":2.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INHBA knockdown inhibits renal fibrosis in mice following ischemia-reperfusion injury by suppressing activation of the TGF-β/Smad signaling pathway.","authors":"Yifei Wang, Qiao Tang, Qian Sun","doi":"10.1186/s12882-025-04443-2","DOIUrl":"10.1186/s12882-025-04443-2","url":null,"abstract":"<p><strong>Background: </strong>Acute kidney injury (AKI) and renal fibrosis are clinical conditions associated with high morbidity and mortality. Renal ischemia-reperfusion (I/R) injury is a major cause of AKI.</p><p><strong>Objective: </strong>This study aimed to investigate the role of inhibin subunit beta A (INHBA) in the pathogenesis of renal fibrosis and the underlying mechanisms during I/R-induced kidney injury using an in vivo model.</p><p><strong>Methods: </strong>A mouse model of renal I/R injury was established. INHBA function was evaluated by intrarenal injection of INHBA-short hairpin RNA (INHBA-shRNA) on day 7 after I/R. Renal function, tubular damage, and interstitial fibrosis were assessed using detection kits, hematoxylin-eosin staining, and Masson's trichrome staining. reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and Western blot analyses were performed to examine the expression of fibrosis-related genes, including fibronectin (FN), collagen I (Col-I), and alpha-smooth muscle actin (α-SMA). Additionally, RT-qPCR, Western blot, and immunohistochemistry were used to determine INHBA expression in different groups. Transforming growth factor beta 1 (TGF-β1) levels in kidney tissue were measured by enzyme-linked immunosorbent assay. The effect of INHBA-shRNA on the TGF-β/Smad signaling pathway was analyzed by Western blot.</p><p><strong>Results: </strong>INHBA-shRNA significantly reduced INHBA expression, serum creatinine levels, 24-hour urinary albumin, and urinary albumin-to-creatinine ratio in I/R-injured mice. It also alleviated renal tubular damage and interstitial fibrosis. Furthermore, INHBA knockdown downregulated the expression of fibrosis markers, inhibited TGF-β1 secretion, and suppressed activation of the TGF-β/Smad signaling pathway, as evidenced by reduced expression of FN, Col-I, α-SMA, phosphorylated Smad2, and phosphorylated Smad3.</p><p><strong>Conclusion: </strong>Knockdown of INHBA attenuates renal fibrosis after I/R injury in mice by suppressing activation of the TGF-β/Smad signaling pathway. This pathway may represent a potential therapeutic target for renal I/R injury.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"526"},"PeriodicalIF":2.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The carbonic anhydrase 3 protein in urine: a potential biomarker to monitor atherosclerotic renal artery stenosis.","authors":"Xiufeng Li, Na Liu, Tianci Liu, Guowei Liang, Changgang Shao, Teng Ma, Man Zhang","doi":"10.1186/s12882-025-04457-w","DOIUrl":"10.1186/s12882-025-04457-w","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"530"},"PeriodicalIF":2.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of acute kidney injury care bundles on patient prognosis: a systematic review and meta-analysis.","authors":"Ying Huang, Lingling Guan, Chao Sun","doi":"10.1186/s12882-025-04349-z","DOIUrl":"10.1186/s12882-025-04349-z","url":null,"abstract":"<p><strong>Background: </strong>Acute kidney injury (AKI) is a severe complication among hospitalized patients. This study aimed to investigate the effect of care bundles on the prognosis of AKI patients.</p><p><strong>Methods: </strong>Electronic databases were searched from January 2012 to December 2023. Randomized controlled trials and cohort studies evaluating the effect of AKI care bundles were included. A meta-analysis using a random-effects model was conducted to explore the efficacy of the AKI care bundle.</p><p><strong>Results: </strong>A total of 12 studies with 30,152 participants were included. Based on the random-effects model, the AKI care bundles significantly improved the AKI severity (RR: 0.77, 95% CI: 0.60-0.98, I² = 64%) and the need for renal replacement therapy (RR: 0.66, 95% CI: 0.46-0.94, I² = 14%). However, our study did not find a statistically significant impact of AKI care bundle on the incidence of AKI incidence (RR: 0.95, 95% CI: 0.81-1.13, I² = 87%), major adverse kidney events (RR: 1.06, 95% CI: 0.65-1.73), in-hospital mortality (RR: 0.93, 95% CI: 0.81-1.07, I² = 19%), and length of hospital stay (MD: -0.16, 95% CI: -0.80, 0.47).</p><p><strong>Conclusion: </strong>This systematic review indicates that the implementation of the AKI bundle is a promising care model for AKI patients. There is a need for more high-quality prospective studies on AKI and patients at high risk of AKI to further determine feasible and standardized models of AKI bundle care.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"519"},"PeriodicalIF":2.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi-ethnic polygenic risk score for chronic kidney disease is associated with increased risk of hypertension in African American individuals.","authors":"Aastha Kakar, Elizabeth M Litkowski, Ashley W Scadden, Mohammad Y Anwar, Iain R Konigsberg, Maggie A Stanislawski, Natalie C DuPre, Riten Mitra, Richard Baumgartner, Laura M Raffield, Ethan M Lange, Leslie A Lange, Kira C Taylor","doi":"10.1186/s12882-025-04425-4","DOIUrl":"10.1186/s12882-025-04425-4","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"524"},"PeriodicalIF":2.