International journal of pharmaceutical sciences and research最新文献

{"title":"A current review from recent literature on novel SARS-CoV-2 Outbreak","authors":"C. Houacine, Ghufran Adawi Ibrahim, Hala Alnasif, Hiba Suliman, I. Khan, Iman Himoudy, Nemet Khalid Nasr, Rawda Mohamedkhair, Rayan Ballal, S. Yousaf, S. I. Elbashir","doi":"10.13040/IJPSR.0975-8232.12(2).692-13","DOIUrl":"https://doi.org/10.13040/IJPSR.0975-8232.12(2).692-13","url":null,"abstract":"The outbreak of a novel coronavirus 2019 was traced back in China in late 2019, followed by their worldwide transmission as a pandemic. From January to August 2020, a total of 1,724 papers were published, where 125 were only published in August 2020, demonstrating the importance and need for current awareness and research to overcome this deleterious virus. This paper briefly highlighted the major characteristics of the SARS-CoV-2 in detail, including; a brief history of coronavirus, various transmission routes, range of mild to severe symptoms, available diagnostic tests, treatment options, measures for infection control and prevention, and particular emphasis on self-acceptance and upholding to face mask-wearing. The impact of the COVID-19 pandemic is limitless and has affected all the nation throughout the horizon; the voyage is indeed hard but not impossible to overcome. However, it is the responsibility of each and every individual to be cautious, know, and understand their role in this difficult situation. To conclude, due to the lack of cohesive data, this review has collated the most recent literature regarding COVID-19 and provided the reader with clear and simple knowledge and instructions on the control and prevention of COVID-19 and hence to protect the most vulnerable population.","PeriodicalId":90866,"journal":{"name":"International journal of pharmaceutical sciences and research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88661531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronavirus to COVID-19 pandemic: An overview","authors":"M. Rana, S. Singla, P. Jaswal, G. Singh","doi":"10.13040/IJPSR.0975-8232.12(3).1332-41","DOIUrl":"https://doi.org/10.13040/IJPSR.0975-8232.12(3).1332-41","url":null,"abstract":"Coronaviruses wrapped with the layers of positive-sense RNA viruses specified by the club-like projections from their surface responsible for a variety of diseases in the animal kingdom. After the two historical episodes of coronaviruses i.e., severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, this time world strike with its highly pathogenic form which is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus disease (COVID-19) is a viral cascade event that starts from Wuhan in December 2019 and becomes a public health emergency of global interest as declared by the World Health Organization. Primarily, bats became an identifiable source of SARS-CoV-2 and their transmission to humans has occured through an unknown intermediate source. Present situation depicts that more than 200+ countries are suffering from the deadly attack of SARS-CoV-2. This virus is dangerous for every age group because of its asymptomatic carrier state that results in acute respiratory diseases. Escalation of this virus occurs very easily through human-to-human transmission via droplets or direct contact, with an estimated incubation period of 7-14 days. Fever is the ubiquitous symptom of SARS-CoV-2 followed by a dry cough. After completing more than a 1-year journey with SARS-CoV-2, now the countries are able to fight pharmacologically with this virus. Prevention strategies recommended by WHO and AYUSH include isolation of suspected and confirmed cases with personal hygiene and immunity enhancing measures. This review enlightened on the epidemiology, history of coronavirus, pathogenesis, comparative analysis, clinical features, recent possible pharmacological and non-pharmacological approaches for COVID-19.","PeriodicalId":90866,"journal":{"name":"International journal of pharmaceutical sciences and research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91249017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurvedic antiviral agents: Overview of medicinal plants perspective","authors":"R. Choudhary, L. Borse, A. Jadhav","doi":"10.13040/IJPSR.0975-8232.12(12).6214-20","DOIUrl":"https://doi.org/10.13040/IJPSR.0975-8232.12(12).6214-20","url":null,"abstract":"In recent years, it has been reported that many herbal plants contain antiviral agents which combat a human disease that is caused by pathogenic viruses. The natural products which are obtained from plants as antiviral agents against viruses have gone through researches to check the efficacy and potentials of the herbal products in the prevention of viral disorders. On the basis of randomized controlled studies and in-vivo studies, and in-vitro studies, some agents are utilized all across the globe. Progressively numerous studies on therapy of antivirals have been increased. Though, efficacy remains disputable for antiviral drugs that are employed for viral disorders. The viral diseases are challenging for the health of people around the world cause significant increase in mortality and enhance crises. There are many synthetic antiviral drugs that have a large number of side effects and have narrow therapeutic