BMC Nephrology最新文献

{"title":"Can GLP-1 receptor agonists slow the progression of Autosomal Dominant Polycystic Kidney Disease?","authors":"Hamad Ali, Barrak Alahmad, Fahd Al-Mulla","doi":"10.1186/s12882-025-04217-w","DOIUrl":"10.1186/s12882-025-04217-w","url":null,"abstract":"<p><p>GLP-1 receptor agonists revolutionized diabetes therapy and offer cardiorenal protection in diabetic kidney disease. Their potential in Autosomal Dominant Polycystic Kidney Disease (ADPKD) is now being explored. Preclinical findings and metabolic improvements (obesity, hypertension, inflammation) indicate promise. Further clinical studies are required to ensure efficacy and safety before clinical integration can be considered. Clinical trial number: Not applicable.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"279"},"PeriodicalIF":2.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxia-inducible factor-1 alpha and nuclear factor erythroid 2-related factor 2 as biomarkers of renal scarring in children with congenital anomalies of the kidney and urinary tract: a prospective case-control study.","authors":"Aylin Gençler, Hakim Çelik, Fatih Padalı, Abit Demir, Safiye Kafadar","doi":"10.1186/s12882-025-04193-1","DOIUrl":"10.1186/s12882-025-04193-1","url":null,"abstract":"<p><strong>Background: </strong>Congenital anomalies of the kidney and urinary tract (CAKUT) represent a diverse group of structural malformations that can lead to renal fibrosis and chronic kidney disease in children. Although hypoxia-inducible factor-1 alpha (HIF-1α) and nuclear factor erythroid 2-related factor 2 (NRF2) have been suspected of fibrotic processes in kidney diseases, their roles in CAKUT-related renal fibrosis remain unclear. In this context, this study was carried out to investigate the relationships between serum levels of HIF-1α and NRF2 and renal elastography findings, i.e., shear wave velocity (SWV) in children with CAKUT-related renal scarring compared to healthy control children.</p><p><strong>Methods: </strong>The population of this cross-sectional study consisted of all consecutive children aged between one month and 18 years who were diagnosed with CAKUT at a tertiary referral center in Sanliurfa, Turkey, between January 2023 and April 2024. The patient group consisted of 44 children in whom dimercaptosuccinic acid (DMSA) scan revealed CAKUT-related renal scarring, and the control group consisted of 44 healthy children matched with the patient group in terms of age and gender.</p><p><strong>Results: </strong>Children with CAKUT had significantly higher serum HIF-1α (p < 0.001) and NRF2 levels (p < 0.001) compared to controls. SWV values were also markedly elevated in the CAKUT group (p < 0.001), reflecting increased renal stiffness. A weak but significant positive correlation was found between HIF-1α levels and SWV values in the CAKUT group (r = 0.314, p = 0.038). However, this correlation was not observed when children with unilateral kidney agenesis were excluded (p = 0.075).</p><p><strong>Conclusions: </strong>Elevated HIF-1α and NRF2 levels were found to be associated with renal scarring in children with CAKUT, highlighting their potential roles as biomarkers for renal fibrosis. The correlation between HIF-1α levels and SWV values suggests that HIF-1α may serve as a predictor of renal fibrosis.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"277"},"PeriodicalIF":2.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing the inequity of access to home Dialysis in Europe: recommendations for action informed by an international consensus exercise.","authors":"Simon J Davies, Bert Bammens, Ilaria de Barbieri, Edwina A Brown, Jan van Cruchten, Dani Gallego, Eric Goffin, Maurizio Gallieni, Sotiroula Gliki, Jeroen P Kooman, Gert Meeus, May-Britt Moeslund-Hansen, Peter Rutherford, Raymond Vanholder, Martin Wilkie, Wim Van Biesen","doi":"10.1186/s12882-025-04188-y","DOIUrl":"10.1186/s12882-025-04188-y","url":null,"abstract":"<p><strong>Background: </strong>Use of Home Dialysis (referring to both peritoneal and home haemodialysis throughout this study), is under-exploited and highly variable across Europe, and this is the case both within as well as between countries. Several, predominantly modifiable barriers have been described that explain this inequity of access, but as yet no recommendations have been agreed upon as to how to address the problem.