Haemodynamically irrelevant pericardial effusion is associated with increased mortality in maintenance hemodialysis patients with end-stage renal disease.

IF 2.4 4区医学 Q2 UROLOGY & NEPHROLOGY

BMC Nephrology Pub Date : 2025-07-01 DOI:10.1186/s12882-025-04233-w

Lizheng Song, Jian Chen, Junwei Xu, Liyun Luo, Mei Xu, Wenyi Tang, Yuxi Huang, Hsi Huang, Man Li, Jianting Ke

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引用次数: 0

Abstract

Background: Pericardial effusion (PE) is common in patients with end-stage renal disease (ESRD) undergoing maintenance haemodialysis (MHD). The prognostic value of a small, haemodynamically non-compromising PE in patients with ESRD who undergo MHD, is currently lacking.

Objective: The purpose of this study was to determine the predictive significance of a small, haemodynamically non-compromising PE in MHD patients with ESRD.

Methods and results: Patients with ESRD who received regular dialysis in the Hemodialysis Center of the Fifth Affiliated Hospital of Sun Yat-sen University from January 2017 to December 2020 were retrospectively analyzed. A total of 352 patients with ESRD receiving MHD were enrolled in this study, including 82 patients with PE and 270 patients without PE. The overall median follow-up time was 2.4 years. Compared to the non-PE group, the mortality rate was higher in the PE group (31.7% vs. 18.5%; P = 0.011). PE was associated with an increased all-cause mortality. The Cox proportional hazard model showed that PE was the risk factor for all-cause death (HR: 1.964; 95%CI: 1.020-3.784; P = 0.044), as well as age (HR: 1.049; 95%CI: 1.022-1.076; P = 0.001), diabetes (HR: 2.404; 95%CI: 1.226-4.713; P = 0.011), hemoglobin (HR: 0.983; 95%CI: 0.969-0.997; P = 0.020) and ultrafiltration rate (HR: 1.082; 95%CI: 1.015-1.153; P = 0.015). Echocardiographic follow-up results showed that the mortality rate in the PE persistence group was significantly higher than that in the PE regression group (44.1% vs. 20.7%, P = 0.049).

Conclusion: In MHD patients with ESRD, even haemodynamically irrelevant PE is associated with an increased risk of all-cause mortality.

Clinical trial number: Not applicable.

查看原文本刊更多论文

与血流动力学无关的心包积液与终末期肾病维持性血液透析患者死亡率增加相关。

背景：心包积液（PE）在接受维持性血液透析（MHD）的终末期肾病（ESRD）患者中很常见。对于接受MHD的ESRD患者，小的、血流动力学上不妥协的PE的预后价值目前尚缺乏。目的：本研究的目的是确定一个小的、血流动力学上不妥协的PE在MHD合并ESRD患者中的预测意义。方法与结果：回顾性分析2017年1月至2020年12月中山大学附属第五医院血透中心定期透析的ESRD患者。本研究共纳入352例接受MHD治疗的ESRD患者，其中PE患者82例，非PE患者270例。总体中位随访时间为2.4年。与非PE组相比，PE组的死亡率更高(31.7% vs. 18.5%；p = 0.011)。PE与全因死亡率增加有关。Cox比例风险模型显示，PE是全因死亡的危险因素(HR: 1.964；95%置信区间:1.020—-3.784;P = 0.044)、年龄(HR: 1.049；95%置信区间:1.022—-1.076;P = 0.001)，糖尿病(HR: 2.404；95%置信区间:1.226—-4.713;P = 0.011)，血红蛋白(HR: 0.983；95%置信区间:0.969—-0.997;P = 0.020)、超滤率(HR: 1.082；95%置信区间:1.015—-1.153;p = 0.015)。超声心动图随访结果显示，PE持续组的死亡率显著高于PE回归组（44.1% vs. 20.7%, P = 0.049）。结论：在MHD合并ESRD患者中，即使是与血流动力学无关的PE也与全因死亡风险增加相关。临床试验号：不适用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Nephrology UROLOGY & NEPHROLOGY-

CiteScore

4.30

自引率

0.00%

发文量

375

审稿时长

3-8 weeks

期刊介绍： BMC Nephrology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.