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney transplant in low resources countries; 6 years of successes and challenges at Benjamin Mkapa Hospital, Tanzania.","authors":"Kessy Charles Shija, Alphonce Chandika, Masumbuko Mwashambwa, Alfred Meremo, Shuzo Kobayashi, Sumi Hidaka, Kazunari Tanabe, Awadh Mohomed, Devotha Mputi, Sabina Matulo Mmbali, Venance John Misago, Okoa Sukunala, Vitus Kajerero, Remigius Rugakingira, Reuben Mkinga, Ahmed Toure, Hindu Ibrahim, Denis Rainer, Anthony Gyunda, Nashon Kagwe, Christina Mwakilasa, Andason Kilovele, Abel Nkono Makubi","doi":"10.1186/s12882-025-04284-z","DOIUrl":"10.1186/s12882-025-04284-z","url":null,"abstract":"<p><strong>Background: </strong>Kidney transplantation (KT) is the optimal treatment for end-stage renal disease (ESRD), requiring multidisciplinary expertise, infrastructure, and reliable access to immunosuppression. This review examines the establishment and sustainability of a KT program at Benjamin Mkapa Hospital (BMH) in Tanzania since its inception in 2018 through a collaboration with Tokushukai Medical group (TMG) from Japan, highlighting successes, challenges, and long-term prospects.</p><p><strong>Methodology: </strong>We retrospectively reviewed the methods employed to establish the KT program and analysed data from 37 KT recipients transplanted between March 2018 and July 2024. Statistical analysis (SPSS version 27) yielded median and proportions, and Kaplan-Meier survival curves for patients' survival and graft survival.</p><p><strong>Results: </strong>BMH successfully established a KT program with TMG collaboration, training 11 medical personnel. The main challenges encountered were shortage of trained staff, inconsistent supply of medical resources and immunosuppressive drugs, long turnaround times for outsourced histocompatibility tests, funding limitations, and a scarcity of kidney donors. Among 37 analysed recipients (70% male, median age 50 years with IQR: 39-56), hypertension (43%) and diabetes (32.5%) were the leading causes of ESRD. The majority of donors were blood-related (84%), with 16% being spouses. Graft survival rates at 1, 3, and 5 years were 94%, 90%, and 90%, respectively, while patient survival rate at 1,3 and 5 were 97%, 81%, and 81%, respectively. The overall estimated mortality rate was 37.3 (95%CI: 14.0-99.4) per 1000 person per years.</p><p><strong>Conclusion: </strong>BMH has successfully sustained a KT program led by a local team following training and mentorship from Japanese experts. The overall estimated mortality rate indicated favourable outcomes for kidney transplant recipients in this low-resource setting comparable to those in developed nations. The hospital's six-year experience demonstrates the feasibility of establishing and maintaining KT services in low-income countries.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"525"},"PeriodicalIF":2.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of blood pressure in adults, children and young people on dialysis: UK kidney association clinical practice guideline.","authors":"Tim Doulton, Mariyam Adam, Katie Durman, Stanley L S Fan, Anna Forbes, Ed Jenkinson, Charlotte Mallindine, Kieran McCafferty, Manish D Sinha, Douglas J Stewart, Pauline Swift, Indranil Dasgupta","doi":"10.1186/s12882-025-04451-2","DOIUrl":"10.1186/s12882-025-04451-2","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"532"},"PeriodicalIF":2.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of infection prevention and control quality improvements in haemodialysis facilities: a scoping review.","authors":"Siyanda A Ngema, Thabiso L A Bale, Tendani S Ramukumba","doi":"10.1186/s12882-025-04459-8","DOIUrl":"10.1186/s12882-025-04459-8","url":null,"abstract":"<p><strong>Background: </strong>Healthcare-associated infections (HAIs) pose significant risks to patients undergoing haemodialysis, necessitating effective infection prevention and control (IPC) strategies. This scoping review aims to summarise and analyse the existing literature on quality improvement (QI) interventions that enhance adherence to infection prevention and control measures in dialysis settings.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across PubMed, Cochrane Library, MEDLINE, EMBASE and Google Scholar databases, identifying 10 relevant studies published between January 2013 and October 2024. The review was conducted according to an established methodology for scoping studies and followed guidelines. Data extraction and analysis were performed to evaluate the effectiveness and applicability of various quality improvement interventions.</p><p><strong>Results: </strong>31 267 records with 10 studies eligible for final review. Post-intervention evaluation varied considerably across studies. The analysis revealed that diverse QI strategies significantly improved adherence to infection prevention protocols, including staff education, protocol standardisation, and multimodal interventions. However, the evaluation of outcomes differed across different contexts. Common patterns identified included the effectiveness of training programs in enhancing staff knowledge and the importance of leadership support in sustaining IPC practices. Additionally, some studies revealed a significant decrease in infection rates following the interventions, highlighting the effectiveness of structured educational efforts in enhancing patient safety and infection control in clinical settings.</p><p><strong>Conclusion: </strong>This review provides valuable insights for healthcare professionals and policymakers to reduce HAIs in dialysis environments, thereby improving patient outcomes and promoting safety within healthcare systems. Future research should focus on implementing and evaluating integrated QI models tailored to local contexts in diverse healthcare settings.</p><p><strong>Clinical trial: </strong>Not applicable.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"527"},"PeriodicalIF":2.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}