</p><p><strong>Methods: </strong>A multi-disciplinary multi-organisational policy forum representing the key stakeholders was held at the EuroPD meeting in Bruges, November 2023 with the purpose of defining solutions and actions that the wider nephrology community should take to reduce disparities in access to home-based therapies. Three key themes were identified by a steering group prior to the forum: Dialysis Provider Motivation, Patient Empowerment and Training and Workforce Issues. Breakout discussion groups for each theme were asked to prioritise up to three actions per theme. These were further refined by the steering group and developed into proposed actions to be taken forward by the kidney failure community.</p><p><strong>Results: </strong>112 registrants attended the forum representing patients (5%), doctors, (57%) nurses, (13%) industry (7%) and various other roles (18%). The following actions were proposed: (1) a granular European audit of financial disincentives affecting decisions of policy makers, providers, patients and industry; (2) engaging national professional societies to challenge complacency towards uptake of home-based therapies; (3) stimulate networking to support small, inexperienced centres; (4) extending access to assisted peritoneal dialysis; (5) greater involvement of patients (locally and nationally) at every step, especially for advocacy; (6) empowering patients with transparent information; (7) mandating inclusion of training and exposure to Home Dialysis in national curricula; (8) promotion of career sub-specialists (doctors and nurses) with specific qualification in Home Dialysis; (9) promoting access to high quality training resources.</p><p><strong>Conclusions: </strong>The kidney failure community can undertake a number of constructive actions to improve equity of access to Home Dialysis. The Policy Forum steering group who are representative of the key stakeholders have committed to taking this programme forward.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"276"},"PeriodicalIF":2.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the blood urea nitrogen to serum albumin ratio and the risk of mortality in patients with chronic kidney disease: a cohort study.","authors":"Kaiying He, Yan Zhu, Wansong Wang, Zhihui Wang, Shiwan Guo, Jing Wu","doi":"10.1186/s12882-025-04214-z","DOIUrl":"10.1186/s12882-025-04214-z","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) is prevalent worldwide, with patients facing significant mortality risk in intensive care units (ICUs). Early identification of high-risk CKD patients is crucial for improving clinical outcomes. The blood urea nitrogen to albumin ratio (BAR) is a simple and measurable indicator, but its relationship with 28-day mortality in CKD patients is not well established. This study aimed to investigate this association.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of eligible CKD patients from the MIMIC IV database. The association between the BAR and 28-day mortality was assessed using Kaplan-Meier survival curves, multivariable Cox regression models, and restricted cubic spline models.</p><p><strong>Results: </strong>A total of 4,625 patients were included, with a 28-day mortality rate of 25.2%. Kaplan-Meier survival curve analysis indicated that patients in the high BAR tertile had significantly lower survival probabilities than those in the low BAR tertile. The adjusted Cox regression model showed that compared to low BAR patients (T1 ≤ 9.8 mg/g), those in T2 (10.0-17.4 mg/g) and T3 (≥ 17.5 mg/g) had increased risks of 28-day mortality, with HRs of 1.49 (95% CI: 1.26-1.76) and 2.04 (95% CI: 1.73-2.40), respectively. Restricted cubic spline analysis indicated a nonlinear association.</p><p><strong>Conclusion: </strong>The BAR is significantly associated with 28-day mortality risk in ICU patients with CKD and may serve as a valuable tool for mortality risk stratification.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"275"},"PeriodicalIF":2.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of RAAS blockade on acute kidney injury in head and neck cancer patients post-chemoradiotherapy.","authors":"Yi-Ting Chen, Yao-Hung Kuo, Chih-Feng Lin, Chun-Wei Wang, Chiao-Ling Tsai","doi":"10.1186/s12882-025-04195-z","DOIUrl":"10.1186/s12882-025-04195-z","url":null,"abstract":"<p><strong>Background: </strong>The incidence of acute kidney injury (AKI) is high among head and neck cancer (HNC) patients following Platinum-based concurrent chemo-radiotherapy (CCRT). However, the effect of renin-angiotensin-aldosterone system (RAAS) blockade on the risk of AKI in HNC patients undergoing CCRT is controversial. This study aimed to investigate the association between RAAS blockade, AKI and survival in HNC patients undergoing CCRT.</p><p><strong>Method: </strong>This retrospective cohort study included 989 HNC patients treated between January 2016 and July 2022, with follow-up extending to July 2022. Among them, 65 (6.6%) patients were using RAAS blockade for hypertension control, while 924 were non-users. Clinical data and demographics were retrieved. Cox regression models were employed to analyze primary outcomes, including AKI and patient survival.