window range, while in the other hand herbal formulations have minimized side effects. The advantages of herbal formulation over synthetic drugs encourage us to devise and expand new herbal moieties against the emerging viral infections. The medicinal plants contain phytochemicals that have antiviral properties. In this paper, the activity of antiviral agents from medicinal plants which have importance in Ayurveda, are discussed along with their source.","PeriodicalId":90866,"journal":{"name":"International journal of pharmaceutical sciences and research","volume":"85 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72423017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANTI-WRINKLE ACTIVITY AND UPLC-MS/MS METABOLIC PROFILING OF POMEGRANATE AND GRAPE SEEDS EXTRACTS","authors":"Sally M. Odah, M. Salama, Wafaa M. Aziz, T. El-Alfy, S. Ezzat","doi":"10.13040/ijpsr.0975-8232.11(8).3679-89","DOIUrl":"https://doi.org/10.13040/ijpsr.0975-8232.11(8).3679-89","url":null,"abstract":"","PeriodicalId":90866,"journal":{"name":"International journal of pharmaceutical sciences and research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88888400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of Oosporein as a New Inhibitor of Influenza Virus Cap-snatching Activity","authors":"Nobuhiro Koyama, Y. Shibagaki, Mitsuru Okuwaki, S. Hattori, H. Tomoda","doi":"10.15344/2394-1502/2020/137","DOIUrl":"https://doi.org/10.15344/2394-1502/2020/137","url":null,"abstract":"During our screening of microbial origins, we found that fungal strain BF-0073 produces an inhibitor of the cap-snatching activity of influenza virus. Compound (1) was isolated from the culture broth of fungal strain BF-0073 by solvent extraction and preparative HPLC. Based on structural analyses using MS and NMR, 1 was identified as oosporein. Compound 1 inhibited the cap-snatching activity of influenza virus A in a dose-dependent manner, with an IC50 value of 20.0 μg/mL. Figure 1: Structure of oosporein.","PeriodicalId":90866,"journal":{"name":"International journal of pharmaceutical sciences and research","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90124131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An overview on COVID-19 outbreak: Epidemic to pandemic","authors":"A. Majumdar, N. Malviya, S. Alok","doi":"10.13040/IJPSR.0975-8232.11%285%29.1958-68","DOIUrl":"https://doi.org/10.13040/IJPSR.0975-8232.11%285%29.1958-68","url":null,"abstract":"COVID-19 is a disease caused by the novel coronavirus,which was initially called 2019-nCoV, consequently termed as SARSCoV-2 by the experts of the International Committee on Taxonomy ofViruses (ICTV) as it is exceptionally alike to the virus that caused theSARS outbreak in 2002 to 2003 World Health Organization already haddeclared COVID-19 as an international emergency as the disease isspreading at alarming levels COVID-19 has affected more than1,016,372 people around the world and killed more than 53,238 people And even where the virus hasn't yet spread, hospitals and clinics aroundthe world have been preparing for a rush forward of coronavirus patientsas a priority over everyday illnesses they treat The label ,internationalemergency? has triggered governments of various countries to activatevigilance plans and probably take emergency measures to protect thepublic, such as more strong travel and trade restrictions It is beingobserved that this is the first time this kind of virus, a coronavirus, hasbeen labeled a pandemic, \"but at the same time, it is being believed that itwill be able to be contained or controlled if adopted proper measures Since information about this virus is rapidly rising, it is the necessity ofthe time to remain updated So in this article, we present on an overviewof the presently obtainable information on the etiology, pathophysiology,epidemiology, clinical manifestations and diagnosis, therapeuticstrategies, and management of this novel coronavirus This review alsoaimed to present the concept of epidemic and pandemic phases accordingto WHO in a defined manner Copyright © 2013 are reserved by the International Journal of Pharmaceutical Sciences and Research","PeriodicalId":90866,"journal":{"name":"International journal of pharmaceutical sciences and research","volume":"25 1","pages":"1958-1968"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73474279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE CORCHORUS HIRSUTUS PLANT MATERIAL SELECTED FOR THE SYNTHESIS OF NANOSILVER Optimized Synthesis of Nanosilver : Optimized","authors":"D. Ashok, S. Raju, K. Rama","doi":"10.13040/ijpsr.0975-8232.10(10).4587-97","DOIUrl":"https://doi.org/10.13040/ijpsr.0975-8232.10(10).4587-97","url":null,"abstract":"The elected work reports for the first time successfully synthesized nanosilver from the aqueous leaf extract of the Carchorus hirsutus plant. Because the phytochemicals within the leaf extract were creditworthy for the reduction of silver ions as the active nanosilver particles, in addition to this, they act as the capping agents who had been environed at the surface of the particles. UV-Vis spectroscopy oversaw the establishment of nanosilver as an appropriate peak detected at 412 nm of surface plasmon resonance has affirmed the colloidal nanosilver. The peaks of Fourier Transform Infrared