</p><p><strong>Results: </strong>There were 65 (6.6%) patients being RAAS blockade users in the study. The mean age of RAAS blockade users was older than that of non-users (61 vs. 55 years old, p < 0.001). Overall, 219 (22.1%) patients developed AKI, including 25 RAAS blockade users. RAAS blockade users had a higher risk of AKI compared to non-users (38% vs. 21%, p = 0.001) and also had a worse mortality rate (35% vs. 22%, p = 0.015). Factors such as male gender, age, RAAS blockade usage, and baseline serum creatinine levels independently predicted the onset of AKI and patient survival.</p><p><strong>Conclusion: </strong>RAAS blockade users developed AKI, which significantly predicted patient survival. Diligent post-CCRT renal function monitoring and hydration in RAAS blockade users are crucial to mitigate AKI risk and potentially improve survival in this patient group.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"274"},"PeriodicalIF":2.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental amalgam associated with SAPHO syndrome and IgA nephropathy: a case report and literature review.","authors":"Yan Cai, Qingqing You, Weina Jiang, Xuyan Liu, Leping Shao","doi":"10.1186/s12882-025-04208-x","DOIUrl":"10.1186/s12882-025-04208-x","url":null,"abstract":"<p><strong>Background: </strong>Exposure to metals is associated with adverse health effects, including multiorgan damage and dysregulation of systemic immune responses. The increasing use of metallic implants in humans, such as dental materials and orthopedic devices, has resulted in chronic endogenous exposure to metal ions. The pathophysiological mechanisms underlying implant-related complications and their clinical implications have not been fully elucidated.</p><p><strong>Case presentation: </strong>We present a case of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome coexisting with IgA nephropathy (IgAN) in the context of dental amalgam exposure. Following amalgam placement, the patient developed palmoplantar pustulosis (PPP) and sternoclavicular arthritis, with a subsequent diagnosis of IgAN. Notably, all the clinical manifestations were markedly resolved after amalgam removal.</p><p><strong>Conclusion: </strong>This case suggests a potential link between SAPHO syndrome, IgAN, and dental amalgam exposure. To our knowledge, this is the first reported case linking these conditions. Further studies are needed to elucidate the mechanisms and clinical implications of metal-induced autoimmune or inflammatory responses.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"273"},"PeriodicalIF":2.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and clinical presentation of kidney amyloidosis have changed over the past three decades: a nationwide population-based study.","authors":"Hilde J Vasstrand, Melinda Raki, Rannveig Skrunes, Sabine Leh, Janne Thomsen, Helga Gudmundsdottir, Arnljot Tveit, Anders Hartmann, Anna V Reisæter, Anders Åsberg, Tale N Wien","doi":"10.1186/s12882-025-04136-w","DOIUrl":"10.1186/s12882-025-04136-w","url":null,"abstract":"<p><strong>Background: </strong>Early diagnosis of kidney amyloidosis is essential for optimal treatment and improved outcomes. This large, nationwide cohort spanning three decades, explores the changing epidemiology and clinical presentation of kidney amyloidosis in Norway, aiming to raise amyloid awareness.</p><p><strong>Methods: </strong>In the 30-year period (1988-2017), we identified 479 patients with biopsy-confirmed kidney amyloidosis from national registries. Past medical records were reviewed for additional amyloid relevant data and cases were divided into groups of non-AA and AA amyloidosis.</p><p><strong>Results: </strong>Overall amyloid biopsy incidence in the registries was stable around 4%, but a shift in types occurred. The AL-dominated non-AA group increased from 1.9% to 2.8% (p = 0.014) while the AA group decreased from 2.6% to 1.3% (p < 0.001). The change in AA was related to less rheumatic disease, partly compensated by an increase in AA in people who inject drugs. The scope and accuracy of amyloid typing improved in the study period, significantly reducing undetermined cases (p < 0.001) and providing more robust diagnoses. Clinical presentation was diverse, but proteinuria was present in 94%. Non-AA patients more often than AA had nephrotic syndrome (70% vs 51%, p < 0.001) and better-preserved kidney-function (median (IQR) eGFR 53(55) vs 27(34) ml/min/1.73 m², p < 0.001). AA patients were younger (p < 0.001) with higher prevalence of hypertension (53% vs 38%, p < 0.001). Notably, AA in people who inject drugs was more advanced and near half presented with end-stage kidney disease. In recent years, non-AA presented with significantly improved serum albumin (p = 0.002), haemoglobin (p = 0.020) and erythrocyte sedimentation ratio (p = 0.029). Additionally, the percentage of non-AA with end-stage kidney disease fell from 26.8% to 8.7% (p = 0.005), possibly indicating earlier diagnosis.</p><p><strong>Conclusion: </strong>The epidemiology of kidney amyloidosis has changed over the past 30 years. Biopsy incidence of non-AA is increased, and findings may suggest an earlier diagnosis. Amyloid typing has improved over time and is reflected in more precise amyloid diagnoses and reduced number of undetermined cases in recent years. Although AA related to rheumatic disease is declining, AA amyloidosis in people who inject drugs represents a growing challenge. The changing epidemiology of kidney amyloidosis may impact clinical presentation and future healthcare needs, emphasising the need for amyloid awareness.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"272"},"PeriodicalIF":2.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using vascular biomarkers to assess heart failure event risk in hospitalized patients with and without AKI.","authors":"Audrey A Shi, Anna Simone Andrawis, Aditya Biswas, Francis P Wilson, Wassim Obeid, Heather Thiessen Philbrook, Alan S Go, T Alp Ikizler, Edward D Siew, Vernon M Chinchilli, Chi-Yuan Hsu, Amit X Garg, W Brian Reeves, David K Prince, Pavan Bhatraju, Steve G Coca, Kathleen D Liu, Paul L Kimmel, James S Kaufman, Mark W Wurfel, Jonathan Himmelfarb, Chirag R Parikh, Sherry G Mansour","doi":"10.1186/s12882-025-04169-1","DOIUrl":"10.1186/s12882-025-04169-1","url":null,"abstract":"<p><strong>Background: </strong>Patients with AKI experience higher rates of heart failure (HF). This study seeks to identify criteria to assess the risk of heart failure post-hospitalization, with a special focus on AKI patients. We hypothesized that the combined use of 9 vascular biomarkers would predict future heart failure events after AKI. Using a study of 1497 hospitalized patients with and without AKI, we found that these 9 vascular biomarkers successfully stratified patients into different risk groups for HF, and were able to improve prediction of HF when added to routine clinical variables.</p><p><strong>Methods: </strong>Using the ASSESS-AKI cohort, we performed an unsupervised spectral cluster analysis with 9 plasma biomarkers measured at 3 months post-hospitalization [Angiopoietin (angpt)-1, angpt-2, vascular endothelial growth factor (VEGF)-A, VEGF-C, VEGF-d, VEGF receptor 1 (R1), solubleTie-2 (sTie-2), placental growth factor (PlGF), and basic fibroblast growth factor (bFGF)] in 1,497 patients, half of whom had AKI. We used a Cox regression analysis to evaluate the associations between the clusters and HF. Models were adjusted for demographics, cardiovascular disease risk factors, medications, ICU status, lung disease, sepsis, clinical center, and 3-month post-discharge serum creatinine and proteinuria. We calculated change in the area under the curve (AUC) for the prediction of HF or death at 3 years by adding the biomarkers to a clinical model selected by a penalized regression with LASSO. We also calculated a net reclassification index for the addition of the biomarkers to the clinical model.</p><p><strong>Results: </strong>Three biomarker-derived clusters were identified: Cluster 1 [n = 302, Vascular Injury (Injury) Phenotype] had higher levels of injury markers, whereas Cluster 2 [n = 728, Vascular Repair (Repair) Phenotype] had higher levels of repair markers. Cluster 3 (n = 467) had lower levels of all markers (Dormant Phenotype). Across the entire cohort, those with the Injury Phenotype had twofold higher risk of a HF event compared to the Repair Phenotype [aHR 2.24 (95% CI: 1.57-3.19)] and noted in both participants with AKI [aHR 2.12 (95% CI: 1.35-3.34)] and without AKI [aHR 2.94 (95%CI: 1.57-5.50)]. The Dormant Phenotype was associated with higher risk of HF events only in participants without AKI. The AUC for the prediction of HF event or death at 3 years by the biomarkers was 0.76 (95% CI: 0.73-0.80), 0.77 (95% CI: 0.73-0.80) for the clinical model, and 0.80 (95% CI: 0.77-0.83) for the combined model. The addition of the biomarkers significantly improved reclassification of HF event or death.</p><p><strong>Conclusions: </strong>Vascular biomarkers can be used to derive phenotypes capable of stratifying future risk of HF events in recently hospitalized patients with or without AKI.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"271"},"PeriodicalIF":2.