Spectroscopy had proved to be phytochemicals responsible for the reduction of nanosilver. The crystalline structure and average diameter found to be 29 nm of the phytosynthesized nanosilver particles were found out using X-ray diffraction studies. The Scanning Electron Microscopy images were rendered the aggregated, semi-spherical to spherical silver nanocrystals. The elemental signals of energy dispersive Xray spectrum substantiate the presence of silver detail as silver weight % is 86.84 and atomic % is 68.45. The atomic force microscope turned into used to take a look at the dimensions, topographical structure of the synthesized nanosilver. Then the antibacterial activity of synthesized nanosilver has been effectively examined by the well-diffusion method in opposition to four harmful bacteria Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas putida, and Bacillus subtilis as evincing high activity. The Corchorus hirsutus mediated nanosilver exerts their cytotoxic impact on MCF7 cell lines of breast adenocarcinoma cells and HeLa cell lines of cervical cancer cells. INTRODUCTION: Present age nanotechnology is the trending research area. Around the globe, researchers from all fields of science and technology are researching nanoscience because of their huge range of applications.","PeriodicalId":90866,"journal":{"name":"International journal of pharmaceutical sciences and research","volume":"125 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73510711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMPACT OF HYDROTHERMAL ISOLATION METHOD ON THE RECOVERY OF FENUGREEK SEED HEMI-CELLULOSE ANALYZED THROUGH FTIR-DSC-SEM INTERPRETATIONS","authors":"G. Deokar, S. Shewale, S. Kshirsagar, P. Ahire","doi":"10.13040/ijpsr.0975-8232.10(10).4677-84","DOIUrl":"https://doi.org/10.13040/ijpsr.0975-8232.10(10).4677-84","url":null,"abstract":"Natural Herbal components like seeds mucilages, exudates, gums, polysaccharides, celluloses, hemicelluloses, starch, etc. are now a day’s exploited as excipients. Literature reveals medicinal, nutraceutical and pharmaceutical uses of fenugreek seed hemicelluloses in dosage form design. Hemicelluloses like galactomannans are water-soluble polysaccharides highly susceptible to hydrolysis either by acidic conditions or by uncontrolled hydrothermal processes. Chances of breakdown of intact polymeric polysaccharides chains into oligosaccharides, disaccharides, monosaccharide, etc. increases. Conversion into basic sugar units may also take place leading to changes in the polymeric behavior of the intact structures. So, in the present research percentage hemicellulose recovery is determined by invasive, indirect method in terms of basic glucose units. FTIR-SEM-DSC analysis was found to be useful characterization tools to interpret and support the recovery details of the hemicellulose isolates. Finally, it is concluded that the method of isolation of any natural component either hemicellulose, cellulose, etc. targeted to be utilized as excipient entity in dosage form design should be strictly optimized because there are numerous factors in processing which may convert these intact high molecular weight polysaccharide polymeric structures into low molecular weight of monomer units which ultimately may lead to alterations in the functional performance of these structures. INTRODUCTION: Various useful plants legumes contain mainly glucans (starches and cellulose), hemicelluloses, and sugars as carbohydrates. Many Legume trees exude gums whereas legume seeds additionally have galactomannans and amyloid as endosperm reserve polysaccharides 1 . All these polysaccharides, gums, celluloses, hemicelluloses, starches are now a day’s exploited as pharmaceutical excipients.","PeriodicalId":90866,"journal":{"name":"International journal of pharmaceutical sciences and research","volume":"732 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74772021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY BASED URINARY METABOLIC PROFILING IN POST TRAUMATIC STRESS DISORDER RATS","authors":"Priya Singh","doi":"10.13040/ijpsr.0975-8232.10(10).4636-43","DOIUrl":"https://doi.org/10.13040/ijpsr.0975-8232.10(10).4636-43","url":null,"abstract":"Though at present, Post-Traumatic Stress Disorder (PTSD) stands to be one of the major mental debilitating psychiatric disorders, however, its clinical diagnosis remains unachieved due to the absence of any biological marker. Hence, this study is aimed at the identification of putative biological underpinnings of PTSD through the metabonomic approach. For this purpose, the animal model based NMR spectroscopy approach was undertaken for profiling of urine samples, for classification of metabolic changes brought about in body due to PTSD. Multivariate statistical analysis techniques, namely Principal Component Analysis (PCA) and Partial Least Square Discriminant Analysis (PLS-DA) were performed on 1H NMR spectral data, which was obtained from both rat urine sets that are, before and after exposing the rats to Underwater Trauma (UT) for PTSD. The behavioral changes were measured and recorded by conducting the Open Field Test (OFT). PCA showed partial separation with PC1 = 49.8% and PC2 = 21.7%, however PLSDA completely separated both urine sets with R 2 = 0.9 and Q 2 = 0.8. Eight endogenous