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of thrombomodulin with the severity of chronic kidney disease: a cross-sectional study.","authors":"Ming Guo, Shaoyuan Cui, Xiaoxiao Liu, Jingyi Feng, Mengfei Li, Zheyi Dong, Jie Wu, Guangyan Cai, Xiangmei Chen, Qinggang Li","doi":"10.1186/s12882-025-04200-5","DOIUrl":"10.1186/s12882-025-04200-5","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory disorders and endothelial dysfunction are prevalent in patients with chronic kidney disease (CKD). Thrombomodulin (TM) possesses both anticoagulant and anti-inflammatory properties. This study aimed to investigate the association between TM levels and the severity of CKD.</p><p><strong>Methods: </strong>This cross-sectional study included two cohorts of patients with CKD from the General Hospital of the Chinese People's Liberation Army. Patients with CKD were categorized into high and low TM groups based on the upper plasma TM reference value. The laboratory indices of patients were compared. Simultaneously, a correlation analysis was performed to identify the association between the TM and each parameter. Patients were categorized into two groups based on eGFR: preserved renal function (eGFR ≥ 60 mL/min/1.73 m²) and significantly impaired renal function (eGFR < 60 mL/min/1.73 m²). Logistic regression analysis and receiver operating characteristic (ROC) curves were used for analysis.</p><p><strong>Results: </strong>A total of 33 patients with CKD were included in the discovery cohort, and 150 were included in the validation cohort. In the discovery cohort, creatinine (P = 0.0028) and urea nitrogen (P = 0.0011) were significantly higher in the high TM group compared to the low TM group, whereas eGFR (P = 0.0005) was lower. In the validation cohort, high TM group exhibited significantly higher creatinine (P < 0.001), urea nitrogen (P < 0.001), and 24-hour proteinuria levels (P < 0.001) compared to the low TM group, while eGFR (P < 0.001) was lower. Merging the discovery and validation cohorts revealed significant positive correlations between TM and IL-2, TNF-α, vWF (Act), vWF (Ag), serum creatinine, urea nitrogen, and 24-hour proteinuria, while eGFR was negatively correlated with TM (P < 0.001). After adjusting for confounders, TM (adjusted odds ratio = 1.31; 95% CI: 1.10-1.57; P = 0.003) was independently and significantly correlated with CKD severity. Using a TM threshold of > 14.55 TU/ml derived from ROC analysis for severity stratification, the AUC was 0.7739 (95% CI: 0.71-0.84) in differentiating CKD severity stages.</p><p><strong>Conclusion: </strong>Serum TM levels demonstrated a significant correlation with CKD severity, suggesting its potential as a biomarker with clinical utility for CKD staging.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"268"},"PeriodicalIF":2.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of serum magnesium level on carotid intima media thickness in hemodialysis patients.","authors":"Ali Veysel Kara, Ridvan Ozdemir, Hamza Inan, Beyza Ozerten Ozdemir, Serhat Hayme, Muharrem Said Cosgun","doi":"10.1186/s12882-025-04168-2","DOIUrl":"10.1186/s12882-025-04168-2","url":null,"abstract":"<p><strong>Background: </strong>We aimed to examine whether serum magnesium level is related to cardiovascular events in hemodialysis patients by investigating the relationship between serum magnesium (Mg) level and carotid intima media thickness (CIMT).</p><p><strong>Methods: </strong>In this cross-sectional study, we evaluated 88 hemodialysis patients. The mean CIMT of these patients was measured and recorded by doppler ultrasonography. Patients were divided into two groups according to their serum magnesium level. Correlation analysis and linear regression analysis were used to define the relationship between study parameters. We divided our patients into 2 groups according to Mg value as group 1 (Mg ≥ 2.3 mg/dl) and group 2 (Mg < 2.3 mg/dl).</p><p><strong>Results: </strong>The mean CIMT of patients with group 1 and group 2 were respectively 0.93 ± 0.22 mm and 1.03 ± 0.22 mm. There was statistically significant difference between two groups in terms of the mean CIMT value (p = 0.045). We found negative, low-level, statistically significant correlations between Mg and mean CIMT ​​(r=-0.272; p = 0.010), calcium and mean CIMT (r: -0.221, p: 0.039) and hemoglobin and mean CIMT (r: -0.215, p: 0.044). According to regression analysis, serum magnesium level and age were found independent risk factors for mean CIMT value (p: 0.004 and p: 0.045).</p><p><strong>Conclusions: </strong>We found a significant relationship between serum Mg level and CIMT, which indicates carotid atherosclerosis.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"270"},"PeriodicalIF":2.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}