metabolites were tracked whose concentration attenuated majorly post PTSD, about the changes recorded. The metabolites included citrate, hippurate, aspartate, n-methyl nicotinamide, betaine, creatine, creatinine, and βhydroxybutyrate. OFT indicated heightened anxiety behavioral changes brought about in post-trauma rats. The metabolites explored were primarily involved with energy metabolism, lipid metabolism, and intestinal microflora metabolism. These observations enable to assess the changes in the physiology of PTSD by evaluating the concentration of these metabolites in urine. This study would have an imperative role in assessing the biological underpinnings of PTSD and can further be taken into account for developing, the clinical screening parameters for PTSD. INTRODUCTION: Increasing stress and unhealthy lifestyles have led people to be more prone to various psychiatric disorders. QUICK RESPONSE CODE DOI: 10.13040/IJPSR.0975-8232.10(10).4636-43 This article can be accessed online on www.ijpsr.com DOI link: http://dx.doi.org/10.13040/IJPSR.0975-8232.10(10).4636-43 These issues are currently being addressed enormously worldwide. Post-Traumatic Stress Disorder (PTSD) is an anxiety disorder 1 , experienced ensuing exposure to a traumatic event or a situation in which an individual faces acute stress 2 . Traumatic event herein refers to any lifethreatening event, e.g.: military combat, physical or sexual assault, natural disasters, or loss of a loved one in some cases. Symptoms include reexperiencing trauma, avoidance, negative thoughts, or mood 3 .","PeriodicalId":90866,"journal":{"name":"International journal of pharmaceutical sciences and research","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84455405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BIOCHEMICAL STUDY OF AN ENDANGERED ETHNOMEDICINAL PLANT CURCULIGO ORCHIOIDES GAERTN. OCCURRING IN PURULIA DISTRICT OF WEST BENGAL, INDIA","authors":"G. Mahato, N. Banerjee","doi":"10.13040/ijpsr.0975-8232.10(5).2417-22","DOIUrl":"https://doi.org/10.13040/ijpsr.0975-8232.10(5).2417-22","url":null,"abstract":"Ethnic peoples from Purulia district of West Bengal in India use a lot of plants for their primary health care without studying phytochemical analysis and biological activities in detail. Main objectives of the present study are to evaluate the antibacterial and antioxidant activities of the whole plant extract of Curculigo orchioides using polar and nonpolar solvents. Total phenol content (TPC) was determined by Folin-Ciocalteu assay using Gallic acid (GA) as standard and total flavonoid content (TFC) by AlCl3 method using quercetin as standard. The antibacterial screening was carried out by agar well diffusion method. Methanol extracts exhibit higher phenol (82.93 ± 2.74 mg of GA E/gm of the sample), flavonoid (48.41 ± 1.94 mg of QE/gm of the sample) and alkaloid (5.56 ± 1.56%) content in comparison to other solvents. Similarly, methanol extracts show higher free radicals scavenging property and there was a positive correlation between IC50 values with total phenol and flavonoid content. A positive correlation exists in total phenol and flavonoid with antioxidant activities. The plant contains high phenolic and flavonoid content and exhibits antibacterial and antioxidant activities support the ethnomedicinal value of the plant. INTRODUCTION: Plants have been used medicinally since prehistoric times. Although, after the discovery of the synthetic drug, the use of natural medicines has decreased drastically. However, synthetic drugs have some side effects 1 , allergic reactions 2 . So, humans seek some alternative source of medicine. Tribals from a rural area of Purulia district are mainly dependent on medicinal plants for their primary health care. One such traditionally used plant is Curculigo orchioides Gaertn. (Hypoxidaceae) commonly known as kalimusli, known in Purulia it as talmuli, is an important endangered medicinal plant used by the tribal people from all over the district for the treatment of carbuncle and cancer. QUICK RESPONSE CODE DOI: 10.13040/IJPSR.0975-8232.10(5).2417-22 The article can be accessed online on www.ijpsr.com DOI link: http://dx.doi.org/10.13040/IJPSR.0975-8232.10(5).2417-22 The plant is a small annual herb characterized by the yellowish flower, blackish tuberous primary root with dense lateral roots, aerial part possessing numerous linear leaves arranged in rosettes. According to WHO 80% world population relies on traditional medicines for the treatment of common illness 3 . At present, phytochemicals are more in demand in comparison to synthetic drugs due to its fewer side effects, lesser immuno-suppressive activity and wide use for the treatment of several diseases 4 . The rhizome of C. orchioides possesses immune stimulant potential 5 , hepatoprotective 6 , antioxidant 7 , and platelet regeneration effect 8 . The present study emphasizes on antibacterial activity against three strains of bacteria, antioxidant activity, total phenol and flavonoid content of the whole plant of Curculigo orchioides. MATERIALS AND ME","PeriodicalId":90866,"journal":{"name":"International journal of pharmaceutical sciences and research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83800409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}